Cognitive Stimulation Therapy (CST) for dementia
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Transcript of Cognitive Stimulation Therapy (CST) for dementia
Cognitive Stimulation Therapy (CST) for dementia
Professor Martin OrrellUniversity College London and
North East London Foundation Trust
Bob Woods, Aimee Spector, Elisa Aguirre, Amy Streater, Juanita Hoe, Zoe Hoare, Ian Russell, Charlotte Gardner,
Vasiliki Orgeta, Fara Hamidi, Phoung Leung, Lauren Yates
new generation psychosocial interventions in dementia
Nine principles:• Theory of action and model• Evidence used in development• High quality evaluation – major RCT/systematic review• Unitary intervention – clearly defined• Evidence of effectiveness on key outcomes • Appropriate outcomes (cognition, behaviour, mood, ADL
institutionalisation, quality of life)• Cost effectiveness• Scalable – training/manual/resources• Transferable – across care systems/countries
NICE-SCIE guidance (2006) www.nice.org.uk
• People with mild/moderate dementia of all types should be given the opportunity to participate in a structured group cognitive stimulation programme … provided by workers with training and supervision … irrespective of any anti-dementia drug received …’
Cognitive Stimulation • Distinguish from cognitive training and cognitive
rehabilitation (Clare & Woods, 2004)
• Cognitive stimulation: – Targets cognitive and social function
– Has a social element – usually in a group or with a family care-giver
– Cognitive activities do not primarily consist of practice on specific cognitive modalities
CST Background• ‘Reality Orientation’ (RO) marked a breakthrough in dementia
care• Criticism of RO: applied in a rote, uninspired way, (Dietch,
Hewitt and Jones, 1989), insensitive to individual needs (Powell-Proctor & Miller, 1982)
• RO Cochrane Review (Spector et al., 2000)- Meta-analysis of 6 RCTs, (125 participants)- Significant improvement in cognition and behaviour following RO,
compared to no treatment or alternative treatment- Need for a treatment which is evidence-based, replicable, cost-
effective and follows principles of person-centred care
The programme1) 14, 45 minute sessions (2 x week, 7 weeks)
2) Participants asked to give a group name
3) RO board
4) Sessions begin with warm up exercise
5) Bridging between sessions, consistency in time, place, participants and facilitators
6) Presenting sessions in a fun and stimulating way
CST trial (Spector et al., 2003)
CST Key Principles
• Orientating people sensitively / when appropriate
• Information processing and opinion rather than factual
knowledge -> implicit learning
• Multi-sensory stimulation
• Flexible activities to cater for group’s needs and abilities
• Using reminiscence (as an aid to here-and-now)
• Building / strengthening relationships
Attrition Rate: n= 201, n=168 at follow up
Significant improvement in the primary outcome measures cognition and quality of life
Improvement in QoL mediated by improvement in cognitive function
Numbers needed to treat for cognition = 6similar to AChEIs
CST trial (Spector et al., 2003)
•23 centres ( 18 residential care and 5 day care)•A multicentre Randomised Controlled Trial (RCT)
Treatment and Control Groups - differences between baseline and
follow up: Cognition (n=201)
MMSEp=0.04
ADASp=0.01
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Treatment and Control Groups - differences between baseline and follow up: Quality of Life (n=201)
p=0.03-1
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ge treatment control
No significant results were found for the secondary outcome measures
- Functional ability (CAPE-BRS)- Depression (Cornell)- Anxiety (RAID)
QoL improved more for women than men
Improvement in QoL mediated by improvement in cognitive function
Numbers needed to treat for cognition = 6similar to AChEIs
CST trial: Other results
Cost- effectivenessFew studies have evaluated cost-effectiveness of apsychosocial intervention
Service use was recorded 8 weeks prior to, and during the 8-week intervention and costs calculated
Incremental cost-effectiveness ratio: balancing mean cost difference Between CST and usual activities with changes in
a) Cognition and b) QoLService use levels generally very modest and remained
stable over time
Cost-effectiveness acceptability curve: probability group is cost-effective for a range of values of decision-makers’ willingness to
pay for one point improvements on MMSE/QoL-AD.
