ChemInform Abstract: N-Propargyl-2-alkynylbenzothiazolium Aza-enediynes: Role of the...

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2002 benzothiazole derivatives benzothiazole derivatives R 0270 09 - 134 N-Propargyl-2-alkynylbenzothiazolium Aza-enediynes: Role of the 2-Alkynylbenzothiazolium Functionality in DNA Cleavage. — Four compounds of type (V) and compound (VII) are prepared and tested as DNA cleavage agents. While compounds (V) are shown to be modest DNA agents, DNA cleavage is also observed with (VII). The structural requirements for DNA cleavage and the correlation of DNA cleavage efficiency with the propensity of these compounds to undergo nucleophilic addition by methanol support a proposed DNA cleavage mechanism involving DNA alkylation by appropriate 2-alkynyl-substituted benzothiazolium salts. — (KUMAR, DALIP; DAVID, WENDI M.; KERWIN, SEAN M.; Bioorg. Med. Chem. Lett. 11 (2001) 22, 2971-2974; Med. Chem. Div., Coll. Pharm., Univ. Tex., Austin, TX 78712, USA; EN) 1

Transcript of ChemInform Abstract: N-Propargyl-2-alkynylbenzothiazolium Aza-enediynes: Role of the...

Page 1: ChemInform Abstract: N-Propargyl-2-alkynylbenzothiazolium Aza-enediynes: Role of the 2-Alkynylbenzothiazolium Functionality in DNA Cleavage.

2002 benzothiazole derivatives

benzothiazole derivativesR 0270

09 - 134N-Propargyl-2-alkynylbenzothiazolium Aza-enediynes: Role of the2-Alkynylbenzothiazolium Functionality in DNA Cleavage. — Fourcompounds of type (V) and compound (VII) are prepared and tested as DNAcleavage agents. While compounds (V) are shown to be modest DNA agents,DNA cleavage is also observed with (VII). The structural requirements for DNAcleavage and the correlation of DNA cleavage efficiency with the propensityof these compounds to undergo nucleophilic addition by methanol support aproposed DNA cleavage mechanism involving DNA alkylation by appropriate2-alkynyl-substituted benzothiazolium salts. — (KUMAR, DALIP; DAVID,WENDI M.; KERWIN, SEAN M.; Bioorg. Med. Chem. Lett. 11 (2001) 22,2971-2974; Med. Chem. Div., Coll. Pharm., Univ. Tex., Austin, TX 78712,USA; EN)

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ChemInform Sheet A4 · 2013. 9. 13. · The ChemInform Reaction Library (CIRX) helps to deal with the enormous number of published reactions as it does not cover all information available

ChemInform Sheet A4 · 2013. 9. 13. · The ChemInform Reaction Library (CIRX) helps to deal with the enormous number of published reactions as it does not cover all information available

Platinum catalysed hydrosilylation of propargylic alcohols · examining the scope of the reaction using secondary propargyl alcohols (Table 2). We soon discovered that propargyl alcohol

Platinum catalysed hydrosilylation of propargylic alcohols · examining the scope of the reaction using secondary propargyl alcohols (Table 2). We soon discovered that propargyl alcohol

Open Access Programming langage in chemiy: a eie of HTML5 ... · Theien J Cheminform Page 3 of 19 HTML5 econtentweviewontheInternetismadepossiblebya unionofseveraltechnologies,mainlyHypertextMarkup

Open Access Programming langage in chemiy: a eie of HTML5 ... · Theien J Cheminform Page 3 of 19 HTML5 econtentweviewontheInternetismadepossiblebya unionofseveraltechnologies,mainlyHypertextMarkup

Topology of Organometallic Radicals How does coordination with transition metals affect reactivity&stereoelectronic parameters of propargyl cation&radical?

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discovery.ucl.ac.uk novel enediyne synthesis from alkynyl...3 Abstract In the last forty years Z-enediynes have been found to facilitate a unique and powerful class of antitumour agent,

discovery.ucl.ac.uk novel enediyne synthesis from alkynyl...3 Abstract In the last forty years Z-enediynes have been found to facilitate a unique and powerful class of antitumour agent,

1. Experimental part3rd step – Synthesis of 1'-(propargyl)-3',3'-dimethyl-6-nitrospiro[2H-1 benzopyran-2,2'-indoline] (BSP-alkyne) To a solutionof 1-propargyl-2,3,3-trimethylindolenine(2.6

1. Experimental part3rd step – Synthesis of 1'-(propargyl)-3',3'-dimethyl-6-nitrospiro[2H-1 benzopyran-2,2'-indoline] (BSP-alkyne) To a solutionof 1-propargyl-2,3,3-trimethylindolenine(2.6

Seidel - propargyl amines

Seidel - propargyl amines

Experimental Studies of Allene, Methylacetylene, and the …jila.colorado.edu/~wcl/wclgroup/Pub downloads/Allene... · 2007. 10. 8. · Studies of Allene, Methylacetylene, and Propargyl

