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![Page 1: Chronic Rhinosinusitis in Children Clinical Presentation Hector Stone-Aguilar, M.D. Pediatric Allergy & Immunology Hospital San Jose de Hermosillo Universidad.](https://reader035.fdocuments.us/reader035/viewer/2022062511/55143cd6550346414e8b474a/html5/thumbnails/1.jpg)
Chronic Rhinosinusitis in Children
Clinical Presentation
Hector Stone-Aguilar, M.D.Pediatric Allergy & ImmunologyHospital San Jose de HermosilloUniversidad del Valle de Mexico
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Clinical presentation of CRS in Children
• To fully define chronic sinusitis has been difficult
• There is a wide variation in clinical expression of the disease
• Discordance between patient symptoms and objective findings
• No one set of diagnostic criteria has been agreed on by all specialty groups
The problem:
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Clinical presentation of CRS in Children
• Clinical criteria to diagnose CRS, as well as the predictive value of these criteria, are not well defined, specially in children
• Historically, the diagnosis of CRS was based on several clinical symptoms, similar to acute RS, but usually less severe
• However, none of these symptoms are specific to sinusitis
The problem:
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Definition of Sinusitis
• Inflammation of 1 or more of the paranasal sinuses
• Acute Sinusitis: less than 4 weeks/duration• Subacute Sinusitis: 4 to 12 weeks/duration• Chronic Sinusitis: longer than 12 weeks
Some guidelines also requiring :– Failure to respond to treatment– One positive imaging study
Dykewicz M, JACI Feb 03
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Definition of Rhinosinusitis
• Inflammation of the nose and paranasal sinuses characterized by two or more symptoms, one of which should be either nasal blockage/obstruction/congestion or nasal discharge (anterior/posterior nasal drip)± facial pain/pressure± reduction or lost of smell
EPOS Guidelines, Rhinology 2007
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Rhinosinusitis
OHNS , 1997
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Definition of Chronic Rhinosinusitis
• More than 12 weeks of symptoms without complete resolution
• Can be subdivided in:– Chronic Rhinosinusitis with Nasal Polyps– Chronic Rhinosinusitis without Nasal Polyps
• CRS also may be susceptible to exacerbations
EPOS Guidelines, Rhinology 2007
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CRS: Symptom-based Diagnosis
• 73.15% of the nonallergic patients with symptom based diagnosed CRS
• 65.34% of the allergic patients with symptom-based diagnosed CRS
Had No CT and endoscopic pathology (Endoscopic score 0 + CT score 0)
Tahamiler R, Allergy 2007
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In general :
The main symptoms associated with rhinosinusitis in children are rhinorrhea,
nasal obstruction, mouth breathing, hyponasal speech, and snoring
but…
Chronic Rhinosinusitis in Children
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Diagnosing CRS in Children: Special issues
Infants and Pre-school children
•Signs/symptoms difficult to evaluate:• Congestion (very subjective/indirect/parent’s biass)• Only anterior rhinorrhea is reported
•Symptoms impossible to evaluate: • Posterior discharge• Sense of smell• Headache / toothache / facial pain
•Symptoms very unspecific :• Cough, irritability, fever, fatigue/decreased activity,
etc.
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Diagnosing CRS in Children: Special issues
Infants and Pre-school children
•Anterior Rhinoscopy : Limited data– Anterior third of nasal cavity– Osteomeatal zone difficult to reach, even w/use of
topical decongestant •Nasal Endoscopy: Ideal but impossible to perform without sedation or anesthesia•CT scan: Also requieres sedation or anesthesia •Sedation/anesthesia: increases costs and risks•Increased value of plain X-Rays at this age ??
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Severity of Sinusitis• Disease severity can be divided into:– Mild (0-3 points)– Moderate (4-7 points)– Severe (8-10 points)
• Using a 10-point scoring system or Visual Analogue Scale (VAS)
EPOS Guidelines, Rhinology 2007
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Diagnosis must be based in a combination of:– Clinical symptoms and evolution
• Age-group related• Previous treatments (type and duration)• Likelihood of allergy involvement: Family history,
allergy stigmata, personal history of other allergic diseases (AD or Asthma)
– Clinical Signs• Anterior rhinoscopy and/or Nasal endoscopy
– Imaging support• Plain X-Rays• CT scans• MRI
Clinical presentation of CRS in Children
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Chronic Rhinosinusitis in Children• By definition, needs to be at least 12 weeks old (3
m.o.)• Ethmoid and maxillary sinuses present at birth• Clinical presentation strongly related to the specific
pediatric age group:– Infants: Persistent or recurrent rhinorrhea after an acute
febrile URIs ( ± AOM, Rhinopharyngitis, Bronchitis)– Pre-schoolars: Persistent rhinorrhea and nasal congestion
w/adenoid and tonsil hypertrophy, serous OM, allergies and asthma.
