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Other bioactive productsU 1300 The First Total Synthesis of Moracin O and Moracin P, and Establishment of the

Absolute Configuration of Moracin O. — The first total syntheses of the naturally occurring benzofurans moracin O and moracin P as protected analogues (VI) and (III), resp., are achieved using a Sonogashira cross coupling followed by in situ cyclization. Furthermore, the absolute configuration of natural moracin O (XI) is established to be (R). The absolute stereochemistry is introduced by employing a Sharpless asymmetric dihydroxylation reaction. — (KAUR, N.; XIA, Y.; JIN, Y.; NGUYEN, T. D.; GAJULAPATI, K.; CHOI, Y.; HONG, Y.-S.; LEE, J. J.; LEE*, K.; Chem. Commun. (Cambridge) 2009, 14, 1879-1881; Mol. Cancer Res. Cent., Korea Res. Inst. Biosci. Biotechnol., Daejeon 305-806, S. Korea; Eng.) — M. Paetzel

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ChemInform 2009, 40, issue 34 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

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ChemInform 2009, 40, issue 34 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim