ChemInform Abstract: A Novel Consecutive Three-Component Coupling—Addition—SNAr (CASNAR)...

1
ChemInform 2009, 40, issue 40 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim www.cheminform.wiley-vch.de Thiopyran derivatives R 0370 A Novel Consecutive Three-Component Coupling—Addition—SNAr (CASNAR) Synthesis of 4H-Thiochromen-4-ones. — The one-pot procedure provides a conve- nient access to the title compounds via coupling of hetaryl chlorides with alkynes under modified Sonogashira conditions followed by addition of sodium sulfide and intramo- lecular SNAr reaction. Furthermore, the method is applied to the synthesis of thiopyra- nopyridiones (XI). — (WILLY, B.; MUELLER*, T. J. J.; Synlett 2009, 8, 1255-1260; Inst. Org. Chem. Makromol. Chem., Heinrich-Heine-Univ., D-40225 Duesseldorf, Germany; Eng.) — Mais 40- 125

Transcript of ChemInform Abstract: A Novel Consecutive Three-Component Coupling—Addition—SNAr (CASNAR)...

Page 1: ChemInform Abstract: A Novel Consecutive Three-Component Coupling—Addition—SNAr (CASNAR) Synthesis of 4H-Thiochromen-4-ones.

www.cheminform.wiley-vch.de

Thiopyran derivativesR 0370 A Novel Consecutive Three-Component Coupling—Addition—SNAr (CASNAR)

Synthesis of 4H-Thiochromen-4-ones. — The one-pot procedure provides a conve-nient access to the title compounds via coupling of hetaryl chlorides with alkynes under modified Sonogashira conditions followed by addition of sodium sulfide and intramo-lecular SNAr reaction. Furthermore, the method is applied to the synthesis of thiopyra-nopyridiones (XI). — (WILLY, B.; MUELLER*, T. J. J.; Synlett 2009, 8, 1255-1260; Inst. Org. Chem. Makromol. Chem., Heinrich-Heine-Univ., D-40225 Duesseldorf, Germany; Eng.) — Mais

40- 125

ChemInform 2009, 40, issue 40 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim