An Official Journal ‘�‘

of the ?�,

American Association

for �

Cancer Research

ClinicalCancerResearch

January 1998 #{149}Volume 4 Number 1pp. 1-264 #{149}ISSN 1078-0432

AMERICAN ASSOCIATION FOR CANCER RESEARCH89th Annual Meeting

Frank J. Rauscher, III, Program Committee Chairperson

Morial Convention Center, New Orleans, Louisiana

March 28-April 1, 1998

Titles of Major Sessions

SPECIAL LECTURESPresidential Address: Donald S. CoffeyClowes AwardBurchenal Award: Bernard FisherRosenthal AwardCain Award: Bruce A. ChabnerRhoads Award: Michael DeanAACR-ACS AwardGoodman Lecture

PLENARY SESSIONNew Horizons in Cancer Research (Frank J.

Rauscher, III)

SYMPOSIAMolecular Determinants of Cellular and

Tumor Responses to Radiation (MichaelB. Kastan)

Successes in Oncogene-based DrugTargeting: Selectivity and Specificity(Alex Matter)

Cancer Gene Therapy: New Concepts andClinical Applications (Jack A. Roth)

Reconstruction of Human Tumorigenesisand Progression: Cancer Genetics InModel Organisms (Anthony Wynshaw-Boris)

Tumor Angiogenesis: An IntegratedApproach (Rakesh K. Jam)

Signaling by wnt- I , �-catenin, and the APCTumor Suppressor in Cancer (PaulPolakis)

Prostate Cancer: Basic Science and ClinicalAspects (Leland W.K. Chung)

The Molecular Basis of ImmuneRecognition: Basic Concepts withTherapeutic Implications (GiorgioTrinchieri)

The bcl-2 Family: Death Agonists andAntagonists (Stanley J. Korsmeyer)

Telomerase and Telomeres in Normal andNeoplastic Cells (Ronald A. DePinho)

Inherited Cancer Susceptibility Syndromes:

Genetics, Genes, and Function (DanielA. Haber)

New Concepts in Chemotherapeutics andDrug Resistance (Susan Band Horwitz)

Cell Death Signaling Pathways: CaspaseCascades and Effectors/Initiators ofApoptosis (Douglas R. Green)

p73/p53: An Emerging Gene Family(William G. Kaelin)

Breast Cancer: Basic Science and Clinical

Aspects (Sofia D. Merajver)Molecular Targets and Endpoints for

Chemoprevention (Waun Ki Hong)Cancer Biology in Context: Stromal, Cell-

Cell, and Cell-ECM Interaction inNormal Development and Cancer (MinaJ. Bissell)

Gastrointestinal Cancer: Basic Science and

Clinical Aspects (Kenneth W. Kinzler)Tumor Virology: Molecular Biology and

Etiology (Karl Munger)Advances in Cancer Vaccine Development

(Dorothee Herlyn)

(Names of confirmed session organizers are in parentheses)

Molecular Diversity-based Approaches toAnti-Cancer Drug Design (Jack D.

Keene)New Mechanisms of Action of Viral and

Cellular Oncogenes (Elizabeth Moran)Genetic Approaches to Diagnosis: The

Impact of Molecular Medicine on EarlyDetection and Diagnosis (DavidSidransky)

Tobacco and Lung Carcinogenesis:Genetics, Biology, and Etiology (Adi F.Gazdar)

Transcriptional Regulation of the Neoplastic

Phenotype (Frank J. Rauscher, III)Restoring Drug Sensitivity to Tumors: New

Concepts from Tumor Biology andPhysiology (William N. Hait)

Emerging Issues for Individual CancerSusceptibility and Risk Assessment (FredF. Kadlubar)

Epigenetics and Cancer (Stephen B. Baylinand Peter A. Jones)

CONTROVERSY SESSIONSHave We Improved the Treatment of

Cancer?Environmental Estrogens and Cancer

(Nancy E. Davidson)Will Multidrug Resistance Modulators Be

Effective in the Clinic?

