Increasing Resilience in Children of Parents with Severe Mental Illness
Compliance Therapy in Severe Mental Illness · Compliance Therapy in Severe Mental Illness Prof...
Transcript of Compliance Therapy in Severe Mental Illness · Compliance Therapy in Severe Mental Illness Prof...
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Compliance Therapy in Severe
Mental Illness
Prof Anthony David
Institute of Psychiatry,
King‟s College London, & Maudsley Hospital London UK, SE5 8AF
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Adherence in general clinical practice is poor
Cramer & Rosenheck. Psychiatr Serv 1998;49:196–201
Adherence (%)
Wide range of estimates across studies may reflect
difficulty of assessing covert non-adherence
0 20 40 60 80 100
Antipsychotics
(3–24 months)
(24 studies)
Antidepressants
(1.5–12 months)
(10 studies)
Non-psychiatric
(0.25–10 months)
(12 studies)
Data shown are mean and range
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Relapse rates of multi-episode antipsychotic-responsive patients*
Pro
po
rtio
n o
f p
ati
en
ts
su
rviv
ing
wit
ho
ut
rela
pse (
%) 100
80
60
40
20
0
0 6 12 18 24
Best case
Real world
Time after discharge (months) *Assumes constant optimal antipsychotic dose relapse rate of 3.5% per month, constant medication
non-adherence rate of 7.6% per month, and constant non-adherence relapse rate of 11% per month
Weiden PJ, Olfson M. Schizophr Bull 1995;21:419–27
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Ability to re-label
symptomsCompliance
Awareness of
illness
The 3 Components of Insight
David AS. Br J Psychiatry. 1990;156:798-808.
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Relapse in 1st episode patients over
1 year: according to compliance
0
5
10
15
20
25
30
35
Compliant Non-compliant
Relapse
Well
Novak-Grubic & Tavcar P. Eur Psychiatry 2002;17:148-54
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Predictors of non-compliance:
First-episode schizophrenia
0
5
10
15
20
25
30
Poor insight Positive
symptoms
Diagnosis EPS, length of
illness, social
class etc
% v
ari
an
ce e
xp
lain
ed
Novak-Grubic & Tavcar P. Eur Psychiatry 2002;17:148-54
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Risk Factors for Nonadherence in Schizophrenia
Insight/ Attitude toward medication
Poor alliance with therapist/ Less OP contact
Poor aftercare environment
Substance abuse
Previous nonadherence
Duration of symptoms
Cognitive impairment
Regimen complexity /Route
Family involvement
Symptom severity
Mood symptoms
Dosage
Age/ Gender/ Ethnicity/ Education level
Consistently associated with
adherence
Not Consistently assoc. with
adherence/inadequate data
Lacro, et al. J Clin Psychiat. 2002;63:892-909.
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Concordance model Compliance model
From Compliance to Concordance
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Adapted from R. Gray et al, 2004
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Three phases of CT:
1. Eliciting the patient‟s stance towards
treatment;
2. Exploration of ambivalence;
3. Working towards treatment
maintenance.
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RCT of Compliance Therapy Effect on Insight
70
60
50
40
30
20
10
0 Pre- 0 6 12 18 therapy
Compliance therapy
Non-specific counseling controls
Time Post-therapy (Months)
Insig
ht (S
AI-
E %
)
Kemp R, et al. Br J Psychiatry. 1998;172:413–419.
