co-processed excipients ppt
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CO-PROCESSED
EXCIPIENTS
Presented by- Mr. Bhaskar N. Bangar Mr. Bhaskar N. Bangar
M. Pharm. (Sem. I)
Under the guidance ofUnder the guidance of
Dr. N. H. Aloorkar Dr. N. H. Aloorkar
(H.O.D. Pharmaceutics)
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Contents…………Contents…………
Definition of excipients
Roles of excipients
Need of excipients
Classification of excipients
Excipients used in solid dosage forms
Excipients used in semi-solid dosage forms
Ideal characteristics of excipients
Excipients used in liquid dosage forms
Co-processed excipients
Conclusion
References 3
Co-processing methodology
What are Excipients?What are Excipients?
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Need of ExcipientsNeed of Excipients
Direct clinical use of the active drug substances is rare
due to the number of reasons:
API handling is difficult or impossible.
Accurate drug dosing is difficult or impossible.
API may cause local irritations or injury.
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API can have unpleasant organoleptic properties.
API can be degraded at the site of administration.
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Cont......
Ideal characteristics of excipientsIdeal characteristics of excipients
It should be non toxic.
It should be physically and chemically stable.
It should be commercially available.
It should have pleasant organoleptic properties.
Economic.
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Roles of excipients in different dosage formsRoles of excipients in different dosage forms
Impart consistency and volume
Improve stability
Increase solubility
Enhance bioavailability
Increase patient compliance and acceptability
Impart weight
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ClassificationClassification of excipientsof excipients
Primary excipients : Diluents
Binders
Disintegrants
Lubricants
Antiadhesives
Glidents
Secondary excipients : Flavoring agents
Sweetening agents
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Commonly used excipients in solid dosage Commonly used excipients in solid dosage formsforms
Diluents Binders Disintegrants Lubricants Antiadhesives Glidents
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Commonly used excipients in liquid dosage Commonly used excipients in liquid dosage formsforms
Vehicle Vehicle
Flocculating agents Antimicrobial agents Antimicrobial agents Antioxidants Sweetening agents Flavoring agents
Suspending agents
Preservatives
SUSPENSIONSUSPENSION EMULSIONEMULSION
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Commonly used excipients in semi-solid dosage Commonly used excipients in semi-solid dosage formsforms
Bases
Preservatives
Antioxidants
Chelating agents
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Co-Processed ExcipientsCo-Processed Excipients
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Manufacturing problems in solid Manufacturing problems in solid dosage dosage forms forms
Product weight variation.
Content non uniformity during mixing.
Loss of excipients.
Poor disintegration time of product.
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Particle propertyParticle property Achieving Excipient functionalityAchieving Excipient functionality
Particle size Flow ability, compressibility, disintegration, dissolution rate.
Particle size distribution Segregation potential.
Particle shape Flow ability, content uniformity, compressibility.
Particle porosity Compressibility, solubility.
Particle Properties Achieving Excipient Particle Properties Achieving Excipient FunctionalityFunctionality
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Excipient selection on the basis of material characteristics
Selection of proportion of excipients
Homogenous dispersion or solution
Co-drying
Co-processed excipient
Co-processing methodologyCo-processing methodology
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Manufacturing of co-processed excipietsManufacturing of co-processed excipietse.g. Dicalcium phosphate (diluent) and magnesium stearate (lubricant)
Steps:Steps:
1. Solubalisation
2. Solvent evaporation
3. Drying
4. Sifting
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Properties of co-processed excipientsProperties of co-processed excipients
Absence of chemical change
Improved flow properties
Improved compressibility Reduced lubricant sensitivity
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AdvantagesAdvantages
Provide a single excipient with multiple functionalities.
Better mouth feel and improved palatibility.
Removal of undesirable properties.
Improvement of organoleptic properties.
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Evaluation parameters for co-processed excipientsEvaluation parameters for co-processed excipients
ParticleParticle size distribution-size distribution-
The particle size distribution can be calculated by
statistical method.
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Carr’s index-Carr’s index-
Carr’s index can be calculated by-
Carr’s index= Tapped Density-Bulk Density Tapped Density ˟˟
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Cont......
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Hausner Ratio-Hausner Ratio-
Hausner Ratio= Tapped Density Bulk Density
Hausner ratio can be calculated by-
Cont......
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REFERENCESREFERENCESAulton’s Pharmaceutics, the design and
manufacture of medicines, third edition by Michael E. Aulton.
Page no: 298-301.B. M. Mithal, A textbook of Pharmaceutical formulation,
vallabh prakashan. Page no. 57-120.Remington- The science & practice of Pharmacy. Page
no. 896-910.Ansel’s Pharmaceutical dosage form. Page no.198-
199, 240-242.www.google.comwww.wikipedia.com/coprocessed excipients
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