METHODS WORKSHOPS ANDEDUCATIONAL SESSIONS

To Be Announced

“MEET-THE-EXPERP’SUNRISE SESSIONS

Cancer Genome Anatomy Project (CGAP):Update and Potential (Paul S. Meltzer)

JAK-STATs: Dedicated Cytokine SignalingPathways (E. Premkumar Reddy)

Histone Acetylation and TranscriptionalRegulation (Tony Kouzarides)

Molecular Genetics of Brain Tumors(Sandra H. Bigner)

Genetic Analysis of Tumor Suppression byCOX-2 Inhibitors (Makoto M. Taketo)

Antisense-based Therapeutics: Basic andClinical Studies (Thale Jarvis)

Gene Transfer to l-Iematopoietic Progenitors(Fulvio Mavilio)

Psychosocial Aspects of Genetic Diagnosis(Caryn E. Lerman)

Nuclear Hormone Receptors amDevelopment and Disease (VincentGigu#{232}re)

B-Cell Lymphomas: Genetics and Biology

(Riccardo Dalla-Favera)Hormonal Regulation of Cell Proliferation

and Differentiation (Lorraine J. Gudas)Alterations of Cell Cycle Controls in Cancer

(Giulio Draetta)Proteases in Cancer: Clinical Significance

and Mechanisms in Metastasis (HenriRochefort)

Inherited Cancers of the Kidney: FamilyStudies, Genes, and Biochemistry (W.Marston Linehan)

Strategies for Combining Chemotherapy andBiotherapy (Antonio C. Buzaid)

New Concepts in Antimetabolites: BasicScience and Clinical Trials (StevenGrant)

Interleukin- 1 2: Biological and ClinicalDevelopments (Giorgio Trinchieri)

Chemoprevention Trials: Progress andPromise (Scott M. Lippman)

Growth Factor Signaling: The IGF-l , IGF-2 System in Cancer (Haim Werner)

Genetics and Biology of Hematologic

Malignancies (Pier Pellici)Radiation Sensitization: Basic and Clinical

Aspects (Rupert Schmidt-Ullrich)Advances in Mechanisms of Drug

Resistance: Basic Science and ClinicalImplications (Susan E. Bates)

Harnessing the Immune System in TumorTherapy: Manipulation, Stimulatory andInhibitory Signals in T Cell Activation(James P. Allison)

Integrin Signaling and Cell Growth Control:Consensus and Controversies (RudolphL. Juliano)

Issues and Applications in MolecularEpidemiology (Barbara S. Hulka)

Familial Cancer Syndromes: DNA Testing

and Clinical Approaches (KenYamaguchi)

Relevance of DNA Damage and Repair forInitiation and Progression ofCarcinogens: Recent Advances (Jan H. J.Hoeijmakers)

Chromosomal Translocations: Genetics,Biology, and Protein Function (James R.Downing)

Advances in the Mechanisms of Invasionand Metastasis (Isaiah J. Fidler)

From Slave to Master: The BiologicalEvents During Melanoma Developmentand Progression (Meenhard Herlyn)

Farnesyl Transferase Inhibitors (Ivan D.Horak)

Topoisomerases: Structure and Function(James Wang)

Progress in Antibody Therapy of HumanCancer (Nancy Hynes)

Animal Models for Chemoprevention(Michael N. Gould)

Further Information: AACR Office . PublicLedger Building . Suite 826 150 S.Independence Mall West . Philadelphia, PA19106-3483 . TELEPHONE: (215) 440-930(3 FAX: (215) 440-9313Email: meetings@aacr.org. For up-to-dateinformation visit the AACR Website athttp://www.aacr.org

