Cerebrospinal fluid
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Transcript of Cerebrospinal fluid
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Cerebrospinal fluid and meninges
Student: Gustavo Duarte Viana, Gomo M.S.Group: 17
Kursk State Medical University2012
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What is liquor cerebralis? Clear liquid, derived from
the plasma and circulates around the brain and its cavities (ventricles) and spinal cord.
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The volume of spinal fluid in an adult is approximately 2.0 ml per kg, or approximately 150ml. In infants up to 4 weeks, average 10 to 60 mL.
500mL/day about.
Quantity of cerebrospinal fluid
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Location of the cerebrospinal fluid Cerebrospinal fluid originates
in the choroid plexus. The choroid plexus is composed of a mass of tiny blood vessels that are located in the lateral third and fourth ventricles.
The remaining CSF, approximately 30%, is formed in other places like the sub-arachnoid and ependymal layer of the ventricles.
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The CSF is formed in the lateral ventricles, circulates through the interventricular foramen ( foramen of Monro) into the third ventricle which has one more choroid plexus and is going accumulating, and then via the cerebral aqueduct into the fourth ventricle, where has one more choroid plexus to produce more cerebrospinal fluid. Here the fluid scapes via the lateral apertures (Luschka, opening to the brain) and the medial foramen (Magendie, opening to the spinal cord) of the fourth ventricle into the subarachnoid spaces, where it diffuses over the brain and spinal cord and from the cisterns it circulates through the freely communicating subarachnoid cisterns at the base of the brain, most of the CSF is directed upward over the cerebral hemispheres and smaller amounts pass downward around the spinal cord. It has been calculated that 430 to 500 ml of CSF are produced every day, so the fluid must be changed every 6 to 7 hours. Respiratory and circulatory changes are believed to change the pressure within the closed system and promote the mixing and diffusion of fluid for reabsorption into venous sinus blood via arachnoids granulations.
Circulation of the cerebrospinal fluid
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Illustrational picture of the circulation of the cerebrospinal fluid
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Protecting the brain and spine trauma. Supplying nutrient to the nervous tissue. Remove degradation products of cellular metabolism. Serves as a pathway for pineal secretions to reach the
pituitary gland
Three main functions of the cerebrospinal fluid
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Chemical level
Sodium 136.0 – 150 .0 m Eg/L
Potassium 2.3 – 2.7 m Eg/L
Chloride 1180.0 – 130.0 m Eg/L
Magnesium 2.4 – 3.0 m Eg/L
Protein 20 – 4 gm/dl (normally diffuses in blood-brain-barrier)
Glucose 45.0 – 60.0 gm/dl
Calcium 2.1- 2.7 m Eg/L
Cholesterol Present in small amount
Creatinine 0.5 – 1.2 gm/dl
Latic acid deohydrogenase Present in small amount
Phosphorus (inorganic) 1.0 – 2.0 gm/dl
Urea 6.0 – 16.0 gm/dl
Uric acid 0.5 – 3.0 gm/dl
Examples of chemicals present in the CSF
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1. Pulsation of the cerebral & spinal arteries
2. Movements of the vertebral column
3. Respiration & coughing
4. Changing of the positions
Factors that facilitate the flow of CSF in subarachnoid space
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CSF sample is obtained by a physician, usually via lumbar puncture in the region L3 andL4.
Sterile technique is often used to reduce the risk of infection.
Care must be taken to avoid damage to neural tissue. Although the sub-araquinoid can be accessed
from other levels, the lower back is preferable, because the needle is inserted below the end of the spinal cord.
Collection of the cerebrospinal fluid
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A syringe is used to collect 6 to 15 ml (babies and small children).
Sample is divided into 3 or 4 tubes (glass tubes should be avoided due to cell adhesion).
2 to 4 ml are placed in each tube.
The tubes are numbered in the order they are obtained.
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Collection of the cerebrospinal fluid
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Tube 1: chemical and serological test
Tube 2: Microbiological test
Tube 3: Hematological test
Tube 4: cytological and Miscellaneous
Each tube is used for a specific purpose:
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important precaution The opening pressure is always measured (90-180 mm of
water), it is high, greater than200 mm, not more than 2 mL of CSF should be removed.High pressure:Eg ICC, meningitis, cerebral edema.Reduced pressure:Eg dehydration, circulatory collapse, loss of CSF.
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colorless
clear
Absence of clot
Density 1.006 to 1.008
pH 7.3
When the sample is received in the laboratory microscopic examination is performed immediately.
general characteristics of the cerebrospinal fluid
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One or more are found:•turbidity•Clot / film•bloody appearance•xanthochromic
abnormalities of the cerebrospinal fluid.
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Turbidity can be caused by leukocytes, erythrocytes, fungi, bacteria, parasites, contrast media, etc.
