Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.
-
Upload
daisy-gray -
Category
Documents
-
view
215 -
download
0
Transcript of Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.
![Page 1: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/1.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
1
In the Name of God
![Page 2: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/2.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
2
Choosing a Future for Epidemiology
Eras and Paradigms
By: Menvyn Susser, MB, Bch, FRCP(E), DPH, and
Ezra Susser, MD, DrPH
American Journal of Public Health May 1996; 86: 668-73.
![Page 3: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/3.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
3
Introduction
![Page 4: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/4.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
4
Introduction The present era of epidemiology is
coming to a close. The focus on risk factors at the
individual level-the hallmark of this era-will no longer serve.
We need to be concerned equally with causal pathways at the societal level and with pathogenesis and causality at the molecular level.
![Page 5: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/5.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
5
The Evolution of Modern
Epidemiology
![Page 6: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/6.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
6
The Evolution ofModern Epidemiology
The underlying idea that marked the beginnings of quantitative epidemiology in the 17th century was concern for the public health and disparities in mortality across society.
The utilitarian approach that Graunt, Petty, and others adopted was entirely in accord with the justifications prevailing over the beginnings of modern science in the 15th and 16th centuries.
![Page 7: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/7.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
7
The Evolution ofModern Epidemiology
(continued)
Driven by the twin forces of capitalism and the Protestant ethic, science was sanctioned by “economic utility” and “the glorification of God.”
This ideology fostered discoveries with immediate technical application in astronomy, navigation, firearms, optics, and many other fields.
![Page 8: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/8.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
8
The Evolution ofModern Epidemiology
(continued)
With the accelerating flow of discovery over the centuries, science as an institution abandoned its utilitarian roots to become an end in itself.
Thus, in the face of the advance guard of industrialization and rapid urbanization, modern epidemiology gradually took shape and then burst into activity with the Sanitary Movement.
![Page 9: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/9.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
9
3 Eras in epidemiology, each with its own dominant
paradigm
Era Paradigm Century
Sanitary statistics
MiasmaGreater part of
the 19th century
Infectious disease
epidemiologyGerm Theory
Late 19th century through first half of 20th century
Chronic disease epidemiology
Black BoxLatter half of 20th century
![Page 10: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/10.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
10
Three Eras in the Evolution of Modem
Epidemiology
![Page 11: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/11.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
11
Sanitary Statistics and Miasma
![Page 12: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/12.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
12
Sanitary Statistics and Miasma
The environmental causes were thought to have broad and multiple manifestations in morbidity and mortality, and the sanitary statistics that were collected as evidence were largely undifferentiated;
that is, they were related more to overall morbidity and mortality than to specific diseases.
![Page 13: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/13.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
13
William Farr
Only in 1839 in England did William Farr begin to use specific diagnostic classifications for
national mortality statistics.
![Page 14: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/14.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
14
Reformists of this era… Edwin Chadwick
was a reformist who argued that disease engendered by the physical environment caused poverty.
Friedrich Engels was a revolutionary who, in documenting the
ills of Manchester factory workers, understood poverty to be the cause rather than the consequence of their ills.
![Page 15: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/15.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
15
Statistics began literally as the study of the state
and of the pertinent data.
The newly formed London Statistical Society was chiefly
concerned with assembling that data.
![Page 16: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/16.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
16
Sanitary Statistics and Miasma (continued)
Epidemiologists, largely autodidacts, were often medical heroes in this era.
Young physicians were excited by the challenge of emergent patterns of disease that seemed rooted in a horrendous environment of urban misery.
![Page 17: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/17.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
17
These epidemiologists: Mapped excess
mortality across the country by district and in relation to housing, infant care, and specific diseases;
Studied a wide range of industries and occupations;
Detected many hazards from dusts, heavy metals, and general working conditions; and
Conducted national surveys of diet, parasite-infested meat, and food contamination.
![Page 18: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/18.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
18
Sanitary Statistics and Miasma (continued)
Unfortunately, these high points of the era closely preceded its culmination.
Unmodified, the miasma paradigm could not survive advances in microbiology, and its demise brought an end to the Sanitary Era.
![Page 19: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/19.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
19
Sanitary Statistics and Miasma (continued)
An irony of the history of public health is that, while the sanitarians were mistaken in their causal theory of foul emanations, they nonetheless demonstrated how and where to conduct the search for causes in terms of the clustering of morbidity and mortality.
The reforms they helped to achieve in drainage, sewage, water supplies, and sanitation generally brought major improvements in health.
Their mistake lay in the specifics of biology rather than in the broad attribution of cause to environment.
