November 02-04, 2015Baltimore, USA

International Conference onClinical Sciences

and Drug Discovery

UNITED Scientifi c Group

CSDD-2015

Sponsors

Day 1 Monday November 02, 2015

Registrations 08:00-09:00 Introduction 09:00-09:30

Keynote Session @ Chesapeake Room: 09:30-11:00

Terry Richard StouchScience for Solutions, LLC.

USA

Terry Stouch, PhD, President of Science for Solutions, LLC, has 30 years’ experience in drug discovery research in large pharma and biotech. He specializes in drug design, property prediction, biomolecular structure, and pharmaceutical data evaluation and modeling spanning most therapeutic areas. He has participated in placing 8 compounds into clinical trials. He consults for pharmaceutical, biotechnology, and software companies, academia, investment firms, and database organizations. He is Senior Editor-in-Chief of the Journal of Computer-Aided Molecular Design, Affiliate Professor at U. Maryland Baltimore, AAAS Fellow, and IUPAC Fellow. He has authored over 70 publications and over 150 invited lectures.

Presentation on: The errors of our ways: accounting for known unknowns in drug discovery research

09:30-10:00

Harold C. SmithUniversity of Rochester

USA

Harold Smith is a tenured professor of biochemistry and biophysics at the University of Rochester, School of Medicine and Dentistry where he conducts basic research as well as training of postdocs, graduate and undergraduate students. His interests include epigenetic regulation through RNA processing by the APOBEC family of enzymes that change the genetic code at the level of DNA mutations and RNA editing. Dr. Smith is the Founder, President and CEO of OyaGen, Inc (www.oyageninc.com), a biotech company focused on drug discovery and development for infectious diseases based on APOBEC enzyme technology.

Presentation on: Going beyond repurposing cancer drugs: identification of novel HIV drug leads that are broadly neutralizing of HIV1 clades and

drug-resistant strains

10:00-10:30

Nikolai ZhelevAbertay University

UK

Nikolai Zhelev is a Professor of Medical Biotechnology and Director of CMCBR at Abertay University, Dundee, Scotland. He is also honorary professor in eight universities in UK, China and Bulgaria. Prof. Zhelev has been involved in founding four start-up biotech companies. He is author of books, patents and papers in the field of DNA damage response, cell cycle regulation and drug discovery and development in oncology and cardiology published in reputed journals such as Nature Medicine. Prof. Zhelev is Managing Editor of BioDiscovery – the first open access international scientific journal in the field of Life Sciences and Medicine, published in Scotland and currently the President of the European BioDiscovery Federation.

Presentation on: Recent advances and novel approaches in the discovery and development of cyclin-dependent kinase inhibitors as new therapeutics

in oncology and cardiology

10:30-11:00

CSDD-2015 | Nov 02-04, 2015 | Baltimore, USA 2

Day 1 Monday November 02, 2015

Lunch @ Eden's Landing Restaurant: 12:40-13:40

Coffee Break @ Pre-function Area: 11:00-11:20

Speaker Session @ Chesapeake Room: 11:20-17:00

Session Chairs: Harold C. Smith, University of Rochester, USA Ram Samudrala, State University of New York, USA

Presentation on: Novel Site Identification by Ligand Competitive Saturation (SILCS) CADD approach Alex MacKerell, University of Maryland, USA11

:20-

11:4

0

Presentation on: Does the hepatitis B antigen HBx promote the appearance of liver cancer stem cells? Mark A. Feitelson, Temple University, USA11

:40-

12:0

0

Presentation on: Radiolabeled methods for ADME of protein therapeutics in preclinical development Jeffrey Kurz, Pfizer, Inc., USA12

:00-

12:2

0

Presentation on: Combination of strontium ranelate plus alfacalcidol in the treatment of postmenopausal osteoporosist Saydiganikhodja I. Ismailov, Uzbekistan Public Health Ministry, Uzbekistan12

:20-

12:4

0

Presentation on: Androgen therapy in adolescents Alan D. Rogol, University of Virginia Medical School, USA

