College of Engineering and Science Updated Nov., 8th 2015...College of Engineering and Science...
Transcript of College of Engineering and Science Updated Nov., 8th 2015...College of Engineering and Science...
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College of Engineering and Science Updated Nov., 8th 2015
RESUME Frank Alexis, Ph.D.
PERSONAL DATA
Associate Professor
Department of Bioengineering
203 Rhodes Engineering Research Center
Clemson University
Clemson, SC 29634
864-656-5003
EDUCATION
Ph.D., Nanyang Technological University, 2005, Materials Science
Engineering.
M.S., Technological University of Montpellier, 2000, Materials Science
and Interfaces.
B.S., Technological University of Montpellier, 1999, Chemistry.
PROFESSIONAL EXPERIENCE
Clemson University, 2015-, Associate Professor of Bioengineering
Nanyang Technological University, 2015-, Visiting Associate Professor,
School of Chemical and Biomedical Engineering
Clemson University, 2009-, Assistant Professor of Bioengineering
Massachusetts Institute of Technology, 2006-2009, Research Associate,
Department of Health Science and Technology.
Brigham and Women’s Hospital, 2006-2009, PostdocFellow, Laboratory
of Biomaterials and Nanomedicine.
CONSULTING EXPERIENCE
Stericoat Inc., Cambridge, Massachusetts (2008), assisted for the
development of novel implant coatings.
LEK Consulting, Los Angeles, California (2014), assisted for providing
insights drug delivery technologies.
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Polymed Inc., Clemson, South Carolina (2015-), assisting for the
development of novel drug delivery product.
MEMBERSHIPS
Member, Biomedical Engineering Society, BMES (2014-)
Member, Society For Biomaterials, SFB (2009- 2012)
Member, American Chemical Society, ACS (2008-2012)
Member, Society of Chemical Industry, SCI (2004- )
PROFESSIONAL ACTIVITIES
Reviewer Journals:
2006-: ASM International
2008-: Molecular Pharmaceutics, Biomacromolecules, Cancer
Epidemiology, Cancer Research.
2009-: Molecular Cancer Therapeutics, Bioconjugates Chemistry, Journal
of Biomedical Materials Research: Part A, Journal of Biomaterial Science:
Polymer Edition.
2010-: Ocular Pharmacology and Therapeutics, Royal Society for
Chemistry, Therapeutic Delivery, Trends in Molecular Medicine,
Advanced Functional Materials, Chemical Papers, Chemistry an Asian
Journal.
2011-: ChemPhysChem, Journal of Biomedical Materials Research: Part
B, European Journal of Pharmaceutics and Biopharmaceutics; Advanced
Materials.
2012-: Nanomedicine, Small, Acta Biomateriala, Langmuir, Expert
Opinion in Drug Delivery, Journal of Nanotechnology, Journal of
Visualized Experiments, Materials, Polymer Degradation and Stability,
Military Medicine.
2013-: ACSNano, Advanced Eng. Mat., Advanced Healthcare Mat., Drug
Discovery Today, Expert Reviews Medical Devices, Open Journal of
Biomedical Research, SCIKNOW, Tissue Engineering.
2014-: Chemical Reviews, Pharmaceutical Patent Analyst, Nanoscale,
Biomaterials, Materials Today, Drug Delivery, International Journal of
Nanomedicine, Archive Medical Research, Drug Delivery and
Translational Research, Journal of Materials Chemistry B, ACS Applied
Materials and Interfaces, International Journal of Pharmaceutics,
Biofabrication, Journal of Bioprocessing and Biotechniques, Analytical
Methods, Colloids and Surfaces Interfaces B, ACS Sustainable Chemistry
and Engineering, Journal of Nanotechnology Nanomedicine and
Nanobiotechnology, International Journal of Molecular Science,
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PLOSONE, Materials and Engineering Part B, Clinical Pharmacology and
Therapeutics.
2015-: Current Neuropharmacology, Current Cancer Drug Targets,
Journal of Controlled Release, Journal of Alloys and Compounds,
Polymer, Angewandte Chemie, ChemNanoMat, Molecular Cancer
Therapeutics, ChemElectroChem, ACS Chemical Biology, Biomaterials,
Applied Surface Science, Chemical Reviews, Nanotoxicology, Applied
Surface Science, Journal of Carbon Research.
2016: ACS Chemical Biology, RCS Chemical Science.
Reviewer Grants/Scholarships:
2004: Singapore A*Star Government Scholarship
2009-: US Army Medical Research and Materiel Command (USAMRMC)
2010: ORAU
2012-: National Science Foundation-Major Research Instrumentation,
Singapore-MIT Alliance for Research and Technology Innovation Grant,
Fonds Recherche Québec - Nature et technologies (FRQNT), American
Association for the Advancement of Science (AAAS), INDO-US
SCIENCE & TECHNOLOGY.
2013-: DoD-PRMRP, Nanyang Technological University-Singapore-Tier
1.
2014-: DoD-BCRP-Nano, Nanyang Technological University-Singapore-
Tier 1.
2015-: DoD-BCRP-Nano, NTU A-Star-Career Development Award,
Nanyang Technological University-Singapore-Tier 1.
Reviewer Books:
2005: Encyclopedia of Biomaterials and Biomedical Engineering, G. E
Wneck and G.L Bowlin. Marcel Dekker, NY.
2013: CRC Book
Reviewer Conferences:
2004: Singapore Science and Engineering Fair
2008-: Nano Science and Technology Institute Conference
2011-: Biomedical Engineering Society Conference, National Conference
for Undergraduate Research, Biomedical Engineering Society Conference
Symposium/Conference Organizer:
2012: Clemson’s Biomaterials Day-Society For Biomaterials,
International Organizing Committee of the IUPAC MacroMolecular
Complexes Conference.
PUBLICATIONS
Book Chapter N=7
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Kolishetti, N., Alexis, F., Pridgen, E., Farokhzad, O. C., Nanoplatform-Based Molecular
Imaging, 1st edition (2011), John Wiley and Sons, Inc., Hoboken, NJ.
Rosen, Y., Mattix, Rao A., Alexis, F. Nanomedicine in Health and Disease, 1st edition
(2011), Taylor and Francis Group, LLC, Boca Raton, FL.
