CK5/6

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description

ER. CK5/6. Flat epithelial atypia. Columnar cell lesions: A spectrum: columnar cell change, columnar cell hyperplasia, flat epithelial atypia FEA has mild cytologic atypia (similar to ADH,DCIS) but without architectural atypia. May be more than one cell layer thick. - PowerPoint PPT Presentation

Transcript of CK5/6

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ER CK5/6

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Flat epithelial atypia

Columnar cell lesions: A spectrum: columnar cell change, columnar cell

hyperplasia, flat epithelial atypiaFEA has mild cytologic atypia (similar to

ADH,DCIS) but without architectural atypia. May be more than one cell layer thick.

Cytology: enlarged nuclei, rounding, crowding, loss of polarity, visible nucleoli, few mitoses.

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IHC in FEA

Not helpful CCC, CCH, FEA, ADH, low grade DCIS all have the

same immunophenotype ER+, PgR+, HER2 -, E-Cadherin+, LMWK+, HMWK-.

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