Computer Simulation of Tumour Response to therapy
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COMPUTER SIMULATION OF TUMOUR RESPONSE TO THERAPY
description
Computer Simulation of Tumour Response to therapy. Introduction. Introduction. Efforts have been made in mathematically simulating tumour growth and response to various therapeutic schemes. - PowerPoint PPT Presentation
Transcript of Computer Simulation of Tumour Response to therapy
COMPUTER SIMULATION OFTUMOUR RESPONSE TO THERAPY
Introduction
Introduction Efforts have been made in mathematically
simulating tumour growth and response to various therapeutic schemes.
Mathematical analysis and discrete mathematics (theory of algorithms, graph theory, cellular automata, finite state machines, etc.) along with probability theory have played central roles in this process.
OrganizationsAlthough This field is new, there are
already organizations working in this field.
EG: In silico oncologyhttp://www.in-silico-oncology.iccs.ntua.gr/
Identification and mapping
Tumour growth simulation
Tumour progression
Two major forms of tumour progression can be distinguished:
avascular (or prevascular) and neovascularized tumour growth.
The Cancer “Story” The tumour spheroid
formation starts with the placement of a single tumour cell at the stage of mitosis
Spatial communication between cells at any angular direction is possible.
The cell lysis and apoptosis products are gradually diffused towards the outer environment of the tumour.
Simulation simplified Tumour expansion is achieved
computationally by shifting a cell chain from the newly occupied cubic element towards the external environment of the tumour in a random direction
Tumour shrinkage is simulated by shifting a cell chain from the external environment of the tumour towards the cell that has to disappear in a direction defined by the cell.
How A virtual 3D tumour reconstruction
based on appropriate combinations of tomographic data collected through T1-weighted gadolinium-enhanced computerized tomography (CT), positron emission tomography (PET), etc. takes place before running the actual simulation.
How Mechanical considerations, such as
the boundary conditions imposed by the skull in the case of brain tumours, are made.
All other information such as biopsy full details are also included in the model
Radiotherapy modeling
Prediction EXERCISE
Predict how will the tumor grow
Predict how will the tumor grow
Predict how will the tumor grow
Predict how will the tumor grow
Questions?!THANK YOU!
