CNS Tuberculosis imaging andCNS Tuberculosis imaging … · CNS Tuberculosis imaging andCNS...
Transcript of CNS Tuberculosis imaging andCNS Tuberculosis imaging … · CNS Tuberculosis imaging andCNS...
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CNS Tuberculosis imaging andCNS Tuberculosis imaging and surgeryg y
Moderators Dr Ashish Suri
Dr Deepak Guptap p
Presented ByPresented ByDr Ajay Bisht
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Tuberculosis As old as recorded history
Symptoms described in the Rig Veda (1500 BC)
Unequivocal lesions in Egyptian mummies
Odier, Ford described meningeal TB 1790
S i l i i W i k d H h 88 Surgical excision Wernicke and Hahn 1882,
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Tuberculosis CNS tuberculosis complicates 10% of all TB
N h fi if iNever the first manifestation
O ithi 6 thOccurs within 6‐12 months
Ci l f Willi f tl i l d th th Circle of Willis more frequently involved than the basilar system
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Mycobacterium tuberculosisAcid fast bacillusDoes not stain on gram
istainObligate aerobesDiffi lt t Difficult to growHigh lipid in cell wall H i i / B i / A iHominis/ Bovine/ Avium
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Pathogenesis May develop during initial infection/ reactivation
Haematogenous disseminationCommonest Focus in brain (Rich focus)Focus in brain (Rich focus)Rupture of focus into subarachnoid/ ventricular space
Contiguous spread
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CNS tuberculosisIntracranial
Parenchymal M i l Meningeal Osseous
Spinal Spinal Parenchymal Meningeal
h dArachnoiditis Osseous
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Epidemiology Incidence varies blacks > whites
Predominantly in the young (50% <10)
Abscess in 4‐8% (20% with HIV)
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Pathology Immature lesions – multiple tubercles in oedematous brain
Mature: avascular mass, nodular extensions, yellowish gritty casseous areasgritty casseous areas
60% attached to dura60% attached to dura
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Pathology (parrenchymal)Can be present anywhere
Cerebellum in children
Cerebral hemisphere and basal ganglia commoner in adults
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Pathology (tuberculoma)Tuberculoma ( classical lesion)Tuberculoma en plaqueTuberculous abscessCystic tuberculomaMultiple grape like tuberculomaMicrotuberculoma Calcified tuberculomaTuberculous encephalopathy
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Pathology (tuberculoma)Dastur described six main types
Parenchymal changes.
(1) Ventriculitis(2) Border‐zone encephalitis( ) I f i(3) Infarction(4) Internal hydrocephalus(5) Diffuse oedema( ) b l(6) Tuberculoma
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Pathology (meningeal)Classically Commonest in 6m – 3 yearsNow adults 50% Thick exudate encasing nerves, vesselsHCP, tuberculoma, arachnoiditisDiffuse perivasculitisInfarcts Pachymeningitis
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Diagnosis Montoux testHb/ ESRCXRELISA CSF PCRImaging Biopsy
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Imaging X rayAngiography of historical significanceCTMRI
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Imaging Tuberculoma
Typically cortical and subcorticalM lti l i %Multiple in 10‐35%Milliary rare ( children)
Meningitis (commonest form of CNS TB)Meningitis (commonest form of CNS TB)Isolated meningitis is rare (5% in children)Basal cisterns
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Imaging (CT tuberculoma)Cerebritis: hypodense areasPerilesional oedema out of proportionEarly tuberculoma: iso to slightly hyper dense ring Early tuberculoma: iso to slightly hyper dense , ring enhancementEvolved : well delineated ring enhancing mass, target sign ( l h l ifi i )(central enhancement or calcification)Healed: often calcify Manifestations Manifestations
Small disc/ ringsLarge rings with central lucencyLarge nodular mass with irregular outlinea ge odu a ass egu a ou eMultiple lesions in 15‐20%
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Caseating tuberculosis granulomainvolving the left temporal lobe.CECT shows a rim-enhancinglesion in the left temporal lobe
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consistent with a caseatingtuberculosis granuloma
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Imaging (MRI tuberculoma)T1 : isointenceT2: central hyper with hypo ring Marked thin rim enhancementHypo on T2: fibrosis, gliosis, macrophage infiltration
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Parrenchymal tuberculosis. contrast-enhanced T1-weighted MR image demonstrates multipleenhancing caseating and non-caseatingtuberculomas predominantly within the left frontal
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tuberculomas, predominantly within the left frontaland parietal lobes
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Milliary CNS tuberculosis. Axial contrast-enhanced T1-
