Chapter 7: Cells and Their Environment. Cell Membrane 1. Function Selectively (semi-) permeable a....
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Transcript of Chapter 7: Cells and Their Environment. Cell Membrane 1. Function Selectively (semi-) permeable a....
Chapter 7: Cells and Their Environment
Cell Membrane
1. Function• Selectively (semi-) permeable
a. Some substances can pass through but others cannot
• Maintains homeostasis a. Used to maintain a stable internal environment b. Cell survives by preventing its interior from mixing w/ a watery environment outside
Cell Membrane cont.
2. Structure• Composed of 2 organic molecules:
1. Phospholipids 2. Proteins • Arranged in a lipid bilayer
Cell Membrane cont.
a. Phospholipid Structure• “Amphipathic molecule”• Consists of:
1. Head (Polar) - Hydrophilic attracts H2O (makes hydrogen bonds)
2. Tail (Non-polar fatty acid chain) - Hydrophobic repels H2O (pushes H2O away from middle)
Cell Membrane cont.
b. Arrangement of Lipid Bilayer1. Membrane fluid-like & flexible like a soap bubble2. Membrane can grow or change * NOTE: Lipid bilayer arrangement is still maintained as new phospholipids will always have heads toward H2O & tails in middle- happens whenever membrane compartments fuse internally
Cell Membrane cont.
3. Forms non-polar interior zone (middle layer) - Polar molecules (glucose, amino acids [AA], ions,
cell wastes) can’t pass through b/c repelled by non-polar tails
*** Advantage: Forms good barrier! - Problem: If cell membranes were made only of
lipids, most substances could not pass into/ out of cells
- Solution: Build into lipid bilayer various kinds of passageways composed of proteins (possesses different shapes, sizes, & channels)
Kinds of Cell Surface Proteins
• Polar molecules floating in non-polar zone• “Like ice cubes in a punch bowl”
Kinds of Cell Surface Proteins cont.
1. Channel Proteins - Acts like “passageways” - Special proteins having
doughnut-shaped channels - Polar substances (glucose, AA,
etc) can enter & pass - Specific channels for certain
substances doors w/ locks - Allows for “2-way” travel
into/ out of cell (facilitated diffusion)
Proteins embedded in cell membrane
Kinds of Cell Surface Proteins cont.2. Receptor Proteins - Acts like “information receivers” - Sends information from outside the cell to inside the
cell - Special outer shape only fits specific substances - If substance matches, information sent inside the cell
and a response will occur inside the cell - Carries out communication functions between cells
chemically a. Many hormones work this way/ ex: insulin b. Nerve impulses between 2 nerve cells/ between
nerve cells & muscle cells/ ex: acetylcholine (ACH)
Signal molecule binds to receptor protein- leads to message being passed on into the cell
Kinds of Cell Surface Proteins cont.
3. Surface Marker Proteins - Acts like “cell identifiers” - Have long external extensions usually made
up of CHOs - Both self-markers & tissue markers present - Some markers function in immune response
Cell Membrane
Solutions
Mixture of solute & solvent 1. Solute substance being dissolved/ ex: sugar,
salt, AA, ions 2. Solvent dissolving substance/ ex: usually H2OEquilibrium - Particles evenly distributed in solventConcentration Gradient - Areas having differences in concentrations - Living cells must have membranes that keep the
watery cytoplasm inside the cell different than the watery environment outside the cell
Solutions Outside a Cell vs Solutions inside a Cell
Solutions Outside a Cell VS Solutions inside a Cell cont.
Solutions Outside a Cell VS Solutions inside a Cell cont.
Membrane Transport Processes1. Passive Transport (3 types)
- NO ENERGY used!!! - From high conc low conc
a. Diffusion- Random movement of dissolved particles
b. Osmosis
- Movement of H2O through membrane - When extra H2O accumulates on 1 side,
pressure increases osmotic pressure
Cont. Passive Transport
c. Facilitated Diffusion (Channel Proteins) - Substances move through specific channel
proteins having pores (differ in size, shape, & polarity)- Substances attaches, pore opens/ ex: how glucose enters most cells
Membrane Transport Processes cont.
2. Active Transport (5 types)- Cells MUST use energy (ATP)- From low conc high conc
a. Proton Pumps - Results in production of ATP - Process called chemiosmosis occurs in side both chloroplasts & mitochondria
Cont. Active Transport b. Sodium-Potassium Pump
- 2 ions moving in opposite directions at the same time
- Process will move 3 sodium ions (Na+) out of cell for every 2 potassium ions (K+) that
comes into the cell - Occurs in nerve cells (impulse) & small intestine (food absorption)
Membrane Transport Processes cont. c. Coupled Channels (Cotransport) - 2 ions moving in together in the same direction
- Na+ outside diffuse rapidly inside cell & pulls in other substances/ ex: glucose, AA, ions -main way sugar and other food molecules
transported into cells
Cont. Active Transport d. Endocytosis
- Larger molecules enter as membrane surrounds substance 1. Pinocytosis intake of liquids 2. Phagocytosis intake of solids - Ex: phagocytes- WBC
Cont. Active Transport
e. Exocytosis - Removal of cell waste
vacuoles & gland secretions through cell membrane/ ex: hormones & enzymes
Cell-Cell Communication
- Needed to coordinate body growth & development 1. Direct Communication
- Physical contact between cells Ex: tight junctions, gap junctions, plasmodesmata 2. Indirect Communication
- No physical contact between cells Ex: endocrine system chemical (hormones)
nervous system chemicals (neurotransmitters)
Cell-Cell Communication cont.
Involves receptor protein channels - Binding of a signal particle to its specific
receptor can influence inside of cell in 3 ways:a. Receptor acts as enzyme causing reaction in
cytoplasm b. Receptor causes formation of second messenger that works inside cell/ ex: cAMP
Cell-Cell Communication cont.c. Receptor can open gates of specific channels proteins
allowing rapid movements of ions through membrane via:Gated Channel Proteins- Have a special area that causes a channel to open/ close when it comes into contact with signals from a cell
1. Chemically Gated Channels- Signal that hits special area
neurotransmitter molecule from outside the cell - Causes gates to open & Na+ to move rapidly
into the cell/ ex: acetylcholine (ACH) (a neurotransmitter)
2. Voltage Gated Channels - Signal that hits special area electric
charge from within cell - Impulse moves along a nerve cell, current
cause gates to open & Na+ moves rapidly into nerve cells
Factors That Affect the Rate of Diffusion
1. Particle size/ pore size 2. Molecular weight3. Solubility of H2O4. Concentration of solvent/ solute5. Temperature6. Pressure7. Organic solvents/ lipid solubility8. Surface area/ volume