Contraception in the Adolescent - OMED 2019...Combined oral contraceptive pills •Start today! Or...
Transcript of Contraception in the Adolescent - OMED 2019...Combined oral contraceptive pills •Start today! Or...
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ContraceptionintheAdolescent
JoyFriedmanMDOctober8,2017
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Disclosures
• Ihavenoactualorpotentialconflictofinterestinrelationtothisprogramorpresentation.• Iwillmentionoff-labeluseofcontraceptivesincludinguseofcontraceptivesformenstrualmanagement,andextendeduseofshortandlongactingcontraceptivemethods.
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Objectives
• Developstrategiestoengageadolescentsinconversationsaboutpregnancyriskandeffectivenessofcontraceptionmethods
• ApplytheCDC/WHOmedicaleligibilitycriteriaforcontraceptiveuse
• Explainthebenefitsandsideeffectprofilesforcontraceptivemethods
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UUSSTTeeeennPPrreeggnnaanncciieess,,BBiirrtthhssaannddAAbboorrttiioonnss,,22001100..Kost KandHenshawS.www.guttmacher.org/pubs/USTPtrends10.pdf
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BBiirrtthhrraatteessffoorrffeemmaalleessaaggeedd1155––1199,,bbyyrraacceeaannddHHiissppaanniiccoorriiggiinn::UUSS11999911––22001155
www.cdc.gov/nchs/products/databriefs/db259.htm
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Birthsper1000FemalesAged15-19YearsbyRace,2007-2015
MartinJA,HamiltonBE,OstermanMJK,etal.Births:Finaldatafor2015.Nationalvitalstatisticsreport;vol 66,no1.Hyattsville,MD:NationalCenterforHealthStatistics.2017.
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PPeerrcceennttaaggeeooffnneevveerr--mmaarrrriieeddtteeeennaaggeerrss1155--1199yyeeaarrssooffaaggeewwhhoohhaavveeeevveerrhhaaddiinntteerrccoouurrssee,,UUSSNNSSFFGGddaattaahttps://www.cdc.gov/nchs/data/nhsr/nhsr104.pdf
Females 2002 2006-2010 2011-201515-19years 45.5% 42.6% 42.4%15-17years 30.3% 27% 28.1%18-19years 68.8% 62.7% 62.9%
Males 2002 2006-2010 2011-2015
15-19years 45.7% 41.8% 44.2%15-17years 31.3% 28% 31.5%18-19years 64.3% 63.9% 64.3%
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MMeetthhooddssooffccoonnttrraacceeppttiioonneevveerruusseeddaammoonnggffeemmaalleessaaggeedd1155––1199wwhhoohhaaddeevveerrhhaaddsseexxuuaalliinntteerrccoouurrssee::UUnniitteeddSSttaatteess,,22000022,,22000066––22001100,,aanndd22001111––22001133
https://www.cdc.gov/nchs/products/databriefs/db209.htm
Thepercentageoffemaleteenagerswhoeverusedemergencycontraceptionincreasedin2006–2010andin2011–2013(p <0.05).2DifferenceinpercentageoffemaleteenagerswhoeverusedDepo-Proveraorthepatchwassignificantlylowerin2011–2013thanin2006–2010(p <0.05).NOTES:Neitherthecontraceptiveringnortheimplantwereavailablein2002.ThenumberofteenagerswhohadeverusedtheIUDin2002wastoosmalltobestatisticallyreliable.
SOURCE:CDC/NCHS,NationalSurveyofFamilyGrowth,2002,2006–2010,and2011–2013.