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weighted MR image shows multiple small high-signal-intensity foci within both cerebral hemispheres
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(a) Sagittal T2- hyperintensity in the cervical spinal cord extending from C2 to C7. Ahypointense nodule representing the granuloma is noted at the C4 level.(b) Sagittal T1 & (c) axial T1- with fat suppression after contrast reveal an area ofsolid nodular enhancement representing non caseating tuberculosis granuloma of
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solid nodular enhancement representing non-caseating tuberculosis granuloma ofthe spinal cord. A smaller enhancing granuloma is also noted at the C2 level on thesagittal image
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MRS
•decrease in NAA/Cr •slight decrease in NAA/Cho•lipid lactate peaks are usually elevated (86%)•lipid-lactate peaks are usually elevated (86%)
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A. Bernaerts, F. M. VanhoenackerTuberculosis of the central nervous system: overview ofneuroradiological findings. Eur Radiol (2003) 13:1876–1890
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Imaging (meningitis)Active Sequelae
Hydrocephalus Ischemia and infarction
Medial lenticulostriate 75%Medial lenticulostriate 75%Thalamoperforating Cortex 25%Bilateral 70%
Atrophy Calcification Calcification
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Imaging (CT meningitis)NCCT:
scans may be normalObliteration of basal cisterns by hypo/ iso dense exudate
l d l hi k ien plaque dural thickeningPopcorn calcificationHydrocephalus Sequelae of chronic meningitisSequelae of chronic meningitis
Infarcts
CECT:Abnormal meningeal enhancement (may persist)Leptomeningeal enhancement sylvian fissures, tentoriumGranulomas in the basal meningesEpendymitis
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Imaging (MRI meningitis)Unenhanced scan: does not show active meningitis
Spine l lCSF loculations
Obliteration of arachnoid spaceLoss of cord outline in cervicodorsal cordThickening and clumping of roots in the lumbar cord
Contrast T1 : basal meningeal enhancementspine
Linear enhancement of cord/ roots
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Tuberculous meningitis. Axial contrast-enhancedT1-weighted magnetic resonance (MR) imageshows florid meningeal enhancement that is mostpronounced within the basal cisterns
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Tubercular meningitis. Axial FLAIR-MR] h i k d h i t it f th b lshowing marked hyperintensity of the basal
cisterns and prominent temporal horns in a patient with mild communicating hydrocephalus
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Caseating dural /epidural tuberculosis granuloma or abscess
a) Axial T2- nodular hyperintensity posterior to the clivus and anterior to the medulla (arrow).a) Axial T2 nodular hyperintensity posterior to the clivus and anterior to the medulla (arrow).
b) Axial T1 contrast- dural/epidural rim enhancement suggestive of caseating tuberculosisgranuloma or abscess.
) S itt l h d T1 th ti d l/ id l t b l i l b
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c) Sagittal enhanced T1- the caseating dural/epidural tuberculosis granuloma or abscessposterior to the clivus. Abnormal meningeal enhancement is present
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Spinal tuberculous meningitis. Sagittal gadolinium-enhanced T1-weighted MR image of the thoracic spine
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demonstrates irregular, linear, nodular meningealenhancement
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Enhanced T1-weighted magnetic resonance imaging with fat suppression show intenseenhancement of the subarachnoid space indicating arachnoiditis
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enhancement of the subarachnoid space indicating arachnoiditis
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b l hTuberculous pachymeningitisRare Common sites of involvement are cavernous sinus, floor of middle cranial fossa and tentorium.Radiographic featuresRadiographic featuresCT
hyperattenuating solid plaque like densities ( l f b )(calcification may be seen)
MRIT1 : hypo intense thickened duramater.ypT2 : hypo intense thickened meninges.T1 C+ (GAD) : intense homogenous enhancement of thickened meninges.
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Management Medical therapy
Surgery indications
Vi i lif h d b ffVision or life threatened by mass effectFailure of response to medical therapyParadoxical increase in lesion size with therapypyDiagnosis in doubt
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Medical therapyMedical therapy
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WHO recommendations
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WHO Treatment of tuberculosis: guidelines – 4th ed.
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D ti f t t tDuration of treatment6 monthsvan Loenhout-Rooyackers JH, Keyser A, Laheij RJ, Verbeek AL, van der Meer JW.Tuberculous meningitis: Is a 6-month treatment regimen sufficient? Int J Tuberc Lung Dis2001;5:128-35.
