ChemInform Abstract: An Efficient Synthesis and Biological Study of Novel Indolyl-1,3,4-oxadiazoles...

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ChemInform 2009, 40, issue 48 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Oxadiazole derivatives R 0290 An Efficient Synthesis and Biological Study of Novel Indolyl-1,3,4-oxadiazoles as Potent Anticancer Agents. — The oxidative cyclization of hydrazones (I) is achieved by grinding with [bis(trifluoroacetoxy)iodo]benzene under solvent-free conditions fur- nishing indolyloxadiazoles (II) rapidly in good yields without any by-product. Com- pounds (IIId), (IIIe), and (V) display potent cytotoxicity and selectivity against human cancer cell lines. — (KUMAR*, D.; SUNDAREE, S.; JOHNSON, E. O.; SHAH, K.; Bioorg. Med. Chem. Lett. 19 (2009) 15, 4492-4494; Dep. Chem., Birla Inst. Technol. Sci., Pilani 333 031, India; Eng.) — H. Hoennerscheid 48- 142

Transcript of ChemInform Abstract: An Efficient Synthesis and Biological Study of Novel Indolyl-1,3,4-oxadiazoles...

Page 1: ChemInform Abstract: An Efficient Synthesis and Biological Study of Novel Indolyl-1,3,4-oxadiazoles as Potent Anticancer Agents.

www.cheminform.wiley-vch.de

Oxadiazole derivativesR 0290 An Efficient Synthesis and Biological Study of Novel Indolyl-1,3,4-oxadiazoles as

Potent Anticancer Agents. — The oxidative cyclization of hydrazones (I) is achieved by grinding with [bis(trifluoroacetoxy)iodo]benzene under solvent-free conditions fur-nishing indolyloxadiazoles (II) rapidly in good yields without any by-product. Com-pounds (IIId), (IIIe), and (V) display potent cytotoxicity and selectivity against human cancer cell lines. — (KUMAR*, D.; SUNDAREE, S.; JOHNSON, E. O.; SHAH, K.; Bioorg. Med. Chem. Lett. 19 (2009) 15, 4492-4494; Dep. Chem., Birla Inst. Technol. Sci., Pilani 333 031, India; Eng.) — H. Hoennerscheid

48- 142

ChemInform 2009, 40, issue 48 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim

Open Access CSgator:kanjintegratedkwebkplatformk forjcompoundksetkanalysis · 2019. 3. 4. · Parkjet al. J Cheminform Pagek6kofk8 currentlackofenoughcompound-targetdataevenafter

Open Access CSgator:kanjintegratedkwebkplatformk forjcompoundksetkanalysis · 2019. 3. 4. · Parkjet al. J Cheminform Pagek6kofk8 currentlackofenoughcompound-targetdataevenafter

RESEARCHARTICLE Assessingtheinformationcontent ......Rodríguez‑Pérezet al. J Cheminform Page6of14 whichyieldedmedianMCCvaluesof0.67(IFP_85) and0.63(EFCP_folded).us,inhibitorswithbinding

RESEARCHARTICLE Assessingtheinformationcontent ......Rodríguez‑Pérezet al. J Cheminform Page6of14 whichyieldedmedianMCCvaluesof0.67(IFP_85) and0.63(EFCP_folded).us,inhibitorswithbinding

AMIT-FINAL THESIS - shodhganga.inflibnet.ac.inshodhganga.inflibnet.ac.in/bitstream/10603/8403/7/07_chapter 2.pdf · oxadiazoles (28) can be 0b with carboxylic acid c (28) is given

AMIT-FINAL THESIS - shodhganga.inflibnet.ac.inshodhganga.inflibnet.ac.in/bitstream/10603/8403/7/07_chapter 2.pdf · oxadiazoles (28) can be 0b with carboxylic acid c (28) is given

RESEARCHARTICLE LargescalecomparisonofQSAR … · 2020. 3. 19. · Boscet al. J Cheminform Page3of16 Dta preparation Compoundstructureswereextractedfromthedatabase inSMILESformatandusingRDKit(version2017_09_01)

RESEARCHARTICLE LargescalecomparisonofQSAR … · 2020. 3. 19. · Boscet al. J Cheminform Page3of16 Dta preparation Compoundstructureswereextractedfromthedatabase inSMILESformatandusingRDKit(version2017_09_01)

 · Esterilidad Comercial Aerobios mesófilos (Conteo en placa) Clostridium peffnnges ... technique at 44 0 C using 5-bromo -4 chloro-3 indolyl -B-D-glucoronide.

