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c haracterist ics of benign lymphoadenosis of oral mucosa

s hu-Xia U, 9 1i-h ng Yu, ½ i-Hua Sun

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Ab sf ºGc tAm : To invs ugaã ô ô ¤ d ä ia I d Eamd ç ² ´ 3 andG rd nä Ø eds ºm d mnô n d ô þ n wm¨ Î " e mgÚ d-oml mtm s a (BØ Ê) .

ME m o m : Ð Ø Ä " Í ± Á B d ¡ º67, Þ 34 ´ Ð ¾÷ * Ö s

were m luaM by immum hM ´ W Vô l SP ª iniû in64 pamm nÊ nM Ø Ø us tm samp16 . Á uw n, 9 WÄ -e

ô n mDM M h dÍ " Ò , 15 ×w n mD M § ¶ ,t dÝ ¶ ,15 Çwn u al Ç uanm s cd l G M m na (0 5Á ), 15 áw nm l pmeanÊ rosis, and 1O from normal t issues- c euwd ô 3ô ¢, â Æm hsa u a ª Ê e Ä s d Ué »e Ê mpl6were alm am lé ´ .

Rm u u 3 : WBe Ô PFÊ sdÞ d ô -67 in ó Â M wm dé pl¿ ia,

m l prÄ Z tXö ¿ is and OEK¤ ½ s signiR@nMy higher É anin BLOM wit h£ut dysplasia and normal mucosa. Themicr ovam »lar dem it y (ÊVD) in BLOM with and Ý ¤ ¢ Ëdysplaà , oml preg ncerm is, ð ¢d o g ã W¿ Ù nma nMYNgher OØrI ln mxm l mtKDÊ . A¢ Ï ã in BLOM aM Å lprô n· rÊ is ½ s signinq noy higM T¤ an in o sÁ andn£rmal muÁî a.

CONCLUSI ON: Beni9n lymph© dg k Ü s d u ± mtk¶ ÊhÑ õ æ æ im6 of Ê ne ria oÞ .

@ 2Þ 5 ¡ ,e W3G Pms aºØ » :ø vie h c Ml û hã ºØ e ved-

Key woM g Ba U9n lymphØ denosis of oral muÁÀa; ô -

67; Mb wvam »lar dg WM Am ptosis

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M ATERIA LS A N D M ETH£ D S

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03AB) as d uofU Á ² AH Sä dom wÔÑÉ ² Þ m m SUE dì ú hm u mÉ iiÒ

M m m M ù ¤ Ù 34© è -67 w mp d d ² " " ve

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m d n Õ £f Ê lls ¶ ú £ r w iÉ out h m Ä " ­ É i q º z CD M com id× d siE

m m m m ead vi ty . A zeas o f m a m m ad o zh n eczo sa , an d

abm sis m m ed uded . Fbz deÇ m inado n d m ü a M V D , R ESU LTSm Þ m m e a n t ob m vd m du b w pow u (x m G Z 'm e w log

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coua Ê w er e zec£ rded õ M V D fb z m d ECí e- LME Mbrown m nu4

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- h d b o o m m ÓHd q pH 7.ä ¤ Ø m m at 37 æ , º h wed m d omb y q tzm d h g £ f eaæ ò m zSF au£ ¹ » 'Z« ÷ ? £ â@É "

d n sed m 50 Ì L o f a lab el m u t tzze c£a mia i ng d ze labeled

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d am k z tbz Ø m u 37æ . A h u m stung w i ² PB S, ² e {¢ ¢ SD}

m d om w u e iam bamd f bz 30 m m at 37 æ w i ² d u ne A »P­ sPM u se m p t h m bem u m d oa m s É Ð op d -

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posiÉ e Á mu o t b m p d Ä Á mÑd , ² e pd m M y m d m d m È } × £

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£nd 1y w h en m eê ¬¶ Á 1 nmucÁlü E iEabdd i² e × Ø s w¶ i ² n£ imzn1nam m am6£n . C d lh s exÔEhE×ibMid ng neÁ £6 c . -º. ­ ® "

