Connective tissue - kpfu.ru• Is a combination of dense regular connective tissue and hyaline...
Transcript of Connective tissue - kpfu.ru• Is a combination of dense regular connective tissue and hyaline...
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Connective tissue
Part 1
CONNECTIVE TISSUE
Part II
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Skeletal CT
Cartilage Bone
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Cartilage
• Specialized form of firm and
resilient CT that can bear
stresses without permanent
distortion
• Consists of cells and
extracellular matrix
• Is covered by perichondrium
• Is an avascular tissue
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Cartilage Cells
• chondroblasts – immature cells– In the inner layer of the
perichondrium and right under in the lacunae
– Synthesize the matrix
• chondrocytes –differentiated cartilage cells– In the center of the
cartilage in the lacunae
– form isogenous groups
– Synthesize cartilage matrix
– Synthesize enzymes braking down the matrix -collagenase, elastase, hyaluronidase
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Cartilage matrix(95% of cartilage volume)
• Fibers collagen type II
• Ground substance:
- Hyaluranan (hyaluronic acid)
- Proteoglycans:
# Core protein
# GAGs:
* chondroitin sulfate
* keratan sulfate
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Perichondrium
• 2 layers:– external – dense CT
– internal – cellular or chondrogenic (loose CT + chondroblasts +blood vessels)
• Function: nutrition, appositional growth, repair
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perichondrium
chondroblasts
chondrocytes
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Growth of cartilage
• Appositional growth- formation of new cartilage
on the surface of pre-existing
cartilage
* Occurs within inner layer of
perichondrium
* Differentiation of
chondroblasts and
chondrogenic cells into the
chondrocytes
* Growth in girth
• Interstitial growth- formation of new cartilage
within the cartilage mass.
* Existing chondrocytes
divide within lacunae
creating isogenous groups
* New chondrocytes secrete
more matrix
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Inte
rstitia
l gro
wth
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Types
of cartilage
– HYALINE
– ELASTIC
– FIBROUSE
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• The most abundant type of cartilage
• Provides support through resilience
• Extracellular matrix looks translucent with no clearly visible collagen fibers (glassy appearance)
• Chondrocytes lay in lacunae
• Found in: fetal skeleton, trachea, most of the laryngeal cartilages, articular cartilage, ends of ribs, external nose, epiphyseal plates
• Mainly covered by perichondrium (except the articular cartilages!)
Hyaline cartilage
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Hyaline cartilage
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Elastic cartilage
• Dense network of elastic fibers in
addition to collagen fibers
• More fibers in the center of the
cartilage
• Provides flexible support and
maintains shape
• Surrounded by a perichondrium
• Found in: external ear, epiglottis,
corniculate and cuneiform cartilages
of the larynx
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Elastic fibers stained by Weigert
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Elastic cartilage – darker staining matrix
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• Is a combination of dense regular connective
tissue and hyaline cartilage
• Consists of chondrocytes and their matrix
material in combination with dense connective
tissue
• Chondrocytes are dispersed among the
collagen fibers singularly, in rows, and in
isogenous groups
• Gives support and rigidity
• Found in: pubic symphysis, annulus fibrosus of
the intervertebral disk, menisci of the knee
joint, some tendons insertions
Fibrous cartilage
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Fibrous cartilage
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• Second to cartilage in ability
to withstand compression
and second to enamel in
hardness
• Consists of extracellular
matrix and cells
• Covered by periosteum from
the outside
• Covered by endosteum from
the inside
Bone tissue
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Functions of bone
• Major support of the body
• Protection for internal organs
• Attachment for muscle tendons, creating
lever systems for body movement
• Harbors hematopoietic organs (red bone
marrow)
• Storage for calcium and other essential
minerals
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Extracellular bone matrix
• Organic part –
50% of volume (25 % of weight)
• Inorganic part –
50% of volume (75% of weight)
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Bone matrix
• It is like reinforced concrete where steel bars are collagen
fibers and cement is hydroxyapatite
• Thus, it is responsible for major functional characteristic of
the bone
• If the mineral is removed, bone is
too flexible
• If the collagen is removed, bone is
too fragile
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Organic components
• Are synthesized by osteoblasts
– Fibers: Collagen type I (90-95%)
– Amorphous substance:
*proteoglycans
*glycoproteins
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Inorganic part
• Mainly Calcium (35%) and
Phosphate (50%), form
hydroxyapatite crystals
• Which make junctions with
collagen
• Some bicarbonate,
potassium, magnesium
and citrate
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Bone Cells
• Osteoprogenitor cells (bone stem cells)
• Osteoblasts (matrix synthesis)
• Osteocytes (maintain matrix)
• Osteoclasts – bone macrophages, bone resorbtion (develop
from blood monocytes)
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Osteoprogenitor cells
• Develop from undifferentiated mesenchyme cells
• Lay in the inner layer of periosteum
• Function – stem cells, they are osteoblasts precursors
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Osteoblasts• Differentiate from osteoprogenitor
cells
• Are on the surface of the bone and around blood vessels
• function – bone matrix synthesis
• once surrounded with secreted matrix, it is referred to as an osteocyte.