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Effect of „Compliance Therapy‟ versus
non-specific counselling on adherence
1.0
0.8
0.6
0.4
0.2
0
0 100 200 300 400 500 600 Time to re-admission (days)
Re-a
dm
issio
n
Adherence (compliance) therapy
Non-specific counselling controls
Kemp R et al. Br J Psychiatry 1998;172:413–9 Maudsley Hosp study – acute in-patients
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Impact of compliance therapy training on
trainee psychiatrists‟ confidence in their skills
1
2
3
4
5
6
7
After BeforeVery
confident
Not
confident
Surguladze S, et al. Psychiatr Bull 2002;26:12–5
Empathise Plan care Set limits Persuade Understand Collaboration
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Impact of consultants‟ views of importance of clinical skills
0
1
2
3
4
5
6
7
Authoritative advice Listening empathically
Before
After
Very
important
Not
important
Surguladze, Timms & David (2001) Psychiatric Bull
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Referred by clinicians as
meeting criteria, n=1218
Total Excluded n= 809
Not IGC schizophrenia n=52
Not meeting other inclusion
criteria n=249
Refused to participate n=366
Other reasons n=142
Adherence therapy
n=204
Completed therapy
n=182
Did not complete
therapy
n=22
1 year follow-up
n=178
Not followed up
n=26
Health Education
n=205
Completed therapy
n=173
Did not complete
therapy
n=32
1 year follow-up
n=194
Not followed-up
n=11
Randomised n=409
KING'SCollege
LONDONFoundedI829
QUATRO STUDY Gray, et al (2006)
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Adherence Therapy: “QUATRO”* Study
2
3
4
5
Health Education Adherence Therapy
Kem
p C
om
pli
an
ce S
cale
Before
After
*Multicentre EU study of OP maintenance Rx
Health Educ. (Control), n=171
Adherence Ther., n=156 Gray, et al (2006) Brit J Psychiat, 189:508-14
No significant effect of Adherence Therapy
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QUATRO Study
• No significant effect of Adherence Therapy
– ?Subgroups may be identified who benefit more
– Baseline levels of adherence were fair -
?ceiling effect
– Patients enrolling for clinical trial are „compliant‟
– Intervention may have more effect post acute
relapse (cf Kemp et al) rather than in maintenance
phase
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Factors that affect treatment adherence
Increase
• Acceptance of illness
• Perception of severity/ susceptibility
• Level of support
• Family stability
• Positive therapeutic alliance
• Formulation/delivery
Decrease
• Side effects
• Poor symptom control
• Complex regimen
• Substance abuse
• Impaired judgement
• Poor doctor–patient relationship
• Poor communication
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Depot conventionals versus oral conventionals: meta-analysis of RCTs
Relapse rates: summary
Adams CE, et al. Br J Psychiatry 2001;179:290–9
To
tal n
=846 (
RR
0.9
6)
(0.8
0–1.1
4)
36%
35%
Depot (n=146/420)
Oral (n=153/428)
0 20 40 60 80 100
Rates of relapse (%)
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46%
19%
Depot versus oral conventionals: meta-analysis of RCTs
Adams CE et al. Br J Psychiatry 2001;179:290–9
Global improvement
Patients (%)
0 20 40 60 80 100
To
tal n
=127 R
R 0
.68
(CI=
0.5
4–0.8
6)
RR = risk ratio
CI = confidence interval
Oral (n=12/62)
Depot (n=30/65)
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Risk of Rehospitalisation by
medication – best results with depot*
Tiihonen et al (2006) BMJ 333: 224-230
*Adjusted for sex, year, length of follow-up,
duration of 1st admission.
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Depot or oral? Patient preference according to current formulation
0
10
20
30
40
50
60
70
80
90
100
%
On Depot (n=76) On Oral (n=146)
Prefers depot
Prefers oral
No preference
Patel et al (2009) Journal of Psychopharmacol, 23: 789–796
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• More CMHT patients on depot
felt people try to force them to
take medication
• 30% vs 2%, p<0.001
People try to force them
depot oral0
20
40
60
80
100
%
• More CMHT patients on oral
felt no-one tried to force them
to take medication
• 90% vs 65%, p=0.01
No-one forces them
depot oral0
20
40
60
80
100
%
Coercion: depot vs oral
Patel, et al. (2009) J Psychophamacol in press.
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CTOs: How do we use them?
Conditions
-Attendance at Appts
-Medication adherence
-Residence specified
N (%)
178 (91.3)
177 (90.8)
103 (52.8)
Antipsychotics @ initiation
-Oral
-Depots
-Clozapine
46 (23.7)
105 (53.8)
23 (11.8)
(n=195) Patel et al (2011) Ther Adv Psychopharmacol 1:37-45
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FIAT: Financial
incentives to
improve adherence
to antipsychotic
maintenance
medication in non-
adherent patients
- a cluster randomised
controlled trial
BMC Psychiatry Study protocol
Stefan Priebe, Alexandra Burton, Deborah Ashby, Richard Ashcroft, Tom Burns, Anthony David, Sandra Eldridge, Mike Firn, Martin Knapp and Rose McCabe.
Will be reporting this year….
http://www.biomedcentral.com/1471-244X/9/61
Trial Registration: Current controlled trials ISRCTN77769281.
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Conclusions
• Partial adherence is a major problem in
medicine, but especially schizophrenia; it is the
major cause of relapse
• Pharmacological and Psycho-social approaches
may improve adherence and insight:
• CBT Approaches – based on collaboration
• Formulation e.g. depots (?associated with coercion)
• Compulsion
• Incentives?
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On disagreements with players, the late maverick English football manager Brian Clough said: “I ask him which way he thinks it should be done, we get down to it, we talk about it for 20 minutes, and then we decide I was right”.