 · Esterilidad Comercial Aerobios mesófilos (Conteo en placa) Clostridium peffnnges ... technique at 44 0 C using 5-bromo -4 chloro-3 indolyl -B-D-glucoronide.

METHODOLOGY Ecientiterativevirtualscreening with … · 2018. 3. 1. · Ahmed et al. J Cheminform Page4of8 10contain‘high-scoring’ligands.eunassignedbin3is excludedfromtraining.Figure

METHODOLOGY Ecientiterativevirtualscreening with … · 2018. 3. 1. · Ahmed et al. J Cheminform Page4of8 10contain‘high-scoring’ligands.eunassignedbin3is excludedfromtraining.Figure

Database fingerprint (DFP): an approach to represent ... · Fernández‑de Gortari et al. J Cheminform DOI 10.1186/s13321‑017‑0195‑1 PRELIMINARY COMMUNICATION Database fingerprint

Database fingerprint (DFP): an approach to represent ... · Fernández‑de Gortari et al. J Cheminform DOI 10.1186/s13321‑017‑0195‑1 PRELIMINARY COMMUNICATION Database fingerprint

NMDA receptor antagonism with novel indolyl, 2-(1,1 ...

NMDA receptor antagonism with novel indolyl, 2-(1,1 ...

Synthesis of bis- and tris(indolyl)methanes catalyzed by ...

Synthesis of bis- and tris(indolyl)methanes catalyzed by ...

Compounds related to 3-alkylamine-1H-indolyl acrylate and ...

Compounds related to 3-alkylamine-1H-indolyl acrylate and ...

Classification System for Solid Supports Used ... - FIZ CHEMIE › fileadmin › user_upload › Cheminform › Spore › _… · FIZ CHEMIE BERLIN - 5 (23) - The remainder of the

Classification System for Solid Supports Used ... - FIZ CHEMIE › fileadmin › user_upload › Cheminform › Spore › _… · FIZ CHEMIE BERLIN - 5 (23) - The remainder of the

Oxadiazoles in Medicinal Chemistry...using high-level quantum molecular calculations is presented. Finally, a novel, fast, and mild synthetic approach to attain structurally diverse

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METHODOLOGY Molecularstructuresenumeration and ......Koch et al. J Cheminform Page5of17 changing4bonds,sinceweaimtondminimaltransfor - mations.Letuscall a 13 and a 24 thetwofixedbonds,with

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The rapid preparation of 2-aminosulfonamide-1,3,4 ... · The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating Ian R.

The rapid preparation of 2-aminosulfonamide-1,3,4 ... · The rapid preparation of 2-aminosulfonamide-1,3,4-oxadiazoles using polymer-supported reagents and microwave heating Ian R.

Blackburn, Jack (2014) The Synthesis, Attempted Synthesis and Applications of 1,2,4-Oxadiazoles

Blackburn, Jack (2014) The Synthesis, Attempted Synthesis and Applications of 1,2,4-Oxadiazoles

ISSN 2229-3566 Review Article  · oxadiazoles and 2-(3-chloro-1- benzo[b]thiophen-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles and was evaluated for Anti- Microbial activity.5 (3)

ISSN 2229-3566 Review Article  · oxadiazoles and 2-(3-chloro-1- benzo[b]thiophen-2-yl)-5-substituted phenyl-1,3,4-oxadiazoles and was evaluated for Anti- Microbial activity.5 (3)

BIOINFORMATICS Review …“.Jónsdóttir et al. Fig. 1. Number of papers in PubMed 1992–2004 containing the keywords ‘bioinformatics’ (top left), ‘chemoinformatics’ or ‘cheminform-atics’,

BIOINFORMATICS Review …“.Jónsdóttir et al. Fig. 1. Number of papers in PubMed 1992–2004 containing the keywords ‘bioinformatics’ (top left), ‘chemoinformatics’ or ‘cheminform-atics’,

ChemInform Sheet A4on chemo-, regio-, and stereo-selective reactions. The RefLib database is included with CIRX and provides reactions abstracted from Theilheimer’s Synthetic Methods

ChemInform Sheet A4on chemo-, regio-, and stereo-selective reactions. The RefLib database is included with CIRX and provides reactions abstracted from Theilheimer’s Synthetic Methods

Heterocyclic Compoundsmu-varna.bg/EN/Students/Documents/organic-chemistry/... · Web viewOther indolic compounds include the plant hormone Auxin (indolyl-3-acetic acid, IAA), the

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MER: a shell script and annotation server for minimal named ......Couto and Lamurias J Cheminform Page 5 of 10 common,sandswesempiricallysfoundsthatsmostsofsthestwo-charactersmatchesswereserrors

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