Moore, T., Graham, E., Mattix, B., Alexis, F., Biomaterials Science: An Integrated
Clinical and Engineering Approach, 1st edition (2012), Taylor and Francis Group, LLC,
Boca Raton, FL.
Venkatraman, S.; Keith, K.; Rosen, Y.; Huang, Y.; Steele, T.W.J.; Alexis, F., Polymers
for Vascular and Urogenital Applications, 1st edition (2012), Taylor and Francis Group, LLC, Boca Raton, FL.
Prior to Clemson:
Alexis, F.; Zeng, J.; Wang, S., Gene Transfer: Delivery and Expression of DNA and
RNA, A Laboratory Manual, 1st edition (2007), Cold Spring Harbor Laboratory Press,
New York, NY.
Pridgen, E.; Alexis, F.; Farokhzad, O. C.; Langer, R., Methods in Bioengineering Book
Series Nanoscale Bioengineering and Nanomedicine, 1st edition (2009), Artech House ,
Boston, MA.
Alexis, F.; Pridgen, E.; Langer, R.; Farokhzad, O. C., Handbook of Experimental
Pharmacology 197, 1st edition (2010), Springer, Berlin, Germany.
Referred Journal Publications N=54
Loo, S.C.J., Moore, T., Banik, B., Alexis, F., “Biomedical Applications of Hydroxyapatite
Nanoparticles”, Current Pharmaceutical Biotechnology 11, 333-342 (2010).
Zha, L., Banik, B., Alexis, F., “Stimuli Responsive Nanogels”, Soft Matter 7, 5908-5916
(2011).
Stone, R., Willi, T.J., Mefford, T., Rosen, Y., Alexis, F., “Targeted Magnetic
Hyperthermia”, Therapeutic Delivery 2, 815-838 (2011).
Banik, B., Alexis, F., “Spatial Functionalization of Polymeric Films”, Cover page of
Biomaterials Forum 33, 3, (2011).
Xiao, Z., Levy-Nissenbaum, E., Alexis, F., Lupták, A., Teply, B.A., Chan, J.M., Shi, J.,
Digga, E., Cheng, J., Langer, R., Farokhzad, O.C., “Engineering of Targeted
Nanoparticles for Cancer Therapy Using Internalizing Aptamers Isolated by Cell-Uptake
Selection”, ACS Nano 6, 696-704 (2012).
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Chen, H., Colvin, D. C., Qi, B., Moore, T., He, J., Mefford, O. T., Alexis, F., Gore, J. C.,
Anker, J. N., “Magnetic and optical properties of multifunctional core-shell
radioluminescence nanoparticles”, J. Mat. Chem. 22, 12802-12809 (2012).
Chen, H., Moore, T.; Qi, B.; Colvin, D.C.; Jelen, E.; Hitchcock, D.A.; He, J.O.; Mefford,
T.; Gore, J.C.; Alexis, F.; Anker, J.N. “Monitoring pH-triggered Drug Release from
Radioluminescent Nanocapsules with X-ray Excited Optical Luminescence.” ACS Nano,
7, 1178-1187 (2013).
Podila, R.; Moore, T.; Alexis, F.; Rao, M.A. “Graphene coatings for enhanced hemo-
compatibility of nitinol stents”. RSC Advances , 3, 1660-1665 (2013).
Podila, R.; Moore, T.; Alexis, F.; Rao, M.A. “Graphene Coatings for Biomedical
Implants”. Journal of Visualized Experiments, 73, e50276 (2013)
Moore, T.L., Pitzer, J., Podila,
R., Wang,
X., Lewis, R.L., Grimes S.W., Wilson, J.R.,
Skjervold, E., Brown, J., Rao, A., Alexis, F., “Polymer Coated Carbon Nanotubes to
Safely Deliver Drugs”, Particles and Particle Systems Characterization, 30, 299 (2013).
Moore, T.L., Pitzer, J., Podila,
R., Wang,
X., Lewis, R.L., Grimes S.W., Wilson, J.R.,
Skjervold, E., Brown, J., Rao, A., Alexis, F. Cover Art in Particles and Particle Systems
Characterization, Vol 30 (2013).
Chi, A.; Clayton, K.; Burrow, T.J.; Lewis, R.; Luciano, D.; Alexis, F.; D’hers, S.; Elman,
NM; “Intelligent drug-delivery devices based on micro- and nanotechnologies”.
Therapeutic Delivery, 4, 77-94 (2013)
Pridgen, E.M., Alexis, F., Kuo, T.T., Levy-Nissenbaum, E., Blumberg, R.S., Langer, R.,
Farokhzad, O.C., “Transepithelial Transport of Fc-Targeted Nanoparticles Across the
Intestinal Epithelium Barrier by the Neonatal Fc Receptor for Oral Delivery”, Science
Translational Medicine, 5, 213 (2013).
Mattix, B.; Poole, T.; Casco, M.; Uvarov, O; Visconti, R. P.; Simionescu,
D.; and Alexis
F.
“Small Diameter Vascular Grafts: Replacement Strategies, Maturation Techniques, and
Challenges”, Journal of Tissue Science & Engineering, 4, 1 (2013).
Mattix, B., Moore, T., Uvarov, O., Pollard, S., O'Donnell, L., Park, K., Horne, D.,
Dhulekar, J., Olsen, T., Duong, N.; Burg, K.; Kraveka, J., Alexis, F. “Effects of Polymeric
Nanoparticle Surface Properties on Interaction with Brain Tumor Environment for Drug
Delivery Applications”. NanoLife, 3, 1343003 (2013)
Mattix, B.; Olsen, T.R.; Moore, T; Casco, M.; Simionescu, D.; Visconti, R; Alexis,
“Accelerated Iron Oxide Nanoparticle Degradation Mediated by Polyester Encapsulation
for Tissue Engineering Into Cellular Spheroids”. Adv. Funct. Mat., 24, 800-807 (2014)
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Chen, H.; Qi, B.; Moore, T.; Colvin, D.C.; Gore, J.C.; Alexis, A.; Mefford, O.T.; and
Anker, J.N.” Synthesis of brightly PEGylated luminescent magnetic up-conversion
nanophosphors for deep tissue and dual MRI imaging. Small, 10, 160-168 (2014).