An Official Journalof theAmerican AssociationforCancer Research

Editor-in-ChiefJohn MendelsohnGrowth factors, hormones, cell growth;

radiation therapy, surgery, subspecially investigation

Deputy EditorWaun 1(1 Hong

Clinical trials targeted at specific malignancies, chemoprevention

Senior EditorsBruce A. Chabner

Clinical pharmacology and pharmacokinetics,

drug metabolism, drug sensitivity and resistance,

drug interactions

Michael B. Kastan

Cell cycle regulation, cell death

Paul SondelImmunotherapy and cytokines-preclinical, and

clinical trials

Beverly A. Teicher

Experimental therapeutics, preclinical

pharmacology, combined modality regimens,

David SidranskyMolecular pathogenesis, molecular correlates

Colleen M. Hubona, Executive Editor, Department of Educational Publishing Services---227, The University of Texas M.D.

Anderson Cancer Center, 1515 Holcombe Boulevard, Houston, Texas 77030. Phone: (713) 792-6014; Fax: (713) 792-6016.

Accelerated mailing of all AACRjournals to A.ACR members In Japan is supported by a generous grant from the

Banyu Pharmaceutical Company, Tsukuba, Japan. One-year subscriptions to Clinical Cancer Research are made

available to third-year hematology/oncology fellows in the United States through the generous support ofRh#{244}ne-Poulenc Rorer Oncology.

C1IJPWGJ Cancer Research is published monthly. one volume per year, by the American Association for Cancer Research, Inc. (AACR). Except for members of the AACR. all subscriptions are payablein advance to AACR, Subscription Office. P.O. Box 1 1806, Birmingham. AL 35202 [Phone: (800) 633-4931 or (205) 995.1567; FAX: (205) 995-1588). to which all business communications. remiftances(in United States cuirency or its equivalent). and subsceiption onleix should be sent. In Japan. send orders and inquizies to (sole agent): USACO Corporation. Tsutsumi Bldg., 13.12. Shimbashi l.chome.Minato-ku, Tokyo 105. Japan; Tel (03) 502.6471. IndividUals who are not AACR members may subsciibe to volure 4 (1998) of Clinical Cancer Research at the rate of $120 U.SJ$160 foreign. ClinicalCancer Research is only available to institutions as a combined subscription with Cancer Research. The combined 1998 institutional subsciiption puce of $795 U.SJ$925 foreign includes $210 U.SJ$250foreign for a subscription to Clinical CancerResearch. (Foreign subscription cost includes cost of swface mail. For faster delivery. expedited mailing rates are available by contacting the AACR PublicationsDepartment.) Canadian subsciibem should add 7% GST. Changes of address notification should be sent 60 days in advance and include both old and new addresses. Member subscribers should send addresschanges to: AACR Member Services, Public Ledger Bldg., Suite 826. 150 South Independence Mall West� Philadelphia. PA 19106-3483. Nonmember subsciibers should send changes of address to: AACR

Subscription Office, P.O. Box I 1806. Birmingham. AL 35202. Copies of the journal which are undeliverable because of address changes will be destroyed.

IIIIIIIIItIIIIIIIIIIIIOhII1IIIIIIIIIIllhIIIIIIIIH1NE-BH2-LH2L

ClinicalCancerResearch

American Association forCancer Research, Inc.

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Margaret Foti

Publications Staff

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Staff Editors

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Editorial Office

Paul F. EngstromEric R. FearonIsaiah J. FidlerRichard M. Fox

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Stephen B. HowellDaniel C. Ihde

John T. IsaacsRobert B. JenkinsDavid H. Johnson

V. Craig JordanBarton A. Kamen

animal therapy models

Jeffrey M. TrentGenerics, cytogenetics

S. B. KayeDavid P. KelsenDavid Khayat

John M. Kirkwood

Donald W. Kufe

Steven M. LarsonJohn S. LazoVictor A. Levin

Allen Lichter

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Jane Weeks

Ralph R. WeichselbaumTheresa L. WhitesideLeonard A. Zwelling

Notice to Members of the American Association for Cancer Research (AACR)