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Osteocytes• Differentiate from osteoblasts
• Have long processes – philopodia by
means of which cells contact and
exchange nutrients
• Cells lay in the lacunae, processe – in
the canaliculi
• Function – bone matrix maintaining
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Osteoclasts• Lay in the Howship’s lacunae
• Large multinucleated cells
• Ruffled border – plasma-membrane infoldings on the side facing the matrix, forming many compartments where enzymes are released
• Function – bone matrix resorption
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PERIOSTEUM
• 2 layers:– external – dense CT
– internal – loose CT +
osteogenic sells + osteoblasts
– Sharpey’s fibers – collagen
fibers that anchor periosteum to
the bone
• Functions: nutrition, growth
of bone in girth, repair
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ENDOSTEUM• Covers inner surface of bones, marrow cavities
• Structure resembles the inner layer of periosteum
• Contains bone and blood cell precursor
• Extends into the Haversian canals
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Types of bones
I. - Primary (woven) bones
- Secondary (lamellar) bones
II. - Long bones
- Flat bones
III. - Spongy (cancellous) bones
- Compact bones
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Primary bone
• First bone tissue that appears in
embryonic development and
fraction repair
• Collagen fibers are arranged in
irregular arrays
• Many cells, less minerals
• Eventually replaced by secondary
bone, except cranial sutures and
alveolus of maxilla and mandible
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Secondary bone
• Mature bone with
collagen fibers that are
arranged in lamellae
• Fiber are well
organized around
vascular canal
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Long bones
-diaphysis (compact bone)
-epiphysis (spongy bone)
-medullary cavity (bone
marrow)
Flat bones
-two layers of compact bone
-spongy bone between them
(diploe)
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Compact bone Spongy bone
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Spongy bone
• 3D lattice of trabeculae with many open spaces
• Slips of bone between spaces – trabeculae, align along the
lines of stress
• Can be primary or secondary bone
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Spongy bones
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Compact bone
(osteon)
• Series of concentric
lamellae around the
Haversian canal
• Haversian canal –
vessels, nerves
• Collagen fibers in one
lamellae are parallel, in
the adjacent lamellae –
perpendicular
• Osteocytes lay in the
lacunae, their filopodia
– in the canaliculi
• Volkmann’s canals –
vascular connections
between osteons
• Interstitial lamellae –
remnants of old lamellae
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Bone formation/
osteogenesis
Intramembranous Endochondral
(mesenchyme) (cartilage model)
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Intramembranous bone formation
• Takes place in the embryonic mesenchyme
• Forms flat bones of the scull, mandible,
clavicles
Mesenchyme cells Osteogenic cells
Organic matrix Osteolasts
Calcification Osteocytes
Periosteum Blood vessels
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Endochondral bone formation
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Bone growth in
length• Epiphyseal plate –
between diaphysis and epiphysis
– Proliferation and growth of cartilage from epiphysis side
– Turnover of cartilage into bone from the diaphysis side
– Growth hormone (pituitary gland)
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Growth of bone in width•By the appositional growth on the bone surface
•Periosteal cell differentiate into the osteoblasts and form bony ridges and then
tunnels around vessels
•Concentric lamellae fill in the tunnel to form the osteon
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Bone remodeling
• Takes place throughout life
• Osteoclasts – remove old bone
• Osteoblasts – deposit new bone
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1. Formation of blood clot at the site of injury
2. Formation of the cartilage callus
3. Formation of woven bone
4. Remodeling and replacing of primary bone by secondary bone
Bone fracture
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Hormone regulation
• PTH (parathyroid gland)
level of Ca in blood
• Calcitonin (thyroid
gland) level of Ca in
blood
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Factors affecting bone tissue:
• Protein deficiency
• Ca deficiency (defect
matrix calcification-
rickets/osteomalacia)
• VitD deficiency (Ca++ is
not absorbed in the
intestines)
• VitA deficiency (defect
synthesis of GAGs and
bone growth)
• VitA excess (early closure
of epiphyseal plates)
• VitC deficiency (defect
collagen synthesis)
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