13:4

0-14

:00

Presentation on: Challenges in the development of safe & effective oral androgen replacement therapy products for adolescent & adult hypogonadal subjects Om Dhingra, SOV Therapeutics, USA14

:00-

14:2

0

Presentation on: Inhibition of siderophore biosynthesis in fungi and bacteria Pablo Sobrado, Virginia Tech, USA

14:2

0-14

:40

Presentation on: Iontophoretic buccal drug delivery: can it be a breakthrough strategy to promote the therapeutic effects of biopharmaceuticals? Sangkil Lee, Keimyung University, South Korea14

:40-

15:0

0

Presentation on: Photodynamic therapy and imaging based on tumor-targeted nanoprobe, pHPMA-conjugated zinc protoporphyrin, and its augmentation Jun Fang, Sojo University, Japan15

:00-

15:2

0

Coffee Break @ Pre-function Area: 15:20-15:40

Presentation on: D-amino acid oxidase inhibitors as pharmaco-enhancers of D-serine Takashi Tsukamoto, Johns Hopkins University, USA

15:4

0-16

:00

CSDD-2015 | Nov 02-04, 2015 | Baltimore, USA 3

Young Researchers Session@ Chesapeake Room: 17:00-17:20

Presentation on: Preclinical characterization of GLS4: an inhibitor of hepatitis B virus core particle assembly Mark A. Feitelson, Temple University, USA16

:00-

16:2

0

Presentation on: Current trend in the sensitivity of Plasmodium falciparum to coartemisinin therapyMukhtar Dauda, Bayero University, Nigeria16

:20-

16:4

0

Presentation on: Synthesis, structure-activity relationship, and biological evaluation of novel benzoquinones as potent inhibitors of 5-lipoxygenaseRosanna Filosa, University of Naples, Italy16

:40-

17:0

0

Presentation on: Non-invasive salivary glucose monitoring using on-chip Nano-biosensorWenjun Zhang, Northeastern University, USA

17:0

0-17

:10

Presentation on: Structure–activity relationship study of Arbidol derivatives as inhibitors of chikungunya virus replicationSelene Collarile, University of Naples, Italy17

:10-

17:2

0

Day 2 Tuesday November 03, 2015

Hiroshi Maeda Sojo University

Japan

Hiroshi Maeda is a world renowned expert in macromolecular therapeutics. He was successful in creating the world first polymeric drug, SMANCS, approved for treatment of hepatoma in Japan. Consequently, he discovered the concept of EPR effect of macromolecular-drugs, ubiquitous mechanism for solid tumor selective targeting of polymeric drugs. He received MS, University of California, Fulbright Fellow, and Ph.D., M.D., Tohoku University. He published more than 450 papers in reputed journals. He was awarded Lifetime-Achievement-Award at Royal-Pharmaceutical-Society, Princess-Takamatsu-Award in Cancer Research, Tomizo-Yoshida-Award, highest award of JCA, and also selected as most cited influential scientist in pharmacology by Thomson Reuters 2014.

Presentation on: Toward full understanding of the EPR effect in primary and metastatic tumor, and issues of heterogeneity: for tumor

selective delivery and imaging using nano-particles

08:30-09:00

Reception: 18:30-20:00

Keynote Session @ Chesapeake Room: 08:30-10:00

CSDD-2015 | Nov 02-04, 2015 | Baltimore, USA 4

Dawei LiShanghai Jiao Tong University

China

Dawei Li completed his Ph.D from Ohio State University and postdoctoral studies from Harvard University School of Medicine in the USA. He is currently a principle investigator in medicinal biotechnology at School of Pharmacy and Center for Cell Engineering and Antibody Medicine at Shanghai Jiao Tong University. He has published more than 25 papers in reputed journals and 4 approved patents. He is a board member of the Committee for Biochemical Pharmaceutics, Shanghai Pharmaceutical Association and a member of Steering Committee for Student Educational Affairs Management at Shanghai Jiao Tong University.