– Scholars and adolescents : Nasal obstruction, headaches, sore throath, hyposmia, irritability, sleep disturbances, etc. (PAR or PNAR)
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Clinical presentation of CRS in Children
• In infants and preschool childrens, most cases of CRS are a chronologic extension of acute infectious sinusitis (viral bacterial)
• In contrast, in older children or adolescents most CRS cases are not an infectious disease but an inflammatory disease, much akin to asthma.
Jones NS, Curr Opinion Pulm Med, 2000
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Clinical evolution of Viral URI’s
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When to suspect CRS in INFANTS
• Continuous or intermittent RHINORRHEA– Anterior, posterior or both– Usually clear initially (days or weeks)– Colored (greenish or yellowish) more dense secretions – It can alternate clear and colored secretions
• Nasal CONGESTION– Mild at the beginning– Worsening in an intermittent pattern in absence of
appropriate treatment– Not as bad as other age groups– Objective findings: mouth breathing, snoring
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• COUGH :– A prominent feature of sinusitis at this age– Starts as “Dry” cough usually for several days– Can continue with “wet” cough all the way– Intermittent along the day, not very intense– Can start or worse at night or bedtime– Usually associated with posterior rhinorrhea – Also associated with coarse and audible ronchi– Maybe a better predictor than rhinorrhea about
the outcome
When to suspect CRS in INFANTS
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• FEVER:– Usually present at the beginning of the clinical picture– Low or mid grade– Fades away after few days (with or without treatment)– Can not be present at all– Can relapse in the course of the disease (worsening)– Its absence doesn’t rule out the possibility of chronic
infection
When to suspect CRS in INFANTS
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• Other possible symptoms:– Irritability– Bad appetite – Sleep disturbances:• Trouble to got sleep• Restless sleeping• Nocturnal awakenings
– Halitosis – Reduced general activity
When to suspect CRS in INFANTS
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• Physical signs, NASAL :– Rhinorrhea (anterior)– Pale and enlarged turbinates– Mucosal edema– Hyperemic mucosa– Middle meatus colored discharge
When to suspect CRS in INFANTS
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Rhinoscopy
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Muco-purulent discharge in the Sinus Ostium zone
Lateral nasal wall
Middle turbinate
Purulent mucus
Septum
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• Physical signs, GENERAL :– Posterior rhinorrhea– Mouth breathing– Pallor– Dark infra-orbital shiners– Halitosis– Tympanic opacity, retraction or hyperemia– Enlarged tonsils– Granular (cobblestone) adenoid tissue in
the pharynx – “rude” breathing– Coarse rhonchi on chest examination
When to suspect CRS in INFANTS
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Serous Otitis Media
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Enlarged Adenoids: Cause or consequence ?
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• Not necessarily associated to respiratory infection
• Mostly related to allergies and asthma• Difficult to distinguish from PAR. Same sort of
signs and symptoms• Usually considered a “complication” of allergic
rhinitis• Nasal or sinusal polyps not frequent at this age
Chronic Rhinosinusitis in PRE-SCHOLARS
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• Congestion more prominent than rhinorrhea• Cough frequently related to asthma or BHR• Headaches, frequently mild or intermittent• Hyposmia rarely reported• Halitosis• Clear or thick mucoid rhinorrhea• Paler and more enlarged turbinates• Intense edema of nasal mucosa
Chronic Rhinosinusitis in PRE-SCHOLARS
Differences with CRS in Infants
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• Moderate to severe nasal congestion/obstruction:– Snoring– Sleeping problems– Dry mouth and sore throat at mornings
• Headaches:– Mild to severe– Frequent or intermittent– Frontal, maxillary or occipital
• Rhinorrhea:– Posterior > anterior
• Halitosis
Chronic Rhinosinusitis in School children and adolescents
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• Daytime somnolence• Tiredness • Poor concentration: altered school performance • Hyposmia• Dysgeusia• Middle ear:
– Hypoacusia, Popping, Buzzing
• Polyps: More frequent than the other pediatric groups
Chronic Rhinosinusitis in School children and adolescents
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Consequences of chronic nasal congestion
• Snoring• Oral breathing• Hyponasal speech• Sleep disturbances• Obstructive Sleep Apneas (OSA)• Dry mouth• Sore throath• Headaches• Daytime somnolence• Poor concentration• Tiredness • Facial and dental changes
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CRS Diagnosis:Plain X Rays: Useful?
