CONTENTS 1334 & 1391science.sciencemag.org/content/sci/359/6382.toc.pdf(air assist delivery): $89....
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GRAPHIC (TOP): A. KITTERMAN/SCIENCE; ILLUSTRATION: DANIEL HERTZBERG 23 MARCH 2018 • VOL 359 ISSUE 6382 1301 SCIENCE sciencemag.org 23 MARCH 2018 • VOLUME 359 • ISSUE 6382 CONTENTS 1334 & 1391 Electron transport in radical polymers NEWS IN BRIEF 1310 News at a glance IN DEPTH 1314 U.K. ATTACK PUTS NERVE AGENT IN SPOTLIGHT Researchers race to understand deadly compound developed by Soviet scientists By R. Stone 1315 ACCOUNTING RULES HOBBLE SPANISH INSTITUTES Staff at centers for solar energy research and oceanography raise alarm By T. Rabesandratana 1316 HAWKING’S BID TO SAVE QUANTUM THEORY FROM BLACK HOLES He struggled to explain why black holes don’t destroy information, a puzzle that may be his greatest legacy By A. Cho 1317 Stephen Hawking, betting man By D. Clery 1318 PROTEIN MAY EXPLAIN MORNING SICKNESS, AND WORSE Two groups point to a possible trigger for vomiting, nausea By R. Dengler 1319 A RESEARCH BEHEMOTH IS BORN IN BRITAIN Expectations are high for the new £6 billion funder, UK Research and Innovation By E. Stokstad FEATURES 1320 THE REALIST Vaclav Smil looks to history for the future of energy. What he sees is sobering By P. Voosen INTRODUCTION 1344 The cancer immunotherapy revolution NEWS 1346 Too much of a good thing? J. Kaiser 1348 Sticker shock J. Couzin-Frankel RESEARCH 1350 Cancer immunotherapy using checkpoint blockade A. Ribas and J. D. Wolchok 1355 Personalized vaccines for cancer immunotherapy U. Sahin and Ö. Türeci 1361 CAR T cell immunotherapy for human cancer C. H. June et al. 1366 The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies L. Zitvogel et al. SPECIAL SECTION Cancer immunotherapy ON THE COVER Artist’s rendering of a patient receiving personalized treatment for cancer. With the help of newly developed immunotherapies, a growing number of patients are partners in their own treatment. For more on techniques and strategies for cancer immunotherapy, see page 1344. Illustration: Daniel Hertzberg INSIGHTS PERSPECTIVES 1328 ARE WOOD PELLETS A GREEN FUEL? A return to firewood is bad for forests and for the climate By W. H. Schlesinger 1330 EARLY LIFE EXPERIENCE SHAPES NEURAL GENOME Transposons accumulate in neurons of pups with lack of maternal care in mice By S. Song and J. G. Gleeson ▶ REPORT P. 1395 1331 RNA TARGETING AND TRANSLATION IN AXONS Local translation of transcripts takes center stage in neuron growth and regeneration By A. Riccio ▶ REPORT P. 1416 1333 FROM ROCK-STABLE TO REACTIVE PHOSPHORUS A low-temperature route converts phosphate into an anion useful in chemical synthesis By J. D. Protasiewicz ▶ REPORT P. 1383 1334 A RADICAL ADVANCE FOR CONDUCTING POLYMERS Organic radical polymers can have much higher electrical conductivities than anticipated By J. Lutkenhaus ▶ REPORT P. 1391 1335 TARGETING ANGIOGENIC METABOLISM IN DISEASE Targeting endothelial cell metabolism offers new therapeutic opportunities for various conditions By X. Li and P. Carmeliet POLICY FORUM 1337 EXPANDED HEALTH SYSTEMS FOR SUSTAINABLE DEVELPMENT Advance transformative research for the 2030 agenda By C. Dye Published by AAAS on April 18, 2021 http://science.sciencemag.org/ Downloaded from
Transcript of CONTENTS 1334 & 1391science.sciencemag.org/content/sci/359/6382.toc.pdf(air assist delivery): $89....
