ChemInform Abstract: Synthesis and Anticancer Activity of 5-(3-Indolyl)-1,3,4-thiadiazoles.
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Transcript of ChemInform Abstract: Synthesis and Anticancer Activity of 5-(3-Indolyl)-1,3,4-thiadiazoles.
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Thiadiazole derivativesR 0300 DOI: 10.1002/chin.201103146
Synthesis and Anticancer Activity of 5-(3-Indolyl)-1,3,4-thiadiazoles. — A facile synthesis of diverse 5-(3-indolyl)-1,3,4-thiadiazoles (II) is reported. Their anticancer activities are evaluated against various human cancer cell lines. Compounds bearing C-2 substituents as benzyl (IIIa), 3,4-dimethoxyphenyl (IIIb), and 4-benzyloxy-3-me-thoxyphenyl (IIIc) and (IIId), show significant cytotoxicity. — (KUMAR*, D.; KUMAR, N. M.; CHANG, K.-H.; SHAH, K.; Eur. J. Med. Chem. 45 (2010) 10, 4664-4668, http://dx.doi.org/10.1016/j.ejmech.2010.07.023 ; Dep. Chem., Birla Inst. Technol. Sci., Pilani 333 031, India; Eng.) — H. Haber
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ChemInform 2011, 42, issue 03 © 2011 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim