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![Page 1: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/1.jpg)
Chlorate and Perchlorate in
Fruits and Vegetables
Alexander Lemke
Residues and Contaminants
Department
![Page 2: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/2.jpg)
Outline
• Introduction of CVUA-S / EURL
• Perchlorate and Chlorate
• Chemistry, Usage, Regulations, Toxicology
• Analytical Method
• Perchlorate Results
• Chlorate Results
• Public Health Risks
![Page 3: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/3.jpg)
• Capital of Baden-Württemberg federal state
• Sister City of St. Louis
• Mercedes-Benz
• Porsche
• ‘Cannstatter Wasen’ Beer Festival
Stuttgart [ˈʒ̊d̥ua̯ɡ̊ɛʕd̥] Pop. 600,000
![Page 4: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/4.jpg)
CVUA Stuttgart Chemical and Veterinary
Investigations Office Stuttgart,
Germany
Functions • Official food control • Animal health • Food industry control • Risk assessment, advisory service • Research • Education
Resources • 243 employees, incl. chemists, microbiologists,
veterinarians • Annual budget 12 Mio. €, thereof 9 Mio. € for staff • Area of the building 13,700 m²
![Page 5: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/5.jpg)
EURL
NRL
NRL
NRL
NRL
NRL
OFL OFL
OFL OFL
OFL
OFL
OFL OFL
OFL
OFL
OFL
OFL
OFL
OFL OFL
European Union Reference Laboratory
for pesticides requiring Single Residue Methods
EURL-SRM
NRL National Reference Laboratory
OFL Official Laboratory in an EU Member State
Main Functions • Technical assistance to OFLs, NRLs, COM
• Method development and validation
• Drafting of QAQC guidelines
• Organization of EU Proficiency Tests
• Networking with NRLs and Official Labs
• Workshops, trainings
• EURL Datapool www.eurl-pesticides-datapool.eu
![Page 6: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/6.jpg)
Recent Perchlorate / Chlorate History
2008 – US Agency for Toxic Substances and Disease Registry (ATSDR)
releases public health statement, after widespread presence of
perchlorates in the environment was found
2009 – US CDC finds perchlorate in infant formula
2010 – Chlorate as herbicide banned in the EU
2012 – High levels of perchlorate found in infant formula in France,
assessed as health risk
2012 – CVUA-S begins analyzing food samples for perchlorate
2013 – CVUA-S begins analyzing food samples for chlorate
![Page 7: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/7.jpg)
Usage / Occurrence of Chlorate
Non-agricultural
use
• Bleaching agent (e.g. paper industry)
• metal industry,
• leather industry,
• pyrotechnics,
• cosmetics (disinfectant)
Agricultural use • Herbicide (banned in 2010 in EU)
• Defoliant
By-product of • water treatment with chlorine,
hypochlorite or chlorine dioxide for
• washing of produce;
• post-harvest washing and
sanitation of food (“Hydro-cooling”)
• sanitation of food processing
equipment
3 ClO- ClO3
- + 2 Cl
-
Cl2 + 2 OH- Cl
- + ClO
- + H2O
2 ClO2 + 2 OH- ClO3
- + ClO2
-
![Page 8: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/8.jpg)
Usage / Occurrence of Perchlorate
Natural Natural formation in atmosphere,
accumulation in arid areas,
Chilean nitrate fertilizer
By-product of
Potential degradation of chlorination
agents
Non-agricultural use solid rocket fuels
(military, aeronautics, pyrotechnics)
ClO
O
OO
-
![Page 9: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/9.jpg)
Toxicity and Regulatory Aspects Chlorate Perchlorate
Classification in the EU Pesticide Contaminant
Impact on human health reversible inhibition of iodine
uptake in the thyroid;
formation of methemoglobin,
erythrocytes lysis, renal failure
reversible inhibition of iodine
uptake in the thyroid
Acute Reference Dose
(ARfD) (EFSA)
0.036 mg/kg bw
= 36 µg/kg bw
none set
Tolerable Daily Intake
(TDI) (EFSA 2014,15)
3 µg/kg bw and day 0.3 µg/kg bw and day
Regulatory Situation in
the EU
Maximum Residue Level
0.01 mg/kg, but actions are only
taken when ARfD >100%
ALARA-Principle as low as reasonably achievable
Reference values set for trade
TDI is the daily amount that can be ingested over a life span, without any risk of undesirable health effects
ARfD is defined as the amount of a substance a person can consume, over the period of one day, at one meal.
![Page 10: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/10.jpg)
Analysis of Chlorate and Perchlorate
• Chlorate and Perchlorate are ions ...
… use ion chromatography?
![Page 11: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/11.jpg)
Analysis of Chlorate and Perchlorate
• Chlorate and Perchlorate are ions ...
… use ion chromatography?
• We routinely analyze 1200+ pesticides and
contaminants using LC (and GC) with mass
spectroscopy technology like MS/MS, Qtrap, time-of-
flight
• New LC-MS/MS based Single Residue Method in 2012:
QuPPe-Method with Hypercarb™-Column
![Page 12: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/12.jpg)
Analysis of Chlorate and Perchlorate
[kjuːb]
http://quppe.eu
![Page 13: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/13.jpg)
Electrochemical production of HCl18O3 and HCl18O4
Isotopically Labelled Internal Standards
(ILIS) for QuPPe
![Page 14: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/14.jpg)
Perchlorate Residues in Food of Plant Origin
Including:
• Fresh Fruit (2498)
• Fresh Vegetables (2966)
• Fruit products (215)
• Vegetable products (244)
• Cereals /-products (146)
• Potatoes (129)
• Mushrooms /-products (201) 5315 (78%)
1377 (20%)
122 (2%)
<0.005 mg/kg≥0.005 ≤0.1 mg/kg >0.1 mg/kg
Total number of samples
Jan 2013-July 2016: 6814
![Page 15: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/15.jpg)
Perchlorate Residues in Food of Plant Origin
0
2
4
6
8
10
12
14
16
>0.01 - ≤0.05 >0.05 - ≤0.1 >0.1 - ≤0.5 >0.5- ≤1.0 >1.0
14.1
4.8
2.4
0.1 0
13.0
2.8 2.2
0.2 0.2
11.5
1.9 1.3
0.2 0.1
8.3
1.1 0.7
0.05 0.05
Aug. 2012 - May 2013
June 2013 - Febr. 2014
March 2014 - Feb. 2015
March 2015 - Feb. 2016
Pe
rcen
tage o
f S
am
ple
s w
ith
Pe
rchlo
rate
Resid
ue
s
Concentration range (mg/kg)
![Page 16: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/16.jpg)
ALARA-Principle: as low as reasonably achievable
Categories Perchlorate Reference Values
(SC PAFF 2015) mg/kg
Samples With High Residues
(03/2015-02/2016)
mg/kg
Fruit and vegetables, with
exception of
0.1 Green beans 0.12
Pumpkin family and leafy
vegetables, with exception of
0.2 Cucumber 0.48
Melon 0.41
Celery and spinach from
greenhouses
0.5 Spinach 0.47
Herbs, rucola, head lettuce, lettuce
from greenhouses
1.0 Rosemary 4.8
Dill 0.3; Parsley 0.26
Arugula 0.22; Head lettuce 0.18
Perchlorate: Reference Values
Source: EUROPEAN COMMISSION DIRECTORATE-GENERAL FOR HEALTH AND FOOD SAFETY: Statement as regards the presence of
perchlorate in food, endorsed by the Standing Committee on Plants, Animals, Food and Feed on 10 March 2015, updated on 23 June 2015;
http://ec.europa.eu/food/safety/docs/cs_contaminants_catalogue_perchlorate_statement_food_update_en.pdf
![Page 17: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/17.jpg)
Perchlorate Residues in Food of Plant Origin
0
2
4
6
8
10
12
14
16
>0.01 - ≤0.05 >0.05 - ≤0.1 >0.1 - ≤0.5 >0.5- ≤1.0 >1.0
14.1
4.8
2.4
0.1 0
13.0
2.8 2.2
0.2 0.2
11.5
1.9 1.3
0.2 0.1
8.3
1.1 0.7
0.05 0.05
Aug. 2012 - May 2013
June 2013 - Febr. 2014
March 2014 - Feb. 2015
March 2015 - Feb. 2016
Pe
rcen
tage o
f S
am
ple
s w
ith
Pe
rchlo
rate
Resid
ue
s
Concentration range (mg/kg)
<1% of samples
above general reference value
for fruits and vegetables
![Page 18: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/18.jpg)
How does Perchlorate end up in food?
• Anthropogenic sources ?
• Superficial vs. systemic contamination?
• By-product of chlorinated washing / process water?
• By-product of chlorinated irrigation water?
• Natural nitrate fertilizers with perchlorate?
![Page 19: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/19.jpg)
Perchlorate – Distribution Within Melons
Peel Sample Fruit Flesh
0.067 Honeydew 0.056
0.020 Galia melon 0.026
0.019 Galia melon 0.023
0.021 Galia melon 0.028
0.046 Cantaloupe 0.033
0.044 Cantaloupe 0.065
Perchlorate (mg/kg)
![Page 20: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/20.jpg)
Perchlorate and Chlorate in Fertilizers Melamine Diethanolamin Triethanolamin
Triazol-
Anilin
Triazol Acetic
acid
Triazole
lactic acid
Cyanuric
acid Chlorate Perchlorate
1 Osmosol 8,4 0,051 0,068 0,51
2 Naersalz GT 15_5_30 29 0,067 0,086 21 37
3 Entec perfect 15_5_20 0,091 0,034 0,30
4 Haifa NK 13_46 0,003 0,076
5 PerlkaKalkstickstoff 1,7 0,11 0,039 0,04 2,4
6 Blaukorn 0,39 0,057 0,033 2,7
7 Nitrophoska 0,041 0,049
8 KaliumKrista 41 0,080 27 14
9 Calcinit 0,027 0,056
10 ASS Bor 7,3 0,031 0,019 0,088
11 Krista K NK 78 0,25 15 20
12 Triabon Langz. 0,041 0,025 0,2 0,88 41
13 Fery NPK_Mg 0,055 0,32 0,061
14 Patentkali 0,016 0,033 0,024
15 Agriplant 15_5_30 0,035 0,024
16 NPK_Duenger 14 0,032 0,087 8,1 11
17 Novatek 0,031 0,019
18 Perlka 5,9 0,13 0,041 0,03 2,1
19 Yara Calcinit 0,014 0,019
![Page 21: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/21.jpg)
Perchlorate and Chlorate - Correlation ?
0
0,5
1
1,5
2
0
0,5
1
Chlorate Perchlorate
Samples with Perchlorate > 0.20 mg/kg
and Chlorate > 0.30 mg/kg
![Page 22: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/22.jpg)
4184 (89%)
439 (9%)
95 (2%)
<0.01 mg/kg≥0.01 ≤0.1 mg/kg >0.1 mg/kg
Chlorate Residues in Food of Plant Origin
Total number of samples
April 2014-July 2016: 4718
Default Maximum Residue Level
0.01 mg/kg
![Page 23: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/23.jpg)
How does Chlorate end up in food?
• Chlorinated irrigation water
• Recycled process water for washing / desinfection
• Washing with chlorinated water after harvest
• Application of contaminated fertilizers
• Illegal use of chlorate as herbicide
![Page 24: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/24.jpg)
Chlorate Residues in Food of Plant Origin
0
1
2
3
4
5
6
7
8
>0.01-≤0.05 >0.05-≤ 0.1 >0.1 -≤0.5 >0.5
7.5%
2.1% 1.8%
0.5%
6.7%
2.0% 1.5%
0.3%
April 2014 - March 2015
April 2015 - March 2016
concentration range (mg/kg)
Pe
rce
nta
ge
of sa
mp
les
![Page 25: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/25.jpg)
Chlorate Residues in Fruit and (Frozen) Vegetables P
erc
en
tage
of sa
mp
les
0
10
20
30
40
50
60
70
80
Summer2014
Winter2014/15
Summer2015
Winter2015/16
2Q 2016
2.4 3.3 1.5 1.7 3.0
18.0 18.3 15.9
18.3 14.7
77.8 75.5
54.3
65.7
76.9
Fruits % ≥0.01 mg/kg Vegetables % ≥0.01 mg/kg Frozen Vegetables % ≥0.01 mg/kg
![Page 26: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/26.jpg)
Chlorate in Fresh and Frozen Vegetables
No. of samples with/without chlorate residues
11
5
44
38
2
34
3
42
12
8
2
12
15
5
10
7
0 10 20 30 40 50 60
fresh
frozen
fresh
frozen
fresh
frozen
fresh
frozen
fresh
frozen
Cauli-
flow
er
Bro
cco
liB
russels
spro
uts
Ch
ive
Sp
inach
without residues (≤0.01 mg/kg)
with residues (> 0.01 mg/kg)
![Page 27: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/27.jpg)
Chlorate Residues in Carrots
0
5
10
15
20
25
30
35
Carrotsfresh
Carrotsprepared
Carrotsfrozen
0
16
5
31 27
5
No of samples with chlorate ≥0.01mg/kg
No of samples
![Page 28: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/28.jpg)