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b o d ezS M d h o m £ gea £ u s e£ si a £p M Hc cy t o p lasm - T £ m ² e Áevaluate ² e d i f f ezea t m u s £ f T U N E L reacd v i ty h each B u t m E

sam p l e- 1 0Þ Cel l s w u e Co m ted m a d£ m ly und er h igh th ei E nE

W WE ¹ Ð ± ² õ ô È £ f w m Ç sm nd m ld am o un t

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4537

SUU½ aIamÓ tsThe mPEesSion of k i-67, MVD Md exuat of TUNELread ve m eld m a gm at msÄ " mpla m s mdp d byt-m t and f Ê t Wù sm s10.OfozWM Î a R 0.05mÞ midu d û 1iEÁnt

R ESU LTSÒ 1e hismlog a l d u n em suÁ £f BU ¯ À m t lm phoufomd Ø oz dense lymph© ytÊ fod c£uid be seea m É ebÑ al Á n h Ï z. Ä e u pm¡ £a of k 3¤67. whid z m m ined

bm wn m m eld , Þ uM k fbm d m nom al ² m² , BI M,BLOM wiÉ dp ph g a, pmÁ ac× £" and o sc c p£sidved disd u± d w d h q Ó h m of Þ m d m amad BØ M ¶ ² out ä ÄPh m  , m 1A)¤Mm Ä ú , mmyd is añ m zd poadve h ë mphoid h md m. ¤I Ee g pm m n

of k i4 7 £bvb m ly inu Ê sd m BL OM ÷ × dp ô m m dh m me sm plm k i-67 p£siÉ û SUM md ei wem m ah d h Ï Ê £f q ¾ö Ä m orÁ m m . × m a ø × ª á £f KL67 d m inq m d h pmq acemus ² am aad o sc c m dEe¹ À £f Í ò " am d s disú Ød d h d y orÁ m 1£ -Ót ze p£siÉ e mm of k i -67 expm Sion m difrezeat g oups

m shown m Tiabk 1.

m e m sittve rates d k 18 7 @­ §¿ ´ Þ in dmerent gm »ps

-PÛ m m zd buL epÛLü " BEê« -§ £0êm mn M wtª ¤ ¾¹ ¹ =

13Ee expresg on £f CD M wu p£sidve m all samples,and dism buted puacu td y, located m the q m ph sm ofmm ª za ú ú d ® m orÁ m ZA). 0 È a ô mb w ï Øm the cOnnÅ dve dsm Ê of m m al mä " a m dd k u m .But m BL OM , BL OM wi² dysplasia and pzm acu m iathd z numbez inCEeased obv i£usly (Fip u e 2B) . A gn atamoun t of miu w essd s d s£ could be found h o se c -M VD m lues m dif tu m t groups m sh m m Tabk Z

®2Ü fÀ¤É ¢» Ö kb.Å ¢Ð .

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ISSN1Þ 7¤9327 ´ 1£ 1219/ R WOrid 3Ga £ØÕ £1 h ª ö t 7, 2Þ s volt»m 11 Numà r 294Õ 8

Figure 2 CDU expmsSion in k BLOM Mth£" dn plasia {lHC Ð 00) and

ÓaÓ 2 MVDh dÎ m Mgm­Ò² , . §SD}£ ±, M¡ ,Øô'N, EMd 2431óznBU3M " 81ó1omBIê÷ Wô d" Hu u e m d n

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w h o h ad u a d ezp a e zeseed £ a £ f É d z sq u am o u s c e l l

cazd n o m a m £ m l q v t t y / £ ro p h q n z W Iú ² Þ m m m

sc £ ç 12 sm p l Ê w u e d a ssi h d m m zm aL an d 3 1 "

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m ² e m zm al m ó D S E d ² a e m m ab m ² n t u Á Ê Sio n

m l y m p h £ 4 d b E d z 1 E m a ¬ ª s t d ² a t ö e e p i É d m i c d h

o f B L O M w i É £ u t d p p h s i a h a d n o t u n d e r g £ n e g e n e d c

h

B: BLOM ± ' 1dé Fdmã ¤ ' C Ð Ø }.

