Cerebral HemorrhageCerebral Hemorrhage10-15% stroke10-15% stroke20-30% in Asia20-30% in AsiaUp to 50%, 30 day Up to 50%, 30 day mortalitymortalityLittle ee!ti"e therapyLittle ee!ti"e therapy#e$ therapies $ill be #e$ therapies $ill be based on based on pathophysiologypathophysiology %CH & 'orse ()t!omes *han %CH & 'orse ()t!omes *han %s!hemi! +troke%s!hemi! +troke1, Ameri!an Heart Asso!iation, Heart -isease and +troke +tatisti!s-2005 Update. 2, /)reshi A%, et al, # 0ngl 1 2ed, 2001.33341350-1350. 3, 6roderi!k 17, et al, +troke, 1888.304805-815. 3, 6roderi!k 17, et al, # 0ngl 1 2ed, 1882.3254933-9350%10%20%30%30%50%50%90%:0%80%100%%CH %s!hemi!DeadDependentIndependent +ites o %ntra!erebral +ites o %ntra!erebral HemorrhageHemorrhage/)ereshi et al, # 0ngl 1 2ed, 2001.33341350-50 Lipohyalinosis & hyalinised "essel $all Char!ot-6o)!hard mi!roane)rysm ;1:5:< Cerebral 2i!robleeds on 2=%Cerebral 2i!robleeds on 2=%Hemosiderin-stained Hemosiderin-stained deposits on gradientdeposits on gradiente!ho 2=% e!ho 2=% 2ay rele!t amyloid 2ay rele!t amyloid angiopathyangiopathy7resent in )p to 20% 7resent in )p to 20% patientspatients1 1Linked to %CH risk ater Linked to %CH risk ater t7At7A2 21, >id$ell +troke, 2002. 2, #ighoghossian 2002 7athophysiologi!al Changes7athophysiologi!al ChangesHematoma ormation Hematoma ormation&=apid shearing or!es, in!reased %C7 =apid shearing or!es, in!reased %C70arly ne)rologi!al deterioration in 23% ?12 ho)rs 0arly ne)rologi!al deterioration in 23% ?12 ho)rs;Leira;Leira et al, #e)rology 2003.534351-9< et al, #e)rology 2003.534351-9