Thwaites GE Hein TT Tuberculous meningitis: Many questions too few answers Lancet
12 months
Thwaites GE, Hein TT. Tuberculous meningitis: Many questions, too few answers. Lancet Neurol 2005;4:160-70
18 months or Longer
Santosh Isac Poonnoose, Vedantam Rajashekhar: Rate of Resolution of histologically verified intracranial tuderculomas. Neurosurgery 53:873-879, 2003
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Treatment
Rate of radiological resolution of intracranial tuberculoma
Series duration of ATT residual lesions %
Wang 1996 (16) 6 20Rajeshwari 1995 (6) 9 12Rajeshwari 1995 (6) 9 12Awada 1998 (2) 12 0Poonnoose 2003 (28) 18 69.2
Santosh Isac Poonnoose, Vedantam Rajashekhar: Rate of Resolution of histologically verified intracranial tuderculomas. Neurosurgery 53:873-879, 2003
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2003
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Medical management d h4 drugs x 3‐4 months
2 drugs x 14‐16 months occasionally longerRegression of size from 4 6 weeksRegression of size from 4‐6 weeksMost resolve in 12‐14 months
R Patir, R Bhatia, Tandon PN. Surgical management of tuberculous infections of thenervous system. Schmidek and Sweet operative neurosurgical techniques 5th edition;nervous system. Schmidek and Sweet operative neurosurgical techniques 5 edition;1617‐1631
AED to continueINH blocks phenytoin metabolismINH blocks phenytoin metabolismSteroids in all irrespective of age and stage
Prasad K, Singh MB. Corticosteroids for managing tuberculous meningitis.
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Cochrane Database Syst Rev 2008;1:CD002244.
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Resistant tuberculosisMDR : resistant to INH and RifampicinEDR/ XDR : MDR + resistance to Quinolones and i j bl d li dinjectable second line drugs
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Second line drugsSecond line drugs
Use at least 4 drugs
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Use at least 4 drugs
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Surgery Severe elevation of ICPThreatening life or visionDo not respond to drugs clinically/ radiologicallyDiagnosis in doubtObstructive hydrocephalus
R Patir, R Bhatia, Tandon PN. Surgical management of tuberculous infections of the nervoussystem. Schmidek and Sweet operative neurosurgical techniques 5th edition; 1617‐1631
Ai di i / li Aim diagnosis/ relieve pressure
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Surgical managementBiopsy of the mass lesionHydrocephalus
Communicating (commoner)Non communicating
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Surgery principlesNon eloquent areas total excision (small lesion)Subtotal/ partial excision (large lesion/ eloquent
)cortex)Conservative excision around vital structuresE i f l li if i i i d Evacuation of central liquifactive portion in deep seated lesionsResidual lesions may respond to medical therapyResidual lesions may respond to medical therapy
R Patir, R Bhatia, Tandon PN. Surgical management of tuberculous infections of the nervous system. Schmidek and Sweet operative neurosurgical techniques 5th edition; 1617‐1631
H d h l Hydrocephalus
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MRC Grading for hydrocephalus
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Grading for hydrocephalusGrading for hydrocephalus
Vellore grading Modified Vellore grading
Palur R Rajshekhar V Chandy MJ Joseph T Abraham J Shunt surgery for hydrocephalous in
Mathew JM, Rajshekhar V, Chandy MJ. Shunt surgery for poor grade patients with tuberculous meningitis and hydrocephalus: Effect of response to external ventricular drainage and other factors on long-term
Palur R, Rajshekhar V, Chandy MJ, Joseph T, Abraham J. Shunt surgery for hydrocephalous in tubercular meningitis: A long-term follow-up study. J Neurosurg 1991;74:64-9
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outcome. J Neurol Neurosurg Psychiatry 1998;65:115-8
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Rajshekhar V. Management of hydrocephalus in patients
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with tuberculous meningitis. Neurol India 2009;57:368-74
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Hydrocephalus Inevitable in those who survive 4‐6 weeksMortality 20‐100%Grade at admission significantEarly shunt for grade I,II
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ETV73.1% success rate for ETV in TBM with hydrocephalus
A chugh, M hussain et al. Surgical outcome of tuberculous meningitis hydrocephalus treated by endoscopic third g g f g y p y pventriculostomy: prognostic factors and postoperative neuroimaging for functional assessment of ventriculostomy: J Neurosurg Pediatrics 3:000–000, 2009
Endovascular revascularization for ischemia
STA MCA bypassThe left superficial temporal artery MCA bypass was found to The left superficial temporal artery–MCA bypass was found to be capable of preventing new ischemic events in the 21‐month follow‐up period
Martin misch, Ultrich‐ wilhelm et al. Prevention of secondary ischemic events by superficial temporalartery–middle cerebral artery bypass surgery after tuberculosis‐induced vasculopathy in a 5‐year‐oldchild:Neurosurg Pediatrics 6:000–000, 2010
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AIIMS DATA (1975 1992)AIIMS DATA (1975‐1992)SUPRATENTORIAL 78
PARIETAL 28
FRONTAL 26
TEMPORAL 155
BG / THALAMUS 4
SELAR/SUPRASELLAR 4
ORBITAL FISSURE 1ORBITAL FISSURE 1
INFRATENTORIAL 50CEREBELLUM 44
CP ANGLE 3
TENTORIUM 1
BRAINSTEM 2BRAINSTEM 2
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Thank you
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