Flgum 3 AmM0¤ts MBLOMM"' dn fM» ô ÒUNEL Emo).

m m¤ maÞ £, aad dÀ d of Á minal cm m had a m u ÉgpmMm don a Ï d ty. I n dze Þ m eedve × " ² £f BIÂ MMEd BEÂ M wi² dp ph Ö a g m t m mmt of p£sidve d isÞ d d be º und in dm mnm of ë mpboM º à d a . Hmm u ,a£ £bð mn diEa m a m zevmle4 ÓEU mdiu ± ² t É ecenter had a stzoag u pad ty o f pEOUfu ad£n, but n£t amalip ant Em d, k cm e É e pm Mm doa of lm ph® mwu a Mad of benign and zeacdve pm M» ã £a. Why weÞ aa da ed BØ M M ± n m ú £ dm Ø Ê m m² hnumber of k i -67 p£sidve cells M d the sm ains m BI Ñ M

wi² out dysplasia had no oh ious d Ea u m hom ² ose mam al mm osa, id m m g ² t e¶ ö d al q lls d d M ì m zaba£EEnaL I n dze epi² d ium of BI Ñ M wiÉ dp ph ga andpzecaneezosis, the number o f posidve cells obvi£uslyinczeased and the disö budon £f posidve cells extendedfm m the lowu bu d h yez Ø É e uppez bu al layeZ M dpricMe cell layer . I n m me samples, p£sidve cells wemdim bu² d m all dze laym £f epi² d im . ÓEU mdiÁ ±² at ² e pmMd m on Øõ d ty of basal d lswas m m± ô ± -A ng oø m sis h a pzà css involved m ² e dw d £pmm t ofnew bb od Ó smh , by k a visb n and m e m on of m sm gvmÁÒlammWÐ . I t is m knpon u u mñ hanism to susu in

tunm gm ic p£m m l m nØ ph sm and m dysÚ sdc lmions,kd m dù ² x² nt mpahm b d ù ² Ôè Ä msa lladn Þ nm m m . 'I Eu ch re, w alm aon of m g £² m s m y k of

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d d ssue su e aad Fh ap e- I a m o ö Ô WOZEL th e i m balan ce

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m zM @ m a m b of d m m M ú ªgm é ª h m Å m ,² ² m da o f hom m sm u m y m ulz m ² e b d Å ² td m m oF " ' . som e smd ies shw ed ² Í epi da m d g ow ²

h m z m m ö z bb ² & , q d a d Õ Ø b z Mm iahh im zazzd s m Þ uId induce d × p m sÊ . ´ m d É s ah

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in d icat ed th aH h e ap £ pm - t¤ ö ' ½eif zi n m n f ly h it hÅr h

B Ø M , B Ø M w i² £ut ä sp h ia, m d pzm m m ² ² m

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ÓE h stä Á ± ² t ² e Mù É d m Þ au o l ² e balm m o f

d l m m ba by ma m a ù d l ap £pm a s w i² d m h a m u md m Hfd u m H m ¢ ô ¤ ² e k d y × s, m m ¤ É Á -S m ilaz m d z m zM be b zd m ² e sad F o f G uan at d ô ä.

Pzw i ous Studi es al so sh £w ed d u t B L O M sh ould b e

m gu dd u a Î nd o f p m q a¡ £ m lesion . h É e p m m t

study, the cd p m M en d£a , m g ogea m is an d Ø £p Ø · o f

B I JO M w u z d m iiaz Ø É " £ f p mm m n og s, aad m B I  MÐ EK- 2 ê FEm i©­ tf F d à nm k ª s sp i a q n dy Md EU

² aa ¤ t m m n m l oml m m . B ut ² e g pm sio£ £ f ² 6 7m sim ilaz m d Iat m nom al m uÑ 'I Tzerd £m É e d m p s

o f cel l pm u f u ad o n , cel l apo pØ é , M d aag o gea m i s m

com ecdv e dssm w m ead i × d m m ep i th elm ; B I Ñ M

h ad d Ee p x m m l o f q zm ¡ m d s. M any h em s m ay m& m² e pm li fm do n o f Canea Á lls, m h m ce ² d z suzvtval b ym a pe o f apop Ø sh m d p m Ê de abm Ð m t ZEJEXE m ² & ó ngu d y- su ge u zd nogenesi s d o r d p r ecm cu o Ø lesb as-

Co m Ï m oa o f p ae a PEesSio n pm a · k w m I head u d

ad Ç M m£ ò ceil cazd Þ m a u d zzo zm al m suØ showed

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