Collaborative Research on Addiction at the National Institutes of Health Update … ·...

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Collaborative Research on Addiction at the National Institutes of Health Update 2016 MARGARET M. MURRAY, PH.D. SUSAN R.B. WEISS, PH.D.

Transcript of Collaborative Research on Addiction at the National Institutes of Health Update … ·...

Page 1: Collaborative Research on Addiction at the National Institutes of Health Update … · 2016-02-23 · Using Social Media to Address Substance Use and Addiction -CA 14-008/009 Goals

CollaborativeResearchonAddictionatthe

National InstitutesofHealthUpdate2016

MARGARETM.MURRAY,PH.D.

SUSANR.B. WEISS, PH.D.

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CRAN MissionCollaborativeResearchonAddictionatNIH

“…toprovideastrongcollaborativeframeworktoenabletheNationalInstituteonAlcoholAbuseandAlcoholism(NIAAA),theNationalInstituteonDrugAbuse(NIDA),andtheNationalCancerInstitute(NCI)tointegrateresourcesandexpertisetoadvancesubstanceuse,abuse,andaddictionresearchandpublichealthoutcomes.”

http://addictionresearch.nih.gov/

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TheCRANBlogSavinga“LostGeneration”:TheNeedtoPreventDrugandAlcoholAbuseinMidlife

Dr.NoraVolkowandDr.GeorgeKoob Jan28,2016

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CollaborativeResearchonAddictionatNIH

• GranteeMeeting(SupplementAwardees)• SocialMediaFOA• DevelopmentofNewProgramAnnouncements

____________________________

• JointT32TrainingReview• CRANStrategicPlan

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Ø 80attendeesincludingseniorandjunior investigators,NIAAA,NIDA,NCIprogramstaff,coveringdiverseareasof research.

SelectDiscussionSummary

§ PanelistsdescribedtheneedtoeducatereviewersinbothtranslationalresearchandCRANresearch,theneedtohaveanappropriatestructureinplace,moreconversationbetweenpreclinicalandclinicalinvestigatorsaboutpolysubstanceabuse,morefocusontheclinicaldilemmasregardingthemosteffectivetreatmentregimen.

§ CRANhasbeengoodbecauseithasprovidedaframeworkforbothpreclinicalandclinicalresearch,butperhapsmostimportantly,ithaselevatedthestatusofpolysubstancework,oftennotseenbeforeasvaluable.

§ CRANmaybemoreimportantforclinicalanddeliverysciencethanotherareasofsubstanceabuseresearch.BecauseofCRAN,barriershavebeenremovedandinvestigatorscanstudythingssuchase-cigarettes(bigepidemicinadolescentmedicine),co-morbiddepression,andprescriptiondrugs,alongwithalcohol.

§ Allpanelistsfeltthatmoreinterdisciplinarytrainingisneeded.

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MoreDiscussionComments• Thereneeds tobeastudysectionputtogether lookingatcollaborationacross

thefieldofaddiction.• IfreviewersareunawareofNIHinterestinthisfunctional integration, thenit

becomeschallenging.• Itiscriticaltochangethewaybothsides(programandinvestigators)think

andoperateforresearch.• CRANmentorshipprogramisneeded.• FosterthetranslationalresearchinterestwithinCRANvianewmechanisms.• CRANgranteescouldworktogetheronreviewarticles.• Institutescouldpublishguidelines formulti-substance research.• Asystematicreviewofmultisubstanceinstrumentsandmeasuresisneeded.• CRANsymposiaatmajorscientificmeetingswouldhelp.

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RFA-CA-14-008/009:UsingSocialMediatoUnderstandand

AddressSubstanceUseandAddictionACRANInitiative

CurrentActivities

June10,2015:GranteeIntroductionWebinarJune22-23,2016:GranteeMeeting

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UsingSocialMediatoAddressSubstanceUseandAddiction -CA14-008/009GoalsoftheRFAweretwo-fold:

• Observationalstudiesusingsocialmediainteractionsassurveillancetoolstounderstandtheepidemiology,riskfactors,attitudes,andbehaviorsassociatedwithalcohol,tobaccoandotherdruguseandaddiction.

• Interventionresearchmeasuringthereach,engagement,andbehavioralandhealthimpactofsocialmedia-basedinterventionsforscreening,prevention,andtreatment.

• ElevenawardsmadeinSeptember2014- sevenR01’sandfourR21’s.

