Chaperone - Molecular Biology
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Transcript of Chaperone - Molecular Biology
The molecular chaperones are proteins required to the proper
folding, transporting and degradation of the other proteins
in vivo
They act as containers for the folding of other protein subunits as they are called heat-shock proteins
Prevent the degradation of proteins in spinal stress conditions, interact with nonnative protein units and participate in the stabilization of
folding and aggregation prevention
Individuals with Alzheimer's disease display
several findings in their blood and cerebrospinal fluid that may reflect
neuropathological changes
Individuals with Alzheimer's disease have lower levels of amyloid-beta peptides and higher
levels of total and phosphorylated tau
concentration
Levels of certain metabolites and proteins
in the plasma might represent responses to
brain changes in Alzheimer's disease
Protein clusterin, appeared to be
associated with atrophy of the
hippocampal region of the brain
and with rapid progression of
cognitive decline
Clusterinbelongs to a
family of extracellular
chaperones
This proteins regulate the
formation and removal of
amyloid
Higher plasma levels of the
clusterin is associated
with severity of disease
Able to stop theprogression ofAlzheimer's disease isa major step in thetreatment of thisdisease and for thiswe must know themolecularmechanisms bywhich this takesplace, so I think thatthis study opens thedoor to many othersthat will improvethe quality life ofpatients.
Diabetic peripheral neuropathy (DPN) is a common
complication of diabetes
and leads to:
High levels of
pain
The death of sensory neurons
numbness in the
extremities
The up regulation of Hsp70 by inhibiting the activity
of Hsp70's regulatory protein, Hsp90, has led to the
reversal of neuronal degeneration in mice with DPN.
Hsp90, a key regulator of Hsp70
and the cellular heat shock
response, had its activity
inhibited by a novel C-terminal
inhibitor, KU-32
I think this study is of great importance as it will
create new medicines that improve health and
reduce the consequence of diabetic patients and
gives patients a better quality of life during their
disease process
And gives patients a
better quality of life during their disease
process
These drugs can reduce the
consequence of diabetic and
alzheimerpatients
It will create new medicines that improve health
Chaperones are essential for the proper
functioning of the proteins in the
organism, so the studies focus on this area
allow doctors to understand the mechanisms
by which they can produce different
pathologies and allows them to focus on the
treatment of patients with a more
effectively.
The identification of this protein allows to
know the mechanism by which the disease
progresses and this gives researchers a guide
that can be used to create drugs that act on
molecular targets identified as decreasing
the progression of symptoms.
MARTINES, S. Lina María. Biología Molecular. Quinta
edición. Medellín 2009. P 133, 140.
Plasma Protein Appears to Be Associated With
Development and Severity of Alzheimer's Disease.
ScienceDaily (July 12, 2010) URL:
http://www.sciencedaily.com/releases/2010/07/1007051
90536.htm
Heat Shock Protein Can Restore Nerve Damage in
Diabetic Mice. ScienceDaily (Aug. 12, 2010) URL:
http://www.sciencedaily.com/releases/2010/08/1008120
70040.htm