Commentaries Infl ammatory bowel disease 1 47 · P Buldrini, M Cicala, R Cuomo, B Germanà, P...
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Contents Volume 65 Issue 1 | GUT January 2016 Commentaries 1 Stool consistency as a major confounding factor affecting microbiota composition: an ignored variable? J A Gilbert, J Alverdy 2 In search for a disease-modifying treatment in irritable bowel syndrome H Törnblom, M Simrén 4 Hepatitis C: new clues to better vaccines? M E Major Endoscopy news 6 EUS-guided gall bladder drainage with a lumen-apposing metal stent: a prospective long-term evaluation D Walter, A Y Teoh, T Itoi, M Pérez-Miranda, A Larghi, A Sanchez-Yague, P D Siersema, F P Vleggaar Helicobacter pylori 9 A large randomised controlled intervention trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradication K-f Pan, L Zhang, M Gerhard, J-l Ma, W-d Liu, K Ulm, J-x Wang, L Zhang, Y Zhang, M Bajbouj, L-f Zhang, M Li, M Vieth, R-y Liu, M Quante, L-h Wang, S Suchanek, T Zhou, W-x Guan, R Schmid, M Classen, W-c You Stomach 19 HNF4 is a therapeutic target that links AMPK to WNT signalling in early-stage gastric cancer H R Chang, S Nam, M-C Kook, K-T Kim, X Liu, H Yao, H R Jung, R Lemos Jr, H H Seo, H S Park, Y Gim, D Hong, I Huh, Y-W Kim, D Tan, C-G Liu, G Powis, T Park, H Liang, Y H Kim Intestinal inflammation 33 The human milk oligosaccharide 2’-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced inflammation Y He, ShuBai Liu, D E Kling, S Leone, N T Lawlor, Y Huang, S B Feinberg, D R Hill, D S Newburg OPEN ACCESS Inflammatory bowel disease 47 Low-dose budesonide for maintenance of clinical remission in collagenous colitis: a randomised, placebo-controlled, 12-month trial A Münch, J Bohr, S Miehlke, C Benoni, M Olesen, Å Öst, L Strandberg, P M Hellström, E Hertervig, P Armerding, J Stehlik, G Lindberg, J Björk, A Lapidus, R Löfberg, O Bonderup, S Avnström, M Rössle, K Dilger, R Mueller, R Greinwald, C Tysk, M Ström, on behalf of the BUC-63 investigators Gut microbiota 57 Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates D Vandeputte, G Falony, S Vieira-Silva, R Y Tito, M Joossens, J Raes 63 Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite production G D Wu, C Compher, E Z Chen, S A Smith, R D Shah, K Bittinger, C Chehoud, L G Albenberg, L Nessel, E Gilroy, J Star, A M Weljie, H J Flint, D C Metz, M J Bennett, H Li, F D Bushman, J D Lewis Neurogastroenterology 73 The normoglycaemic biobreeding rat: a spontaneous model for impaired gastric accommodation C Vanormelingen, T Vanuytsel, T Masaoka, G De Hertogh, H Vanheel, P V Berghe, R Farré, J Tack OPEN ACCESS OPEN ACCESS OPEN ACCESS This article has been chosen by the Editor to be of special interest or importance and is freely available online. This article has been made freely available online under the BMJ Journals Open Access scheme. See http://gut.bmj.com/site/about/guidelines.xhtml#open This journal is a member of and subscribes to the principles of the Committee on Publication Ethics http://publicationethics.org/ An international journal of gastroenterology and hepatology Impact Factor: 14.660 Editor Emad El-Omar (UK) Deputy Editor (Hepatology) Alexander Gerbes (Germany) Deputy Editor (Luminal Gastroenterology) William Grady (USA) Deputy Editor (Endoscopy) Thomas Rösch (Germany) Associate Editors Matias Avila (Spain) Martin Blaser (USA) Guy Boeckxstaens (Belguim) Patrice Cani (Belgium) Silvio Danese (Italy) Thomas Gress (Germany) Arthur Kaser (UK) Ernst Kuipers (The Netherlands) Jake Liang (USA) Herbert Tilg (Austria) Fabien Zoulim (France) Editorial Office Gut BMJ Journals BMA House, Tavistock Square London, WC1H 9JR, UK T: +44 (0)20 7383 6394 F: +44 (0)20 7383 6668 E: [email protected] Twitter: @Gut_BMJ ISSN: 0017-5749 (print) ISSN: 1468-3288 (online) Disclaimer: Gut is owned and published by BMJ Publishing Group Ltd, a wholly owned subsidiary of the British Medical Association and the British Society of Gastroenterology. The owners grant editorial freedom to the Editor of Gut. Gut follows guidelines on editorial independence produced by the World Association of Medical Editors and the code on good publication practice of the Committee on Publication Ethics. Gut is intended for medical professionals and is provided without warranty, express or implied. Statements in the Journal are the responsibility of their authors and advertisers and not authors’ institutions, the BMJ Publishing Group, the British Society of Gastroenterology or the BMA unless otherwise specified or determined by law. Acceptance of advertising does not imply endorsement. To the fullest extent permitted by law, the BMJ Publishing Group shall not be liable for any loss, injury or damage resulting from the use of Gut or any information in it whether based on contract, tort or otherwise. Readers are advised to verify any information they choose to rely on. Copyright © 2015 BMJ Publishing Group Ltd and British Society of Gastroenterology. All rights reserved; no part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without prior permission Gut is published by BMJ Publishing Group Ltd, typeset by Techset and printed in the UK on acid-free paper. Gut (ISSN: 0017-5749) is published monthly by BMJ Publishing Group and is distributed in the USA by Air Business Ltd. Periodicals postage paid at Jamaica NY 11431 POSTMASTER: send address changes to Gut, Air Business Ltd, c/o Worldnet Shipping Inc., 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA. MORE CONTENTS Caption: Laoshan Mountain Rock Pool and Waterfall, Shandong Province, China. See in this issue the landmark study by Pan et al on mass eradication of H pylori infection.
Transcript of Commentaries Infl ammatory bowel disease 1 47 · P Buldrini, M Cicala, R Cuomo, B Germanà, P...
Contents Volume 65 Issue 1 | GUT January 2016
Commentaries1 Stool consistency as a major confounding factor
affecting microbiota composition: an ignored variable?J A Gilbert, J Alverdy
2 In search for a disease-modifying treatment in irritable bowel syndromeH Törnblom, M Simrén
4 Hepatitis C: new clues to better vaccines?M E Major
Endoscopy news6 EUS-guided gall bladder drainage with
a lumen-apposing metal stent: a prospective long-term evaluationD Walter, A Y Teoh, T Itoi, M Pérez-Miranda, A Larghi, A Sanchez-Yague, P D Siersema, F P Vleggaar
Helicobacter pylori9 A large randomised controlled intervention
trial to prevent gastric cancer by eradication of Helicobacter pylori in Linqu County, China: baseline results and factors affecting the eradicationK-f Pan, L Zhang, M Gerhard, J-l Ma, W-d Liu, K Ulm, J-x Wang, L Zhang, Y Zhang, M Bajbouj, L-f Zhang, M Li, M Vieth, R-y Liu, M Quante, L-h Wang, S Suchanek, T Zhou, W-x Guan, R Schmid, M Classen, W-c You
Stomach19 HNF4� is a therapeutic target that links AMPK
to WNT signalling in early-stage gastric cancerH R Chang, S Nam, M-C Kook, K-T Kim, X Liu, H Yao, H R Jung, R Lemos Jr, H H Seo, H S Park, Y Gim, D Hong, I Huh, Y-W Kim, D Tan, C-G Liu, G Powis, T Park, H Liang, Y H Kim
Intestinal infl ammation33 The human milk oligosaccharide
2’-fucosyllactose modulates CD14 expression in human enterocytes, thereby attenuating LPS-induced infl ammationY He, ShuBai Liu, D E Kling, S Leone, N T Lawlor, Y Huang, S B Feinberg, D R Hill, D S Newburg
OPEN ACCESS
Infl ammatory bowel disease47 Low-dose budesonide for maintenance of
