ChemInform Abstract: L-Proline-Catalyzed Multicomponent Reaction of 3,4-Dihydro-(2H)-pyran,...
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ChemInform 2010, 41, issue 10 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Fused pyrimidine derivatives R 0515 DOI: 10.1002/chin.201010162 L-Proline-Catalyzed Multicomponent Reaction of 3,4-Dihydro-(2H)-pyran, Urea/ Thiourea, and Aldehydes: Diastereoselective Synthesis of Hexahydropyrano Pyrimidinones (Thiones). — Simple one-pot reaction is catalyzed by TFA/L-proline and is applied to a variety of aromatic aldehydes. The products are precursors for many bioactive molecules including fused oxazines which are used in tuberculosis chemo- therapy. — (PANDEY, J.; ANAND, N.; TRIPATHI*, R. P.; Tetrahedron 65 (2009) 45, 9350-9356; Div. Med. Process Chem., Cent. Drug Res. Inst., Lucknow 226 001, India; Eng.) — Y. Steudel 10- 162
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Transcript of ChemInform Abstract: L-Proline-Catalyzed Multicomponent Reaction of 3,4-Dihydro-(2H)-pyran,...
www.cheminform.wiley-vch.de
Fused pyrimidine derivativesR 0515 DOI: 10.1002/chin.201010162
L-Proline-Catalyzed Multicomponent Reaction of 3,4-Dihydro-(2H)-pyran, Urea/Thiourea, and Aldehydes: Diastereoselective Synthesis of HexahydropyranoPyrimidinones (Thiones). — Simple one-pot reaction is catalyzed by TFA/L-proline and is applied to a variety of aromatic aldehydes. The products are precursors for many bioactive molecules including fused oxazines which are used in tuberculosis chemo-therapy. — (PANDEY, J.; ANAND, N.; TRIPATHI*, R. P.; Tetrahedron 65 (2009) 45, 9350-9356; Div. Med. Process Chem., Cent. Drug Res. Inst., Lucknow 226 001, India; Eng.) — Y. Steudel
10- 162
ChemInform 2010, 41, issue 10 © 2010 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