Presentation on: Monoclonal antibody targeting of tumour micro environment

09:30-10:00

Steven LaPlanteNMX Research and Solutions, Canada

Steven LaPlante is a faculty member at the University of Quebec INRS-IAF, founder of NMX Research and Solutions, visiting scientist at the Broad Institute and consultant at Harvard Medical School and other institutions. He is a senior biophysical medicinal chemist with +20 years of drug design experience in the pharmaceutical industry. He has a proven track record of creating innovative solutions to chemical and biological challenges. He is an NMR specialist who developed novel fragment-, structure- and property-based strategies that led to drug candidates and advanced drugs for HCV and HIV

Presentation on: Discovering quality drug seeds by practical NMR-based fragment screening

09:00-09:30

Coffee Break @ Pre-function Area: 10:00-10:20

Session Chairs: Nikolai Zhelev, Abertay University, UK Krishnan Chakravarthy, NanoAxis, LLC., USA

Presentation on: Human noroviruses contain multiple and diverse antiviral targets Brent E. Korba, Georgetown University Medical Center, USA

10:2

0-10

:40

Presentation on: Small molecules targeting human oncogenes: promising anti-cancer therapeutics Daekyu Sun, University of Arizona, USA10:4

0-11

:00

Presentation on: Reliability of the dog prostate cancer-1 model for translational research aiming to recapitulate in canines the advanced form of prostate cancer in manSimone Chevalier, McGill University, Canada11

:00-

11:2

0

Speaker Session @ Chesapeake Room: 10:20-16:20

CSDD-2015 | Nov 02-04, 2015 | Baltimore, USA 5

Presentation on: Predicting the binding partners of novel ligands via computational chemogenomics Maria Kontoyianni, Southern Illinois University Edwardsville, USA11

:20-

11:4

0

Presentation on: Sigma-1 receptor: the novel therapeutic target for neurodegenerative disordersShang-Yi Anne Tsai, NIDA/NIH IRP Baltimore, USA11

:40-

12:0

0

Presentation on: Interactomics: computational analysis of novel drug opportunitiesRam Samudrala, State University of New York, USA

13:2

0-13

:40

Presentation on: Label-free resonant waveguide grating biosensor for drug and biology discoveryYe Fang, Corning Incorporated, USA13

:40-

14:0

0

Presentation on: Hypoxia-inducible factor-2a inhibits solid tumor growth through up-regulation of apoptosisGeorge G. Chen, The Chinese University of Hong Kong, China14

:00-

14:2

0

Presentation on: Compounds that stimulate neurotrophic factor expression may reduce alpha-synuclein pathologyRuth G. Perez, Texas Tech University Health Sciences Center El Paso, USA14

:20-

14:4

0Day 2 Tuesday November 03, 2015

Lunch @ Eden's Landing Restaurant: 12:20-13:20

Coffee Break @ Pre-function Area: 15:00-15:20

Presentation on: The application of pipeline pilot (FRESH) in drug lead-optimizationQi Shi, HCL Technologies, USA

15:2

0-15

:40

Presentation on: Anti-amyloid beta (Aβ) mAb reduces retinal deposition of Aβ & activated C3 in age-related macular degeneration mouse modelIan R. Catchpole, GlaxoSmithKline Medicines Research Centre, UK15

:40-

16:0

0

Presentation on: Preclinical studies in neonatal hypoxic ischemic encephalopathy: therapeutic hypothermia and mast cell stabilizationShyama D. Patel, Weill Cornell Medical College, USA16

:00-

16:2

0

Presentation on: New use of metals as nano-sized radiation enhancersAgnes Pottier, Nanobiotix, France

12:0

0-12

:20

Presentation on: Activation and evasion on immune system with using nano carriers of molecular assembliesShunsaku Kimura, Kyoto University, Japan14

:40-

15:0

0

CSDD-2015 | Nov 02-04, 2015 | Baltimore, USA 6

Presentation on: Central and toxicological activity of Nicandrin B a withanolide, extracted from Datura feroxLilian Fernandes Silva, University of Eastern Finland, Finland16

:20-

16:3

0

Presentation on: Assessment of maternal drug intake by bio monitoring during pregnancy until the 3rd perinatal yearHenrike Hoeke, University of Leipzig, Germany16

