Dr. RAGHU PRASADA M SMBBS,MDASSISTANT PROFESSORDEPT. OF PHARMACOLOGYSSIMS & RC.

1

Central Nervous System (CNS) - Brain and spinalcord

Peripheral Nervous System (PNS) - Locatedoutside the brain & spinal cordAutonomicNervous System (ANS) & the somatic

The PNS receives stimuli from the CNS & initiatesresponses to the stimuli after it’s interpreted by thebrain

Parasympathetic Nervous Systemcholinergic Sympathetic Nervous SystemAdrenergic Enteric Nervous SystemENSboth

Acetylcholine –preganglionicPost ganglionic AchException-post ganglionic sympathetic fibres toapocrine glandsCholinergic fibresAll somatic motar neuronsAll preganglionic fibresPost ganglionic parasympathetic fibres

ADRENERGICRECEPTORLOCATION

BETA 1RECEPTOR

BETA2 RECEPTOR BETA 3 RECEPTOR

LOCATION HEART ANDJG CELLS INKIDNEY

B-BRONCHIBLOOD VESSELS

U-UTERUS, URINARY TRACT,L-LIVERG-GITEYE

ADIPOSE TISSUE

SELECTIVEAGONIST

DOBUTAMINE SALBUTAMOL,TERBUTALINE

BRL

SELECTIVEANTAGONIST

METAPROLOLATENOLOL

BUTOXAMINE CYANOPINDOLOL

POTENCY OFNA ASAGONIST

MODERATE WEAK STRONG

ADRENERGICRECEPTOR

ALFA 1 ALFA2

LOCATION POST JUNCTIONAL ONEFFECTOR ORGANS

PREJUNCTIONAL ON NERVE ENDINGS ,ALSO POST-J UNCTIONAL IN BRAIN,PANCREATIC BETA CELLS AND EXTRAJUNCTIONAL IN BLOOD VESSELS,PLATELETS

FUNCTION GI SMOOTH MUSCLES-CONTRACTIONGLAND-SECRETIONGUT- RELAXATIONLIVER-GLYCOGENESISHEART-ARRHYTHMIAS

INHIBITION OF TRANSMITTER RELEASEVASOCONSTRICTIONDECREASED SYMPATHETIC FLOWDECREASED INSULIN RELEASEPLATELET AGGREGATION

SELECTIVEAGONIST

PHENYLEPHRINEMETHOXAMINE

CLONIDINE

SELECTIVEANTAGONIST

PRAZOCIN, TERAZOCINTAMSULOSIN

YOHIMBINE, ROUWOLCINE

EFFECTIVEPATHWAY

IP3/DAG, PHOSHOLIPASEA2

CAMPK+ channel, Ca CHANNEL, IP3 /DAG

PARASYMPATHETICRECEPTOR

LOCATION AGONIST ANTAGONIST

NN GANGLIA , ADRENALMEDULLA

NICOTINEANATOXIN

TRIMETHAPHANALFABUNGAROTIXINMECAMYLAMINE

NM NEUROMUSCULARJUNCTION

NICOTINEEPIBATIDINE

TUBOCURARINE

m1 GASTRIC GLANDS,AUTONOMICGANGLIA AND CNS

OXOTRIMORINE PIRENZEPINETELENZEPINE

m2 HEART METHACHOLINE METHOCTRAMINETRIPITRAMINE

m3 SMOOTH MUSCLES,GLANDS,ENDOTHELIUM

BETHANECHOL DARIFENACINTOLTERIDINEHEXAHYDROSILDENAFIL

Homotropic receptor interactionHeterotropic receptor interaction

Purines –ATP, adenosineNO-nitric oxideEndothelinVascular homeostasis

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