CF Pyridine CompoundsCF Pyridine Compounds PRODUCTS LIST · 4 Bis‐CF 3 Pyridine ‣ 25g ‣ 5g...

CF3

CF3

CF3

CF3

CF3

N

ＰＲＯＤＵＣＴＳＬＩＳＴＰＲＯＤＵＣＴＳＬＩＳＴ

ＣＦ　 Pyridine Compounds3‐ＣＦ Pyridine Compounds３‐

ｘ

N

Y

Ｆ

Ｆ

Ｆ

Ｎ

ＦＣ３ＦＣ３

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3CF -Pyridine compounds are expected to enhance the activities and/or functions of medicines.3CF -Pyridine compounds are expected to enhance the activities and/or functions of medicines.

１

α‐ＣＦ　 Pyridine

Chemical Name【PRO_NO】

2,6-ＣＴＦ

NF３C Cl

2-Chloro-6-(trifluoromethyl)pyridine

39890-95-4

‣ 5ｇ

mp　33℃

‣ 25ｇ

3,2,6-ＡＣＴＦ【ISK-a-1】 117519-09-2

3-Amino-2-chloro-6-(trifluoromethyl)pyridine

F

NH２

N Cｌ３C

mp　96-97℃

‣ 5ｇ‣ 25ｇ‣ ｋｇ～

2,6-ＡＴＦ

NF３C NH２

2-Amino-6-(trifluoromethyl)pyridine

34486-24-3【ISK-a-3】 mp　79-81℃‣ 5ｇ

3

‣ 5ｇ2,3,6-ＤＣＴＦ【ISK-a-2】

N CｌF３C

Cｌ 2,3-Dichloro-6-(trifluoromethyl)pyridine

89719-90-4 mp　40℃

N F３CCl

Cl

Cl Cl 2,3,4,5-Tetrachloro-6-(trifluoromethyl)pyridine

22652-31-92,3,4,5,6-ＴＣＴＦ ‣ 5ｇ

6-ＴＦＮＡ

NF３C

CO H２ 6-(Trifluoromethyl)nicotinic acid

231291-22-8

‣ 5ｇ‣ 25ｇ‣ ｋｇ～

3,6-ＨｍＴＦ

NF３C

OH 6-(Trifluoromethyl)pyridine-3-methanol

386704-04-7 oil‣ ｋｇ～‣ 5ｇ

6-ＴＦ-3-ＣＨＯ

2,6-ＣＴＦ-3-ＣＡＭ

NF３C

CHO

NF３C

O

NH２

Cｌ

6-(Trifluoromethyl)pyridine-3-carboxaldehyde

386704-12-7 mp 52-56℃

2-Chloro-6-(trifluoromethyl)pyridine-3-carboxamide

386704-05-8

‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ

‣ ｋｇ～

2,6,-ＨｍＴＦ

2,6-ＨＴＦ-3

6-ＴＦ-2-ＣＯＥｔ

-ＣＡＭ

2

6-(Trifluoromethyl)pyridine-2-methanol

2-Hydroxy-6-(trifluoromethyl)pyridine-3-carboxamide ‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ

‣ 5ｇ

NF３COH

NF３C

O

NH２

OH

NF３COEt

O

Ethyl 6-(trifluoromethyl)picolinate

1）

131747-53-0

116548-03-9

1010422-92-0

mp　27-28℃

mp 54-56℃

mp 230-231℃

oil

mp 215-217℃

‣ ｋｇ～

mp　195℃

【ISK-a-4】

【ISK-a-5】

【ISK-a-6】

【ISK-a-7】

2）

CF - Pyridine Derivatives3CF - Pyridine Derivatives3★This catalogue introduces our main organic intermediates : “CF -Pyridines” .3

CAS No. Physical properties QuantityChemical structureAbbreviated Name

“ CF -Pyridine” means the pyridine compound substituted with a trifluoromethyl(CF ) group 3 on its second (α-)position.