Officers for 1997-1998

President: Donald S. Coffey, Johns Hopkins University School of Medicine, Baltimore, MD 21287-2 101

President-Elect: Webster K. Cavenee, Ludwig Institute for Cancer Research, La Jolla, CA 92093-0660

Treasurer: Bayard D. Clarkson, Memorial Sloan-Kettering Cancer Center, New York, NY 10021

Executive Director: Margaret Foti, AACR, Public Ledger Bldg., Suite 826, Philadelphia, PA 19 106-3483

Annual Dues

The annual dues of active members of the AACR are $175, $50 of which may be applied to a subscription to Clinical Cancer

Research. Corresponding members of the Association will be charged an appropriate fee to offset periodicals postage costs. Payment

of dues and changes of address of members of the Association should be sent promptly to Margaret Foti, Executive Director, AACR,Public Ledger Bldg., Suite 826, 150 South Independence Mall West, Philadelphia, PA 19106-3483; Phone: (215) 440-9300; FAX:

(215) 440-9313.

Submission of Manuscripts

Clinical Cancer Research, a journal of the American Associationfor Cancer Research, publishes original articles describing clinicalresearch on the cellular and molecular characterization, prevention,diagnosis, and therapy of human cancer. Its focus is on innovativeclinical research and translational research which bridges the labo-

ratory and the clinic. Clinical Cancer Research is especially inter-ested in clinical trials evaluating new treatments for cancer; researchon molecular abnormalities that predict incidence, response to ther-

apy, and outcome; and laboratory studies of new drugs and biolog-

ical agents that will lead to clinical trials in patients. All submissions

undergo peer review. Papers should be sent directly to an appropn-ate Senior Editor or to the Editor-in-Chief for review. See “Instruc-

tions for Authors” (page ii of this issue) for complete mailing

addresses of the Editor-in-Chief, Deputy Editor, and Senior Editors.

Back Issues and Single Copy Sales of the Journal

Copies of back stock of the journal may be ordered fromAACR Subscription Office, P.O. Box 11806, Birmingham, AL

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Cancer Research, Inc., since these articles are considered to be inthe public domain. In the case of articles supported by federalgrants or contracts, copyright transfer to the American Association

for Cancer Research, Inc., is required. The federal governmentmay retain a nonexclusive license to publish or republish such

material.The Journal will routinely allow authors (or others with the

permission of the authors) to include select parts of a copy-righted article in reviews, books, or subsequent papers, upon

written request to the AACR Director of Publications. Requests

to reproduce an article in its entirety will be considered on anindividual basis and permission may be granted contingent upon

payment ofan appropriate copyright fee. All reproduction requestsmust include a brief description of intended use and a stamped,

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No responsibifity is accepted by the Editors, by the Amer-jean Association for Cancer Research, Inc., or by CadmusJournal Services for the opinions expressed by contributorsor for the content of the advertisements.

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Advertisement insertion orders and copy must be received onemonth prior to the date of issue in which the advertisement is

to be published. The journal is mailed on approximately the 1stday of the month of issue. Inquiries about advertising should bedirected to: M. J. Mrvica Associates, Inc., 2 West Taunton

Ave., Berlin, NJ 08009 [Telephone: (609) 768-9360; FAX:

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Copyright and Permissions

Authors who wish to publish in Clinical Cancer Research must

formally transfer copyright to the proprietor of the journal, theAmerican Association for Cancer Research, Inc. It is under-

stood by this transfer that the authors relinquish all exclusiverights of copyright ownership, including the rights of reproduc-tion, derivation, distribution, sale, and display.

Authors who prepared their articles as part of their officialduties as employees of the U.S. Federal Government are notrequired to transfer copyright to the American Association for

Clinical Cancer Research is abstracted and/or indexed in Can-cer Lit, Chemical Abstracts, and Current Contents (Clinical

Medicine).

Clinical CancerResearch (ISSN 1078-0432) is published monthlyby the American Association for Cancer Research, Inc., Public

Ledger Bldg., Suite 826, 150 South Independence Mall West,Philadelphia, PA 19106-3483 for $50 annually for members and

$120 for individual nonmembers. Clinical Cancer Research is

only available to institutions as a combined subscription withCancer Research. The combined 1998 institutional subscriptionprice of $795 includes $210 for a subscription to Clinical Cancer

Research. Periodicals postage paid at Philadelphia, PA and addi-tional mailing offices. POSTMASTER: Send address changes toAACR Subscription Office, P.O. Box 11806, Birmingham, AL

35202. Copyright 1998 by the American Association for CancerResearch, Inc. Printed on acid-free paper in the U.S.A.

1 998 AACR Annual Meeting

March 28-April 1, 1998

New Orleans, LA

For complete information about the meeting, visit the AACR Website at

http://www.aacr.org

157 A Sensitive and Specific Radioimmunoassay for LY309887,a Potent Inhibitor of Glycinamide Ribonucleotide Formyl-transferase. Dennis L. Coleman, Nedjelko Canak, Gary D.Place, Chum Shih, and Ronald R. Bowsher.

165 In Vivo Toxicity and Pharmacokinetic Features of B43(Anti-CD19)-Genistein Immunoconjugate in NonhumanPrimates. Yoav Messinger, Yuri Yanishevski, Onur Ek, TamerZeren, Barbara Waurzyniak, Roland Gunther, Lisa Cheistrom,Mridula Chandan-Langlie, Elizabeth Schneider, Dorothea E.Myers, William Evans, and Fatih M. Uckun.

171 Antitumor Activity of Actinonin in Vitro and in Vivo. YangXu, Lawrence T. Lai, Janice L. Gabrilove, and David A.Scheinberg.

177 Prognostic Impact of Urokinase-type Plasminogen Activator(PA), PA Inhibitor Type-i, and Tissue-type PA AntigenLevels in Node-negative Breast Cancer: A Prospective Study

on Multicenter Basis. Seung un Kim, Eiichi Shiba, TetsuroKobayashi, Eiji Yayoi, Junkou Furukawa, Yuichi Takatsuka,Eisei Shin, Hiroki Koyama, Hideo Inaji, and Shin-ichiro Takai.

183 Translocations Involving Chromosome LZpll-l3, Metho-trexate Metabolism, and Outcome in Childhood B-Progen-itor Cell Acute Lymphoblastic Leukemia: A Pediatric On-cology Group Study. V. Michael Whitehead, Mary-JaneVuchich, Linda Cooley, Stephen J. Lauer, Donald H. Mahoney,Jon J. Shuster, Claudine Payment, Mark L. Bernstein, John J.Akabutu, Tom Bowen, Barton A. Kamen, Michael S. Watson,A. Thomas Look, D. Jeaneue Pullen, and Bruce Camitta.

189 Prognostic Value of p53 and Urokinase-type PlasminogenActivator in Node-negative Human Breast Cancers.Jean-Philippe Peyrat, Laurence Vanlemmens, Joelle Fournier,Guillemette Huet, Francoise R#{233}villion,and Jacques Bonneterre.

197 Genetic Changes and Telomerase Activity in Human RenalCell Carcinoma. Volker Rohde, Hans-Peter Sattler, BirgitOehlenschlager, Stefan Forster, Thomas Zwergel, GerhardSeitz, and Bemd Wullich.

203 TP53 and Long-Term Prognosis in Colorectal Cancer: Mu-tations in the L3 Zinc-binding Domain Predict Poor Sur-vival. Anne-Lise B#{216}rresen-Dale, Ragnhild A. Lothe, Gunn I.Meling, Pierre Hainaut, Torleiv 0. Rognum, and Eva Skovlund.

211 Genetic Abnormalities in Parathyroid Nodules of UremicPatients. Jerry Chudek, Eberhard Ritz, and Gyula Kovacs.

215 Gene Amplification as a Prognostic Factor in Primary BrainTumors. Jeffrey J. Olson, David Barnett, Jin Yang, RobertoAssietti, George Cotsonis, and C. David James.

223 RET/NTRKJ Rearrangements in Thyroid Gland Tumors ofthe Papillary Carcinoma Family: Correlation with Clinico-pathological Features. Italia Bongarzone, Paolo Vigneri, LuigiMariani, Paola Collini, Silvana Pilotti, and Marco A. Pierotti.

229 Telomerase Enzyme Activity and RNA Expression during

the Multistage Pathogenesis of Breast Carcinoma. KazuoYashima, Sara Milchgrub, Lauren S. Gollahon, Anirban Maitra,M. H. Saboorian, Jerry W. Shay, and Adi F. Gazdar.

235 Clinical Features of Ovarian Cancer in Japanese Womenwith Germ-Line Mutations of BRCAJ. Hiroshi Aida, KoichiTakakuwa, Hiroshi Nagata. Ikunosuke Tsuneki, MasashiTakano, Shoji Tsuji, Takeshi Takahashi, Takahiko Sonoda,

Masayuki Hatae, Katsuyuki Takahashi, Kazuo Hasegawa,Hideki Mizunuma, Nagayasu Toyoda, Hiroyuki Kamata, YuichiToni, Noriyasu Saito, Kohei Tanaka, Michiaki Yakushiji,Tsutomu Araki, and Kenichi Tanaka.

241 Evaluation of Epidermal Growth Factor-related GrowthFactors and Receptors and of Neoangiogenesis in Corn-pletely Resected Stage I-lIlA Non-Small-Cell Lung Cancer:Amphiregulin and Microvessel Count Are IndependentPrognostic Indicators of Survival. Gabriella Fontanini,Michelino Dc Laurentiis, Silvana Vignati, Silvana Chine, MarcoLucchi, Vanessa Silvestri, Alfredo Mussi, Sabino Dc Placido,Giampaolo Tortora, A. Raffaele Bianco, William Gullick, Carlo

Alberto Angeletti, Generoso Bevilacqua, and FortunatoCiardiello.

251 Bypass of Abnormal MDM2 Inhibition of p53-dependentGrowth Suppression. Raymond D. Meng, Helen Shih, Nita S.Prabhu, Donna L. George, and Wafik S. El-Deiry.

Leffers to the Editor

261 Correspondence re: C. Caserini et a!., Apoptosis as a Deter-

rninant of Tumor Sensitivity to Topotecan in Human Ovar-ian Tumors: Preclinical in Vitro/in Vivo Studies. Clin CancerRes., 3: 955-961, 1997. Letter by V. R. Bulusu. Reply byGraziella Pratesi, Paola Perego, Rosanna Supino, and FrancoZunino.

263 AACR Bulletin BoardInstitution of Page Charges

Annual Meeting

Late-Breaking Research Session at the AACR Annual Meeting

AACR Research Fellowships

AACR Special Conferences in Cancer Research

264 Author Index

i Instructions for Authors

Academic Position for aResearch-Oriented Medical Oncologist

The UStYNorris Comprehensive Cancer Center at the Uni-

versity of Southern California School of Medicine has createda new tenure track faculty position for a research-orientedmedical oncologist to take a leadership role in an interdisci-plinary, translational research program, centered around themolecular biology/genetics/therapeutics of breast cancer. The

research program will take advantage of well-established din-ical NIH-funded research programs of the campus includingthe USC/Norris Breast Center with its rich racial-ethnic diver-sity of Los Angeles County.

Candidates will be considered for appropriate faculty rankin the Division of Medical Oncology of the Department of

Medicine with salary commensurate to rank and experience.

New state-of-the-art research facilities and generous start-upresearch support are available for the successful candidate.

