Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by...
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Transcript of Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by...
![Page 1: Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser,](https://reader037.fdocuments.us/reader037/viewer/2022100423/5a4d1b477f8b9ab0599a3a86/html5/thumbnails/1.jpg)
Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms
by Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser, Hui Hao-Shen, Ina Nissen, Sabine Girsberger, Thomas Lehmann, Jakob Passweg, Martin Stern,
Christian Beisel, Robert Kralovics, and Radek C. Skoda
BloodVolume 123(14):2220-2228
April 3, 2014
©2014 by American Society of Hematology
![Page 2: Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser,](https://reader037.fdocuments.us/reader037/viewer/2022100423/5a4d1b477f8b9ab0599a3a86/html5/thumbnails/2.jpg)
Targeted NGS in MPN: study design and workflow.
Pontus Lundberg et al. Blood 2014;123:2220-2228
©2014 by American Society of Hematology
![Page 3: Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser,](https://reader037.fdocuments.us/reader037/viewer/2022100423/5a4d1b477f8b9ab0599a3a86/html5/thumbnails/3.jpg)
Frequency and distribution of mutations in patients with MPN. (A) Number of patients with mutations in the genes is indicated.
Pontus Lundberg et al. Blood 2014;123:2220-2228
©2014 by American Society of Hematology
![Page 4: Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser,](https://reader037.fdocuments.us/reader037/viewer/2022100423/5a4d1b477f8b9ab0599a3a86/html5/thumbnails/4.jpg)
Analysis of sequential samples: clinical correlations and risk stratification.
Pontus Lundberg et al. Blood 2014;123:2220-2228
©2014 by American Society of Hematology
![Page 5: Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser,](https://reader037.fdocuments.us/reader037/viewer/2022100423/5a4d1b477f8b9ab0599a3a86/html5/thumbnails/5.jpg)
Clonal evolution in MPN patients carrying somatic mutations in epigenetic modifier genes.
Pontus Lundberg et al. Blood 2014;123:2220-2228
©2014 by American Society of Hematology
![Page 6: Clonal evolution and clinical correlates of somatic mutations in myeloproliferative neoplasms by Pontus Lundberg, Axel Karow, Ronny Nienhold, Renate Looser,](https://reader037.fdocuments.us/reader037/viewer/2022100423/5a4d1b477f8b9ab0599a3a86/html5/thumbnails/6.jpg)
Model of MPN disease evolution and risk stratification in correlation to mutational events.
Pontus Lundberg et al. Blood 2014;123:2220-2228
©2014 by American Society of Hematology