www.cheminform.wiley-vch.de

Pyran derivativesR 0340 A Facile One-Pot Green Synthesis and Antibacterial Activity of 2-Amino-

-4H-pyrans and 2-Amino-5-oxo-5,6,7,8-tetrahydro-4H-chromenes. — This envi-ronmentally benign synthesis of pyrans (IV) and tetrahydrochromenes (VI) proceeds under solvent-free conditions in the presence of magnesium oxide as catalyst affording the target compounds in good to very good yields. The catalyst can be reused for second and third consecutive cycles without significant loss in activity. Compounds (IVa), (IVd), (IVh) and (VIc)—(VIg) show complete inhibition of growth of Gram-positive and Gram-negative bacteria, but are four to eight times less active than ampicillin. — (KUMAR*, D.; REDDY, V. B.; SHARAD, S.; DUBE, U.; KAPUR, S.; Eur. J. Med. Chem. 44 (2009) 9, 3805-3809; Dep. Chem., Birla Inst. Technol. Sci., Pilani 333 031, India; Eng.) — H. Hoennerscheid

48- 143

ChemInform 2009, 40, issue 48 © 2009 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim