Codeine detoxification
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Transcript of Codeine detoxification
Codeine detoxification.By Nwanevu Sylvanus & Herman.
Introduction.
• Codeine - 3-methylmorphine is an opiate which is a natural isomer of methylated morphine.
• It was isolated in 1832 in France by Pierre Robiquet.
• It is the most widely used opiate in the world.
Structure.
Applications of codeine.
• It can be used as a pain killer in combination with paracetamol, aspirin to enhance the effect.
• Can also be used as a recreational drug.
• It is used to suppress premature labor contractions, also in myocardial infarctions.
• As sedative & anti hypertensive drug.
Adverse effects.
• Drowsiness, constipation, euphoria, urinary retention
• Rare effects include seizure & anaphylaxis.
Detoxification.• Codeine is converted to morphine by
enzyme cytochrome p450 - CYP2D6
• It undergoes N-demethylation to form Norcodeine by CYP3A4.
• UGT2B7 ( UDP- Glucuronosyltransferase-2B7) conjugates codeine, norcodeine, & morphine to corresponding 3- & 6-glucuronides.
Conclusion.
• Stay safe, don't abuse drugs!
• It is advised to only take drugs prescribed by a Doctor.
Thanks for your attention.