Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H...
Transcript of Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H...
![Page 1: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/1.jpg)
![Page 2: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/2.jpg)
Chemistry &
Biochemistry
![Page 3: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/3.jpg)
Chemistry &
Biochemistry
Graduate program overview
![Page 4: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/4.jpg)
Chemistry &
Biochemistry
Graduate program overview
•
•
•
•
•
•
•
![Page 5: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/5.jpg)
The Department of
Chemistry & Biochemistry
![Page 6: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/6.jpg)
Chemistry &
Biochemistry
Graduate program overview
![Page 7: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/7.jpg)
The Department of
Chemistry & Biochemistry
![Page 8: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/8.jpg)
Chemistry &
Biochemistry
Current positions of some our recent graduate students.
![Page 9: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/9.jpg)
The Department of
Chemistry & Biochemistry
![Page 10: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/10.jpg)
Chemistry &
Biochemistry
Techniques
![Page 11: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/11.jpg)
Chemistry &
Biochemistry
O
EtO
O
OEt
OBn
KOH
O
EtO
O
OH
OBn
(Racemic)PLE
O
EtO
O
OH
OBn
0 5 10 15 20 25 30
0
5000
10000
15000
20000
25000
30000
35000
Saponification Product (Racemic)
AU
(m
V)
Time (min)
0 5 10 15 20 25 30
0
5000
10000
15000
20000
25000
30000
35000
4000070 % EE
PLE Hydrolysis Product
AU
(m
V)
Time (min)
R
S
S
S
Ala Gly Cys
Cys
Lys
Lys
Asn Phe Phe
Phe
Trp
ThrThrSer
Residues of interest in this projectPeptide bonds susceptible to proteolytic degradationSusceptible to in vivo reduction
![Page 12: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/12.jpg)
Chemistry &
Biochemistry
![Page 13: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/13.jpg)
Chemistry &
Biochemistry
(a) (b)
(c) (d)
(e) (f)
(a) (b)
(c) (d)
(e) (f)
siRNA delivery to cancer cells
RNA fluorescent labeling
![Page 14: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/14.jpg)
Chemistry &
Biochemistry
![Page 15: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/15.jpg)
Chemistry &
Biochemistry
NS
N
S
NHO
N
O
NH
N
O
NH2
S
N
O
NH
ONH
O
HN
O
HN
O
HN
NH
O
S
N O
S
S
N
N
S
O
OH
HN
CO2H
cyclothiazomycin
O
O
OOH
H3CN(CH3)2
H
H
H HO
OO
HNO
OHH3CO
H3CO
iPrO
NCl
OO
HO
H3C
CH3
OH
Kedarcidin Chromorphore
ab
H
OH
HO
H3C
N
H
H
H3C
Magellanine
O
O
N
CH3
HO
Palhinine A
= spirocyclic quaternary carbon
![Page 16: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/16.jpg)
Chemistry &
Biochemistry
![Page 17: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/17.jpg)
Chemistry &
Biochemistry
![Page 18: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/18.jpg)
Chemistry &
Biochemistry
![Page 19: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/19.jpg)
Chemistry &
Biochemistry
![Page 20: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/20.jpg)
Chemistry &
Biochemistry
b
![Page 21: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/21.jpg)
Chemistry &
Biochemistry
![Page 22: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/22.jpg)
The Department of
Chemistry & Biochemistry
Image courtesy - http://www.theadp.com
![Page 23: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/23.jpg)
Hattiesburg, Mississippi
Recreation
http://www.longleaftrace.org/ Longleaf trace: A 41-mile bikers fantasy!
Longleaf Trace: Rails-to-Trails 42 paved miles–Hattiesburg to Prentiss
![Page 24: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/24.jpg)
Hattiesburg, Mississippi
Recreation (contd..)
Camping, hiking, canoeing and mountain biking
18 screen movie theatre
Monthly performances
18 screen movie theatre
Over 50 stores! Belk, Dillard’s and Sears
![Page 25: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/25.jpg)
Hattiesburg, Mississippi
Recreationhttp://www.kegandbarrel.com/
http://mugshotsgrillandbar.com/
Keg and Barrel Local Watering Hole
Southern Miss Golden Eagles Sports!!!
![Page 26: Chemistry - University of Southern Mississippi...Chemistry & Biochemistry O E tO O O E t O Bn K O H O E tO O O H O Bn P L E (R a c e m ic ) O E tO O O H O Bn 0 5 10 15 20 25 30 0 5000](https://reader030.fdocuments.us/reader030/viewer/2022040222/5e42ffc7ff531f200779c5de/html5/thumbnails/26.jpg)
Hattiesburg, Mississippi
Other amenities..
On campus USM daycare
Affordable housing with modern amenities
Close, affordable health care