Mattix, B.; Olsen, T.R.; Gu, Y.; Casco, M.; Herbst, A.; Simionescu, D., Visconti, R. P.,
Kornev, K.G.; and Frank Alexis, “Biological Magnetic Cellular Spheroids as Building
Blocks for Tissue Engineering”, Acta Biomateriala, 10, 623-629 (2014).
Mattix, B.; Olsen, T.R.; Casco, M.; Reese, L.; Poole, L.T.; Zhang, J.; Visconti, R.;
Simionescu, A.; Simionescu, D.; Alexis, F. “Janus Magnetic Cellular Spheroids for
Vascular Tissue Engineering”, Biomaterials, 35, 949-960 (2014).
Moore, T.L., Podilakrishna, R.; Rao, A.; Alexis, F. “Systemic Administration of Polymer-
Coated Nano-Graphene to Deliver Drugs to Glioblastoma”, Particle and Particle Systems
Characterization, In Press, Covert Art, (2014).
Moore, T.L.; Grimes, S.W.; Lewis, R.L.; Alexis, F.“Multilayered Coated Carbon
Nanotube to Deliver Dasatinib”. Mol. Pharm., 11, 276-282 (2014).
Moore, T.; Chen, H.; Morrison, R.; Wang, F.; Anker, J.N., Alexis, F. “Nanotechnologies
for Non-invasive Measurement of In Vivo Drug Release”. Mol. Pharma., 11, 24-39 (2014)
Ilyinskii, P.O., Roy, C.J.; O’Neil, C.P.; Browning, E.A.; Pittet, L.A.; Altreuter, D.H.;
Alexis, F.; Tonti, E.; Shi, J.; Basto, P.A., Radovic-Moreno, A.F.; Iannacone, Langer, R.S.,
Farokhzad, O.C.; von Andrian,U.H.; Johnston, L.P.M.; and Kishimoto, T.K. “Adjuvant-
Carrying Synthetic Vaccine Particles Augment the Immune Response to Encapsulated
Antigen and Exhibit Strong Local Immune Activation without Inducing Systemic
Cytokine Release”. Vaccine, 32, 2882-2895 (2014).
Alexis, A.; and Anker, J.N.”Theranostic nanotechnologies: moving beyond imaging the
localization of the drug”. Therapeutic Delivery (Editorial), 5, 97-100 (2014).
Chen H, Sulejmanovic D, Moore T, Colvin DC, Qi B, Mefford OT, Gore JC, Alexis F,
Hwu SJ, Anker JN. “Iron-Loaded Magnetic Nanocapsules for pH-Triggered Drug Release
and MRI Imaging.” Chem Mater., 26, 2105-2112 (2014).
Chen H, Qi B, Moore T, Wang F, Colvin DC, Sanjeewa LD, Gore JC, Hwu SJ, Mefford
OT, Alexis F, Anker JN. “Multifunctional Yolk-in-Shell Nanoparticles for pH-triggered
Drug Release and Imaging.” Small, 10, 3364-3370 (2014)
Alexis F. “Nano-polypharmacy to treat tumors: coencapsulation of drug combinations
using nanoparticle technology.”Mol Ther., Commentary Article, 22, 1239-1240 (2014)
Olsen, R.T.; Alexis, F.; “Bioprocessing of Tissues using Cellular Spheroids”, Journal of
Bioprocessing and Biotechniques, Editorial, 4, e112 (2014)
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Pridgen EM, Alexis F, Farokhzad OC. “Polymeric Nanoparticle Technologies for Oral
Drug Delivery.” Clin Gastroenterol Hepatol., 12, 1505-1510 (2014)
Moore, T.L.; Wang, F.; Chen, H.; Grimes, S.W.; Anker, J.N.; Alexis, F.; "Polymer Coated
Radioluminescent Nanoparticles for Imaging Drug Delivery into Cells". Adv. Funct. Mat.,
37, 5815-5823 (2014).
Olsen, T. R., Mattix, B., Casco, M.; Herbst, A., Williams, C., Tarasidis, A., Evans, G.,
Jenkins, L., McMahan, C.L., Simionescu, D., Visconti, R.P., Alexis, F.; Processing
cellular spheroids for histological examination. Journal of Histotechnology, 37, 138-142
(2014)
Olsen, T. R., Casco, M.; Mattix, B., Herbst, A., Williams, C., Tarasidis, A., Evans, G.,
Jenkins, L., McMahan, C.L., Simionescu, D., Visconti, R.P., Alexis, F. “Preparing and
Processing Complex Tissue Constructs Composed of Cellular Spheroids”. Journal of
Cytology and Tissue Biology. 1: 002 (2014)
Olsen, T.R., Davis, L.; Nicolau, SE; Duncan, C.C.; Whitehead, D.C.; Van Horn, B.A.; and
Alexis, F.; “Non-Invasive Deep Tissue Imaging of Iodine Modified Poly(caprolactone-co-
1-4-oxepan-1,5-dione) Using X-Ray”. Acta Biomaterialia, 20, 94-103 (2015).
Pridgen EM, Alexis F, Farokhzad OC. “Polymeric Nanoparticle Drug Delivery
Technologies for Oral Delivery Applications.” Expert Opinion Drug Delivery., 12, 1459-
1473 (2015).
Nicolau, SE; Davis, L.; Duncan, C.C.; Olsen, T.R., Alexis, F.; Whitehead, D.C.; Van
Horn, B.A.. “An Oxime Graft Strategy for Iodinated Poly(epsilon-caprolactone) X-ray
Opaque Materials. Journal of Polymer Science: Polymer Chemistry Part A, 53, 2421-2430
(2015).
Casco, M., Olsen, T. R., Herbst, A., Grace Evans , Taylor Rothermel , Lauren Pruett
Simionescu, D., Visconti, R. P., Alexis, F. “Iron Oxide Nanoparticles Stimulates Extra-
Cellular Matrix Production into Cellular Spheroids”, Acta Biomaterialia, Submitted
(2015).
Campbell, McKenzie L. Guerra, Fernanda. D.;Dhulekar, Jhilmil; Alexis, Frank;
Whitehead, Daniel. C.; “Target-Specific Capture of Enviromentally Relevant Gaseous
Aldehydes and Carboxylic Acids with Functional Nanoparticles.” Chemistry, 21, 14834-
42 (2015).
Timothy R. Olsen, Megan Casco, Austin Herbst, Grace Evans, Taylor Rothermel, Lauren
Pruett, Jared Reid, Kelly Berry, Michael P. Jaeggli, Dan T. Simionescu, Richard P.