3

‐α-

β‐ＣＦ Pyridine3

2

‣ 5ｇ‣ 25ｇ

‣ 5ｇ

2,6,3-ＤＣＴＦ

N Cｌ

F３C

Cｌ【ISK-b-1】

2,6-Dichloro-3-(trifluoromethyl)pyridine

55304-75-1 oil　(mp 6℃）　


69045-84-7 mp 9℃　2,3,5-ＤＣＴＦ

N Cｌ

F３C Cｌ

2,3-ＣＴＦ

N Cｌ

F３C

2,5-ＣＴＦ

N Cｌ

F３C


65753-47-1 mp 38℃　

52334-81-3


mp　27-29℃

‣ 5ｇ‣ 25ｇ

‣ 5ｇ

2,5-ＡＴＦ

2,3-ＡＴＦ【ISK-b-4】

N

F３C

NH２

N

F３C

NH２

2,3-ＨＴＦ

N OH

F３C

【ISK-b-3】

3-(Trifluoromethyl)pyridin-2-ol

22245-83-6 mp 152℃　


74784-70-6 mp 42℃


183610-70-0 mp　67-69℃

‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ‣ ｋｇ～

‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ

2,5-ＣｍＴＦ【ISK-b-5】

【ISK-b-8】2,5,6,3-ＴＣＴＦ

3,5-ＣＴＦ

3-ＴＦＰＡ

N

F３C

Cl

ｌC

Cｌ

N

F C

Cｌ

３

N

F３C ｌC

N

F３C

CO H２

2-Chloromethyl-5-(trifluoromethyl)pyridine

128790-14-7 oil

2,5,6-Trichloro-3-(trifluoromethyl)pyridine


oil 85148-26-1

3-(Trifluoromethyl)picolinic acid

87407-12-3 mp 116-117℃

80289-91-4

‣ 5ｇ‣ 25ｇ

‣ 5ｇ

3-ＴＦ-2-ＣＯ　Ｅｔ

N

F３C

OH

5-(Trifluoromethyl)pyridine-2-methanol


31181-84-7

952182-76-2 NOEt

O

F３C

2,5-ＨｍＴＦ

2

oil

mp　48-55℃

oil

‣ 5ｇ‣ 25ｇ

‣ 25ｇ

【ISK-b-2】

【ISK-b-7】

【ISK-b-9】

【ISK-b-10】

【ISK-b-11】

【PRO_NO】１）

2）

“ CF -Pyridine” means the pyridine compound substituted with a trifluoromethyl(CF ) group 3 on its third (β-) position.

3 -

Chemical NameCAS No. Physical properties

QuantityChemical structureAbbreviated Name

‣ 5ｇ‣ 25ｇ‣ ｋｇ～

‐β

γ‐ＣＦ　 Pyridine3

3

5-ＴＦ-2-ＣＯ　Ｅｔ

104040-74-6 mp 170-176℃　

3,5-ＣTＦ-2-ＣＯ　Ｅｔ2

2,5-ＭTＦ

2,3-ＭＴＦ

2,5-ＨＴＦ

2,3,5-ＡＣＴＦ

N

F３C

OH

ｌC

NH２

F３C

N

2-Mercapto-3-(trifluoromethyl)pyridine

5-(Trifluoromethyl)pyridin-2-ol

33252-63-0


79456-26-1 mp　93-94℃

N

F３C

OEt

O


N

F３C

OEt

O

ｌC

N

F３C

SH

Ethyl 3-chloro-5-(trifluoromethyl)picolinate

2-Mercapto-5-(trifluoromethyl)pyridine

128072-94-6

128073-16-5

76041-72-0

【ISK-c-1】

【ISK-c-2】

【ISK-c-3】

【ISK-c-4】

2,6,4-ＤＣＴＦ

2,4-ＣＴＦ

2,4-ＡＴＦ

4-ＴＦ

2,3,5,6,4-ＴＣＴＦ

2,6,4-ＡＣＴＦ

N

F３C

NH２

N Cｌ

F３C

N

F３C

CｌN

３FC

Cｌ

Cｌ Cｌ

N Cｌ

F３C

Cｌ

N

F３C

NH２Cｌ


39890-98-7 oil

2-Ｃhloro-4-(trifluoromethyl)pyridine

81565-18-6 oil


106447-97-6 mp　67-70℃

4-(Trifluoromethyl)pyridine

oil

3796-24-5

2,3,5,6-Tetrachloro-4-(trifluoromethyl)pyridine

oil

122599-19-3


34486-23-2

‣ 25ｇ

‣ 5ｇ‣ 25ｇ

2

N SH

F３C

oil

mp　47-48℃

mp　178-180.5℃

mp 154-156℃　

‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ

mp　40-43℃‣ 5ｇ

‣ 5ｇ

‣ 5ｇ

‣ 5ｇ

‣ 5ｇ‣ 25ｇ

【ISK-b-6】

‣ 5ｇ

‣ kg ～

‣ 25ｇ

‣ 25ｇ

【PRO_NO】１）

2）

“ - CF -Pyridine” means the pyridine compound substituted with a trifluoromethyl(CF ) group 3 on its fourth ( -) position.

