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Conformational Flexibility Influences Structure-Function Relationships in Nucleic Acid N-Methyl Demethylases

Sodiq O. Waheed,a,& Rajeev Ramanan,a,& Shobhit S. Chaturvedi,a Jon Ainsley,b Martin Evison,b

Jennifer M. Ames,c Christopher J. Schofield,d, * Christo Z. Christov,a,b * and Tatyana G. Karabencheva-Christovaa,b *

a Department of Chemistry, Michigan Technological University, Houghton, Michigan 49931,

United States. b Faculty of Health and Life Sciences, Northumbria University, Newcastle upon Tyne, NE1 8ST,

United Kingdom. c Centre for Research in Biosciences, Faculty of Health and Applied Sciences, University of the

West of England, Bristol, BS16 1QY, United Kingdom. Present address: Jenny Ames Consulting

Ltd, Reading, RG6 5PY, United Kingdom. d The Chemistry Research Laboratory, The Department of Chemistry, Mansfield Road,

University of Oxford, Oxford, OX1 3TA, United Kingdom. &S.O.W., and R.R. made equal contributions to this article.

*C.J.S., C.Z.C and T.G.K.C. are joint corresponding authors.

Electronic Supplementary Material (ESI) for Organic & Biomolecular Chemistry.This journal is © The Royal Society of Chemistry 2019

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Table of Contents Methods

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List of Figures S7 S8 S9 S10

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List of Tables S21

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Table S3

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Table S4

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A B

C D

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