ChemInform Abstract: Convenient Synthesis of an Isoxazole Compound, KRIBB3, as an Anticancer Agent.
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ChemInform 2012, 43, issue 42 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Isoxazole derivatives R 0240 DOI: 10.1002/chin.201242135 Convenient Synthesis of an Isoxazole Compound, KRIBB3, as an Anticancer Agent. — KRIBB3 (XI), which exhibits strong antimigratory and antimitotic activities against cancer cells, is prepared in a practical synthetic way. The approach may provide easy access to KRIBB3 analogues with various substitution patterns for structure— -activity relationships, as well as for large quantities for in vivo studies. — (LEE, H. K.; YUN, E.; MIN, J. H.; YOON, K. S.; CHOUNG, D.-H.; LEE*, S.; Synth. Commun. 42 (2012) 13, 1890-1894, http://dx.doi.org/10.1080/00397911.2010.546551 ; Biother. Res. Cent., Korea Res. Inst. Biosci. Biotechnol., Daejeon 305-806, S. Korea; Eng.) — A. Forchert 42- 135
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Transcript of ChemInform Abstract: Convenient Synthesis of an Isoxazole Compound, KRIBB3, as an Anticancer Agent.
Isoxazole derivativesR 0240 DOI: 10.1002/chin.201242135
Convenient Synthesis of an Isoxazole Compound, KRIBB3, as an Anticancer Agent. — KRIBB3 (XI), which exhibits strong antimigratory and antimitotic activities against cancer cells, is prepared in a practical synthetic way. The approach may provide easy access to KRIBB3 analogues with various substitution patterns for structure—-activity relationships, as well as for large quantities for in vivo studies. — (LEE, H. K.; YUN, E.; MIN, J. H.; YOON, K. S.; CHOUNG, D.-H.; LEE*, S.; Synth. Commun. 42 (2012) 13, 1890-1894, http://dx.doi.org/10.1080/00397911.2010.546551 ; Biother. Res. Cent., Korea Res. Inst. Biosci. Biotechnol., Daejeon 305-806, S. Korea; Eng.) — A. Forchert
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ChemInform 2012, 43, issue 42 © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim
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