![Page 20: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/20.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
20
Infectious Disease Epidemiology and the Germ
Theory
![Page 21: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/21.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
21
Infectious Disease Epidemiology and the Germ
Theory
Year Scientist Findings
1840 Jakob HenleHypothesized that infection by minute organisms was a major cause of disease
1849-1854 John Snow Analytic epidemiology on the organismic cause of cholera
1865 Louis PasteurDemonstration of a living organism as the agent in an epidemic afflicting silkworms
![Page 22: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/22.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
22
Infectious Disease Epidemiology and the Germ
Theory (continued)
Studies of infection and contagion in human disease-for instance, tuberculosis, anthrax, and leprosy followed.
Finally, in 1882, Henle's one-time student Robert Koch established a mycobacterium as “the cause” of tuberculosis.
![Page 23: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/23.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
23
Henle, Snow, Pasteur, and Koch can well stand as
symbolic founding figures of the new era.
![Page 24: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/24.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
24
Infectious Disease Epidemiology and the Germ
Theory (continued)
Despite these origins, the new paradigm of disease that followed from their work, the germ theory, led in the end to the narrow laboratory perspective of a specific cause model namely, single agents relating one to one to specific diseases.
![Page 25: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/25.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
25
Infectious Disease Epidemiology and the Germ
Theory (continued)
Single agents were sought by:The isolation and culture of organisms from disease sites,The experimental transmission of these microorganisms, andThe reproduction of lesions.
The appropriate responses were:To limit transmission by vaccines,To isolate those affected, and, ultimately,To cure with chemotherapy and antibiotics.
Laboratory-based diagnosis, immunization, and treatment gained precision with every new advance.
![Page 26: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/26.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
26
Infectious Disease Epidemiology and the Germ
Theory (continued)
The epidemiology of populations and environmental exposures, and the social dynamics of disease that had flowed from the miasma theory, went into decline, replaced by a focus on control of infectious agents.
Epidemiology was often a derivative pursuit rather than a creative science in its own right.
![Page 27: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/27.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
27
The new era scarcely maintained the epidemiological advances of
the 19th century:in the design and conduct of field surveys,the construction of national statistical systems for vital data, andthe statistical analyses of large numbers
![Page 28: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/28.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
28
Infectious Disease Epidemiology and the Germ
Theory (continued)
The search for other than microbiological causes of disease in the environment stumbled if it did not altogether cease.
In the same period, the search for a viral cause for the growing scourge of poliomyelitis was of course ultimately justified.
As early as 1905, Ivar Wickman in Sweden and, a decade later, Wade Hampton Frost in the United States had
concluded from epidemiological data that widespread transmission of silent infection by some unknown agent was the underlying factor in the summer epidemics that were devastating the children of the better-off classes in particular.
![Page 29: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/29.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
29
The irony of the Sanitary Era was
here reversed.
While, within their limited frame of reference, the germ theorists were
accurate in their causal attributions for many diseases, their narrow focus
retarded the creative use of bacterial discoveries to advance
the science of epidemiology.
![Page 30: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/30.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
30
With the emerging predominance of chronic
disease of unknown cause,
under any credible causal paradigm, the social and physical environment
had now to be reckoned with once more.
![Page 31: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/31.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
31
Chronic Disease Epidemiology and the Black
Box
![Page 32: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/32.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
32
Chronic Disease Epidemiology and the
Black Box World War II serves
as a convenient watershed for the beginning of the Chronic Disease Era and the black box paradigm.
By this time, also, chemotherapy and antibiotics had been added to the medical armamentarium.
Shortly after the war ended in 1945, it was clear that, in the developed world, rising chronic disease mortality had overtaken mortality from infectious disease.
![Page 33: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/33.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
33
The prevailing epidemiology of our day expressed the effort to understand and control the new chronic
disease epidemics.
Again the era was, at the outset, driven by public health concepts.
![Page 34: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/34.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
34
Chronic Disease Epidemiology and the
Black Box (continued)
Chronic disease epidemiology took firm hold with the first undeniable successes in this endeavor.
British epidemiologists Richard Doll, Austin Bradford Hill, Jeremy Morris, Thomas McKeown, and others were key figures.
This paradigm related exposure to outcome without any necessary obligation to interpolate either intervening factors or even pathogenesis.
![Page 35: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/35.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
35
Epidemiologists were faced once more, as in the Sanitary Era, with
major mortal diseases of completely unknown origin.
![Page 36: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/36.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
36
The studies of lung cancer were particularly influential in giving
the new paradigm credibility.
![Page 37: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/37.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
37
The best biological support to be found for the smoking-lung cancer
relationship
The best biological support to be found for the smoking-lung cancer relationship was quite indirect, residing in the demonstration by the Kennaways and their colleagues that tars applied to the skin of mice were carcinogenic.
