Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W....
-
Upload
lorena-harrell -
Category
Documents
-
view
214 -
download
0
Transcript of Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W....
![Page 1: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/1.jpg)
Cerebral Networks of Speech Motor Control: fMRI Data
H. Ackermann, K. Mathiak, I. Hertrich,
W. Grodd, A. Riecker
Departments of Neurology and Neuroradiology,
University of Tübingen
5th International Conference onSpeech Motor ControlNijmegen, June 7 – 10, 2006
![Page 2: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/2.jpg)
Cerebral Organization of Speech Motor Control: The Beginnings
Petersen et al. 1988, 1989 (PET study)but see Sidtis et al. 1999
![Page 3: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/3.jpg)
Cerebral Organization of ….
Petersen et al. 1988, 1989, Posner & Raichle 21999
supplementary motor area (SMA)BL sensorimotor cortex LH insular cortexBL medial cerebellum
Wise et al. 1999: left anterior insula engaged in „articulatory planning“ (Dronkers 1996, but see Hillis et al. 2002)
![Page 4: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/4.jpg)
P Indefrey, WJM Levelt. The spatial and temporal signatures of word production components. Cognition 2004;92:101-144
review of 82 imaging studies on word production
cerebral correlates / time course of the following successive stages of speech production:
lexical selection, phonological code retrieval, syllabification, self-monitoring, phonetic / articulatory processes (Levelt, Roelofs & Meyer 1999)
![Page 5: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/5.jpg)
Indefrey & Levelt 2004
![Page 6: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/6.jpg)
Cerebral Network of Phonetic /
Articulatory Processes
12 areas pertaining to the central-motor system:
R/L ventral motor and sensory regions, R dorsal motor region, R SMA, R/L cerebellum, R/L thalamus, R midbrain
5 areas not pertaining to the central-motor system,
e.g., orbitofrontal and occipitotemporal regions
Indefrey & Levelt 2004
![Page 7: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/7.jpg)
Syllable Rate Control: fMRI Experiment I
figure
Riecker et al. 2005
normal subjects, overt (aloud) syllable repetitions (“pa”), 2.0 / 2.5 / 3.0 / 4.0 / 5.0 / 6.0 Hz, applied via earphones
![Page 8: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/8.jpg)
Experiment I: Signal Analysis
1. Parametric approach:
1.1. hemodynamic main effects across all
repetition rates versus baseline
1.2. positive linear, negative linear andnonlinear rate / response
functions Büchel & Friston 1996,
1998
2. Connectivity analyses based upon time series of hemodynamic activation
![Page 9: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/9.jpg)
Experiment I: Signal Analysis
1. Parametric approach:
1.1. hemodynamic main effects across all
repetition rates versus baseline
1.2. positive linear, negative linear andnonlinear rate / response
functions Büchel & Friston 1996,
1998
2. Connectivity analyses based upon time series of hemodynamic activation
![Page 10: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/10.jpg)
Overt Syllable Repetitions IMain Effects
normal subjects
Riecker et al. 2005
![Page 11: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/11.jpg)
Guenther et al. 2006
![Page 12: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/12.jpg)
Experiment I: Signal Analysis
1. Parametric approach:
1.1. hemodynamic main effects across all
repetition rates versus baseline
1.2. positive linear, negative linear andnonlinear rate / response
functions Büchel & Friston 1996,
1998
2. Connectivity analyses based upon time series of hemodynamic activation
![Page 13: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/13.jpg)
Overt Syllable Repetitions IIRate / Response Functions
Riecker et al. 2005
![Page 14: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/14.jpg)
Overt Syllable Repetitions IIIGroup Averages
Riecker et al. 2005normal subjects
Insel links
0
2
4
6
1 2 3 4 5 6
Caudatum links
0
2
4
6
1 2 3 4 5 6
Putamen / Pallidum
0
2
4
6
1 2 3 4 5 6
Thalamus
0
2
4
6
1 2 3 4 5 6
![Page 15: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/15.jpg)
JJ Sidtis, SC Strother, DA Rottenberg. Predicting performance from functional imaging data: Methods matter. NeuroImage 2003;20:615-624
question: can functional imaging data predict performance?
task: syllable repetitions as fast as possible
syllable rate = (- 3.55 * right caudate) + (2.51 * left inferior frontal) + 5.60
more efficient organization at higher rates (p.c.)