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Willingness to pay for additional point on MMSE/QoL scales (£)
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Cost-effectiveness (Knapp et al., 2006)
CST is more cost-effective than usual activities using both outcome measures:
• Incremental cost-effectiveness ratio: £75.32 per additional point on MMSE (111 euros), £22.82 per point on QoL-AD (33.2 euros)
• Donepezil had considerably larger cost per incremental outcome gain (AD2000, 2004)
Conclusions: Small costs were outweighed by larger gains likely that decision makers will see CST as cost-effective.
Limitations – short time span, mainly focused on people in residential care
• Need to evaluate potential longer-term effects of CST• Cochrane review no clear evidence of longer-term effects
• Follow on from 7 week/14 session programme
• 16 session weekly programme (45 mins)
• 35 people with dementia
• 2 residential homes had MCST + controls
• 2 residential homes had CST only +controls
Pilot - Maintenance CST (Orrell et al., 2005)
Maintenance CST - MMSE Results(Orrell et al., 2005)
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Baseline7 weeks23 weeks
Pilot - Maintenance CST
• Over 23 weeks people with dementia receiving MCST continued to show cognitive improvements
• Cognition declined in CST only and control groups
• Interpretation limited as it was a pilot study - Groups no randomised - Small sample
• Large multicentre trial is required
Development of the MCST trial programme
Maintenance CST development
• Extract features of research trials which had demonstrated effectiveness
• New included themes : Useful tips (caring from oneself, memory tips, use of calendars, alarms) and Visual Clips from Requena (2007) and Olazaran (2004)
• Development of the evidence-based programme, 24 sessions of maintenance based on the CST and MCST pilot programme sessions plus new identified studies
• Presentation of the draft version 1 in a consensus conference to develop draft version 2 of the manual.
Modelling the programme9 Focus Groups(Aguirre et al., 2010)
• 17 people with dementia, 13 staff and 18 family carers • Inductive thematic analysis to examine user perceptions of the
Maintenance CST programme • Mental stimulating highly valued by PWD, finding it vital in
order to keep them healthy and active.• Most family carers and staff very positive attitudes towards
cognitive stimulation programmes BUT some concerns were raised:
- When use it or lose it doesn’t apply - Concerns with regards lose of confidence, anxiety or sense of
inferiority.
• Positive agreement was found among 14 themes and suggestions were made for the 5 remaining themes.
• Carers and staff rated using money and current affairs very low - felt that using money could be a sensitive topic and current affairs was a theme that people with dementia wouldn't relate to
• In contrast people with dementia expressed a great interest in the using money theme and in the news
Focus Groups results(Aguirre et al., 2010)
RCT of Maintenance CST• Need sample size of 230 people with mild/moderate
dementia. (60 Alzheimer’s Type plus Donepezil)
• 50% sample to be recruited from community and 50% from care homes
• People with dementia will be recruited into CST groups (8 to 10 per group).
• Complete initial CST programme - x2 weekly 45 min sessions for 7 weeks
• Primary outcome measures -cognition and quality of life
Maintenance CST vs. CST
8 to 10 ParticipantsCST group A
8 to 10 participantsTAU
Randomised 236
BASELINE ASSESSMENT
7 WEEKS CST
Twice a week (14 session)
BASELINE ASSESSMENT 2
3 MONTH Follow Up
24 WEEKS MCST
Once a week (24 session)
6 MONTH Follow Up
8 to 10 ParticipantsCST group B
8 to 10 participantsMCST
Randomised 272
CST Predictors of change
• 272 recruited to CST groups as first stage of Maintenance CST Trial and 236 completed 7 weeks
• Improvement 1.09 MMSE points (p < 0.001), ADAS-Cog 2.34 points (p< 0.001)
• Improvement 1.85 DEMQOL points (p < 0.003)• Female gender was associated with higher
improvement • use of ACHEIs did not alter improvement
Maintenance CST Trial – first results
• 236 participants (123 MCST/123 CST only)• After 6 months MCST
– Quality of life better QoL-AD p = 0.04 • After 3 months MCST
– Quality of life better (proxy) DEMQOL p = 0.04, QoL-AD = 0.008
– ADCS-ADL better p = 0.05• MMSE improved in MCST group 0.85 points
• Qualitative study investigating experiences of the people attending CST groups, their carers and group facilitators (N=34)
• Data analysed using Framework Analysis
• Two main themes:' Positive experiences of being in the group’ & ‘Changes experienced in everyday life’
• Experience of CST seen as being emotionally positive
• Most reported some cognitive changes.
