Clou computing in pharma-industry

8/7/2019 Clou computing in pharma-industry

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By.

Tumbi Mohammed Khaled

Second [email protected]


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What

Cloudcomputing

meansto

you???Different definition by different persons.

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The Fifth Generation of Computing

after

Web

Mainframe Computers

Personal Computer

Client-Server Computing

Cloud computing

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moving computing and data

away from the desktop andportable PC, and simply

displaying the results of

computing that takes place in a

centralized location and is then

transmitted via internet tousers screen.

John Markoff

(Google)

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Cloud computing is a model for enabling

convenient , on-demand network access to a

shared pool of configurable computing

resources (e.g., networks, servers, storage,

applications, and services) that can be

rapidly provisionedand released with minimal

management effort or service provider

interaction

Source: NIST Cloud Computing Project5


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Cloud computing is a general term for

anything that involves delivering hostedservices over the Internet

.Wall Street Journal

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History of Cloud Computing

Concept dating back to the 1960s byJohn

McCarthy, a computer scientist, brought up the

idea that "computation may someday be

organized as a public utility

Idea that revolutionized Cloud Computing:

Utility computing

Grid computing

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Understanding Cloud Architecture:Individual users connect to

the cloud from their own

personal computers or

portable devices, over the

Internet.

The hardware in the cloud (and the operating system

that manages the hardware connections) is invisible

To these individual users,

the cloud isseenas a

single application,

device, or document.

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How Cloud Computing Works?Sun Microsystems slogan is The network is

the computer, and thats as good as any to

describe how cloud computing works

A network of computers functions as a single

computer to serve data and applications to usersover the Internet.

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Types of Clouds

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Public Clouds

Private Clouds Hybrid Clouds


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Different Services in

Cloud computing

Software as aService (SaaS) :Under this layer,

Applications are delivered through the

medium of the Internet as a service

Instead of installing and maintaining

software, you simply access it via the Internet

Freeing yourself from complex software and

hardware management an installation

procedure

Who is using this in Pharma 11


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Pfizer

Biotherapeutics & Bioinnovation Center has

used Amazon cloud services to develop and

refine models in antibody-antigen dockingusing RosettaDockandRosettaAntibody

software, shortening the process to 2-3

hoursfrom 2-3 days.

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Cambridge Soft

CambridgeSoft announced ChemBioOfficeCloud,an integrated informatics suite available over theInternet

Other Clouds provided by Cambridge SoftBioAssay Cloud (Data management service forClinical Trials)

Inventory Cloud

E-Notebook Cloud

Registration Cloud

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Schrdinger

Cloud solutions to run Schrdingers chemical

simulation and molecular modeling software

in collaboration with cycle computing

Schrdinger argues as Computation is central

to drug discovery but too often it is rate-

limiting due to lackcomputational power

Schrdinger is already running Glide on cloud

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Symyx Technologies

A Accelrys owned chemoinformatics

company

Symyx customers are already doing big QSAR

calculations and homology modeling using

Amazons EC2

They say Its all about trust; its all about

value

i.e. there is a risk but you have to compensate

risk with the cost15


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Infrastructureas aService (IaaS)

Products offered via this mode,

Include the remote delivery (through the

internet) of a full computer infrastructure (e.g.,

virtual computers, servers, storage devices, etc.)

In 2010 White House Uses Amazon cloud (EC2)

storage service to store mail from US nationals to

US President Obama as suggestion of Round tablemeeting 2010 (Approx 3500 mail/sec)

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IaaS and Eli Lilly

10th largest pharmaceutical company in the

world

Moved entire R&D environment to cloud

Results:

Time to deliver new services greatly reduced

New server: 7.5 weeks 3 min 64 node Linux cluster: 12 weeks 5 min

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Pros

Cons

&

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High-volume

low-costPay for what you useReduced Hardware

equipment for end usersLower Hardware and

Software Maintenance

Need not invest on multiplelicensing

Rapid Elasticity

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Pros


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Pros

Accessibility

Improved Performance

Instant Software Updates

Better Collaboration

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ConsThe cons can be mainly classified into:-

Traditional security

Confidentiality

Integrity

Availability

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Traditional security

These concerns involve computer and

network intrusions or attacks that will be

made possible or at least easier by moving to

the cloud

These may includes:-

VM-level attacks

Phishing cloud provideretc

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Availability

It means availability of data 24*7

Availability is the area where cloud based

infrastructure appears to have had its largest (or

at least most highly publicized) challenges to date

For example, consider some of the cloud-related

outages which have been widely reported

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1.Maintenance Induced Cascading

Failures

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Gmail get off the

cloud for about

100 minutes

But by chance

data get

recovered bycloud recovery


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And Let's Not Forget About Power

Issues

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The cloud

provider

Amazon EC2

server get a

sleep,

and wake afteraround4 Hours


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Data Lock-in

How does a cloud useravoid lock-in to a particularcloud-computing vendor?

The data might itself belocked in a proprietaryformat, and there are alsoissues with training and

processes. There is also theproblem of the cloud userhaving no control overfrequent changes in cloud-

based 26


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Confidentiality

The most talked

security concern

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Third-party data controlThe confidential data may be wrongly

use by the cloud provider


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Ways to reduce the risk of

Confidentiality

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Cloud Computing & Host-Based Intrusion

Detection: Give alert on any intrusion

One exampleof a tool that

can help

with thistask is OSSEC


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Healthy Virtualization

Virtualization of computers or operatingsystems hides the physical characteristics of acomputing platform from users; instead it

shows another abstract computing platform.A hypervisor is a piece of virtualizationsoftware that allows multiple operatingsystems to run on a host computerconcurrently

Virtualization providers include VMware,Microsoft, and Citrix Systems

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Private Clouds

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Private Clouds

Use the Private

clouds

But

Lack ofElasticity


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References

Buyya, R., Yeo, C. S., Venugopal, S., Broberg, J. and Brandic, I.,

Cloud computing and emerging IT platforms: Vision, hype, and

reality for delivering computing as the 5th utility, Future

Generation Computer Systems 25 (2010) 599-616.

Dudley, J. T. and Butte, A. J., In silico research in the era of

cloud computing, Nature biotechnology 28 1181-1185 (2010)

Sultan, N., Cloud computing for education: A new dawn?,

International Journal of Information Management 30 109-116.

Schatz, M. C., Langmead, B. and Salzberg, S. L., Cloud

computing and the DNA data race, Nature biotechnology 28

691-693.

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Clou computing in pharma-industry

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