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SocialMediaRFAGrantees&*RelatedProjectsPIName,Grant# ProjectTitle

Kim,AnniceR01CA192240

UsingSocialMediaDataforE-CigaretteSurveillanceandPolicyResearch

Oesterle,SabrinaR21DA039466

UsingFacebooktoRecruit ParentstoaParentingProgramtoPreventTeenDrugUse

Schulte, MaryaR21DA039459

PURPOSE:ASocialMediaInterventionforParentSupport

Vrieze,ScottR01AA023974

SocialMedia,OnlineMeasures,&SubstanceUseDevelopmentinAdolescent Twins

Weitzman,Elissa*R21AA023901

Detecting YouthDrinkingandAssociationswithAlcoholPolicies viaSocialMedia

Young,SeanR21DA039458

AdaptingtheHopeSocialMediaIntervention toReducePrescription DrugAbusef

PIName,Grant# ProjectTitleBerg,CarlaR21CA198455

Policy,advertisingandsocialmediarelated toe-cigarette consumerbehavior

Bickel,WarrenR01DA039456

TheSocialInteractome ofRecovery:SocialMediaAsTherapyDevelopment

Cavazos-Rehg,PatriciaR01DA039455

Implications ofSocialMediaContent andEngagementForAlcoholAndMarijuanaUse

Carlson,Robert*R56DA038366

NIDANational EarlyWarningSystemNetwork(IN3)

Curtis,BrendaR01DA039457

Predicting AODRelapseandTreatment CompletionfromSocialMediaUse

Daniulaityte, RamintaR01DA039454

Trending:SocialMediaAnalysistoMonitor CannabisAndSyntheticCannabinoid Use

Ge,YongR21AA023975

MiningPatternsofSubstancebyYoungAdultswithSocialMediaData

Graham,AmandaR01CA192345

SocialDynamicsOfSubstanceUseinOnlineSocialNetworksforSmokingCessation

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FY15FundingOpportunitiesNovelTargetstoImproveAdolescentSubstanceAbuseTreatmentandPrevention(PA:R34,R01)AdolescentBrainCognitiveDevelopment(ABCD)Study(RFAs:U01,U24)

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NovelTargetstoImproveAdolescent(andYoungAdult)SubstanceAbuseTreatmentandPreventionAimedatunderstandingmechanismsaswellasdevelopingnoveltreatmentsandpreventioninterventionsthattargetbehavioralmechanismsrelevanttosubstanceuseandabuse,including:impulsivity,risk-takingpropensity,sensationseeking,distresstolerance,delaydiscounting,self-regulation,andstressreactivity.

• PA15-035-ResearchAimedatNovelBehavioralTargetstoImproveAdolescentSubstanceAbuseTreatmentandPreventionInterventions(R34)1/5/2015-1/8/2018(changedtoincludeyoungadultsuptoage25).

• PA-15-036 - ResearchAimedatNovelBehavioralTargetstoImproveAdolescentSubstanceAbuseTreatmentandPreventionInterventions(R01)1/5/2015– 1/8/2018(Changedtoincludeyoungadultsuptoage25).

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DevelopingFundingOpportunities

WorkgroupsFormingtoDevelopProgramAnnouncementsinthefollowingareas:§ ImplementationofSystem-LevelChangestoImproveSubstance

AbuseTreatmentandPrevention§ LoriDucharme,NIAAA;TishaWiley,NIDA;LizGinexi,NCI

§ TargetAssessment,Engagement,andDataReplicabilitytoImproveTreatmentOutcomes§ BrettHagman,NIAAA;WillAklin,NIDA;GlenMorgan,NCI

§ TranslationalStudiesonPoly-SubstanceAbuseandAddiction§ IvanaGrakalic,NIAAA;ShellySu,NIDA;GlenMorgan,NCI

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ResearchTraining◦ InstitutionswithNIAAA,NIDA,NCItrainingprograms,butlimited“cross-institute”training

◦Disincentives(e.g.,inreview)forprogramsthatproposetotrainstudentsinotherICpriorityareas

◦ Expertpanelconvenedtodiscusshowtoovercomethesebarriers

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PanelRecommendationsØInstituteLeadership conveytoinvestigatorsandreviewersthatcross-substanceresearch/trainingisapriority

ØWorkshops,SymposiatoconveyInstitutes’prioritiestothefieldandtosolicitinputonopportunitiesforresearchandtraining

Response-- SupplementstoT32programsforadditionaltrainingslotsthat:

• Exposetraineestocross-cuttingresearchareasoftobacco,alcohol,andothersubstanceuse,abuse,andaddictionandrelatedhealth-consequences;

• Preparetraineestoconductindependentresearchincross-cuttingareas.

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NIAAAandNIDAtohaveInstitutionalNRSAApplicationsReviewedbyaCommonPanelofExpertsbeginningin2016Issued:Dec17,2015:ForapplicationssubmittedforMay25,2016(nonAIDS)andSeptember7,2016(AIDS)duedatesforJanuary2017Council.