Visconti, and Frank Alexis.” Longitudinal Stretching for Maturation of Vascular Tissues
Using Magnetic Forces”. Cardiovascular Engineering and Technology, Submitted (2015).
Guerra, F. D.; Whitehead, Daniel. C., Alexis, F. ”Nanotechnology in Environmental
Remediation: Current Status and Challenges”, Submitted (2015).
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Prior to Clemson:
Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S.,"Study of the Initial Stages of
Drug Release from a Degradable Matrix of Poly (d,l-lactide-co- glycolide)", Biomaterials
25, 813-821 (2004).
Alexis, F., Rath, S. K, Venkatraman, S., “In Vitro Study of Release Mechanisms of
Paclitaxel and Rapamycin from Drug-Incorporated Biodegradable Stent”, Journal of
Controlled Release 98, 67-74 (2004).
Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S., “Controlled drug release of
bioerodible polymers: effect of drug type and composition”, Journal of Controlled
Release 102, 333-344 (2005).
Alexis, F., "Factors Affecting Degradation and Drug Release Mechanisms of Bioerodible
Polymers", Polymer International 54, 36-46 (2005).
Tang, G.P., Zeng, S., Alexis, F., Yang, Y.Y., Wang, S., “Low Molecular Weight
Polyethylenimine Copolymerized with B-cyclodextrin for Gene Delivery”, Journal of
Gene Medicine 8, 736-744 (2006).
Alexis, F., Rath, S. K., Gan, L-H., Venkatraman, S.,”Some Insight into Hydrolytic
Scissions Mechanisms in Bioerodible Polyesters”, Journal of Applied Polymer Science
102, 3111-3117 (2006).
Alexis, F., Lo, S.L., Wang, S., “Covalent Attachment of Low Molecular Weight
Polyethylenimine Improves Tat-Peptide Mediated Gene Delivery", Advanced Materials
18, 2174-2178 (2006).
Zhang, L., Radovic-Moreno, A., Alexis, F., Gu, F.X., Basto, P., Langer, R, Farokhzad, O.
C., “Co-Delivery of Hydrophobic and Hydrophilic Drugs from Nanoparticle-Aptamer
Bioconjugates”, ChemMedChem. 2, 1268-1271 (2007).
Gu, F.X., Karnik, R., Wang, A. Z., Alexis, F., Levy-Nissenbaum, E., Hong, S., Langer,
R., Farokhzad, O. C.,” Targeted Nanoparticles for Cancer Therapy”, NanoToday 2, 14-21
(2007).
Alexis, F., Basto, P., Levy-Nissenbaum, E., Radovic-Moreno, A., Zhang, L., Langer, R.,
Molnar, L., Farokhzad, O. C.,”HER-2 Targeted Nanoparticle-Affibody Bioconjugates for
Breast Cancer Therapy“, ChemMedChem. 3, 1839-1843 (2008).
Zhang, L., Chan, J. M., Gu, F.X., Rhee, J-W., Wang, A.Z., Radovic-Moreno, A., Alexis,
F., Langer, R, Farokhzad, O. C., “Self-Assembled Lipid-Polymer Hybrid Nanoparticles:
A Robust Drug Delivery Platform”, ACS Nano 2, 1696-1702 (2008).
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Alexis, F., Radovic-Moreno, A., Rhee, J-W, Richie, J. P., Langer, R., Farokhzad, O. C.,
"New Frontiers in Nanotechnology for Cancer Treatment", Journal of Urological
Oncology 26. 74-85 (2008).
Wang, A. Z., Bagalkot, V., Vasilliou, C., Gu, F.X., Alexis, F., Zhang, L., Shaikh M.,
Yuet, K. , Cima, M., Langer, R., Farokhzad, O. C., Kantoff, P.W., Bander, N.H., Jon, S.,
Farokhzad, O. C., "Superparamagnetic Iron Oxide Nanoparticle-Aptamer Bioconjugates
for Combined Prostate Cancer Imaging and Therapy”, ChemMedChem. 9, 1311-1315
(2008).
Alexis, F., Pridgen, E., Langer, R., Farokhzad, O. C., "Factors Affecting the Clearance
and Biodistribution of Polymeric Nanoparticles", Molecular Therapeutics 5, 505-515
(2008).
Conference Proceedings: (Peer Reviewed)
Banik, B.L., Rogers, M., Dhulekar, J., Moore, T.L., Alexis, F., “Synthesis and Testing of
Biomolecules to Target Bone”, Proceedings of the National Conference of
Undergraduate Research, Ithaca College, Ithaca, NY, (2011).
Banik, B.L., Rogers, M., Dhulekar, J., Moore, T.L., Alexis, F., “Synthesis and Testing of
Biomolecules to Target Bone”, Proceedings of the ACC Meetings of Minds, University of
Miami, Miami, FL, (2011).
Keith, K., Mattison, S., Collier, M., Lewis, R., Alexis, F. “Testing Chemotherapeutic
Drugs for Synergistic Toxicity Using Several Cancer Cell Lines”, Proceedings of the
ACC Meetings of Minds, University of Miami, Miami, FL, (2011).
Wright-Walker, C. J., DesJardins, J. D., Alexis, F., LaBerge, M., “Tribological
Evaluation of a Drug Enriched Ultra-High Molecular Weight Polyethylene for Enhanced
Total Joint Replacement Bearing Surface Functionality”, Proceedings of the Society For
Biomaterials Meeting, Orlando, FL, (2011).
Mattix, B., Reese, L., Pollard, S., Anderson, J., Carpenter, K., Davda, L., Breece, J.,
Alexis, F.”Effects of Polymeric Nanoparticle Surface Properties on Interaction with Brain
Cancer Cells”, Proceedings of the Southeast Regional IDeA Meeting, New Orleans, LA,
(2011).
Mattix, B., Uvarov, O., Willi, T., Reese, L., Pollard, S., Frankel, B., Alexis, F. “ Effects
of Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor
Environment”, Proceedings of the SC INBRE Scientific Symposium, Columbia, SC,
(2012).
Mattix, B., Reese, L., Poole, T., Visconti, R., Simionescu, D., Simionescu, A., Jenkins,
L., Bruce, T., Alexis, F. “Assembly of Engineered Blood Vessels Using Magnetic
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Forces.” Proceedings of the SC Project for Organ Biofabrication Scientific Symposium,
Columbia, SC, (2012).
