Co-Transporters

Na+/Glucose Symport

Vibrio cholerae

ProkaryoteWater-bourne pathogenProduces Cholera Toxin

Chloride Ion Channel (CFTR) involved in Cystic Fibrosis

CFTR = Cystic Fibrosis Transmembrane conductance Regulator

K = LysineR = Arginine

CFTR Channel Protein

Healthy Lung

Lung epithelial cells Lung epithelial cells

Lung epithelial cells Lung epithelial cells

Cystic Fibrosis Lung

MisfoldedCFTR proteinDegraded in ER

CF Gene Therapy

Flu virus withNormal CFTR gene

Na+/K+ ATP-dependent Active Transporter (Pump)

Pg. 396

(see also Fig. 12-12)

K+ “Leak” Channel