Containers and closures
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Transcript of Containers and closures
Prepared and presented by Ibrahim bin Abdullah for MSU Diploma Pharmacy
BOTTLES AND CONTAINERS
PACKAGING MATERIAL
Glass
Plastic
AdvantagesDisadvantages
AdvantagesDisadvantages
GLASSAdv
• Inert• Impervious• Easy inspection• Easy to clean• Easy to sterilize• Easy to shape
Disadv
• Fragile• Release alkali• Expensive• Heavy
PLASTICAdv
• Flexible• Light• Can be heat-sealed• Easily moulded• 2o packaging• Cheap
Disadv
• Less inert• Cracking, distortion• Less permeable• Heat sensitive• Charged• Easily leached
GLASS
Type 1 Type 2
Type 3 Type 4
Type
Know made, advantages, disadvantages and uses of each type
INJECTION
CONTAINER
INJECTION CONTAINERCharacteristics
Material should not affect the content
Must be strong enough to withstand the changes of
temperature and pressure (heat sterilization)
Protect the contents from harmful light radiations
Must be suitable for repeated use
Easy to clean
Cheap enough to discard
Should be transparent and colourless
INJECTION CONTAINERType
Single-dose injections of small
volume
Multiple-dose
injections
Single-dose injections
of large volume
AmpoulesCartridges
Glass bottlesPVC collapsible bagsSemi-rigid polythene containers
CLOSURES
CLOSURESCharacteristics
Good ageing qualities
Satisfactory hardness and elasticity
Resistance to sterilisation condition
Impermeable (resistant) to moisture and air
Negligible release of undesirable substances
Negligible extraction of injection ingredients