Comprehensive surgical management of the paralyzed diaphragm
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Transcript of Comprehensive surgical management of the paralyzed diaphragm
Comprehensive Surgical Comprehensive Surgical Management of the Paralyzed Management of the Paralyzed
DiaphragmDiaphragm
Matthew R. Kaufman, MD, FACSPlastic & Reconstructive Surgery
The Center for Treatment of Paralysis and Reconstructive
Nerve Surgery
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Surgical Management of the Paralyzed Diaphragm
• No financial disclosures
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Phrenic NerveAnatomy
• Originates from C3-C5– Primarily C4
• Motor innervation to diaphragm
• Sensory fibers– Pleura – Pericardium– Abdominal
components
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Phrenic Nerve AnatomyAccessory Phrenic Nerve
• Occurs in 15-25% of people• A branch of C5 which would otherwise
pass to subclavius• Begins lateral to the phrenic nerve in the
neck • Obliquely traverses scalenus anterior• Joins the phrenic nerve at the root of the
neck• Also supplies diaphragm with efferent
fibers
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Phrenic Nerve AnatomyAccessory Phrenic Nerve
Accessory Phrenic Nerve
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Respiratory Physiology•Volitional (day time)
breathing controlled by respiratory control center
•Night breathing regulated by CO2 levels measured in brain
•Signals go down nerves in the neck, chest to diaphragm
•Phrenic nerve branches out into the diaphragm muscles
•The diaphragm muscles contract drawing in air
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm ParalysisEtiology
• Peripheral (Phrenic Nerve Injury)
– Iatrogenic• Surgery• Anesthetic Blocks• Chiropractic
– Trauma• Blunt• Penetrating
– Neuropathy / Neuritis
– Viral
• Central – Spinal Cord Injury– Cord Compression– Central
Hypoventilation Syndrome
• Ondine’s Curse
– Tumors
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm ParalysisPhrenic Nerve Injury
• Demographics– Usually unilateral– Rarely ventilator or oxygen dependent– Severe limitations in physical functioning– Association with sleep-disordered breathing– PFTs often normal or near-normal– Abnormal Sniff Test– Told by MD: “…just learn to live with it…”– Some are offered diaphragm plication
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Phrenic Nerve InjuryEtiology
• Iatrogenic– Neck
• Interscalene Block• Cervical Epidural• Neck Dissection• Carotid Bypass• Chiropractic
Manipulation
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Phrenic Nerve InjuryEtiology
• Iatrogenic – Mediastinal / Chest
• Carotid-Subclavian Bypass• Aortic Surgery• Thymectomy• Coronary Bypass• Thoracic Outlet Release
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Phrenic Nerve InjuryMediastinal Surgery
• Thymectomy
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencyDiaphragm Paralysis
• Spinal Cord Injury– Usually C3 or higher (rarely C4-C5)– Ventilator Dependent– Tracheostomy Dependent
• Central Hypoventilation Syndrome– Ondine’s curse– Oxygen dependent– Ventilator/ Bi-Pap at night
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencyDiaphragm Paralysis
• Spinal Cord Injury (SCI)– 11,000 new cases/year– >50% cervical level– Interruption of descending bulbospinal respiratory
pathways• Respiratory paresis or paralysis
– Primary cause of death after SCI, regardless of level – Respiratory *
*National Spinal Cord Injury Statistical Center, 2006
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencySpinal Cord Injury
• Effect of SCI on Respiration– Paralysis of respiratory muscles
• Diaphragm– Major inspiratory muscle– Innervated by phrenic
motoneurons C3-5
• Accessory respiratory muscles– Intercostals– Thoracic/Abdominal muscles
– Reduction in tidal volume– Blunted response to hypercapnia
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencySpinal Cord Injury
SCI is among the most expensive condition among all causes for hospitalization.