AsingleSpecialEmphasisPanelwillbesetupeachyeartoreviewapplicationsreceivedbyNIDAandNIAAAinresponsetotheparentFundingOpportunityAnnouncements:PAR-14-015 (T32)andPA-14-016 (T35). ThepanelswillbejointlymanagedbystafffromNIAAAandNIDAwhowillensurethatappropriateexpertiseisincludedtoreviewthefullbreadthofresearchtrainingproposedinalloftheapplications,includingthoseapplicabletoeachinstituteaswellasthoseresponsivetomulti-substancepriorityareas.

NoticeofInformation:NOT-DA-16-007

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Why?• Increaseefficiency• Increasepoolofreviewersandbroadentheexpertise•Messagetotheresearchcommunity• Opportunitytoenhancetraininggoalstoincludemultiplesubstancesandaddmentoringexpertise• Addressreviewerbias—e.g.,programspenalizedfortraineesstudyingotherIC’spriorityareas(drugsforNIAAA;alcoholforNIDA)

NotalltrainingwillbeCRAN:Institutespecifictrainingprogramswillstillbesupported.

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Howwillthisbeimplemented?§NIAAA/NIDAWorkingGroup:MarkSwieter,AbeBautista,SusanMcGuire,RichardRippe,MimiGhim,LindseyGrandison,KathyYoung,MinnaLiang,R.V.Srivinas

§AlternatingleadIC-- bothICSROsandESAsinvolved

§DevelopProceduresandGuidelinesforReviewers

§FAQsforProgramStaffandApplicants

§AllinformationpostedonCRAN,NIAAA,andNIDAwebsite

Staytuned……

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CRANSTRATEGICPLAN:2016-2021

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CRANMission

“…toprovideastrongcollaborative frameworktoenabletheNational InstituteonAlcoholAbuseandAlcoholism(NIAAA),theNational InstituteonDrugAbuse(NIDA),andtheNationalCancerInstitute(NCI)tointegrateresourcesandexpertisetoadvancesubstanceuse,abuse,andaddictionresearchandpublichealthoutcomes.”

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CRANseekstofillgapsinresearchby:

Ø Expandingresearchtrainingtoincreasescientificexpertiseinmulti-substanceresearchØ CreatingcoretechnicalfacilitiesandcommondatabasesforsuchresearchØ FacilitatingaparadigmshiftinaddictionresearchculturebothwithinNIHandacrosstheresearchcommunities.

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GoalsandObjectives

§ TheultimategoalisforCRANtoinvestigateanddifferentiatethecommonanddistinctivefeaturesofthedifferentmanifestationsofaddictionalongthediseasecontinuum.

§ CRANencouragesfundingtotargetemergingand/orunder-recognizedopportunitiesaddressingmultiplesubstanceuseandcomorbidityacrossthelifespan,involvingdifferentlevelsofanalysis,fromthecellular/moleculartohealthservicesandpolicyresearch.

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StrategicApproachesAdvancingBasicScience:◦ Developanimalmodelsofpolysubstanceuse.◦ Identifynewtargets(e.g.,genes,epigeneticmarks,biochemicalpathways,neuralcircuits)asbiomarkersorleadsformedicationsdevelopment totreatmultipleaddictions.

PromotingClinicalResearch:◦ Determinetheefficacy/utilityofcoordinatedefforts toscreenformultiple substances.

◦ Implementmulti-armedclinicaltrialstoassessoutcomesforvarioussubstancesaloneandincombination tooptimize resourcesandspeedmedicationsandothertreatmentdevelopment.

◦ Developimprovedapproachesfortreatingmulti-substanceaddictionsandothercomorbidconditions (e.g.,mentalillness,chronicpain,HIV).

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StrategicApproachesImprovingPublicHealthandReducingHealthDisparities◦ Focusonpolysubstanceuseinvulnerablepopulations(e.g.,pregnantwomen,theelderly;peoplewithmedicalcomorbidities,suchasHIVorHCV).

◦ Identifyandteststrategiestoovercomebarriersanddisincentivestoadoptionofresearch-basedtreatmentsformultipleaddictionsinthecommunity,criminaljusticesystem,andhealthcaresystems.

◦ Conductimplementationresearchtoimprovetreatmentaccessibilityinvariouspopulations,andundertheAffordableCareAct(ACA).

◦ Promoteresearchontheadversehealthconsequencesofpoly-substanceuse.◦ Supportresearchtodevelopmoreeffectiveprogram,policy,andcommunicationinterventionstargetingsubstanceabuse,andtobetterdisseminateandimplementexistingevidence-basedinterventions.

LeverageDataSystemsandShareResourcesamongtheCRANICs(andothersasappropriate)

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InSummaryWeencouragetheresearchcommunitytoleveragetheopportunitiesprovidedbyCRANtoconsidertheirresearchprioritiesinordertodevelopabetterunderstandingoftheinfluenceofmultiplesubstancesonbraindevelopment,drugusepatternsandtrajectories,healthandpublichealthconsequences,treatment,prevention,andimplementationscience


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