Poole, T., Mattix, B, Reese, L., Alexis, F. “Magnetic Spheroids For Tissue Engineering
Applications.” Proceedings of the National Conference on Undergraduate Research,
Weber State University, Ogden, Utah, (2012).
Wright-Walker, C. J.; Golightly, C. E.; Alexis, F.; DesJardins, J. D.; LaBerge, M.;
“Tribological Evaluation of a Drug Enriched Ultra-High Molecular Weight
Polyethylene for Enhanced Total Joint Replacement Bearing Surface Functionality”;
Proceedings of the Society For Biomaterials Conference, New Orleans, (2012).
Moore, T. L.; Stoner, B.; Morrison, R.; Simionescu, A.; Simionescu, D.; Recknor, C.;
Alexis, F.; “Targeted, Multifunctional Nanoparticles for Controlled Delivery of Anabolic
Bone Therapy Drugs”. Proceedings of the Society For Biomaterials Conference, New
Orleans, (2012).
Mattix, B.; Poole, T.; Casco1, M.; Visconti, R.; Simionescu, D.; Simionescu, A.;
Alexis, F.; “Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids
as Tissue Engineered Building Blocks”. Proceedings of the Society For Biomaterials
Conference, New Orleans, (2012).
Dawson, B.; “Periorbital Implant for Treatment of Cytomegalovirus”. Proceedings of the
South Carolina-Louis Stoke Alliance for Minority Participation (LSAMP) Conference,
Columbia, (2012).
Horne, D.; “Effects of Polymeric Nanoparticle Surface Properties on Interaction with
Brain Tumor Environment”. Proceedings of the South Carolina-Louis Stoke Alliance for
Minority Participation (LSAMP) Conference, Columbia, (2012).
Alexis, F.; “Polymer Coated CNTs to Safely Delivery Drugs”. Proceedings of the ACS
SERMACS Meeting, Raleigh, (2012).
Uvarov, O.; Mattix, B.; Pollard, S.; O’Donnel, L.; Horne, D.; Dhulekar, D.; Frankel, B.
Alexis, F.”An Investigation of Functionalized Nanoparticles Interactions with Brain
Cancer Cells” .I”. Proceedings of the ICMAT, Singapore, (2012)
Moore, T.; Morrison, R.; Stoner, B.; Simionescu, A.; Simionescu, D.; Recknor, C.;
Alexis, F. “Targeted, Multifunctional Nanoparticles for Controlled Delivery of Anabolic
Bone Therapy Drugs.”Proceedings of the Biomedical Engineering Society Annual
Meeting, Atlanta, (2012).
Mattix, B.; Poole, T.; Casco1, M.; Visconti, R.; Simionescu, D.; Simionescu, A.;
Alexis, F. “Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids
as Tissue Engineered Building Blocks”. Proceedings of the Biomedical Engineering
Society Annual Meeting, Atlanta, (2012).
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Chen H., Moore T., Qi B., Colvin D.C., Jelen E., Hitchcock, D., He J., Mefford O.T.,
Gore J.C., Alexis F., Anker J.N., “Monitoring pH-triggered drug release from
radioluminescent nanocapsules with X-ray excited optical luminescence,” Proceedings of
the ACS SERMACS Meeting, Raleigh, (2012).
Alexis, F. “Drug Delivery and Imaging Technologies Using X-Ray”, ICMAT, Singapore,
(2013).
Olsen, T., Alexis F.; “Cellular Spheroid Fusion Using Magnetic Forces to Fabricate a
Vascular Tissue”, Society For Biomaterials, (2013).
Olsen, T., Casco, M., Simionescu, D., Visconti, R., Alexis, F.”Accelerating Cellular
Spheroid Fusion Using Magnetic Forces to Fabricate a Vascular Tissue "Blood Vessel
Tissue Engineering", Accepted. Biomedical Engineering Society, San Antonio, Accepted
(2014).
Olsen, T., Whitehead, D., Van Horn, B., Alexis, F. ”Non-Invasive Deep Tissue Imaging
of Polymer Degradation Using X-Ray”, Accepted. Biomedical Engineering Society, San
Antonio, Accepted (2014).
Prior to Clemson:
Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S., “Factors Affecting the Drug
Release Mechanisms of PLGA 53/47 and PLLA”, Proceedings of the International
Conference of Materials Processing for Properties and Performance (MP3), Singapore,
Singapore, (2002).
Alexis, F., Rath, S. K., Boey, F.Y.C., Venkatraman, S., “Comparative Study of Drug
Release from Matrices Made of PLLA and PLGA Copolymers”; Proceedings of the
International Conference on Materials for Advanced Technologies, Singapore,
Singapore, (2003).
Alexis, F., “HER-2 Targeted Nanoparticle-Affibody Bioconjugates for Breast Cancer
Therapy”, Proceedings of the American Association Cancer Research Annual Meeting,
Los Angeles, CA, (2007).
Alexis, F., “HER-2 Targeted Polymeric Nanoparticles for Breast Cancer Therapy”,
Proceedings of the Nano Science and Technology Institute Conference, Santa Clara, CA,
(2007).
Conference Proceedings (Not reviewed)
Banik, B.L., Rogers, M., Moore, T.L., Alexis, F., “Synthesis and Testing of Biomolecules
to Target Bone”, Southeast Biomedical Engineering Career Conference, Clemson, SC,
(2010).
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Moore, T., Przestrzelski, B., Lewis, R., Jelen, E., Dhulekar, J., Stoner, B., Bloomquist,
C., Simionescu, D., Simionescu, A., Recknor, C., Alexis, F. “Targeted Nanoparticles to
Deliver Drugs for Prolonged Periods of Time to Bone Tissue.”, SCMEDTECH
Conference, Charleston, SC, (2011).
Stoner, B., Morrison, R., Przestrzelski, B., Dhulekar, J., Lewis, R., Jelen, E., Moore, T.,
Simionescu, D., Simionescu, A., Recknor, C., Alexis. F., “Targeted Nanoparticles to
Deliver Drugs Through Controlled Release Kinetics to Bone Tissue”, SFB-Memphis
Biomaterials Day, University of Memphis, Memphis, TN, (2011).
