ChemInform Abstract: Parallel Solution-Phase Synthesis of Mechanism-Based Cysteine Protease...

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2002 amino acids, peptides amino acids, peptides U 0400 13 - 194 Parallel Solution-Phase Synthesis of Mechanism-Based Cysteine Protease Inhibitors. — Free allylic amines (V) react with carboxylic acids preloaded onto hydroxynitrobenzophenone resin to afford amides which are epoxidated with dimethyldioxirane. Opening of the epoxides is achieved by thiol addition using support-bound guanidine base in refluxing THF to give an alcohol which is oxidated with Dess–Martin periodinane. The present sequence to synthesize cysteine protease inhibitors combines the use of liquid–liquid extractions, volatile or solid-supported reagents and support-bound scavengers to avoid column chromatographic purifications of intermediates. — (LEE, ALICE; ELLMAN, JONATHAN A.; Org. Lett. 3 (2001) 23, 3707-3709; Dep. Chem., Univ. Calif., Berkeley, CA 94720, USA; EN) 1

Transcript of ChemInform Abstract: Parallel Solution-Phase Synthesis of Mechanism-Based Cysteine Protease...

Page 1: ChemInform Abstract: Parallel Solution-Phase Synthesis of Mechanism-Based Cysteine Protease Inhibitors.

2002 amino acids, peptides

amino acids, peptidesU 0400

13 - 194Parallel Solution-Phase Synthesis of Mechanism-Based CysteineProtease Inhibitors. — Free allylic amines (V) react with carboxylicacids preloaded onto hydroxynitrobenzophenone resin to afford amides whichare epoxidated with dimethyldioxirane. Opening of the epoxides is achieved bythiol addition using support-bound guanidine base in refluxing THF to give analcohol which is oxidated with Dess–Martin periodinane. The present sequenceto synthesize cysteine protease inhibitors combines the use of liquid–liquidextractions, volatile or solid-supported reagents and support-bound scavengersto avoid column chromatographic purifications of intermediates. — (LEE,ALICE; ELLMAN, JONATHAN A.; Org. Lett. 3 (2001) 23, 3707-3709; Dep.Chem., Univ. Calif., Berkeley, CA 94720, USA; EN)

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Cysteine Protease cDNA Open Reading Frame JONG THIN THIN ... of Putative Sago Palm Cysteine...Analysis of Putative Sago Palm Cysteine Protease cDNA Open Reading Frame Jong Thin Thin

Cysteine Protease cDNA Open Reading Frame JONG THIN THIN ... of Putative Sago Palm Cysteine...Analysis of Putative Sago Palm Cysteine Protease cDNA Open Reading Frame Jong Thin Thin

Scholars Research Library...Several results on cloning and expression of protease gene in E. coli were reported such as intracellular protease from Pyrococcus furiosus [9], cysteine

Scholars Research Library...Several results on cloning and expression of protease gene in E. coli were reported such as intracellular protease from Pyrococcus furiosus [9], cysteine

Analysis of Structures, Functions, and Epitopes of Cysteine Protease ...

Analysis of Structures, Functions, and Epitopes of Cysteine Protease ...

Identification of Parasitic Cysteine Protease …proteases are categorized into clans and they are diverse in terms of sequence or structural identity and possibly arose independently12.

Identification of Parasitic Cysteine Protease …proteases are categorized into clans and they are diverse in terms of sequence or structural identity and possibly arose independently12.

Introduction - Estudo Geral · Web viewLeupeptin is a protease inhibitor of small molecular weight that has been shown to inhibit the lysosomal cysteine proteases cathepsins B, H

Introduction - Estudo Geral · Web viewLeupeptin is a protease inhibitor of small molecular weight that has been shown to inhibit the lysosomal cysteine proteases cathepsins B, H

Mapping, Complementation, and Targets of the Cysteine Protease Actinidin in Kiwifruit1[C]

Mapping, Complementation, and Targets of the Cysteine Protease Actinidin in Kiwifruit1[C]

ueaeprints.uea.ac.uk€¦  · Web viewTrypanosoma. brucei. was investigated. Isobolographic analysis was used to determine the interaction between cysteine protease inhibitors (K11777,

ueaeprints.uea.ac.uk€¦  · Web viewTrypanosoma. brucei. was investigated. Isobolographic analysis was used to determine the interaction between cysteine protease inhibitors (K11777,

Epoxide electrophiles as activity-dependent cysteine protease pro¢ling ...med.stanford.edu/bogyolab/pdf/11048948.pdf · Epoxide electrophiles as activity-dependent cysteine protease

