Company presentation SMS-oncology

Let’s talk about the D in direction

SMS-oncology

“Oncology trials ask for oncology experts”

An extra dimension in clinical cancer research2

Founded upon a need for a niche player

http://www.sms-oncology.com/

SMS-oncology

Oncology dedicated

Founded in 2007

Office in Amsterdam, NL

Our customers:


Full-service oncology CRO

Small / mid-size biotech80%

Other (CROs, VCs) 15%

Pharma5%

SMS-oncology

We are appreciated and trusted by these and many other clients:


Our clients

Oncology services

We collaborate closely together with our clients to opening up potential

opportunities, by providing a variety of tailor-made services, including:


Customizing to your needs & delivering a tailor made solution

Clinical operations Consultancy 4D Service

Oncology services

6

Consultancy – expert oncology drug development advice

An extra dimension in clinical cancer research

Advice underpinning drug development strategy

(Pre) clinical development plan

Target indication selection

Target product profile

Medical affairs and scientific expertise

Medical writing

Clinical trial design

KOL identification and SAB

Supporting biotech and VC

Due diligence

GAP analysis

Regulatory support



Oncology services

7

Clinical Operations – study conduct from A to Z


Our full range of clinical services:

Site and Investigator selection

Regulatory submissions

Site Management and monitoring

Project Management

Medical Affairs

Pharmacovigilance

Biometrics

Specialized in:

Early phase oncology trials

Immuno-oncology trials


Oncology services

8

Extensive European KOL network


Making use of our

European network of

specialized oncology

centers relevant for the

specific patient population

Performing in depth

feasibility studies to

identify the suitable

sites and motivated

investigators

Addressing our KOL

relations for scientific

and clinical input and

promoting activities to

colleagues

Stimulating patient recruitment and study compliance




Oncology services


Geographical presence

Extensive European KOL network

Renowned oncology institutes where we perform

our trials incl.:

Netherlands Cancer Institute (NKI, Amsterdam, the Netherlands)

Institut Jules Bordet (Bruxelles, Belgium)

Gustave Roussy (Paris, France)

Vall d’Hebron Institute of Oncology (VHIO, Barcelona, Spain)

The Royal Marsden Hospital (London, UK)

In-house and home-based CRAs covering

Europe

Centralized Project Management from

Amsterdam > global coverage

European coverage

Oncology services

10

Our unique 4D Service – providing Direction


Consultancy &

Medical Affairs

Data ManagementClinical Operations

Providing Direction along the Drug, Data, Dossier path (4D)

Integrating ClinOps with DM and Consultancy for proactive guidance

“Insights & Analytics Reports” to be on top of your data, safeguard quality and

enable informed decision making

Experience & expertise

Since the founding of SMS-oncology, we have:

11

Oncology trials ask for oncology experts


Provided over 75

consultancy projects

Expert advice regarding

the clinical development

of oncology compounds

to sponsors

Gained experience in a

wide range of indications

and drug modalities

Served over 65 clients

From small biotech to big

pharmaceutical companies,

of which many return for

continuing collaboration

Performed over 70 clinical

projects

Phase I to IV oncology

studies (full or functional

services) throughout Europe

and US



Tumor indications

Solid tumors

Bladder cancer

Breast cancer

Brain tumors

Cervical cancer

Colorectal cancer

Glioblastoma

Head and neck cancer

Kidney cancer

Liver cancer

Lung cancer

Melanoma

Neuroendocrine tumors

Ovarian cancer

Pancreas cancer

Prostate cancer

Sarcoma

All comer trials (various solid tumors)

Hematologic malignancies

Acute Myeloid Leukemia (AML)

Chronic Lymphoid Leukemia (CLL)

Hematologic malignancies

Leukemia

Multiple Myeloma

Our knowledge and expertise have been acquired through our longstanding hands-on experience in oncology clinical trials and product development, involving numerous and diverse therapeutic modalities. This has allowed us to fully understand the challenges of developing anti-cancer drugs in the highly competitive oncology market.



Drug modalities

Chemotherapy (related):

e.g. anthracyclines, liposomal

platinum compound, taxanes

chemotherapy conjugates

(e.g. nanoparticle-based)

Small molecules:

HDAC inhibitors

Angiogenesis inhibitors (e.g.

anti-VEGF)

Integrin receptor antagonist

Tyrosine kinase inhibitors

(TKIs)

Hormonal therapies:

Aromatase inhibitors

Biological therapies:

Gene therapy

Immuno-modulators

Non-specific immune

stimulation

Immune checkpoint inhibitor

Adoptive cell transfer of

autologous cancer-specific T

cells

Vaccines

Monoclonal antibody

Oncolytic virus

Other:

Liposomal corticosteroid

Nutraceuticals

Oligonucleotides (e.g. miRNA-

based molecules)

Peptides & radiolabeled proteins

Our advantages

14

The benefits of SMS-oncology for our sponsors


Responsiveness,

Quality & Flexibility

Responsiveness, flexibility and fast-decision making

Personal involvement of management team

Tailor made solutions

Oncology Experts

In-depth know-how of oncology trials

Dedicated and experienced professionals

Extensive European network of Key Opinion Leaders (KOLs)

Providing Direction

Strategic clinical development advice

Turning complex data into meaningful insights

Proactively addressing challenges

Business Development team

15

Contact us for more information


SMS-oncology

Science Park 408, 1098 XH Amsterdam, The Netherlandswww.sms-oncology.com+31 (0)20 4350 580

Ms. Lindy Bosch MSc

Business [email protected]+31 (0)6 211 97 552

Mr. Raymond Hoffmans PhD

Chief Business Development [email protected]+31 (0)6 249 72 552


mailto:[email protected]

mailto:[email protected]

Company presentation SMS-oncology

Health & Medicine

Transcript of Company presentation SMS-oncology