Reese, L., Mattix, B., Poole, T., Visconti, R., Simionescu, D., Simionescu, A., Jenkins,
L., Bruce, T., Alexis, F., “ Magnetic Cell Spheroid For Tissue Engineering Applications”,
SFB-Clemson University Biomaterials Day, Clemson University, Clemson, SC, (2011).
Poole, T., Mattix, B., Reese, L., Visconti, R., Simionescu, D., Simionescu, A., Jenkins, L.
Bruce, T., Alexis, F., “Magnetic Spheroids For Tissue Engineering Applications”,
Southeast Biomedical Engineering Career Conference, University of Virginia, Herndon,
VA, (2011).
Uvarov, O., Mattix, B., Willi, T., Reese, L., Pollard, S., Frankel, B., Alexis, F.” Effects of
Polymeric Nanoparticle Surface Properties on Interaction with Brain Tumor
Environment”, SFB- Memphis Biomaterials Day, University of Memphis, Memphis, TN,
(2012).
Moore, T.L.; Britton, T.; Jelen, E.; Mattix, B.; Frankel, B.; Alexis, F.; “Delivery of Non-
toxic Drug Loaded Nanoparticles for Enhancing Brain Cancer Therapy”. SCBIO
Conference, Charleston, (2012).
Mattix, B.; Poole, T.; Casco, M.; Visconti, R.; Simionescu, D.; Simionescu, A.; Alexis, F.
“Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids as Tissue
Engineered Building Blocks”. SCBIO Conference, Charleston, (2012).
Moore, T.; Podila, R.; Rao, A.; Alexis, F. “Graphene Coated Technology for Biomedical
Implants.” SFB- Clemson University Biomaterials Day, Clemson, (2012).
Casco, M.; Poole, T.; Visconti, R.; Simionescu, D.; Simionescu, A.; Mattix, B.; Alexis, F.
“Spatial Control of Magnetic Nanoparticles Integrated with Cellular Spheroids as Tissue
Engineered Building Blocks.” SFB- Clemson University Biomaterials Day, Clemson,
(2012).
Uvarov, O.; Willi, T.J.; Reese, L.; Pollard, S.; O’Donnell, L.; Horne, D.; Dhulekar, J.;
Frankel, B.; Mattix, B.; Alexis, F. “Effects of Polymeric Nanoparticle Surface Properties
on Interaction with Brain Tumor Environment.” SFB- Clemson University Biomaterials
Day, Clemson, (2012).
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Moore, T.; Mattix, B.; Grimes, S.; Dhulekar, J.; Kraveka, J.; Frankel, B.; Alexis, F.
“Delivery of Non-toxic Drug Loaded Nanoparticles for Enhancing Brain Cancer
Therapy.” SC INBRE Symposium, Columbia, (2013).
Moore, T.; Wang, F.; Morrison, R.; Musgrave, L.; Anker, J.N.; Alexis, F.
“Radioluminescent Polymer Coated Nanoparticles for Imaging Drug Delivery to the
Brain.” SC INBRE Symposium, Columbia, (2013).
Mattix, B.; Uvarov, O.; Pollard, S.; O’Donnell, L.; Park, K.; Horne, D.; Dhulekar, J.;
Kraveka, J.; Frankel, B.; Alexis, F. “Effects of Polymeric Nanoparticle Surface Properties
on Interaction with Brain Tumor Environment for Drug Delivery Applications.” SC
INBRE Symposium, Columbia, (2013).
PRESENTATIONS
Alexis, F., The Road of Academia, SFB-Clemson Biomaterials Day, Clemson University
(07-22-2009).
Alexis, F., Nanotechnology and Biomaterials, Summer Science Engineering and
Architecture educational program (SSEEA), Clemson University (08-07-2009).
Alexis, F., Targeted Nanoparticles for Drug Delivery, Clemson University Nanomaterial
Group, Clemson University (08-12-2009).
Alexis, F., Targeted Nanoparticles for Drug Delivery, Clemson University Nanomaterial
Group, Clemson University (08-12-2009).
Alexis, F., Targeted Polymeric Nanoparticles for Drug Delivery Applications, School of
Materials Science, Nanyang Technological University (05-25-2010).
Alexis, F., Biomedical research and Technologies at Clemson University, School of
Materials Science, Nanyang Technological University (05-24-2010).
Alexis, F., Targeted Nanoparticles for Drug Delivery, Institute of Environmental
Toxicology, Clemson University (02-16-2010).
Alexis, F., Nanoparticle Drug Delivery Systems for Therapeutic Applications,
Department of Regenerative Medicine, Medical University of South Carolina (12-13-
2010).
Alexis, F., Targeted Nanoparticles for Drug Delivery, Neuroscience Grand Round,
Department of Neuroscience, Medical University of South Carolina (03-07-2010).
Alexis, F., Engineered Nanotechnologies for Biomedical Applications, School of
Materials Science, Nanyang Technological University (06-30-2011).
14
Alexis, F., Engineered Nanotechnologies for Medical Applications, Department of
Biological Sciences, Clemson University (11-14-2011).
Alexis, F., Engineered Nanotechnologies for Medical Applications, Department of
Pharmacology and Toxicology, East Carolina University (11-17-2012).
Alexis, F., Assembly and Maturation of Engineered Linear Blood Vessels Using
Magnetic Cellular Spheroids, SC Project for Organ Biofabrication Scientific Symposium,
Columbia (02-10-2012).
Alexis, F.; “Polymer Coated CNTs to Safely Delivery Drugs”. Proceedings of the ACS
SERMACS Meeting, Raleigh, (2012).
Alexis, F. “From Inert Nanomaterials to Functional Structures”. NASA Ames Research
Center, San Jose, (2012).
Alexis, F. “Nanoparticle Delivery of Non-Toxic Drugs for Enhancing Brain Cancer
Therapy”. Institute of Applied Neurosciences, Charleston, (2012).
Alexis, F. “Safely Integrating Nanotechnologies With Tissue Engineering”. University of
South Carolina, Columbia, (2012).
Alexis, F. “Safely Integrating Nanotechnologies With Tissue Engineering”. University of
Chulalongkorn, Thailand, (2013).
Alexis, F. “Safely Integrating Nanotechnologies With Tissue Engineering”. Nanyang
Technological University, Singapore, (2013).
Alexis, F. “Drug Delivery and Imaging Technologies Using X-ray”. ICMAT, Singapore,
(2013).
Alexis, F. “Biological Magnetic Cellular Spheroids as Building Blocks for Tissue
Engineering”, University of South Carolina, Columbia, SC.
F. Alexis “Career Panel-Vanderbilt University’s Biomaterials Day”, Vanderbilt
University, Nashville, (2013).
Alexis, F. “Assembly and Maturation of Engineered Blood Vessels Using Magnetic
Cellular Spheroids”, South Carolina EPSCoR/IDeA Conference, Columbia, (2014)
Alexis, F. “Biodegradable and Biocompatible Imaging Agents”, Medical University of
South Carolina; Center for Biomedical Imaging, Charleston, (2014).
Alexis, F. “Safely Integrating Nanotechnologies With Tissue Engineering”. Nanyang
Technological University, 3D Printing Center, Singapore, (2015).
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Alexis, F. “Functionalized Nanoparticles for Specific Removal of Gaseous Pollutants”.
ICMAT, Singapore, (2015).
Alexis, F. “Biodegradable and Biocompatible Imaging Agents”. University of West
Virginia, (2015).
INTELLECTUAL PROPERTY
“X-Ray Excited Optical Materials and Methods for High-Resolution Chemical
Imaging”. Anker, J., Chen, H.; Alexis, F., Utility Patent (2011).
Trademark-"Call Me GloberTM": Under-represented Undergraduate Research Abroad.
Alexis, F., Burg, K. (2012).
Print (Copyright)-“Tissue Engineering on the Dome!” Alexis, F., Burg, K. (2012).
Licensed to Slicedtomato.
“Receptor targeted nanoparticles for enhanced transcytosis mediated drug delivery”
Pridgen, E.; Alexis, F.; Langer, R.; Farokhzad, O. (2013)-Provisional Patent.
“Biodegradable Polyester-Based X-ray Imaging Agents and Methods of Making and
Using Thereof”, Alexis F., Whitehead, D.C., Van Horn, B. (2014)-Provisional Patent.
“Pollutant remediation Using Biodegradable Polymers” D. Whitehead, Alexis, F., (2014)-
Provisional Patent. Five companies have establish licensing interests.
“Novel Anti-inflammatory Nanoparticle Scaffolds for Periodontal Treatment”;
Kirkwood, K.; Alexis, F. (2015)-Provisional Patent.
Prior to Clemson: "Targeted Drug Delivery Using Human IgG Fc Fragment", Alexis, F., Farokhzad, O. C.,
Kuo, T., Pridgen, E., Radovic-Moreno, A., Langer, R., PCT/US2007/85318 (Licensed by
BIND Biosciences and SELECTA Biosciences).
"Poly (Amino Acid)-Targeted Drug Delivery", Alexis, F., Zhang, L., Chan, J., Basto, P.,
Levy-Nissembaum, E., Langer, R., O. Farokhzad, O. C., PCT/US08/05949 (Licensed by
BIND Biosciences).
"Amphiphilic Compound Assisted Polymeric Particles for Targeted Delivery". Zhang, L.,
Radovic-Moreno, A., Gu, F.X., Alexis, F., Langer, R., Farokhzad, O. C.,
PCT/US2008/059480 (Licensed by BIND Biosciences).
"Oligonucleotide Systems for Targeted Intracellular Delivery", Levy-Nissenbaum, E.,
Farokhzad, O. C., Langer, R., Alexis, F., PCT/US2007/017539 (Licensed by BIND
Biosciences).
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"Adjuvant Incorporation in Immunonanotherapeutics", Alexis, F., Iannacone, M., Chi, J.,
Basto, P., Moseman, A., Von Andrian, U., Langer, R., Farokhzad,
O.C.,PCT/US2008/11932 (Licensed by SELECTA Biosciences).
"Nicotine Immunotherapeutics", Von Andrian, U., Farokhzad, O.C., Alexis, F.,
Iannacone, M., Basto, P., Chi, J., Moseman, A., Langer, R., PCT/US2008/428408
(Licensed by SELECTA Biosciences).
"Engineered Antibody and Antibody Fragments for Oriented Conjugation-Method of
Preparation and Uses Thereof", Alexis, F., Aizu, W., Kuo, T., Pridgen, E., Farokhzad,
O.C., Langer, R., (2008), provisional patent.
"Nanoparticle Technology for the Delivery of Multiple Molecules- Methods of
Preparation and Uses Thereof", Pridgen, E., Alexis, F., Westernof, K., Marein, S.,
Bander, N., Kantoff, P., Farokhzad, O.C., Langer, R., (2008) provisional patent.
"Vaccine Nanotechnology", Von Andrian, U., Farokhzad, O.C., Langer, R., Tobias, J.,
Moseman, A., Zhang, L., Basto, P., Iannacone, M., Alexis, F., (2008) (Licensed by
SELECTA Biosciences).
"Targeting of Antigen Presenting Cells with Immunonanotherapeutics", Chi, J., Alexis,
F., Iannacone, M., Moseman, A., Basto, P., Langer, R., Farokhzad, O.C., Von Andrian,
U., PCT/US08/11932. (Licensed by SELECTA Biosciences).
"Immunonanotherapeutics that Provides IgG Humoral Response Without T-Cell
Antigen", Iannacone, M., Alexis, F., Basto, P., Moseman, A., Chi, J Langer, R.,
Farokhzad, O.C., Von Andrian, U., (Licensed by SELECTA Biosciences).
HONORS AND AWARDS
Third place at the Singapore Young Person’s Lecture Competition, Institute of Materials
South East Asia (2004).
Phage Display of Proteins and Peptides Training, Cold Spring Harbor Laboratory (2009)
Most cited article in ChemMedChem (2007)
Most accessed article in Molecular Pharmaceutics (2008-2014)
Cover Art in Particles and Particle Systems Characterization, Vol 30 (2013)
ACS Nano Podcast of an interview with Dr. Anker and Alexis; Episode 67: ACS Nano;
February 2013 "Managing Editor Heather Tierney highlights features and research
content from Volume 7, Issue 2. In this episode we hear about monitoring pH-triggered
drug release using radioluminescent nanocapsules. Featuring an interview with authors
Frank Alexis and Jeffrey Anker."
