Clinicopathologic Conference

Marife BonifacioVirgi Lea Claudine Esquivel

Co-Neil RelatoVincent Reolalas

Arriving at Diagnosis

Watery diarrhea Leukocytosis Infectious

Inflammatory bowel disease

Melena / Hematochezia

Metabolic acidosis, electrolyte disturbance Metabolic

Arriving at Diagnosis

Watery diarrhea Leukocytosis Infectious

Inflammatory bowel disease

Metabolic

Melena / Hematochezia

Metabolic acidosis, electrolyte disturbance

NeoplasticAnorexia, generalized body weakness, hematochezia

rectal mass

Neoplastic

Exocrine Pancreas

Colorectum

Paraneoplastic Syndrome

Neuroendocrine Tumor

Steatorrhea, jaundice

Hypercalcemia

Improves with fastingOBSTRUCTIVE LESION

VILLOUS ADENOMA Secretory diarrhea*

Secretory diarrhea**

*Journal here**Journal here

Differential DiagnosesClinical Manifestation VIPoma Carcinoid Syndrome McKittrick

Wheelock Synd.Acute presentation ü1 ü3

Watery diarrhea ü ü üGen. body weakness ü ü üRectal mass ü üRash ü2

*1ü ü4

1 Singh et al (2007) VIPoma: a rare cause of acute diarrhea4Badr et al (1997) Dermatomyositis in association with tubulovillous adenoma: resolution after resection of adenoma. South Med J 90(3):321-4

Dry oral mucosa ü ? üHypotension ü ? üElectrolyte imbalance ü ü üMetabolic acidosis ü ü üRAD ü

Assessment

Pathophysiology

References