Epoxide electrophiles as activity-dependent cysteine protease pro¢ling ...med.stanford.edu/bogyolab/pdf/11048948.pdf · Epoxide electrophiles as activity-dependent cysteine protease

Immunolocalization of a Cysteine Protease in Vacuoles, Vesicles, and Symbiosomes of Pea

Immunolocalization of a Cysteine Protease in Vacuoles, Vesicles, and Symbiosomes of Pea

2012 Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Se

2012 Simultaneous Treatment of Human Bronchial Epithelial Cells with Serine and Cysteine Protease Inhibitors Prevents Se

Cysteine Proteases and Cell Differentiation: Excystment of ...ec.asm.org/content/2/6/1234.full.pdf · when cysteine protease inhibitors were added in the nutrient ... (Z-Leu-Leu-Leu-al),

Cysteine Proteases and Cell Differentiation: Excystment of ...ec.asm.org/content/2/6/1234.full.pdf · when cysteine protease inhibitors were added in the nutrient ... (Z-Leu-Leu-Leu-al),

A Mendelian Randomization Study - Research Repositoryrepository.essex.ac.uk/17471/1/1-s2.0-S0735109716344382-main.pdfC ystatin C (encoded byCST3 on 20p11.21) is a potent cysteine protease

A Mendelian Randomization Study - Research Repositoryrepository.essex.ac.uk/17471/1/1-s2.0-S0735109716344382-main.pdfC ystatin C (encoded byCST3 on 20p11.21) is a potent cysteine protease

Chymotrypsin Proteases ClassNucleophile(s)Base Covalent Intermediate Serine protease Cysteine protease Aspartyl protease Metalloprotease (Zn) Ser/water.

Chymotrypsin Proteases ClassNucleophile(s)Base Covalent Intermediate Serine protease Cysteine protease Aspartyl protease Metalloprotease (Zn) Ser/water.

Eimeripain, a Cathepsin B-Like Cysteine Protease ...Eimeripain, a Cathepsin B-Like Cysteine Protease, Expressed throughout Sporulation of the Apicomplexan Parasite Eimeria tenella

Eimeripain, a Cathepsin B-Like Cysteine Protease ...Eimeripain, a Cathepsin B-Like Cysteine Protease, Expressed throughout Sporulation of the Apicomplexan Parasite Eimeria tenella

Different patterns of apoptosis in response to cisplatin ...induced by caspases in the apoptosis “execution” phase. Caspases belong to a cysteine protease family that cleaves critical

Different patterns of apoptosis in response to cisplatin ...induced by caspases in the apoptosis “execution” phase. Caspases belong to a cysteine protease family that cleaves critical

The structure of the cysteine protease and lectin-like ...

The structure of the cysteine protease and lectin-like ...

Managing the Care of Patients Receiving Antiresorptive ... · Other antiresorptive drugs. Cathepsin K, a cysteine protease expressed in osteoclasts, degrades type 1 collagen.

Managing the Care of Patients Receiving Antiresorptive ... · Other antiresorptive drugs. Cathepsin K, a cysteine protease expressed in osteoclasts, degrades type 1 collagen.

SspB CYSTEINE PROTEASE OF Staphylococcw aurem …Lack of Activity of SspB on Resorufin-labeled casein ..... 87 . PART 1: INTRODUCTION =- 5-= - . 4 -. 1. Staphylococcus aureus i) Identification

SspB CYSTEINE PROTEASE OF Staphylococcw aurem …Lack of Activity of SspB on Resorufin-labeled casein ..... 87 . PART 1: INTRODUCTION =- 5-= - . 4 -. 1. Staphylococcus aureus i) Identification

2018 891 24 B ; á (Autophagy) (Cysteine-containing aspartate … · 2018 891 24 B ; á (Autophagy) (Cysteine-containing aspartate protease, Caspase) (cell strain) (Yamanaka factors)

2018 891 24 B ; á (Autophagy) (Cysteine-containing aspartate … · 2018 891 24 B ; á (Autophagy) (Cysteine-containing aspartate protease, Caspase) (cell strain) (Yamanaka factors)

Mch2, a New Member of the Apoptotic Ced-3IIce Cysteine … · Mch2, a New Member of the Apoptotic Ced-3IIce Cysteine Protease Gene Family1 Teresa Fernandes-Alnemri, Gerald Litwack,

Mch2, a New Member of the Apoptotic Ced-3IIce Cysteine … · Mch2, a New Member of the Apoptotic Ced-3IIce Cysteine Protease Gene Family1 Teresa Fernandes-Alnemri, Gerald Litwack,