Indeed, for another 4 decades, no direct analogy with the epidemiological studies of smoking existed in animal experiments.
![Page 38: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/38.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
38
Step by step, the complexities of chronic disease epidemiology
emerged,
first in matters of design and causal inference and, in parallel a little later,
in matters of statistical analysis.
![Page 39: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/39.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
39
Chronic Disease Epidemiology and the
Black Box (continued)
Epidemiologists were obliged to depart from the specific-cause model of the germ theory.
The metaphor of a “web of causation” characterized the multicausal nature of public health problems, particularly those of chronic disease.
Later, analytic issues and statistical refinement became a driving force.
The sharpening of technique led to a cycle of continual refinement.
![Page 40: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/40.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
40
The black box paradigm remains the prevailing
model,
and virtually all contemporary epidemiologists have made use
of it.
![Page 41: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/41.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
41
Typical black box approaches eventually led to the major
discovery of the role of folate deficiency in neural tube defects.
![Page 42: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/42.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
42
Momentum for a New Era
Two forces, characteristic of our time are blunting the black box
paradigm.
transformation in global health patternsnew technology
![Page 43: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/43.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
43
Transformation in Global Health Patterns
With regard to health patterns, none has had more impact than the human immunodeficiency virus (HIV) epidemic.
Although epidemiology has made some notable contributions to understanding the epidemic, black box epidemiology is ill equipped to address epidemic control.
Analysis of mass data at the individual level of organization alone, as implied by the black box paradigm, does not allow us to weigh at which points in the hierarchy of levels intervention is likely to be successful.
![Page 44: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/44.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
44
Transformation in Global Health Patterns (continued)
In retrospect, our confidence during the Chronic Disease Era about the control of infectious diseases seems naive and also blind to the less developed world.
For the majority of the world's population, chronic infections-tuberculosis, syphilis, malaria, and many others-were never under control.
Similarly, our confidence in our ability to control chronic noncommunicable diseases themselves by modifying behavior that carries risk has been shaken.
Again, knowledge of risk factors and interventions directed solely at changing the behavior of individuals, even across several communities, have proven insufficient.
![Page 45: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/45.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
45
The black box paradigm alone
does not elucidate societal forces or their relation to
health.
![Page 46: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/46.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
46
New Technology The developments
that will drive research and that can lead epidemiology to a new paradigm reside primarily
In biology and biomedical techniques on the one hand, and
In information systems on the other.
Biology and biomedical techniques have transformed the ability of epidemiologists to comprehend human disease at the microlevel.
![Page 47: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/47.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
47
Learning from the new technology has only begun.
![Page 48: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/48.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
48
New Technology (continued)
The potential contribution of these advances to epidemiology is an exquisite refinement of the definition and measurement of susceptibility, exposure, and outcome.
Such refinement also clarifies the intervening pathways and so elucidates with precision causal processes and not merely causal factors.
![Page 49: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/49.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
49
Technology at the societal level in the form of the global
communication network…
can provide instant access to-and enable the continuous assemblage of-existing stores of vital statistics and other relevant health and social data across the world.
bring comprehension of large-scale phenomena and even systems within our grasp.
![Page 50: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/50.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
50
Conclusion
![Page 51: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/51.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
51
Conclusion When research under
the current black box paradigm in its pure form relies on risk ratios that relate exposure to outcome with no elaboration of intervening pathways, it forfeits the depth offered by our new biological knowledge.
Because of an implicit and sometimes explicit commitment to analyzing disease solely at the individual level, research under this paradigm also dispenses with the potential breadth offered by new information systems in placing exposure, outcome, and risk in societal context.
![Page 52: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/52.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
52
The apogee of the black box paradigm is heralded by
epidemiology texts of the 1980s.
These mark two trends.
![Page 53: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/53.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
53
These mark two trends:
1. They move away from the public health orientation of the pioneers of the Chronic Disease Era.
2. At the same time, analysis edges out design as the central focus.
![Page 54: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/54.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
54
Conclusion (continued)
In the evolution of modem epidemiology, dominant paradigms have been displaced by new ones as health patterns and technologies have shifted.
As happened with previous paradigms, the black box, strained beyond its limits, is soon likely to be subsumed if not superseded entirely by another paradigm.
This paradigm reflects a particular era in our development as a discipline.
![Page 55: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/55.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
55
In our view, we stand at the verge of a new era.
![Page 56: Choosing a Future for Epidemiology - Eras and Paradigms 1 In the Name of God.](https://reader035.fdocuments.us/reader035/viewer/2022062422/56649e705503460f94b6d507/html5/thumbnails/56.jpg)
Choosing a Future for Epidemiology - Eras and Paradigms
56
Thank You!