Severity of Injury
Avg Yearly Expenses 1st Yr
Avg. Yearly ExpensesSubsequent
Estimated Lifetime Costs 25 yrs old
Estimated Lifetime Cost 50 yrs old
High (C1-C4) Tetraplegia $775,567 $138,923 $3,059,184 $1,800,958
Low (C5-C8) Tetraplegia $500,829 $56,905 $1,729,754 $1,095,411
Yet a 20 year old tetraplegic on MV has their life expectancy drop by ~18 yrs vs. non-depenadent1
National Spinal Cord Injury Statistical Center, Birmingham, Alabama January 2008Treatment of Pulmonary Disease Following Cervical Spinal Cord Injury, Evidence
Report/Technology Assessment, Number 27
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencyImpact On the Diaphragm
• Compared 14 brain dead donors on PPV to 8 controls
• 18 hours of PPV causes marked atrophy
• 57% decrease Type 1 slow twitch
• Active muscles atrophy faster
• Inactivity leads to oxidative stress
• Increased proteolysis
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencyDiaphragm Paralysis
• A CNS problem with no clinical CNS solution
• Peripheral nerve solution(s)– Electrical stimulation– Nerve transfer– Electrical stimulation +
Nerve transfer
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencySpinal Cord Injury
• Above level of injury– Functioning nerves
• At level of injury– Inability to propagate a nerve stimulus– Cannot respond to externally applied
electrical stimulus• Below level of injury
– Inability to propagate a nerve stimulus– May respond to externally applied
electrical stimulus
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencyCongenital Central Hypoventilation
Syndrome(Ondine’s Curse)• Demographics
• Rare disorder (1 in 200,000/U.S.)• No known cure
• Pathophysiology• Problem integrating chemoreceptor
input to central ventilatory controllers• Genetic mutation identified• Association with Hirschprung’s disease
• Characteristics• Breathe reasonably well while awake• Apneic during sleep - require ventilatory
support • A third require ventilatory support
24h/day
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencyDiaphragm Pacing
• Purpose– Electrically pulse phrenic nerves (or nerve/muscle
interface), causing diaphragmatic excursion• Goal
– Reduce or eliminate ventilator dependency • Experience
– Avery• 25 years • 82% rate of permanent diaphragmatically-paced
breathing– Synapse
• Recently FDA approved• SCI trial (100% paced with intact nerves)
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencyDiaphragm Pacing
• Criteria – Chronic respiratory failure– Central neurological disorder or High
Spinal injury – Preserved phrenic nerve integrity– Acceptable pulmonary function– Normal level of consciousness– Appropriate care and support
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencyDiaphragm Pacing
• Procedure (Avery)– Small incisions– Intraoperative
neurophysiological testing– Implantation of electrodes
and receiver• Diaphragm conditioning• Long-term pacing
Case Western University
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Pacemaker
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Pacemaker
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Pacemaker
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Pacemaker
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Pacemaker
Avery Biolabs
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
NeuRx Diaphragm Pacing System™
• External Pulse Generator “Paces” Diaphragm
• Home based conditioning replaces Mechanical Ventilation
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Pacemaker
• NeuRx Diaphragm Pacing Device (Synapse) – Laparoscopic placement– Electrodes (4) applied to nerve/muscle junction– Avoid nerve manipulation– Application for neurodegnerative conditions (ALS)
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencyDiaphragm Pacing
• Benefits– Lower rate of pulmonary complications– Improved venous return– Normal breathing and speech– Ease of eating and drinking– Increased patient mobility– Cost-effective
• Risks– Phrenic nerve injury– Wire displacement
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencyDiaphragm Pacing
• Limitations– Lack of voluntary control of breathing– Only inspiration is triggered, thus cough may be weak– Inability to time spontaneous inspiratory efforts– No benefit for unilateral injuries*– C3-5 injuries may not be candidates due to Wallerian
degeneration*
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm ParalysisNeurotization
• Nerve transfers (Neurotization)– Definition
• Transferring intact, functioning nerves to phrenic nerves in order to restore function to the diaphragm
– Advantages• Tremendous experience with this technique for brachial
plexus, extremities, facial nerve
