CENTURION UNIVERSITY OF TECHNOLOGY AND

MANAGEMENT, ODISHA

SCHOOL OF BASIC SCIENCES

5-YEAR INTEGRATED M.Sc. PROGRAMME

IN

APPLIED CHEMISTRY

2012-17

3rd YEAR COURSE STRUCTURE & SYLLABUS

SEMESTER-V SEMESTER-VI

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Subject Code

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Sl no

Subject Code

Subject

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1 MSCH3501 PHYSICAL CHEMISTRY-II 3+1+0 4 1 MSCH3601 PHYSICAL CHEMISTRY-III 3+1+0 4

2 MSCH3502 INORGANIC CHEMISTRY-II

3+1+0 4 2 MSCH3602 INORGANIC CHEMISTRY-III 3+1+0 4

3 MSCH3503 ORGANIC CHEMISTRY-I 3+1+0 4 3 MSCH3603 ORGANIC REACTION MECHANISM

3+1+0 4

4 MSCH3504 APPLIED CHEMISTRY 3+1+0 4 4 MSCH3604 CHEMISTRY OF NATURAL PRODUCTS

3+1+0 4

5 MSFE3501 FREE ELECTIVE-II 3+1+0 4 5 MSCH3605 INSTRUMENTAL METHODS OF ANALYSIS

3+1+0 4

6 MSCL3501 CHEMISTRY LABORATORY-3

0+0+3 2 6 MSCL3601 CHEMISTRY LABORATORY-5 0+0+3 2

7 MSCL3502 CHEMISTRY LABORATORY-4

0+0+3 2 7 MSCL3602 CHEMISTRY LABORATORY-6 0+0+3 2

TOTAL CREDITS 24 TOTAL CREDITS 24

5TH SEMESTER

MSCH3501 PHYSICAL CHEMISTRY-II (3-1-0)

Module -I

Conductivity of solution: Arrhenius theory of electrolytic dissociation and its limitations, strong & weak

electrolytes, Ostwalds dilution law its uses and limitations, Derivation of Debye-Huckel-Onsager’s

conductance equation for strong electrolytes and its validity, Transport number, definition &

determination (Hittorf method & moving boundary method).

Electromotive force: Electrolytic and Galvanic cells, reversible & irreversible cells, conventional

representation of electrochemical cells, Types of reversible electrodes-gas metal ion, metal-metal ion,

metal-insoluble salt-anion and redox electrodes. Standard electrode potential, sign conventions,

electrochemical series and its significance. Electrode reactions, Nernst equation, derivation of cell EMF

and single electrode potential, Reference electrodes-standard hydrogen electrode, EMF of a cell and its

measurements, computation of cell EMF, calculation of thermodynamic quantities of cell reactions(ΔG,

ΔH, ΔS & K), polarization, over potential and hydrogen overvoltage, Concentration cell with and without

transference, liquid junction potential, application of concentration cells, determination of valency of ions,

solubility product, activity coefficient, potentiometric titrations.

Module –II

Equilibria in Electrolytes: Determination of the dissociation constant of a weak monobasic acid by

conductance and e.m.f. methods, ionic product of water and its determination (conductance and e.m.f.

methods), determination of solubility product of a sparingly soluble salt, applications of solubility product

principle, pH of cells, determination of pH by E.M.F. methods (Hydrogen, quinhydrone and glass

electrodes).

Hydrolysis of salts: Determination of the hydrolysis constant and degree of hydrolysis by conductance,

e.m.f. and distribution methods.

Module –III

Phase Equilibria of two component system: Solid-liquid equilibria, simple eutectic – Bi-Cd, Pb-Ag systems,

desilverisation of lead. Solid solutions–compound formation with congruent melting point (Mg-Zn) and

incongruent melting point, NaCl-H2O, CuSO4-H2O system. Liquid-liquid mixtures–Ideal liquid mixtures,

Raoult’s and Henry’s law. Non-ideal system-azeotropes-HCl-H2O and ethanol-water systems. Immiscible

liquids, steam distillation. Nernst distribution law-thermodynamic derivation, applications.