200 WBC / microl can cause slight turbidity, the greater number of leukocytes = higher turbidity,
At least 400 RBC / microl are needed to cause slight turbidity,
May appear oily after radiological procedures
turbity
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Clot is always abnormal and is always due to increased level of proteins, especially fibrinogen,
The clot formation is common in protein levels above 1,000 mg / dL (also present at lower levels)
Film is composed of fibrinogen and white blood cells,
clot / pellicle
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Specimens from patients who suffered subarachnoid hemorrhage or cerebral haemorrhage may have a pink-
colored supernatant and yellow when the sample is centrifuged within an hour after you collected.The term that describes
the colored supernatant is xanthochromic. The color varies with the substance that causes the coloration and the time interval after the incident that the sample is examined.
Xanthochromic
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Meningis are menbrane covering the brain and spinal cord.
Meningis consists of three menbranes. 1- Dura mater 2- arachinoid mater 3- Pia mater strong “tough mater” spidery, holds blood vessesl “delicate mother”A- Falx cerebriB- Falx cerebelliC- Tentorium cerebelliD- Diaphragma sella
Meningis
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The meninges
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Thick dense inelastic membrane and the outermost layer of the meninges.(pachymeninx)
Bilaminar: • Endosteal layer: ◦Peristoneum, inner surface of the skull bone. ◦Not contineous with dura mater of the spinal cord. • Meningeal layer: ◦Dura mater proper covering the brain and contineous with
dura mater of the spinal cord. ◦Folded inwards as 4 septa between part of the brain. ◦The function of this septa is restrict the rotatory
displacement of the brain. They are closely united except along certain lines, where they
separate to form venous sinuses.
Dura mater
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1. Falx cerebri- lies between the cerebral hemisphere in the longitudinal cerebral fissure.
◦contains the superior and inferior sagittal sinuses between its two layers. 2. Falx cerebelli- it is a small sickle-shaped fold, attached to the internal
occipital crest and projects forward between the two hemispheres of the cerebellum.
3. Temtorium sellae- separates posterior cranial fossa from the middle cranial fossa.
◦ separates the occipital and temporal lobes from the cerebellum and intentorial brainstem.
4. Diaphragma sellae – forms the roof of the hypophyseal fossa. ◦ contains an aperture through which the hypophyseal stalk
(infundibulum) passes.
Septa of the dura mate
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Septa of the meningesFalx cerebri
Falx cerebeli
Tentorium cerebeli
Diaphragma Sellae
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Falx cerebi
Tentorium cerebeli
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Delicate, impermeable and avascular membrane covering the brain.
Lying between dura and pia mater. Separete from dura mater by a potential space, the
subdural space. Separed from pia mater by the arachinoid space. The outer and inner surface are covered with flattened
mosothelial cells.
Arachinoid mater
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1- epidural space- is located between the peristoneum and the outer layer of the Dura mater, contains venous tissue, loose connective tissue and lymphatics.
2-subdural space – is a potential space between the Dura and Arachinoid mater, intracranially transmits the superior cerebral veins venous lacunae of the superior sagittal sinus.
3- arachnoids space- located between the Arachinoid and Pia mater, contains the CFS, surrounds the entire brain and spinal cord.
Spaces between the meninges
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Pia mater (leptomeninx) is a delicate and highly vascular membrane, closely covers the surface of the brain and spinal cord.
Filum terminale – extends from the conus medulares to the end of the dural sac and fuses with it.
Pia mater
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The Pia mater
Pia mater close to the brain
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The meninges
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Meningitis is inflammation of the meninges. The infection occurs most often in children, teens, and young adults. Also at risk are older adults and people who have long-term health problems, such as a weakened immune system.
There are two main kinds of meningitis: ◦Viral meningitis is fairly common. It usually does not cause serious illness.
In severe cases, it can cause prolonged fever and seizures. ◦Bacterial meningitis is not as common but is very serious. It needs to be
treated right away to prevent brain damage and death. The two kinds of meningitis share the same symptoms. It’s very important to
see a doctor if you have symptoms, so that he or she can find out which type you have.
Meningitis can also be caused by other organisms and some medicines, but this is rare.
Meningitis is contagious. The germs that cause it can be passed from one person to another through coughing and sneezing and through close contact.
Meningitis
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Dandy-Walker Syndrome: A congenital brain malformation of the openings called foramina Luschka and Magendie, it is characterized by increased fluid in the brain.
Symptoms of Dandy-walker Syndrome:◦Hydrocephalus◦Increased intracranial pressure◦Sow motor development◦Progressive macrocrania (abnormally enlarged of skull)◦Irritability◦Vomiting ◦Convulsions◦Ataxia◦Nystagmus (Jerky eyes)
Dandy-walker Syndrome
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Hydrocephalia
The term hydrocephalus is derived from the Greek words "hydro" meaning water and "cephalus" meaning head.It is excessive accumulation of fluid in the brain.
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Nystagmus
Nystagmus is a condition of involuntary eye movement, acquired in infancy or later in life, that may result in reduced or limited vision, it is cause by the high cranial pressure due the big amount of CSF.