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Preetam Giri, Group D

Development of Tissue Scaffold using Poly(Lactic acid)/Soy protein

composite material

Preetam Kumar GiriGroup D

ChE/MSE 802

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Functions of a scaffold:

Allow cell growth and proliferation

Enable diffusion of vital cell nutrients

Biodegrade after complete tissue regeneration

Requirements for a scaffold material:

Porous

Biodegradable

Low immunogenicity

Induction of tissue regeneration

Tissue Scaffold: Overview

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Poly(Lactic acid)(Vainionpaa et al., Prog. Polym. Sci., 679-716, 1989)

• First used in 1966

• Tensile Strength : 42 ~ 51 MPa

• Poor water uptake

• Solution in 1982: PLA/PGA Composite

• Later solutions: PLA/Collagen or Chitosan

Pros Cons

Good mechanical properties Poor biodegradability

Good biocompatibility Issues with PLA composites

Inexpensive and easily available

No active promotion of cell growth

Eleswarapu et al., Plos One, 2011

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Soy Protein(Vaz et al., J. Biomed Mater. Res 65A, 60-70, 2003)

Pros Cons

Actively drives cell growth Protein – protein aggregation

Significant biodegradability and biocompatibility Excessive water uptake

• First used in early 2000’s

• Tensile Strength: 30 ~ 35 MPa

• Excellent water uptake

• Isoflavones!

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Poly(Lactic acid)/Soy Protein Blends(Fang et al., J. Applied Polymer Science, Vol. 114, 754-759, 2009)

• First used in 2006

• Tensile strength: 30~35 MPa

• Improved water uptake

• Lower Tm => reduced crystallinity

• Major issue: Compatibility!

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Connection and Proposed Research

1989: PLA2003: Soy

Protein

2009: PLA/Soy Protein Blends

Future: PLA/Soy Protein Tissue Scaffold?

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PLA SOY