Clinical Aspects of Hyponatremia & Hypernatremia
Transcript of Clinical Aspects of Hyponatremia & Hypernatremia
![Page 1: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/1.jpg)
Clinical Aspects of Hyponatremia &Hypernatremia
![Page 2: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/2.jpg)
Case Presentation: History
62 y/o male is admitted to the hospital with a 3 monthhistory of excessive urination (polyuria) and excess waterintake up to a gallon per day. His wife noted that he hadlost weight, became forgetful and irascible.
![Page 3: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/3.jpg)
Case Presentation: Physical Examination
Emaciated, somnolent 62 y/o man in no acute distress.Multiple signs of dehydration were evident including lowblood pressure upon standing (orthostatic hypotension),loss of normal skin reslience, sunken eyeballs, and lowintravascular volume. In addition he was confused,disoriented and had reduced level of consciousness.
![Page 4: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/4.jpg)
Case Presentation: Laboratory I
Blood Tests: Sodium 150 mEq/L (Nl 138-142)Chloride 106 mEq/L (nl 95-100)Kidney Function Decreased 50%Calcium 16.5 mg/dl (Nl 8-10)Urine Tests: Specific gravity 1.008 (Nl for dehydration 1.025-1.035),Urine sodium Na 15 mEq/L (low), Osm 280 mOsm (low
for dehydration)
![Page 5: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/5.jpg)
Case Presentation: Laboratory II
• Serum protein electrophoresis: Abnormal amount of pure(monoclonal) immunoglobulin
• Bone Marrow Biopsy: Multiple Myeloma- a malignanttumor of plasma (immune system) cells that causes
– Monoclonal immunoglobulin excess
– high blood calcium by break down of the skeleton.
![Page 6: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/6.jpg)
Signs of Polyuria due toRenal Concentrating Defect
• Orthostatic Hypotension
• Low urine osmolality
• Hypernatremia– Excess free water loss
– Insufficient free water intake
![Page 7: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/7.jpg)
Polyuria: Differential Diagnosis
• Volume Depletion
– Diabetes Insipidus
• Central
• Nephrogenic
– Diuretics
• Osmotic
• Drugs
• Normal Volume
– Primary Polydipsia
![Page 8: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/8.jpg)
Systemic Consequences of Chronic Hypercalcemia(High Blood Calcium Concentration)
• Neuro: Altered Mental Status, Muscle Weakness
• GI: Anorexia, nausea and vomiting
• Renal Concentrating Defect– Polyuria, polydipsia
– Hypernatremia (coupled with decreased intake ofwater from loss of appetite and altered mental status)
![Page 9: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/9.jpg)
Consequences of Hypercalcemia:Renal, Fluid and Electrolyte
• Volume Depletion• Decreased intake due to anorexia, nausea and vomiting
• Nephrogenic diabetes insipidus (NDI) causing free water loss
• Hypernatremia from Nephrogenic Diabetes Insipidus
• Renal Insufficiency• Decreased blood flow to kidney
• Calcification of the kidney itself
![Page 10: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/10.jpg)
Diabetes Insipidus (DI)
• Excessive water loss bythe kidney
• Inability of kidney toconcentrate the urine– Deficiency of
Antidiuretic Hormone(ADH)–Central DI
– Renal resistance toADH
ADHH2O
Central DI– Lack of
ADH
Nephrogenic DI– Resistance to
ADH
![Page 11: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/11.jpg)
Nephrogenic Diabetes Insipidus:Common Causes
• Many chronic renal diseases
• Electrolyte disorders• High Blood Calcium Hypercalcemia
• Low Blood Potassium Hypokalemia
• Drugs– including Lithium, AMP-B, Demeclocycline, Gentamicin, cisplatin, others
• Dietary abnormalities, e.g. decreased NaCl or proteinintake
![Page 12: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/12.jpg)
Hyper (High) natremia and Hypo (Low)
natremia: Water deficiency and water excess
Na 140
Normal WaterWater Deficiency
Na 150
Water Excess
Na 130
![Page 13: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/13.jpg)
Pathogenetic Mechanisms of Hypernatremia
Condition Serum Sodium Example
Pure Water Loss Na Diabetes InsipidusTBW
Sodium and Na Osmotic DiuresisWater Loss TBW
Sodium Gain Na Hypertonic NaHCO3
TBW
![Page 14: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/14.jpg)
Central Diabetes InsipidusNormal PersonWater restricted
Patient with Central DIWater Restricted
Urine Flow LowUosm 1000
Urine Flow HighUosm 200
HighAVP
ZeroAVP
H20
H20
H20
H20
H20
H20
Cortex
M edulla
![Page 15: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/15.jpg)
Nephrogenic Diabetes InsipidusNormal PersonWater restricted
Patient with Nephrogenic DIWater Restricted
Urine Flow LowUosm 1000
Urine Flow HighUosm 250
HighAVP
HighAVP
H20
H20
H20
H20
H20
H20
Cortex
M edulla
![Page 16: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/16.jpg)
Hypercalcemia as a Cause ofNephrogenic Diabetes Insipidus
• Any chronic hypercalemic state
• Common cause of NDI in Adults
• Mild hypernatremia (145-150) typical
• Decreased renal function common
• Reversible with correction of hypercalcemia
(unless severe nephrocalcinosis)
![Page 17: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/17.jpg)
Hypercalcemia and NephrogenicDiabetes Insipidus
• Hypercalcemia Causes Polyuria
• Vasopressin Resistant Concentrating Defect
• Direct Effect of Calcium on
Renal Water Handling
• Independent of GFR, PTH, Vitamin D, Calcitonin
![Page 18: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/18.jpg)
How does Hypercalcemia causeNephrogenic Diabetes Insipidus?