Experimental Studies of Allene, Methylacetylene, and the …jila.colorado.edu/~wcl/wclgroup/Pub downloads/Allene... · 2007. 10. 8. · Studies of Allene, Methylacetylene, and Propargyl

Filtered circular fingerprints improve either prediction ... · Gütlein and Kramer J Cheminform () DOI 10.1186/s13321-016-0173-z RESEARCH ARTICLE Filtered circular fingerprints improve

Filtered circular fingerprints improve either prediction ... · Gütlein and Kramer J Cheminform () DOI 10.1186/s13321-016-0173-z RESEARCH ARTICLE Filtered circular fingerprints improve

Antitumor Antibiotics: Bleomycin, Enediynes, and MitomycinSteven G. Van Lanen received his B.S. (1998) degree in Molecular Biology from the University of WisconsinsMadison. In 2003

Antitumor Antibiotics: Bleomycin, Enediynes, and MitomycinSteven G. Van Lanen received his B.S. (1998) degree in Molecular Biology from the University of WisconsinsMadison. In 2003

GPURFSCREEN: a GPU based virtual screening tool …people.cse.nitc.ac.in/jayaraj/files/gpurfscreen...Jayaraj et al. J Cheminform DOI 10.1186/s13321-016-0124-8 SOFTWARE GPURFSCREEN:

GPURFSCREEN: a GPU based virtual screening tool …people.cse.nitc.ac.in/jayaraj/files/gpurfscreen...Jayaraj et al. J Cheminform DOI 10.1186/s13321-016-0124-8 SOFTWARE GPURFSCREEN:

RESEARCHARTICLE OpAccess ......Jiangiet al. J Cheminform Pagej2jofj26 playerindrugabsorption,distribution,metabolism, excretion,andtoxicity(ADMET)[5, 6],andhasalsobeen ...

RESEARCHARTICLE OpAccess ......Jiangiet al. J Cheminform Pagej2jofj26 playerindrugabsorption,distribution,metabolism, excretion,andtoxicity(ADMET)[5, 6],andhasalsobeen ...

RESEARCHARTICLE Assessingtheinformationcontent ......Rodríguez‑Pérezet al. J Cheminform Page6of14 whichyieldedmedianMCCvaluesof0.67(IFP_85) and0.63(EFCP_folded).us,inhibitorswithbinding

RESEARCHARTICLE Assessingtheinformationcontent ......Rodríguez‑Pérezet al. J Cheminform Page6of14 whichyieldedmedianMCCvaluesof0.67(IFP_85) and0.63(EFCP_folded).us,inhibitorswithbinding

Memory of Chirality in Cascade Rearrangements of Enediynes ...€¦ · 10/11/2011  · Bertrand, M. Org. Lett., 2010, 12, 3590-3593. Roxanne Atienza Short Literature Presentation

Memory of Chirality in Cascade Rearrangements of Enediynes ...€¦ · 10/11/2011  · Bertrand, M. Org. Lett., 2010, 12, 3590-3593. Roxanne Atienza Short Literature Presentation

Cooperative Catalysis - ETH Zürich · PDF fileCooperative Catalysis 1. ... oxidative activation) ... the -allyl palladium complex with propargyl alcohol) is obtained in 85 % yield

Cooperative Catalysis - ETH Zürich · PDF fileCooperative Catalysis 1. ... oxidative activation) ... the -allyl palladium complex with propargyl alcohol) is obtained in 85 % yield

-Supporting Information- and Glycidyl Propargyl Ether ... · S1-Supporting Information-“Clickable PEG” via Anionic Copolymerization of Ethylene Oxide and Glycidyl Propargyl Ether

-Supporting Information- and Glycidyl Propargyl Ether ... · S1-Supporting Information-“Clickable PEG” via Anionic Copolymerization of Ethylene Oxide and Glycidyl Propargyl Ether

Propargyl vinyl ethers and tertiary skipped diynes: …digital.csic.es/bitstream/10261/132386/1/Garcia_Tellado...Propargyl vinyl ethers and tertiary skipped diynes: two pluripotent

Propargyl vinyl ethers and tertiary skipped diynes: …digital.csic.es/bitstream/10261/132386/1/Garcia_Tellado...Propargyl vinyl ethers and tertiary skipped diynes: two pluripotent

([eta]4-1,5-Cyclooctadiene)[(R)-(+)-5,5',6,6',7,7',8,8' …iucrdata.iucr.org/x/issues/2017/09/00/pk4016/pk4016.pdf · enediynes, affording excellent enantiomeric excesses [Shibata

([eta]4-1,5-Cyclooctadiene)[(R)-(+)-5,5',6,6',7,7',8,8' …iucrdata.iucr.org/x/issues/2017/09/00/pk4016/pk4016.pdf · enediynes, affording excellent enantiomeric excesses [Shibata

J. Bukowczan - Various methods for one pot synthesis of triazoles from quinolinesulfonamides with propargyl group

J. Bukowczan - Various methods for one pot synthesis of triazoles from quinolinesulfonamides with propargyl group

Electronic spectrum of the propargyl cation (H C H ...

Electronic spectrum of the propargyl cation (H C H ...