clinical remission in collagenous colitis: a randomised, placebo-controlled, 12-month trialA Münch, J Bohr, S Miehlke, C Benoni, M Olesen, Å Öst, L Strandberg, P M Hellström, E Hertervig, P Armerding, J Stehlik, G Lindberg, J Björk, A Lapidus, R Löfberg, O Bonderup, S Avnström, M Rössle, K Dilger, R Mueller, R Greinwald, C Tysk, M Ström, on behalf of the BUC-63 investigators
Gut microbiota57 Stool consistency is strongly associated with
gut microbiota richness and composition, enterotypes and bacterial growth ratesD Vandeputte, G Falony, S Vieira-Silva, R Y Tito, M Joossens, J Raes
63 Comparative metabolomics in vegans and omnivores reveal constraints on diet-dependent gut microbiota metabolite productionG D Wu, C Compher, E Z Chen, S A Smith, R D Shah, K Bittinger, C Chehoud, L G Albenberg, L Nessel, E Gilroy, J Star, A M Weljie, H J Flint, D C Metz, M J Bennett, H Li, F D Bushman, J D Lewis
Neurogastroenterology73 The normoglycaemic biobreeding rat:
a spontaneous model for impaired gastric accommodationC Vanormelingen, T Vanuytsel, T Masaoka, G De Hertogh, H Vanheel, P V Berghe, R Farré, J Tack
OPEN ACCESS
OPEN ACCESS
OPEN ACCESS
This article has been chosen by the Editor to be of special interest
or importance and is freely available online.
This article has been made freely available online under the BMJ
Journals Open Access scheme.
See http://gut.bmj.com/site/about/guidelines.xhtml#open
This journal is a member of and subscribes to the principles of the
Committee on Publication Ethics
http://publicationethics.org/
An international journal of
gastroenterology and hepatology
Impact Factor: 14.660EditorEmad El-Omar (UK)
Deputy Editor (Hepatology)Alexander Gerbes (Germany)
Deputy Editor (Luminal Gastroenterology)William Grady (USA)
Deputy Editor (Endoscopy) Thomas Rösch (Germany)
Associate EditorsMatias Avila (Spain)
Martin Blaser (USA)
Guy Boeckxstaens (Belguim)
Patrice Cani (Belgium)
Silvio Danese (Italy)
Thomas Gress (Germany)
Arthur Kaser (UK)
Ernst Kuipers (The Netherlands)
Jake Liang (USA)
Herbert Tilg (Austria)
Fabien Zoulim (France)
Editorial Offi ceGut
BMJ Journals
BMA House, Tavistock Square
London, WC1H 9JR, UK
T: +44 (0)20 7383 6394F: +44 (0)20 7383 6668E: [email protected]: @Gut_BMJ
ISSN: 0017-5749 (print)ISSN: 1468-3288 (online)
Disclaimer: Gut is owned and published by BMJ Publishing Group Ltd, a wholly owned subsidiary of the British Medical Association and the British Society of Gastroenterology. The owners grant editorial freedom to the Editor of Gut. Gut follows guidelines on editorial independence produced by the World Association of Medical Editors and the code on good publication practice of the Committee on Publication Ethics.
Gut is intended for medical professionals and is provided without warranty, express or implied. Statements in the Journal are the responsibility of their authors and advertisers and not authors’ institutions, the BMJ Publishing Group, the British Society of Gastroenterology or the BMA unless otherwise specifi ed or determined by law. Acceptance of advertising does not imply endorsement.
To the fullest extent permitted by law, the BMJ Publishing Group shall not be liable for any loss, injury or damage resulting from the use of Gut or any information in it whether based on contract, tort or otherwise. Readers are advised to verify any information they choose to rely on.
Copyright © 2015 BMJ Publishing Group Ltd and British Society of Gastroenterology. All rights reserved; no part of this publication may be reproduced, stored in a retrieval system or transmitted in any form or by any means, electronic, mechanical, photocopying, recording or otherwise without prior permission
Gut is published by BMJ Publishing Group Ltd, typeset by Techset and printed in the UK on acid-free paper.
Gut (ISSN: 0017-5749) is published monthly by BMJ Publishing Group and is distributed in the USA by Air Business Ltd. Periodicals postage paid at Jamaica NY 11431 POSTMASTER: send address changes to Gut, Air Business Ltd, c/o Worldnet Shipping Inc., 156-15, 146th Avenue, 2nd Floor, Jamaica, NY 11434, USA.
MORE CONTENTS �
Caption: Laoshan Mountain Rock Pool and Waterfall,
Shandong Province, China. See in this issue the
landmark study by Pan et al on mass eradication of
H pylori infection.
gutjnl_65_1_TOC.indd 1gutjnl_65_1_TOC.indd 1 07/12/15 4:42 PM07/12/15 4:42 PM
Contents Volume 65 Issue 1 | GUT January 2016
82 Randomised controlled trial of mesalazine in IBSG Barbara, C Cremon, V Annese, G Basilisco, F Bazzoli, M Bellini, A Benedetti, L Benini, F Bossa, P Buldrini, M Cicala, R Cuomo, B Germanà, P Molteni, M Neri, M Rodi, A Saggioro, M L Scribano, M Vecchi, G Zoli, R Corinaldesi, V Stanghellini
91 A mechanistic multicentre, parallel group, randomised placebo-controlled trial of mesalazine for the treatment of IBS with diarrhoea (IBS-D)C Lam, W Tan, M Leighton, M Hastings, M Lingaya, Y Falcone, X Zhou, L Xu, P Whorwell, A F Walls, A Zaitoun, A Montgomery, R Spiller
Pancreas100 Peripancreatic fat necrosis worsens acute
pancreatitis independent of pancreatic necrosis via unsaturated fatty acids increased in human pancreatic necrosis collectionsP Noel, K Patel, C Durgampudi, R N Trivedi, C de Oliveira, M D Crowell, R Pannala, K Lee, R Brand, J Chennat, A Slivka, G I Papachristou, A Khalid, D C Whitcomb, J P DeLany, R A Cline, C Acharya, D Jaligama, F M Murad, D Yadav, S Navina, V P Singh
Hepatology112 The broad assessment of HCV genotypes 1
and 3 antigenic targets reveals limited cross-reactivity with implications for vaccine designA von Delft, I S Humphreys, A Brown, K Pfafferott, M Lucas, P Klenerman, G M Lauer, A L Cox, S Gaudieri, E Barnes
124 STK33 promotes hepatocellular carcinoma through binding to c-MycT Yang, B Song, J Zhang, G-S Yang, H Zhang, W-F Yu, M-C Wu, J-H Lu, F Shen
OPEN ACCESS
OPEN ACCESS
OPEN ACCESS
OPEN ACCESS
134 Additive antitumour response to the rabbit VX2 hepatoma by combined radio frequency ablation and toll like receptor 9 stimulationB Behm, P Di Fazio, P Michl, D Neureiter, R Kemmerling, E G Hahn, D Strobel, T Gress, D Schuppan, T T Wissniowski
144 Glutathione peroxidase 4 is reversibly induced by HCV to control lipid peroxidation and to increase virion infectivityC Brault, P Lévy, S Duponchel, M Michelet, A Sallé, E-I Pécheur, M-L Plissonnier, R Parent, E Véricel, A V Ivanov, M Demir, H-M Steffen, M Odenthal, F Zoulim, B Bartosch
Recent advances in basic science155 The role of mast cells in functional GI disorders
M M Wouters, M Vicario, J Santos
Recent advances in clinical practice169 Sensitivity to wheat, gluten and FODMAPs in
IBS: facts or fi ction?R De Giorgio, U Volta, P R Gibson
JournalScan179 GI highlights from the literature
M H McLean
Editor’s quiz: GI snapshot32 Seeing a cause for blindness in severe
pancreatitisA D Hopper, D Gosling, S Patwary, D Partridge, M Peterson
PostScript182 Letters
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