Text Books:

1. Elements of Physical Chemistry: P.W.Atkins, Oxford University Press

2. A text book of Physical Chemistry: S.Glasstone, The Macmillan Press Ltd

3. Principles of Physical Chemistry: B.R.Puri, L.R.Sharma, and M.S.Pathania,Vishal Publishing co.

4. Essentials of Physical Chemistry: B.S.Bahl, G.D.Tuli & A.Bahl, S. Chand & co.

Reference Books:

1. Advanced Physical Chemistry: Gurdeep Raj, Goel Publishing House, Meerut.

2. Advanced Physical Chemistry: Gurtu Snehi, Pragati Prakashan, Meerut.

MSCH 3502 INORGANIC CHEMISTRY-II (3-1-0)

Module- I

Chemistry of first row transition elements: Electronic configuration, oxidation states, stability of

oxidation states, colour and paramagnetism, complex formation characteristics.

Coordination compounds: Werner’s theory, coordination number, effective atomic number concept,

chelates, isomerism, nomenclature, Factors influencing the formation of complexes, valence bond theory,

interpretation of common octahedral, tetrahedral & square plannar complexes, Limitation of valence bond

theory.

Module-II

Redox reactions & inorganic preparations: Redox reactions shown by potassium dichromate, potassium

chromate, potassium manganate, potassium permanganate, sodium thiosulphate, preparation, properties &

structure of potassium ferrocyanide, sodium nitroprusside, potassium cobaltinitrite, Hexammine

cobalt(III)chloride.

Chemistry of lanthanides: Electronic structure, oxidation states, lanthanide contraction and its effects,

separation of lanthanides(ion exchange method only).

Metal Carbonyls: Preparation and structure of mononuclear carbonyls of chromium, iron and nickel,

Preparation and structure of the binuclear carbonyls Mn2(CO)10, Fe2(CO)9.

Nuclear & Radiation Chemistry: Measurement of radioactivity, nuclear reactors-fast breeder reactors,

fuels used in nuclear reactors, separation of isotopes, moderators, coolants, nuclear reactors in India,

applications of nuclear chemistry in energy tapping, carbon dating, isotopic labeling studies & nuclear

medicines.

Module - III

Non-aqueous solvents: Classification of solvents, Liquid ammonia & Liquid sulphur dioxide solvent

system with reference to (a) Acid base reaction (b) Solvolysis and (c) Precipitation reaction

Bio-inorganic Chemistry: Oxygen transportation by haemoglobin, Essential & trace elements in

biological processes, metalloporphyrins with special reference to haemoglobin & myoglobin, Biological

role of alkali & alkaline earth metal ions with special reference to Ca++, K+, & Na+, Nitrogen fixation,

Toxicity of Cd, Pb & Hg.

Text Books:

1. Basic Inorganic Chemistry: F.A.Cotton, G.Wilkinson & P.Gaus, John wiley and sons.

2. Selected Topics in Inorganic Chemistry: Malik, Madan & Tuli, S.Chand & Company Ltd.

3. Principles of Inorganic Chemistry: B.R.Puri, L.R.Sharma, and Kalia, Vishal Publishing co.

4. Modern College Chemistry(Vol III): S.Guru, B.K.Mahapatra, R.C.Mishra, K.D.Sharma, Kalyani

Publishers.