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Challengesinprovisionofcontraceptiontoteens
• Confidentialityissues:perceivedorreal• Privacyissues:EOBforprivatelyinsuredadolescents;EHRbreaches• Accessissues:distancetotraveltoclinics,hoursofoperation• Fundingforcontraceptionandfutureofmandatedcontraceptioncoveragewithnoco-payuncertain• Theteenagebrain:invincibility,rewardsofrisktakingbehaviors,attentionspan
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Startingtheconversation
• Warmup:patient-centeredquestionstounderstandtheiragendabeforeaskingaboutsexualhistory• OneKeyQuestion:Wouldyouliketobecomepregnantinthenextoneyear?• RULEformotivationalinterviewing
• Resist the“rightingreflex”ortellingthepatientwhattodo• Understand thepatient’smotivations:openendedquestions• Listen andusereflectionstodemonstratediscrepanciesifneeded• Empower thepatienttomakechangesandsupportself-efficacy
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USMECKey
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2016USMECandSPRApp
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UsingtheMECApp
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TThhrroommbboossiiss::ssyynneerrggiissttiiccrriisskkffaaccttoorrssTrenor,Chungetal.Pediatrics,2011
Riskfactor RiskEstimate Riskestimate+COCCOC - 3-5xPregnancyandpostpartum
4.3-10x
FactorVLeidenheterozygote
4-8x 28-35x
ProthrombinG20210Aheterozygote
2-3x 16x
Trauma/surgery 2-5x 5-12.5xTravel 2-4x 14-20xObesity 1.7-2.4x 10-24xSmoking(15+cig/day) 1.4-3.3x 8.8x
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RReellaattiivveerriisskkffoorrvveennoouusstthhrroommbbooeemmbboolliissmm::ASRM,Fertil Steril 2016
RRrelativetonon-users
RRrelativeToEE/LNG
Absoluterisk
Notpregnant,nottakinghormones
1 - VTE:1-5/10,000
EE/LNG 2.8(CI2.0-4.1) - EE/Drosperinone 3.8(CI2.7-5.4) 1.3(CI1.0-1.8) Pregnancy 4.29* VTE:5-20/10,000
PE:1Post-partum 4.29* VTE:40-65/10,000
PE:16/10,000*4.29CI(3.49-5.22)forpregnancyandpostpartum
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VVTTEErriisskkiinnCCHHCCuusseerrssaaccccoorrddiinnggttootthheerroouutteeooffaaddmmiinniissttrraattiioonnaannddttyyppeeooffpprrooggeessttiinnSitruk-Ware.Hormonalcontraceptionandthrombosis.Fertil Steril 2016.
Author Drosperinone+EE NGMN+EE(patch) ETN+EE(ring)FDA-CDCcohort2012 RRofVTE95%CI
1.74(1.42-2.14)
1.55(1.17-2.07)
1.56(1.02-2.37)
Lidegaardcohort2012 RRvs.non-use95%CI
7.9(3.5-17.7)
6.5(4.7-8.9)
RRvs.LNGusers95%CI
2.3(1.0-5.2)
1.9(1.3-2.7)
Dinger AdjustedHRvs.OC95%CI
0.8a0.4-1.5
0.8b0.5-1.6
Jick2010 RRvs.LNGusers95%CI
1.1(0.6-2.1)
aAdjustedHRvs.LNGOC(2007) bAdjustedHRvs.OC(2013)
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Paragard Mirena/Liletta Skyla KyleenaMechanismofaction/dose
Copperreleasing 52mgLNG(20mcgdaily)
13.5mgLNG(14mcgdaily)
19.5mgLNG(17.5mcgdaily)
YearapprovedbyFDA
1988 2001Mirena2015Liletta
2013 2016
Yearseffective 10-12 5-7Mirena3-7Liletta
3 5
BleedingPattern Heavier,longerduration,morecramps
Spottingandirregularbleedinginitially,lighterovertime
Spottingandirregularbleedinginitially,irregularbleedingmaypersist;lighterperiodsovertime
Spottingandirregularbleedinginitially,irregularbleedingmaypersist;lighterperiodsovertime
Likelihoodofamenorrhea
NA 20%atoneyear50%at5years
6%atoneyear12%at3years
12%atoneyear23%at5years
Notablecharacteristics
CanbeusedasECwithin5days
Bioequivalentdevices,Lilettalowercostandlabelledforallwomen
Slightlysmallerapplicatoranddevice,marketedtowardsnulliparouswomen
Slightlysmallerapplicatoranddevice,marketedtowardsnulliparouswomen
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HowtoprepareyourpatientforanIUD
• ScreenforSTI(ideally)• Discusshormone-containingvscopper-containingoption• Prepareherforunpredictablebleedingwithhormone-containingIUD;donotpromiseamenorrhea• Reinforceabstinenceorconsistentcontraceptiveandcondomuseinmonthbeforeinsertion• Prepareherforsomecramping:NSAID1hourbeforetheprocedure
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PostIUDcare
• Stringcheck• AnnualGyn exam• RoutineSTIscreening
Frombedsider.org
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SubdermalImplant:Nexplanon®
• Effectiveforupto3years• >99.9%effectiveforpreventionofpregnancy• Rapidreturntofertility• Discrete– devicemaybeseenandshouldbepalpable• Mechanismofactionispreventionofovulation,thinningoftheendometrium,thickeningofcervicalmucus