![Page 16: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/16.jpg)
Rate Control / Basal Ganglia:
Brown 2003: Oscillatory nature of human basal
ganglia activity
Logigian et al. 1991: Tremor oscillations may pace
repetitive voluntary motor behaviour (finger
flexion / extension, oral diadochokinesis)
Possible control mechanism of syllable
repetitions: adjustment of inherent basal ganglia
oscillations to the pacing signal
![Page 17: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/17.jpg)
Overt Syllable Repetitions IIIGroup Averages
Riecker et al. 2005
Cerebellum z=-24
0
2
4
6
1 2 3 4 5 6
Cerebellum z=-57
0
2
4
6
1 2 3 4 5 6
normal subjects
![Page 18: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/18.jpg)
Syllable Rate Control: fMRI Experiment II
Hypothesis: differential contribution of basal ganglia and cerebellum to syllable rate control
Task: covert (silent) syllable repetitions, 2.5 / 4.0 / 5.5 Hz,
paced via earphones
Design: block design (8 blocks, R/A, 10 meas)
Analysis: categorical and parametric (rate and time effects) analysis using SPM99
Wildgruber et al. 2001
![Page 19: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/19.jpg)
Covert Syllable Repetitions: R/R-F
Wildgruber et al. 2001
![Page 20: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/20.jpg)
Syllable Rate in Dysarthric SubjectsAcoustic Analyses
Ackermann et al. 1995
Review: Hertrich, Ackermann. Acoustic analysis of durational ... In: Lebrun Y (ed). From the Brain to the Mouth. Dordrecht 1997, 11-47Review: Ackermann, Mathiak, Ivry. Temporal organization of „internal speech” ... Behav Cogn Neurosci Rev 2004;3:14-22
![Page 21: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/21.jpg)
Overt Syllable Repetitions IIIGroup Averages
Riecker et al. 2005normal subjects
Insel links
0
2
4
6
1 2 3 4 5 6
Caudatum links
0
2
4
6
1 2 3 4 5 6
Putamen / Pallidum
0
2
4
6
1 2 3 4 5 6
Thalamus
0
2
4
6
1 2 3 4 5 6
![Page 22: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/22.jpg)
Finger Tapping TasksRate / Response Functions
Riecker et al. 2003normal subjects
![Page 23: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/23.jpg)
Summary Part 1: Cerebral Rate Control
Convergence of clinical-behavioural findings and
functional imaging data:
Striatum: normal speaking rate / hastening
phenomenon - negative fMRI rate / response
functions
Cerebellum: reduced syllable rate (> 3 Hz) –
fMRI threshold effect at about 3 Hz
for a review see Ackermann & Hertrich 2000, Ackermann et al. 2004
![Page 24: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/24.jpg)
Cerebellar Functions
![Page 25: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/25.jpg)
Experiment I: Signal Analysis
1. Parametric approach:
1.1. hemodynamic main effects across all
repetition rates versus baseline
1.2. positive linear, negative linear andnonlinear rate / response
functions Büchel & Friston 1996,
1998
2. Connectivity analyses based upon time series of hemodynamic activation
![Page 26: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/26.jpg)
Time course of
hemodynamic
activation
Riecker et al. 2005
![Page 27: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/27.jpg)
time (s)
effectsize
Two Cerebral Networks of Speech Motor Control ???
bold lines: very high correlations (>0.9)
thin lines: high correlations (0.75-0.9)
![Page 28: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/28.jpg)
Syllable Rate Control: fMRI Experiment II
Hypothesis: differential contribution of basal ganglia and cerebellum to syllable rate control
Task: covert (silent) syllable repetitions, 2.5 / 4.0 / 5.5 Hz,
paced via earphones
Design: block design (8 blocks, R/A, 10 meas)
Analysis: categorical and parametric (rate and time effects) analysis using SPM99
Wildgruber et al. 2001
Covert production of fluent speech (highly overlearned word strings): Wildgruber et al. 1996, Ackermann et al. 1998, Riecker et al. 2000
![Page 29: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/29.jpg)
Inner / Silent / Covert Speech
internal speech = “prearticulatory, but otherwise fully parsed speech code” (Levelt 1989)
“close functional equivalence between motor imagery and motor preparation” (Jeannerod 1994)
inner speech = “window” into articulatory planning processes (preceding movement execution)
but: Sokolov 1968, 1972
![Page 30: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/30.jpg)
Covert Syllable Repetitions: R/R-F
Wildgruber et al. 2001LC: -21, -60, -24 / RC: 24, -57, -24
![Page 31: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/31.jpg)
Guenther et al. 2006: DIVA model
![Page 32: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/32.jpg)
effectsize
Two Cerebral Networks of Speech Motor Control ???
anterior insula / speech production: Ackermann & Riecker 2004
![Page 33: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/33.jpg)
Hemodynamic activation of intrasylvian cortex
in association with
anticipation / application of painful stimuli,
spider phobia (sensitive to therapy),
swallowing & tactile stimulation of the tongue,
stress urinary incontinence (sensitive to therapy),
high-intensity emotional facial expressions,
aesthetic judgments of beauty,
olfactory functions.
NeuroImage, vol 29, no 1, January 1, 2006
![Page 34: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/34.jpg)
Speech and Anterior Insula
Insular cortex part of the cerebral representation of the autonomic nervous system, e.g., cardiac functions or respiration, e.g., Harper et al. 2005
pre-setting of laryngeal and respiratory muscles
However, no insular activation during whistling, Dresel et al. 2005
for a review see Ackermann & Riecker 2004
![Page 35: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/35.jpg)
Hemodynamic activation of intrasylvian cortex
in association with
anticipation / application of painful stimuli,
spider phobia (sensitive to therapy),
swallowing & tactile stimulation of the tongue,
stress urinary incontinence (sensitive to therapy),
high-intensity emotional facial expressions,
aesthetic judgments of beauty,
olfactory functions.
NeuroImage, vol 29, no 1, January 1, 2006
![Page 36: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/36.jpg)
time (s)
effectsize
Insel links
0
2
4
6
1 2 3 4 5 6
Caudatum links
0
2
4
6
1 2 3 4 5 6
Putamen / Pallidum
0
2
4
6
1 2 3 4 5 6
Thalamus
0
2
4
6
1 2 3 4 5 6
Part 1: Rate / Response Functions ofHemodynamicActivation
Part 2:Time Course of Hemodynamic Activation
![Page 37: Cerebral Networks of Speech Motor Control: fMRI Data H. Ackermann, K. Mathiak, I. Hertrich, W. Grodd, A. Riecker Departments of Neurology and Neuroradiology,](https://reader036.fdocuments.us/reader036/viewer/2022081520/56649ce65503460f949b4366/html5/thumbnails/37.jpg)
NEUROLOGIE Dirk Wildgruber
Axel RieckerIngo Hertrich Klaus Mathiak
Hermann Ackermann
Michael Erb Uwe Klose
Wolfgang Grodd
NEUROLOGY
NEURORADIOLOGY
Participants