3

Chemical NameCAS No. Physical properties

QuantityChemical structureAbbreviated Name

γγ

‐

４

Bis ‐ＣＦ　 Pyridine3

‣ 25ｇ

‣ 5ｇ

‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ

‣ 5ｇ

‣ 5ｇ

N

OH

F３C O

CｌN

３FC

Cｌ

4-ＴＦＮＡ

2,5,4-ＤＣＴＦ


4-(Trifluoromethyl)nicotinic acid

158063-66-2

89719-92-6

2,3,6-ＣＢｉＴＦ2-Chloro-3,6-bis(trifluoromethyl)pyridine

N Cｌ

３FC

F３C 175136-26-2 oil

N Cｌ

３FCF３C

Cｌ

2,6-Dichloro-3,5-bis(trifluoromethyl)pyridine

142889-02-9

【ISK-d-3】

【ISK-d-4】2,6,3.5-ＤＣＢiＴＦ

3,5-ＢiＴＦ

2,4,5-

109919-25-7N

F３C

Cl

３FC

N

３FCF３C

2-Chloro-4,5-bis(trifluoromethyl)pyridine

3,5-Bis(trifluoromethyl)pyridine

20857-47-0

oil

N

Cｌ

３FCF３C

Cｌ 3,5-Dichlolo-2,6-bis(trifluoromethyl)pyridine3,5,2,6-ＤＣＢiＴＦ

ＣＢiＴＦ

122599-10-4

【ISK-d-2】

2,6-ＢiＴＦ

NF３C F３C

2,4,6-ＣＢiＴＦ

３ N

F３C

CｌF C

2,6-Bis(trifluoromethyl)pyridine

2-Chloro-4,6-bis(trifluoromethyl)pyridine

81565-21-1

455-00-5

‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ

4-ＴＦ-2-ＣＯ　Ｅｔ２

NOEt

O

３FC

Ethyl 4-(trifluoromethyl)picolinate ‣ 5ｇ

1171919-08-6

‣ 5ｇ‣ 25ｇ

‣ 5ｇ‣ 25ｇ

mp　147-149℃

oil

oil

mp　75-76℃

mp　30℃

mp　57-58℃

oil

mp　57-58℃

【ISK-c-5】

【ISK-d-5】

【ISK-d-6】

CF3

Ｎ

ＩＳＨＩＨＡＲＡＳＡＮＧＹＯＫＡＩＳＨＡ，ＬＴＤ

Chemical Name【PRO_NO】１）

2）

CAS No. Physical propertiesQuantityChemical structureAbbreviated Name

“ CF -Pyridine” means the pyridine compound substituted with two trifluoromethyl (CF )3 groups.

3

1) Product number on CAS Online Datebase2) Please inquire about prices etc.

【Notes】

‣ ｋｇ～

‐Bis-

CF3

CF3CF3

CF3

N

N

N

E-Mail ： [email protected]

Since the early 1980 s, we have been carrying out research and development on newpharmaceutical compounds and agrochemicals based on CF -pyridine chemical. Therefore, we can accommodate customer s needs in this field with confidence.

３

We can not only provide the cataloged compounds, but also consult for the compounds you propose.

Ｎ

ＦＣ３ＦＣ３

ＮＮ

ＦＣ３ＦＣ３ＦＣ３ＦＣ３ＦＣ３ＦＣ３

Both properties of C group and Pyridine ring are combined to generate a varietyof unique properties and activities on C -Pyridine compounds.

３FF３

ringPyridine -ＣＦ３

・ CH ｰmimic ・ Polarity ・

Ｂlocking ・Ｈｙｄrophobicity

・ N-unshared electron pair

・ Hydrophilicity ・ Basicity

＊　　 Confidence and Technique with Customer　＊

・Biochemical stability to oxidative metabolism・Interaction with intracellular protein and/or nucleic acid・Enhancement of bioabsorbability and/or pharmaceutical action・Reduction of toxicity and/or side effect

ｘ

N

Y

Ｆ

Ｆ

Ｆ

・Biochemical stability to oxidative metabolism・Interaction with intracellular protein and/or nucleic acid・Enhancement of bioabsorbability and/or pharmaceutical action・Reduction of toxicity and/or side effect

,etc,etc

＊　　 Confidence and Technique with Customer　＊＊　　 Confidence and Technique with Customer　＊

( ver.1812 )

We aim for customer s ease and satisfaction in supplying.Your order, inquiry, and consultation are always welcome!　

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CF Pyridine CompoundsCF Pyridine Compounds PRODUCTS LIST · 4 Bis‐CF 3 Pyridine ‣ 25g ‣ 5g...

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Transcript of CF Pyridine CompoundsCF Pyridine Compounds PRODUCTS LIST · 4 Bis‐CF 3 Pyridine ‣ 25g ‣ 5g...