Chapter 16 (Part 3) Fatty acid Synthesis. ACP vs. Coenzyme A.

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Chapter 16 (Part 3) Fatty acid Synthesis
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Transcript of Chapter 16 (Part 3) Fatty acid Synthesis. ACP vs. Coenzyme A.

Chapter 16 (Part 3)

Fatty acid Synthesis

ACP vs. Coenzyme A

Fatty Acid Synthesis Occurs in the Cytosol

Citrate synthaseCitrate Lyase

Malate dehydrogenase

Malate EnzymePyruvate

carboxylase

Acetyl-CoA Carboxylase

Acetyl-CoA + HCO3- + ATP malonyl-CoA + ADP

Acetyl-CoA

Carboxylase

Regulation of Acetyl-CoA Carboxylase (ACCase)

Animal Fatty Acid Synthase

Further Processing of Fatty acids: Desaturation and Elongation

Allosteric regulation of fatty acid synthesis occurs at ACCase and the carnitine acyltransferase