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23 MARCH 2018 • VOL 359 ISSUE 6382 1301SCIENCE sciencemag.org
23 MARCH 2018 • VOLUME 359 • ISSUE 6382
CONTENTS1334 & 1391Electron transport in
radical polymers
NEWS
IN BRIEF
1310 News at a glance
IN DEPTH
1314 U.K. ATTACK PUTS NERVE AGENT IN SPOTLIGHTResearchers race to understand
deadly compound developed by Soviet
scientists By R. Stone
1315 ACCOUNTING RULES HOBBLE SPANISH INSTITUTESStaff at centers for solar energy research
and oceanography raise alarm
By T. Rabesandratana
1316 HAWKING’S BID TO SAVE QUANTUM THEORY FROM BLACK HOLESHe struggled to explain why black holes
don’t destroy information, a puzzle that
may be his greatest legacy By A. Cho
1317 Stephen Hawking, betting manBy D. Clery
1318 PROTEIN MAY EXPLAIN MORNING SICKNESS, AND WORSETwo groups point to a possible trigger
for vomiting, nausea By R. Dengler
1319 A RESEARCH BEHEMOTH IS BORN IN BRITAINExpectations are high for the new
£6 billion funder, UK Research and
Innovation By E. Stokstad
FEATURES
1320 THE REALISTVaclav Smil looks to history for the
future of energy. What he sees is
sobering By P. Voosen
INTRODUCTION
1344 The cancer immunotherapy revolution
NEWS
1346 Too much of a good thing?
J. Kaiser
1348 Sticker shock J. Couzin-Frankel
RESEARCH
1350 Cancer immunotherapy using checkpoint blockade
A. Ribas and J. D. Wolchok
1355 Personalized vaccines for cancer immunotherapy U. Sahin and Ö. Türeci
1361 CAR T cell immunotherapy for human cancer C. H. June et al.
1366 The microbiome in cancer immunotherapy: Diagnostic tools and therapeutic strategies L. Zitvogel et al.
SPECIAL SECTION
Cancer immunotherapy
ON THE COVER
Artist’s rendering of a patient receiving personalized treatment for cancer. With the help of newly developed immunotherapies, a growing number of patients are
partners in their own treatment. For more on techniques and strategies for cancer immunotherapy, see page 1344. Illustration: Daniel Hertzberg
INSIGHTS
PERSPECTIVES
1328 ARE WOOD PELLETS A GREEN FUEL?A return to firewood is bad
for forests and for the climate
By W. H. Schlesinger
1330 EARLY LIFE EXPERIENCE SHAPES NEURAL GENOMETransposons accumulate in
neurons of pups with lack of
maternal care in mice
By S. Song and J. G. Gleeson
▶ REPORT P. 1395
1331 RNA TARGETING ANDTRANSLATION IN AXONSLocal translation of transcripts
takes center stage in neuron
growth and regeneration
By A. Riccio
▶ REPORT P. 1416
1333 FROM ROCK-STABLE TO REACTIVE PHOSPHORUSA low-temperature route
converts phosphate into an
anion useful in chemical synthesis
By J. D. Protasiewicz
▶ REPORT P. 1383
1334 A RADICAL ADVANCE FOR CONDUCTING POLYMERSOrganic radical polymers can have
much higher electrical conductivities
than anticipated By J. Lutkenhaus
▶ REPORT P. 1391
1335 TARGETING ANGIOGENIC METABOLISM IN DISEASETargeting endothelial cell metabolism
offers new therapeutic opportunities for
various conditions By X. Li and P. Carmeliet
POLICY FORUM
1337 EXPANDED HEALTH SYSTEMS FOR SUSTAINABLE DEVELPMENTAdvance transformative research
for the 2030 agenda
By C. Dye
DA_0323TOC.indd 1301 3/21/18 11:03 AM
Published by AAAS
on April 18, 2021
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23 MARCH 2018 • VOL 359 ISSUE 6382 1303SCIENCE sciencemag.org
CONTENTS1330 & 1395Maternal care and genome
plasticity
23 MARCH 2018 • VOLUME 359 • ISSUE 6382
1391 CONDUCTING POLYMERSA nonconjugated radical polymer
glass with high electrical conductivity
Y. Joo et al.
▶ PERSPECTIVE P. 1334
1395 NEURODEVELOPMENTEarly life experience drives structural
variation of neural genomes in mice
T. A. Bedrosian et al.
▶ PERSPECTIVE P. 1330; PODCAST
1399 PLANT SCIENCEA single fungal MAP kinase controls
plant cell-to-cell invasion by the rice
blast fungus W. Sakulkoo et al.