Listed in a Nature Biotechnology article as Top Translational Junior Faculty in 2013
Frontispiece in Advanced Functional Materials, In Press (2014)
Guest Speaker, Nanyang Technological University, Convocation 2015
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SPONSORED RESEARCH
“IDeA Networks of Biomedical Research Excellence (INBRE)”; National Institute of
Health, Target Faculty, $17,975,442, ($147,122), (2010-2015).
“Anabolic Targeted Bioactive Nanoparticles for Osteroporosis Therapy”; South Carolina
Space Grant Consortium, Principal Investigator; $30,000, ($30,000), (2010-2011)
“Controlled Self Assembly of Novel Magnetic Cell Spheroids for the Fabrication and
Maturation of Linear Blood Vessels”; American Heart Association, Principal
Investigator, $152,406, ($133,526), (2012-2014).
“Biodegradable Lactide Nanoparticles for the Destruction of Malodorous Organics”;
Animal Co-Products Research and Education Center, Co-Principal Investigator,
$50,000, ($8,000), (2012-2013).
“Controlled Assembly and Maturation of Linear Blood Vessels”, SC EPSCoR/IDeA-
GEAR, National Science Foundation, Principal Investigator, 40,000, ($40,000), (2012-
2013).
“Biodegradable Lactide Nanoparticles for the Destruction of Malodorous Organics”;
Animal Co-Products Research and Education Center, Co-Principal Investigator,
$30,000, ($5,000), (2013-2014).
“Biodegradable Lactide Nanoparticles for the Destruction of Malodorous Organics”;
Animal Co-Products Research and Education Center, Co-Principal Investigator,
$70,000, ($14,000), (2014-2015).
“Novel Anti-Inflammatory Nanoparticle Scaffolds for Periodontal Treatment”;
International Association for Dental Research-GSK Innovation in Oral Care Awards, Co-
Principal Investigator, $80,000, ($30,000), (2014-2015).
“IRES: Call Me Glober-Under-Represented Undergraduate Bioengineering Research in
Singapore”; National Science Foundation, Principal Investigator, $220,000, (2015-2018).
“Lactide Nanoparticles for the Remediation of Rendering Malodorants”; Animal Co-
Products Research and Education Center, Co-Principal Investigator, $70,000, ($30,000),
(2015-2016).
“Accessing Kilogram-Scale Quantities of Functional Nanoparticles for the Remediation
of Industrial Environmental Contaminants”, Clemson University-Technology Maturation
Grant Award, Co-Principal Investigator, 70,000, ($30,000), (2015-2016).
“Immune Reactivation and Apoptosis Induction in Breast Cancer with Bifunctional
Fusion Proteins Using Nanotechnology”, Greenville Health System, Co-Principal
Investigator, 20,000, ($4,000), (2015-2016).
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“Biodegradable X-ray Contrast Polymeric Nanoparticle for Deep Tissue Imaging of Oral
Cancer Tumors”, Center for Oral Health Research (COHR) Pilot & Feasibility Project
Program Award, National Institute of Health, Co-Principal Investigator, 30,000,
($10,000), (2015-2016).
OTHER SPONSORED ACTIVITY Symposium Award, Society For Biomaterials, $5200, (2011-2012).
Equipment grant, National Science Foundation, $683,437.00, (2011-2014).
Travel Award, SCNASA-EPSCoR, $3,750, (2012-2013).
GRADUATE STUDENT ADVISING
Doctoral Graduates
Graduated: N=4 PhD students
Moore, T. “Development of Novel Theranostic Nanomaterials”, (Graduated, 8/2013).
Mattix, B “Integrating Nanomaterials in Tissue Engineering”, (Graduated, 8/2013).
Olsen, T. “Maturation of Tissue Engineered Blood Vessels”, (Graduated, 05/2015).
Alexander, A. “siRNA Delivery to Treat Head and Neck Cancer”, (Graduated 07/2015).
Current: N=2
Guerra, F. “Biodegradable Lactide Nanoparticles for the Destruction of Malodorous Organics”,
05/2017, (Major Advisor).
Casco M. “ Magnetic Cellular Spheroids:”, 05/2017, (Major Advisor)
Masters Graduates
Graduated: N=4 MS students
Jelen, E. “Drug Delivery to the Bone”, (Graduated, 8/2012).
Willi, T.J. “Synthesis of Novel Polymer-Drug Bioconjugates”, (Graduated, 12/2012).
DeCroes, O. “Targeted Drug Delivery for Glioblastoma Therapy”, (Graduated, 8/2014)
Dhulekar, J. “Drug Delivery for Neuroblastoma Therapy”, (Graduated, 8/2014)
TEACHING
Undergraduate Courses Taught
Co-Instructor:
CME241L, Metrics Laboratory, F09, S10
BIOE401, Senior Biomedical Design, S10
BIOE201, Introduction to Biomedical Science, F10, F11, F12, F13, F14
BIO491, Research in BIOE, F09, S10, F10, F11, S11, F12, S12, S13, F13, S14, F14
BIOH491, Honors Research in BIOE, F09, S10, F10, F11, S11, F12, S12, S13, F13, S14,
F14
New Course Development
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BIOE449, Introduction to Drug Delivery Systems, S11, S12, S13, S14, S15
BIOE460, Singapore Summer Research, Su11, Su12, Su13, Su14, Su15
BIOE460, Thailand Summer Research, Su14, Su15
Graduate Courses Taught
Instructor:
BG6001 (SCBE, NTU), Advanced Biomaterials, F15
UNIVERSITY AND PUBLIC SERVICE
Committees
Department: Member, ABET (2009-2011)
Member: Study Abroad Programs (2010- )
Chair: Page Morton Hunter Seminar Series (2010-)
Chair: C. Dayton Riddle Seminar Series (2012)
Member: Student Award (2012-2014)
Chair: Quality Enhancement Plan-Critical Thinking (2013-)
University: Member: Eportfolio assessment (2012)
Member: Quality Enhancement Plan (2012-)
Member: ACC Inter-Institutional Academic Collaborative (2013-)
Member: Intellectual Property Committee (2013-)
Other Service
ETS Proficiency Profile /Measure of Academic Proficiency & Progress (MAPP) (2010)
Phonathon, Bioengineering, (2010)
ETS Proficiency Profile /Measure of Academic Proficiency & Progress (MAPP) (2011)
Arizona State University-Nanotechnology and Society Survey (2011)