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Plain X-rays vs. CT scan in Sinusitis
• The sensitivity of Plain X-Ray compared to CT was:– 77% (30/39)
• The specificity of the radiograph to CT was 81% (25/31).
• The positive likelihood ratio is 4.05 and • The negative likelihood ratio is 0.28.• Conclusions - The difference between radiographs
and CT for diagnosing sinus disease in this population is relatively small but favors CT exam.
Garcia, DP Radiographic imaging studies in pediatric chronic sinusitis J Allergy Clin Immunol, 94:523-530, 1994.
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CRS Diagnosis:CT scan: Gold standard ?
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‘Limited’ CT Scan
Garcia D, JACI sept 1994
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Emmanuel IA, Otolaryngology Head Neck Surg 2000
Sinusitis severity Index (grading):(Glicklich)
• Grade 0: mucosal thickening of ≤ 2 mm in any sinusal wall
• Grade 1: Any unilateral disease or abnormality• Grade 2: Bilateral disease limited to ethmoid
or maxillary sinuses• Grade 3: Bilateral disease with frontal or
sphenoidal involvement (any)• Grade 4: Pansinusitis.
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CRS Diagnosis:CT scan: Gold standard ?
HWANG et al, OHNS april, 2003
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CRS Diagnosis:CT scan: Gold standard ?
Unilateral involvement of the right maxillary sinus and structural abnormalities:MT concha bullosa and paradoxical curvature of middle turbinate, stretching
the OMC
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Nasal Endoscopy
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Clasification of the severity of polyposis by endoscopy
• 0 - No visible polyps• 1 - Polyps confined to the middle meatus• 2 - Polyps beyond middle meatus but did
not occlude the nasal cavity• 3 - Polyps obstructing completely the nasal
cavity
Mackay IS y Lund VJ, 1997
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Nasal / Sinusal Polyposis in Children
• If nasal polyps are present in young children, MUST rule out:1. Aspirin Exacerbated Respiratory Disease (AERD)2. Cystic Fibrosis (CF)3. Genetic involvement
• But still most probably related to Perennial or Persistent Allergic Rhinitis
• Polyps related to Perennial Non-Allergic Rhinitis are rare at this age
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Etiology of CRS in Children• Infection:– Viral/Bacterial – Biofilms– Fungal?
• Allergy– Allergic Rhinitis: Persistent >
Intermittent • Gastroesophageal Reflux• Obstruction /Structural– Adenoid > Tonsils Hypertrophy– Septal deviation– Other: concha bullosa, Haller cells,
agger nasi cells
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Etiology of CRS in Children• Immunodeficiency
– IgA deficiency– Transient Hipogammaglobulinemia– IgG sub-class deficiency ( IgG2 + IgG4)– Selective (polysaccaride) IgG deficiencies– CVI
• Cystic Fibrosis• Ciliary Dyskinesia• Aspirin Exacerbated Respiratory Disease• Other: very uncommon
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Hamilos D, JACI oct 2011
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Conclusions:• CRS is frequent in children• No one set of diagnostic criteria has been agreed on by all
specialty groups• CRS in children have special features that are different of
CRS in adult population• There are differences also in the clinical presentation of the
different pediatric age groups• The diagnosis of CRS in children is based almost exclusively
in clinical data. Use CT or endoscopy in selected cases.• There are very few controlled clinical studies of CRS in
children. All Guidelines based in adult studies and transpolated to children.
• The most common causes are bacterial infections and/or allergies. Other causes are really not frecuent or rare, but still have to rule out them if not responsive