• Decreased delivery of solute to the loop of Henle(reduced GFR)
• Inhibition of NaCl transport in the
thick ascending limb
• Inhibition of vasopressin-mediated waterpermeability in the terminal collecting duct
![Page 19: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/19.jpg)
Hypercalcemia and NephrogenicDiabetes Insipidus
• Direct Effect of Calciumon Renal water Handling
• Vasopressin-Resistant
• Independent of GFR,PTH, Vitamin D andCalcitonin
AVPResistance
Ca++
Free H20 Excretion
Ca2+
![Page 20: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/20.jpg)
Osmotic DiuresisNormal PersonWater restricted
Normal person Mannitol InfusionWater Restricted
Urine Flow LowUosm 1200
Urine Flow HighUosm 400
HighAVP
HighAVP
H20
H20
H20
H20
H20
H20
Cortex
M edullaM
Na
Na
Na
Na
Na
M M M M
M
M
M
M
M
Na
![Page 21: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/21.jpg)
Osmotic Diuresis
Poorly reabsorbed Osmolyte
H20 H20 H20
Na Na Na
H20H20H20
Na Na Na
HypotonicSaline
Osmolyte = glucose, mannitol, urea
![Page 22: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/22.jpg)
0
200
400
600
800
1000
1200
1400
1600
0 2 4 6 8 10 12 14
Solute Excretion (mOsm/min/1.73 m2)
Uri
ne
Con
cen
trat
ion
(m
Osm
/L)
Effect of Osmotic Diuresis on Uosm
Normal
Complete Central DI
Partial Central DI
![Page 23: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/23.jpg)
How to determine the cause of polyuric states:Water Deprivation and ADH responsiveness
• Step 1: Water deprivation
• Step 2: Measure Urine Osmolality
• Step 3: Administer exogenous dose of ADH
• Step 4: Repeat Urine Osmolality Measurement toevaluate response to ADH
![Page 24: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/24.jpg)
Differentiating Polyuric States :Dehydration and AVP Stimulation Tests
Condition Uosm Maxdehydration
Uosm Maxafter AVP
% Change Uosm Increase
Normal 1068 ± 69 979 ± 79 -9 ± 3 < 9%
PsychogenicPolydipsia
738 ± 53 780 ± 73 5 ± 2 < 9%
PartialCentral DI
438 ± 34 549 ± 28 28 ± 5 > 9% < 50%
CompleteCentral DI
168 ± 13 445 ± 52 183 ± 41 >50%
NephrogenicDI
124 174 42 < 50%
Miller et al. Ann. In. Med 73:721, 1970
![Page 25: Clinical Aspects of Hyponatremia & Hypernatremia](https://reader034.fdocuments.us/reader034/viewer/2022051405/589d90a81a28abc2498bbf72/html5/thumbnails/25.jpg)
Calculating Water Deficit in HypernatremiaDue to Pure Water Loss
• Serum Na 150, Normal Na 140, 70 kg man
• Total Body Water Deficit =
BW in kg x 0.6 x [150 -140]
70 x 0.6 x [0.06] = 2.8 L140
TBW factor:Use 0.6 male0.5 female0.45 elderly