Chlorate Residues in Prepared Carrots from different manufacturers
0
0,1
0,2
0,3
0,4
0,5
0,6
<0.01 0.036
0.049
0.043
0.071
0.28
0.24
0.14
0.54
0.097
mg/kg
A
Origin Netherlands B
Origin USA C
Origin USA
D
Origin unknown
0.5
0.4
0.3
0.2
0.1
0.6
![Page 29: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/29.jpg)
Chlorate Residues in Asparagus
0
5
10
15
20
25
30
35
40
Peru Italy Germany Greece Spain
1 3
39
9
4 7
0 0 0
7
No
. o
f sa
mple
s
Residues ≤ 0.01 mg/kg Residues > 0.01 mg/kg
![Page 30: Chlorate and Perchlorate in Fruits and Vegetables - Startseitecvuas.untersuchungsämter-bw.de/pdf/CVUAS_IAFP2016_Chlorate... · • Capital of Baden-Württemberg federal state •](https://reader030.fdocuments.us/reader030/viewer/2022020302/5a7b1e6e7f8b9a2e358ba519/html5/thumbnails/30.jpg)
Commodity Origin Chlorate
(mg/kg)
% ARfD exhaustion
for most vulnerable
age group
Chive frozen Unknown 3.8 2.5 %
Coriander leaf Thailand 1.7 0.6 %
Egg plant Netherlands 1.2 83 %
Chili pepper Uganda 0.96 168 %
Asparagus green Peru 0.91 12 %
Head lettuce Germany 0.72 127 %
April 2015 – March 2016
Chlorate – Acute Exposure from Single Samples
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Chlorate: Acute Dietary Exposure Estimate
Age Class Me
an e
xp.
µg/
kg b
w /
day
95
th p
erc
en
tile
µg/
kg b
w /
day
Infants 7.6 17.3
Toddlers 7.2 15.3
Other Children 5.2 11.0
Adolescents 3.0 7.2
Adults 2.9 6.9
Elderly 2.9 6.0
Very elderly 2.7 5.3
ARfD: 36 µg/kg bw
main contributor: drinking water !
Source: EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain), 2015. Scientific Opinion on risks for public health related to the presence of chlorate in food.
EFSA Journal 2015;13(6):4135, 103 pp. doi:10.2903/j.efsa.2015.4135
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Chlorate: Chronic Dietary Exposure Estimate
main contributor: drinking water !
Age Class Me
an e
xp.
µg/
kg b
w /
day
95
th p
erc
en
tile
µg/
kg b
w /
day
Infants 2.6 4.3
Toddlers 3.2 5.2
Other Children 2.4 3.9
Adolescents 1.4 2.3
Adults 1.3 2.2
Elderly 1.1 1.9
Very elderly 1.1 1.8
TDI: 3 µg/kg bw /day
Most vulnerable subpopulation:
Younger age groups with iodine deficiency
Source: EFSA CONTAM Panel (EFSA Panel on Contaminants in the Food Chain), 2015. Scientific Opinion on risks for public health related to the presence of chlorate in food.
EFSA Journal 2015;13(6):4135, 103 pp. doi:10.2903/j.efsa.2015.4135
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Conclusion (1)
• Food safety control for perchlorate contamination is working
• Low public health risk for average consumer at current
average chlorate exposure levels
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Conclusion (2)
• Current regulatory situation for chlorate is unsatisfactory,
both for food companys and food safety officials
• MRL of 0.01 mg/kg or future ALARA-reference value for
chlorate might still be a good idea because:
• cumulative and synergistic effects,
• formation of carcinogenic halogenated DBP
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Conclusion (3)
• More research and data needed!
• Chlorate occurrence in food
• Human dietary exposure to chlorate
• Human health impact of chlorate
• Impact of food processing on chlorate residues
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Conclusion (3)
• Compliance with general food safety regulations requires
desinfection of some kind on most production stages
• Efforts to reduce chlorate residues in food must not have an
negative impact on microbiological food safety.
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