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Howtoprepareyourpatientforthesubdermalimplant
• Discusslikelysideeffectofunpredictablebleeding– fewerthan1/3willhaveheavyorprolongedbleeding• ScreenforSTI• Discussinsertionprocedure:lessthan5min,lidocaineinjectionisthemostuncomfortablepartoftheprocedure• Shewillhavetowearabandageonherarmfortherestofthedayandshouldwaittil thefollowingdaytoshower• Usecondomsorabstainforatleast1week
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DDeeppoottmmeeddrrooxxyypprrooggeesstteerroonneeaacceettaattee(DMPA,DepoProvera®)
• Scheduleshotsevery11-13weeks• Efficacyintypical-usesettingis97%• Decreasedmenstrualbleedinginmostusersafter6-9monthsusewithamenorrheain46-55%ofusersafter1year• Private,convenientmethod• Progestinonly– canbeusedinpatientswithcontraindicationstoestrogenuse• Mechanismofactionispreventionofovulation,thickeningofcervicalmucus,thinningendometrium
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DDMMPPAA
• Worksfor14weeksminimum• Takes7daystostartworking• Bonemineralizationisaffectedduringuse• Maybereversibleafterdiscontinuationinspine>hip
• Donotneedtodiscontinueuseafter2yearsforbonehealth• Nomonitoring(=NoDEXAscans)• Weightgainissignificantin25%ofusers
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IItt’’ssookkttooQQuuiicckkSSttaarrtt
• Checkurinepregnancytest**• GivePlanBifindicatedsamedayastakingDepo• InformpatientthatittakesDepo7daystostartworking– usecondomsorabstain• Repeaturinepregnancytestin2-3weeks• Noevidenceofteratogenicity
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CCoonnttrraacceeppttiivveeppaattcchh(OrthoEvra®/Xulane®)
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CCoonnttrraacceeppttiivveeppaattcchh
• Efficacyintypical-usescenarioisthesimilartothepill– 91%• Takes7daystostartworking– usebackupcontraceptionorabstain• CanQuickStartthepatch(andprovidewithPlanBifneeded)• Commoncomplaintswithstartingincludenausea,breasttenderness,headaches,stickyresidue,marksontheskin• IncreasedsystemicexposuretoestrogenthanwithOCPalthoughlowerpeaklevelsofestrogen;maynottranslatetoincreasedriskofVTE• Mechanismofactionispreventingovulation,thickeningcervicalmucus• Maynotworkaswellinwomen>90kg
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IInnttrraavvaaggiinnaallrriinngg::NNuuvvaarriinngg®®
• Sameasthepatchandpill– 3weeksofhormonesthen1weekoff• ORitcanbeusedcontinuously– usefor4weeksandskiphormonefreeinterval• Canusecardboardtamponapplicatortoinsertit• Limitring“holidays”to3hoursorusebackupcontraceptionfor7days• Commonsideeffectsincludeheadache,leukorrhea• LessestrogenexposurethanOCPbutriskofVTEsimilartoOCP
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CCoommbbiinneeddoorraallccoonnttrraacceeppttiivveeppiillllss
• Mostcommonlyusedhormonalcontraceptivemethod• Typical-usefailurerateforadolescentwomeninoneyearofuseis9%• Mechanismofaction– thickeningthecervicalmucus,inhibitionofovulation,thinningendometrium• 7daystostartworking• Manyformulations• Tryamonophasicwith30-35mcgE2forteens• Lowerestradiol(E2):20mcgifsideeffects
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CCoommbbiinneeddoorraallccoonnttrraacceeppttiivveeppiillllss
• Starttoday!OrSundayorfirstdayofmensesorwhenever– juststart!• If>5daysfromLMPthenusebackupcontraceptionfor7days
• Quickstartdemonstratedbetteroddsofstartingasecondpack,butnobetteradherenceat3and6months• NosignificantdifferenceinnumberofusersexperiencingbreakthroughbleedingwithQuickStartvs.conventionalstart• Demonstratewithactualpackageifpossible,asktoseetheirpackofpillsatfollowupvisitsifpatienthasitwithher• Anticipatemissingpillsanddiscusshowtomanage
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CCOOCC::eexxtteennddeeddoorrccoonnttiinnuuoouussccyycclliinngg
• Patientsdothisallthetimewhetherwediscussitornot• Anotherreasontoprescribemonophasicpillsforteens
• Fewermenstrualsymptoms:headaches,PMS,dysmenorrhea,fewermissedpillsanddecreasedchancesforovulation• Insurancemaydictatepatient’sabilitytogetanotherpackifsheskipsplacebos;someinsurancecompaniescoverthe84/7packs• Ifthisisnotaproblem,patientcantry42/7,63/7or84/7orjusttakethemcontinuouslyuntilbreakthroughbleedingoccurs,thenstop7days
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DDooeesstthheeppiillllccaauusseewweeiigghhttggaaiinn??