Laboratory or clinical research experience is required. USC isan equal opportunity employer. Interested candidates shouldsend a cirriculum vitae and names of three references to thefollowing address by March 1, 1998:

Michael F. Press, M.D., Ph.D.Breast Cancer Research Program

USC/Norris Comprehensive Cancer Center1441 Eastlake Avenue, Room 5410

Los Angeles, CA 90033Phone: (213) 764-0563

Fax: (213) 764-0122

The Rush Cancer Institute is seeking to recruit a senior

physician to establish and run a PhaseIJII program in

chemotherapeutic agents. The Institute and its Affiliates

constitute 8 Hospitals which together see over 6,000new cancer patients each year. The position being of-

fered is tenured and applicants should have at least 5

years experience in this area. Laboratory and personnel

support will be provided to the individual chosen for this

position. Applications and inquiries should be sent to

Rush-Presbyterian-St. Luke’s Medical Center,

Dr. Donald Braun

Scientific Program Director

The Rush Cancer Institute

1653 W. Congress Parkway

Chicago, Illinois 60612

telephone #312-563-2190 or fax #312-455-9635.

Hit our Home Page

on the

World Wide Web!

http://www.aacr.org

Our web site features:

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Information about AACR Research Fellowships

and Travel Awards

Plus ...

The latest AACR newsletter, and much more!

,� �

1�’CER %�

Eugene P. SchonfeldMedical Research Award

f or Basic Research in Renal Cancer

$60,000 to a young M.D. or Ph.D.

Proposal in NIH format, nine pages or less,

including references.

Funding for direct costs only.

Describe use of funds and other support.

Award is payable over a two year period in equal

. payments of $30,000.

Candidates should be not more than 5 years past

post-doctoral degree and have access to a lab.

Send vita and three letters of recommendation,

and 10 copies of proposal.

Deadline April 1 , 1998.

Decisionjune 3, 1998.

Focus on theory, originality, technical approach,

and potential for new contributions.

Funds will be available by July 19, 1998.

Call the National Kidney Cancer Association at

847.332.1051 for details.

National Kidney,G��r Association

1234 Sherman Avenue, Suite 203Evanston, Illinois 60202-1375

AMERICAN ASSOCIATION FOR CANCER RESEARCH (AACR)

AACR-HBCU Faculty Award in Cancer Research

Supported by a generous grant provided by the

Comprehensive Minority Biomedical Program of the National Cancer Institute

The American Association for Cancer Research (AACR) is extremelypleased to announce the availability of Awards in Cancer Research for

full-time faculty members of Historically Black Colleges and Universities

(HBCUs). Supported by a generous grant provided by theComprehensive Minority Biomedical Program of the National CancerInstitute, AACR-HBCU Faculty Awards in Cancer Research will bepresented annually by the American Association for Cancer Research toscientists at the level of Assistant Professor or above at an HBCU who

are engaged in meritorious basic, clinical, or translational cancer

research.

The purpose of this Award program is to increase the scientificknowledge base of faculty members at Historically Black Colleges and

Universities, and to encourage them and their students to pursue careersin cancer research. Awardees will receive financial support for theirparticipation in the 89th AACR Annual Meeting, March 28-April 1, 1998,

in New Orleans, LA. The 1998 AACR Annual Meeting will attract

approximately 7,500 scientists from around the world; will provide the

latest findings in the most rapidly developing areas of basic, clinical,

and translational cancer research; and will feature major presentations

from prominent scientists who are making important advances in thefield.

The American Association for Cancer Research, a scientific society of

more than 13,500 researchers working in all subfields of basic, clinicaland translational cancer research, is extremely pleased to sponsor this

faculty award.

Application Deadline - January 30, 1998

For Further InformationIf after reading the enclosed information you have any questions concerningthe application process or Award criteria, or if you have not received the

Official Application Form, contact: HBCU Award Coordinator, AmericanAssociation for Cancer Research, Telephone: (215) 440-9300, FAX: (215) 440-

9412, E-mail: felder@aacr.org.