• A reconstructive option for patients not candidates for pacing
• Or, perhaps to enhance results of pacing
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm ParalysisNeurotization
• Krieger & Krieger (2000)– 6 patients– C3-5 injuries– Intercostal to phrenic + pacemaker
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm ParalysisNeurotization
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm ParalysisNeurotization
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm ParalysisSpinal Accessory Neurotization
• Potential Advantages– Tremendous experience in brachial plexus reconstruction– Higher axonal density in the donor nerve
• Intercostal: 1093• Spinal Accessory : 2145• [Phrenic: 800]
– Functionally linked to phrenic – Performed through neck incisions – Lower morbidity (no thoracotomy)
• Disadvantage• Longer distance for axonal regrowth
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm ParalysisSpinal Accessory Nerve
Brainstem
Spinal Cord
Dual Origins
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Re-innervation Spinal Accessory Neurotization
• Goal– To provide ventilator-dependent patients the ability for
voluntary respiratory control +/- a diaphragm pacemaker
• Techniques– Transfer a branch of functioning Cr XI to
nonfunctioning phrenic bilaterally
• Status– Ongoing protocol – IRB Approval
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Paralysis
Spinal Accessory Neurotization
• Phrenic Nerve
• Spinal Accessory Nerve
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Paralysis
Spinal Accessory Neurotization
• Anticipated outcomes– Spontaneous diaphragm function– Improve pacemaker results– Low morbidity– Another treatment for diaphragm paralysis– REDUCED COST
• Medicare/Medicaid reimbursed?
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Ventilator DependencySummary of Potential Treatment
Options• Diaphragm Pacemaker
– C-spine (C3 or higher) or Central abnormality
• Neurotization– C3 or higher, OR Central– Functioning donors– Poor pacemaker candidate
• Neurotization +/- Pacemaker– C3-5– Extensive direct injury to nerve
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Unilateral Diaphragm Paralysis
Phrenic Nerve Injury
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Phrenic Nerve Grafting
Nerve Interposition Graftor Nerve “Bypass”
Neck
Chest
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Phrenic Nerve Grafting
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Phrenic Nerve Grafting
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Re-Innervation
“Re-Innervation of the Paralyzed Diaphragm: Application of Nerve Surgery Techniques following Unilateral Phrenic Nerve Injury”. Kaufman et al.*
– N=12– Unilateral, symptomatic diaphragm paralysis– Minimum 6 months– No spontaneous improvement
*Submitted for publication to CHEST journal 10/10
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Re-Innervation
• Evaluations– Sniff Test– Phrenic Nerve Conduction Study– Diaphragm EMG– PFTs– Standardized Quality of Life Survey
• Assess Physical Functioning
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Re-Innervation
• Results– 8 males, 4 females– Mean age 54 (range 40-68)– Etiology
• Anesthetic Blocks (2)
• Surgery (6)
• Chiropractic Manipulation (2)
• Traumatic Event (2)
– Right (3), Left (9)
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Re-Innervation
• Results– Treatment offered
• Neurolysis (12)
• Interposition nerve graft (7)
• Neurotization (2)
– Operative time • Mean= 165 minutes (range 50-250)
– Hospital stay• Mean= 2 days (range 1 to 4)
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Re-Innervation
Quality of Life Improvements
Normal function = 100
Diaphragm Re-Innervation
Improvements in PFTs
Diaphragm Re-InnervationPhrenic Nerve Grafting
Return of Diaphragmatic Function 10 months following grafting
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Re-Innervation
• Sniff test– 8/9 improved
• Incomplete assessments in 4/12– (2) too early to be tested– (1) expired from unrelated cardiac event 8 months later– (1) no improvement at 8 months*
• Complications– (1) infection at sural nerve harvest site
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Diaphragm Re-InnervationConclusions
• Documentation of diaphragm re-innervation following nerve grafting– 67% objective improvements in diaphragm function
• A problem with almost no other treatment options– Diaphragm plication
• Restoring physiologic function always superior to “piggybacking” dead muscle
• Additional investigation – Standard of care for diaphragm paralysis?
Center for Treatment of Paralysis and Reconstructive Nerve Surgery
Thank You!
Center for Treatment of Paralysis and Reconstructive Nerve Surgery