:30-

16:4

0

Presentation on: Encapsulation of ICAM-1 targeted nanocarriers into chitosan-alginate microbeads provides gastric protection and controlled release for oral drug deliveryRasa Ghaffarian, University of Maryland - College Park, USA16

:40-

16:5

0

Presentation on: Nanoparticles modified with tumor-targeting MUC-1 aptamer deliver miR-34a for effective gene therapy against non-small cell lung cancerXiongwei Deng, Beijing University of Technology, China16

:50-

17:0

0Day 2 Tuesday November 03, 2015

Session Chairs: Steven LaPlante, NMX Research and Solutions, Canada Hiroshi Maeda, Sojo University, Japan

Presentation on: Developing new nano medicine technologies for the treatment of chronic painKrishnan Chakravarthy, NanoAxis, LLC., USA08

:30-

08:5

0

Presentation on: Wonders of cigarette smoke: hurting heart and serving cancerWasana Sumanasekera, Sullivan University College of Pharmacy, USA

08:5

0-09

:10

Presentation on: Combined cancer therapy with SR-A agonist and dendritic cellsJong-Young Kwak, Ajou University, Korea

09:1

0-09

:30

Presentation on: Alterations in metabolism of brain amino acids and inhibitory effects on PKC are possibly correlated with anticonvulsant effects of the isomeric mixture of α- and β-amyrin from Protium heptaphyllumGislei Frota Aragao, Federal University of Ceara, Brazil09

:30-

09:5

0

Day 3 Wednesday November 04, 2015

Coffee Break @ Pre-function Area: 09:50-10:10

Presentation on: Discovery of sub-type specific muscarinic receptor antagonists as potential alternative to atropineApurba K. Bhattacharjee, Georgetown University, USA10

:10-

10:3

0

Speaker Session @ Chesapeake Room: 08:30-12:30

Young Researchers @ Chesapeake Room: 16:20-17:00

CSDD-2015 | Nov 02-04, 2015 | Baltimore, USA 7

Networking & Lunch @ Eden's Landing Restaurant Break: 12:30-13:30

Presentation on: Impact of quaternary structure dynamics on drug discovery – an updateEileen K. Jaffe, Fox Chase Cancer Center, TUHS, USA

10:5

0-11

:10

Presentation on: Targeted delivery of miR-203 by self-assembly nano-carrier suppresses esophageal cancer growth and metastasisFang Zhang, Beijing University of Technology, China11

:10-

11:3

0

Presentation on: Rational use of medicines in Qatar - public knowledge, attitudes, and practicesEl Sayed Ahmed Baraya, Primary Health Care Corporation, Qatar11

:30-

11:5

0

Presentation on: Anti-microbial potential of novel synthetic nicotine derivativesParesh Gandhi, Advance Research Products LLC, USA

11:5

0-12

:10

Presentation on: Anti-protozoal potential of aporphine and protoberberine alkaloids from Annickia kummeriae (Engl. & Diels) Setten & Maas (Annonaceae)Hamisi M Malebo, National Institute for Medical Research, Tanzania12

:10-

12:3

0

Presentation on: Caveolin-1 in pulmonary hypertension: a friend or a foe?Rajamma Mathew, New York Medical College, USA

10:3

0-10

:50

Presentation on: Metformin alone or combined with CAPE protects against benign prostate hypertrophy in rats: role of ER-α/IGF-1R/Phosphoinositide 3-kinase/Akt signalingMai F. Tolba, Ain Shams University, Egypt

P-01

Presentation on: Phytochemical composition, antioxidant and antimicrobial activities of the essential oils from Fraxinus dimorpha coss & dur Msou Soufiane, Cadi Ayyad University Marrakech, Morocco

P-02

Presentation on: An evaluation of anticancer activity of Diallyl disulfide analogs: an active principle of GarlicVikas Saini, University of Delhi, India

P-03

DAY 1 Poster Session @ Billie Holiday Room

CSDD-2015 | Nov 02-04, 2015 | Baltimore, USA 8