• Findings support the mechanisms of change suggested by the previous RCT of CST.
CST mechanisms of change
CST in practice
• Past research in dementia care training have shown variable and limited findings.
• Most studies showing that staff training does not lead to any lasting change.
Method• Survey of 152 people who had attended a one-day CST training
course (50% - 76 responded) after 3 months +• Questionnaire on starting CST groups and obstacles
Measures • Attitude towards dementia (ADQ)• Job satisfaction (JS) • Learning transfer (LTSI)
CST in practice• 27 took up CST (36%) and 49 did not (64%)
• CST group scored significantly better on work environment and ability / enabling on LTSI
• No differences between groups on the other measures
• No relationship between job title, place of work, gender, age or ethnicity and starting CST group
• Individuals with better learning characteristics may be more likely to take up CST following training
• Simple factors such as a lack of staff time and resources may prevent people from doing CST
CST in practice(Spector, Aguirre and Orrell 2010)
• Delivered by carer 2 times a week for 20-30 minutes
• 75 individual CST sessions
• 25 week programme
• Themed activities eg: Number Games
• Manuals and resource workbook
What is the Individual CST programme?
Field testing - Support• Weekly support calls
• Majority of carers have not requested help or advice about the programme, technique, or activities
• Support outside weekly scheduled calls: 2 requests
Barriers
2Health of carer and person
with dementiaMotivation
1Finding the time to
do sessions
Positive outcomes for carersThe programme
has given me more tolerance
We’ve had some nice enjoyable times doing the
activities together
The programme has given me ideas I never would have
thought of
I feel like I have a purpose when
spending time with dad
I’m glad we have iCST, it has given
us a lot of help
It made us realise that parts of mum’s memory work, and
others don’t
It has taught us how to work on the things
that matter, and ignore the things
that don’t
I cannot say how much of a difference this has made to my relationship with my
mother
Positive outcomes for people with dementia
My dad’s mood is lifted during
sessions
My mum seems more confident and like her old
self
Mum is more alert after sessions
Mum’s conversational skills seem to
have improved
Mum is enjoying the activities
Recruit N= 306 participants
Baseline data collectionRemote
randomisationN= 153 individual
CSTN= 153 TAU
Outcome measures at 13 weeks
Follow up at 26 weeks N= 260
Methods / Design of Main RCT
Cochrane Review 2012Woods, Aguirre, Orrell, Spector
• 15 trials, 407 treatment and 311 controls participants• Length of intervention varied: 1 to 24 months• MMSE difference at follow up = 1.74 points (Z = 5.57, p
< 0.00001)• Holden Communication Scale SMD = 0.47 (Z = 3.22, p =
0.001) • Wellbeing/QoL SMD = 0.38 (Z = 2.76, p = 0.006)• Depression (GDS) SMD = 0.34 (Z = 1.88, p = 0.06)• No benefits to ADL, behaviour, or carers measures
Future CST work• ADI World Alzheimer Report recommends CST• Training evaluation part of the SHIELD programme• Defining cognitive change - neuropsychology of CST• Individualised CST for family carers: home-based work
CST website: www.cstdementia.com
Join the CST Network - email [email protected]