CANCER 1403 Lymph node metastases can
invade local blood vessels, exit the
node, and colonize distant organs
in mice E. R. Pereira et al.
1408 Lymph node blood vessels provide
exit routes for metastatic tumor
cell dissemination in mice
M. Brown et al.
1411 BIOCHEMISTRYThe biosynthesis of methanobactin
G. E. Kenney et al.
1416 CELL BIOLOGYLocally translated mTOR controls
axonal local translation in nerve injury
M. Terenzio et al.
▶ PERSPECTIVE P. 1331
SCIENCE (ISSN 0036-8075) is published weekly on Friday, except last week in December, by the American Association for the Advancement of Science, 1200 New York Avenue, NW, Washington, DC 20005. Periodicals mail postage (publication No. 484460) paid at Washington, DC, and additional mailing offices. Copyright © 2018 by the American Association for the Advancement of Science. The title SCIENCE is a registered trademark of the AAAS. Domestic individual membership, including subscription (12 months): $165 ($74 allocated to subscription). Domestic institutional subscription (51 issues): $1808; Foreign postage extra: Mexico, Caribbean (surface mail) $55; other countries (air assist delivery): $89. First class, airmail, student, and emeritus rates on request. Canadian rates with GST available upon request, GST #125488122. Publications Mail Agreement Number 1069624. Printed in the U.S.A.Change of address: Allow 4 weeks, giving old and new addresses and 8-digit account number. Postmaster: Send change of address to AAAS, P.O. Box 96178, Washington, DC 20090–6178. Single-copy sales: $15 each plus shipping and handling; bulk rate on request. Authorization to reproduce material for internal or personal use under circumstances not falling within the fair use provisions of the Copyright Act is granted by AAAS to libraries and others who use Copyright Clearance Center (CCC) Pay-Per-Use services provided that $35.00 per article is paid directly to CCC, 222 Rosewood Drive, Danvers, MA 01923. The identification code for Science is 0036-8075. Science is indexed in the Reader’s Guide to Periodical Literature and in several specialized indexes.
DEPARTMENTS
1309 EDITORIAL Lumping and splitting
By Jeremy Berg
1434 WORKING LIFEThe freedom of choice
By Irini Topalidou
Science Staff ............................................1306
New Products ........................................... 1422
Science Careers ....................................... 1423
1340
1Mat
pla
RESEARCH
IN BRIEF
1373 From Science and other journals
RESEARCH ARTICLES
1376 INFECTIONHyperglycemia drives intestinal
barrier dysfunction and risk for
enteric infection C. A. Thaiss et al.
REPORTS
1383 INORGANIC CHEMISTRYPhosphoric acid as a precursor to
chemicals traditionally synthesized
from white phosphorus
M. B. Geeson and C. C. Cummins
▶ PERSPECTIVE P. 1333
1386 MATERIALS SCIENCEBioinspired spring origami
J. A. Faber et al.
BOOKS ET AL.
1340 BEFORE WE CALLED IT “CLIMATE CHANGE”A researcher collects accounts of
scientists’ first inklings that the Arctic
was in trouble By S. Boon
1341 KNOWLEDGE, WISDOM,AND THE BRAINA neuroscientist’s battle with brain cancer
prompts a personal reflection on identity
and the disease process By A. Hayden
LETTERS
1342 SHORTFIN MAKO SHARKSTHREATENED BY INACTIONBy D. W. Sims et al.
1342 MITIGATE RISK FOR MALAYSIA’S MANGROVESBy A. Aldrie Amir
1343 INDIA’S PH.D. SCHOLAROUTREACH REQUIREMENTBy A. S. D. Rajput
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