7/28/2019 Cjpro-Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children With Auti

1/3

Document1

Considered judgement on quality of evidence

Key question:

HBOT therapy improve symptoms of Autism and Autism

related disease

Evidence table ref:

1. Volume of evidenceComment here on any issues concerning the quantity of evidence available on this topic and itsmethodological quality.

-no clearly defined question-appears the paper is designed to debunk a previous study-no specific research base

2. ApplicabilityComment here on the extent to which the evidence is directly applicable to the NHS in Scotland.

- the evidence was presented poorly and thus is not applicable to the NHS

3. GeneralisabilityComment here on how reasonable it is to generalise from the results of the studies used asevidence to the target population for this guideline.

There was no specific target population. They used individuals with autism spectrum, PDD NOSand Aspergers. Only 16 people were used from any one of these three (while related they are

not the same), diseases.

4. ConsistencyComment here on the degree of consistency demonstrated by the available of evidence. Wherethere are conflicting results, indicate how the group formed a judgement as to the overalldirection of the evidence

The judgment was made before the study was done. The study was shown to be done after thestudy done by Rossinger et al. The results disprove the study. If the study were doneindependently of the other the results would be taken more seriously.

5. Clinical impactComment here on the potential clinical impact that the intervention in question might havee.g.size of patient population; magnitude of effect; relative benefit over other management options;resource implications; balance of risk and benefit.

If the intervention works, the impact is huge. It would change so many lives and theworld.

6. Other factorsIndicate here any other factors that you took into account when assessing the evidence base.

I took into account the population, lack of a specific question, lack of p values, lack of

7/28/2019 Cjpro-Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children With Auti

2/3

Document1

confounding, and validity

7/28/2019 Cjpro-Controlled Evaluation of the Effects of Hyperbaric Oxygen Therapy on the Behavior of 16 Children With Auti

3/3

Document1

7. Evidence statementPlease summarise the development group's synthesis of the evidencerelating to this key question, taking all the above factors into account, andindicate the evidence level which applies.

Evidence level

This is designed to be a case control study. The biggest problem is thatthere was no control

3B

8. RecommendationWhat recommendation(s) does the guideline development group draw fromthis evidence? Please indicate the grade of recommendation(s) and anydissenting opinion within the group.

Grade ofrecommendation

The authors were convinced of their results. However based uponthe results I have found, the article is being dismissed for any

evidence.

moderate