• StudiesshownoadditionalweightgaininOCPuserswhencomparedwithnon-users(onaverage)• Pillsdonothavecalories• Somepatientsmayfeelhungry– avoidfastfood,junkfood,increaseexerciseanddecreasescreentime
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PPrrooggeessttiinnoonnllyyppiillllss((PPOOPPoorr““tthheemmiinniippiillll””))
• NorestrictionsforuseforpatientswithHTN,migrainewithaura,familyhistoryofVTEinfirstdegreerelative• Doesinteractwithenzymeinducinganticonvulsants• Notusefulforsuppressingformationofovariancysts• Noplaceboweek,mayresultinamenorrheaorunpredictablebleeding• Mechanismofaction:thickeningcervicalmucus• Shortdurationofaction– wait2hrs aftertakingthepilltohavesex• If>3hrs late,usebackupcontraceptionforthenext48hrs
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RReemmeemmbbeerr??TThhiissiissyyoouurrrreemmiinnddeerr..
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MenstrualCycle
UPA:DelaysLHsurgeLNG:PreventsLHsurge
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UUlliipprriissttaall AAcceettaatteeiissmmoorreeeeffffeeccttiivveetthhaannLLNNGGEECCaatt7722hhoouurrss((aanndduuppttoo112200hhoouurrss))aafftteerruunnpprrootteecctteeddiinntteerrccoouurrssee
1.80%&2.60%&
5.50%&
0.00%&
1.00%&
2.00%&
3.00%&
4.00%&
5.00%&
6.00%&
Ulipristal&acetate& Levonorgestrel& No&treatment&
Pre
gnan
cy R
ate
(Per
cent
)
Pregnancy)Rate)
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EECC::DDiissppeelllliinnggtthheemmyytthhss
• ECpillsareNOTabortifacientmedications• ECdoesnotharmanexistingpregnancy;Ulipristal Acetateisnotwellstudiedinpregnantwomen• Disruptnormalfolliculardevelopmentbydelayingorinhibitingovulation• ECPDONOTpreventfertilizationorimplantation• ECParenoteffectiveoncefertilizationoccurs• ECusedoesnotaffectfuturefertility,evenwithrepeatuse
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PPrroovviissiioonnaallEEmmeerrggeennccyyCCoonnttrraacceeppttiioonn
• ProvideRxforECatthetimeofclinicvisit• Forpatientsusingcondomsonlyforcontraception• ForpatientsusingshortactingmethodsorDMPA• Forpatientswhoareunsureaboutbirthcontrolandthinkingitover
• InsuranceplansoftendictatecoverageandlackofavailabilityofElla®maylimitaccess• PlanB®andgenericsareavailableOTCwithoutascript– noagelimitbutiscostly:$40-$55atapharmacyandfor$25atafterpill.com• Ella®isavailablebyRxonlyandviaonlinepharmacyforpurchaseatkwikmed.com$67
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Insummary• Beanapproachableadult• Askteensthe“onekeyquestion”routinely• Usemotivationalinterviewingtounderstandtheiragendaregardingcontraception• Considerifanycontraindicationstospecificcontraceptives• Offerthemosteffectivemethodsasfirstlinemethodsforteens• Anyeffectivecontraceptionisbetterthannocontraception!• Recommenddualprotectionwithcondomsandcontraceptives• Offerprovisionalemergencycontraceptionwhenappropriateandexplainwhenitwouldbeused
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Frombedsider.org