Challenges and opportunities · Magnetic fluid hyperthermia Taken from A. Andrade et al. 2011,...

David Serantes, Roy Chantrell, Daniel Baldomir

2nd Workshop on Magnetic Nanoparticles for Hyperthermia

Challenges and opportunities

Applied Physics Department and Instituto de Investigacións Tecnolóxicas

Universidade de Santiago de Compostela, SPAIN

Computational Magnetism Group, University of York

Santiago de Compostela, July 15th 2019

Magnetic NPs - agents for nanomedicine


2nd Workshop on Magnetic Nanoparticles for Hyperthermia Challenges and opportunities

Magnetic fluid hyperthermia

Taken from A. Andrade et al. 2011,

Coating Nanomagnetic Particles for

Biomedical Applications,



Magnetic fluid hyperthermia

Taken from A. Andrade et al. 2011,

Coating Nanomagnetic Particles for

Biomedical Applications,


Magnetogenetics


Magnetic fluid hyperthermia Magnetogenetics


Clinical application since 2013

glioblastoma multiforme

In-vivo magnetogenetic control of

neuronal activities in freely moving mice

Stanley et al. Nat. Med. 2014



Magnetic fluid hyperthermia Magnetogenetics


Clinical application since 2013

glioblastoma multiforme

In-vivo magnetogenetic control of

neuronal activities in freely moving mice



…despite the foreseen potential, no extended

routines of daily clinical practice yet

…difficulties? ways for improvement?

Still limited success




Multiple problems

• Biocompatibility

• Aggregation within cells

• Degradation

• Efficient delivery

• Self-heating changes

• ...



Multiple problems

• Biocompatibility

• Aggregation within cells

• Degradation

• Efficient delivery

• Self-heating changes

• ...

no accurate models able to describe the behaviour of

the MNPs in the viscous cell media, under AC fields

2 key

challenges

• Accurate description of heat dissipation

• To account for reorientation/displacement

Physics point of view:



Critical problems

1. procedural: incapability to account for ΔT≈0 heat-triggered experiments.



Usual global (average) entire-sytem approach no longer valid

Critical problems

Need to study the heat dissipated at the individual particle level,

i.e. local heat, in addition to the global (average system) one

Need to build nm-scale time-resolved temperature profiles – requisite: accurate knowledge of the power dissipated by each particle within the system




Critical problems


2. interpretative: usual heating mechanisms unable to explain accurate results



Critical problems

vs.Other heating (or non-heating)

mechanisms at play??





Critical problems



3. descriptive: available theoretical tools unable to grasp key experimental features

K. Simeonidis et al., Sci. Rep. 6:38382 (2016)



Critical problems



3. descriptive: available theoretical tools unable to grasp key experimental features

Experiment

K. Simeonidis et al., Sci. Rep. 6:38382 (2016)

Reorientation and SAR change

Displacement (aggregation - interactions)



Program

09:00 David Serantes (USC)Welcome/Overview of key hyperthermia (and magnetogenetics) aspects to address from a

basic-physics point of view

Theoretical challenges Chair: Pablo Taboada (USC)

09:10 Roy Chantrell (University of York) Single-particle heating

09:35 Oksana Chubykalo-Fesenko (ICMM-CSIC) Field-driven alternation between actuation domains

10:00 Òscar Iglesias (Universitat de Barcelona) Aggregates and dipolar interactions

10:25 Hamid Kachkachi (Univ. Perpignan) Beyond the non-interacting AC susceptibility approximation

10:50 Coffee break

Particle properties identification Chair: Verónica Salgueiriño (Universidade de Vigo)

11:30 Karen Livesey (University of Colorado) Better understanding relaxation times in MNPs, and ZFC/FC curves

11:55 Lucía Gutiérrez (Universidad de Zaragoza) AC susceptibility: A tool to track the transformations of MNPs

12:20 Lluís Balcells (ICMAB-CSIC) Spontaneous formation of nanoparticle chains

12:45 Sergiu Ruta (University of York) Optimisation of properties for magnetic hyperthermia beyond LRT

13:15 Lunch

Other biomedical uses Chair: Oksana Chubykalo-Fesenko (ICMM-CSIC)

14:15 José Rivas (USC) Magnetic Tissue Engineering

14:40 Beatriz Pelaz (USC) Drug release

15:05 Pablo del Pino (USC) Magnetogenetics

15:30 Ondrej Hovorka (Univ. of Southampton) Identification of nanoparticles for diseases detection

16:00 Serantes/Chantrell/Baldomir Closing of the workshop

Challenges and opportunities · Magnetic fluid hyperthermia Taken from A. Andrade et al. 2011,...

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