Reference Books:

1. Concise Inorganic Chemistry: J.D.Lee, ELBS with Champman& Hall.

2. Advanced Inorganic Chemistry, Vol-I: Gurdeep Raj, Goel publishing House.

MSCH 3503 ORGANIC CHEMISTRY-I (3-1-0)

Module-I

Stereochemistry: Baeyer’s strain theory. Theory of strainless rings. Conformation and stability of

cyclohexane and monosubstituted cyclohexanes, cyclohexanol, bromocyclohexane and methyl

cyclohexane. Locking of conformation in t-butyl cyclohexane. Stereoselective and stereospecific

reactions : i) Stereochemistry of addition of halogens to alkenes: syn- and anti-addition. Example –

Addition of bromine to 2-butene. (mechanism not expected) ii)Stereochemistry of elimination reaction:

syn and anti- elimination Example – Dehydrohalogenation of 1-bromo -1, 2 - diphenylpropane.

Aromatic Compounds: Preparation, properties and important reactions of aromatic compounds

Aldehydes, ketones, carboxylic acid.

Polynuclear hydrocarbons: Introduction, Naphthalene – Constitution and Haworth synthesis. Physical

properties. Chemical properties: Electrophilic substitution (Nitration, sulphonation and halogenation)

reactions, oxidation and reduction. Derivatives of Naphthalene : Methods of preparation, electrophilic

substitution reactions (nitration & sulphonation), coupling reaction and uses of – i) α-- and β- Naphthol.

(ii) α- and β- Naphthylamine.

Module-II

Carbohydrate: Monosaccharide D-glucose – Open chain structure. Chain lengthening of Aldoses –

Kiliani synthesis. Chain shortening of Aldoses – Weerman’s reaction. Configuration of D-glucose from

D-arabinose. Muta-rotation with mechanism. Ring structure of D-glucose – Determination of size of ring

by, i) Methylation method ii) Periodic acid treatment method iii) X – ray analysis.

Disaccharides – Introduction, maltose, sucrose and lactose – Sources, structural formulae and uses.

Polysaccharides – Introduction, starch, cellulose – Sources, structural formulae and uses.

Heterocyclic compounds: Six membered heterocycles (Pyridine, quinoline), Pyridine: Methods of

synthesis. Physical properties. Chemical reactions : Quinoline Synthesis - Skraup’s synthesis Physical

properties. Reactions of quinoline : Fused Heterocycles: Indole, Urides and Purines, Indole. Synthesis –

Fischer Indole Synthesis. Physical properties. Chemical reactions: Urides and Purines: Structure and

properties only

Module-III

Synthetic dyes: Introduction, chromophore, auxochrome. Qualities of good dye. Classification based on

constitution and methods of applications. Witt’s theory – Colour and constitution. Synthesis of Diamond

black F, Orange IV, Malachite green, phenolphthalein, Alizarin and Indigo.

Amino acids: Amino acids: Synthesis: (Strecker, Gabriel, acetamido malonic ester, azlactone);

isoelectric point, ninhydrin reaction.

Vitamins: Classification and nomenclature of vitamins, structure and synthesis of Vitamin B & C

Drugs and antibiotics: Drug, types, Sulpha Drug, antimalarial drugs, Elementary treatment of antibiotics

with a detail study of Chlorophenicol.

Text Book:

1. A text book of Organic Chemistry - Arun Bahl and B. S. Bahl S. Chand and Company Ltd.6th

Edition.

2. Organic Chemistry Vol. I, II and III - S. M. Mukharji, S. P. Singh, R. P. Kapoor Wiley Estern,

Limited, New Delhi.

3. Heterocyclic Chemistry Synthesis, Reactions and Mechanism - Raj K. Bansal Wiley Easter Ltd.

New Delhi.

Reference Book:

1. Reaction Mechanism and reagents in Organic Chemistry - G. R. Chatwal Himalaya Publishing

House New Delhi.

2. Stereochemistry conformation and mechanism - P. S. Kalsi, New Age International Publishers.

3. Organic Chemistry Volume I and II - I. L. Finar ELBS with Longman.

4. Organic Chemistry Volume I and II - William Kemp ELBS with Macmillion .

MSCH 3504 APPLIED CHEMISTRY (3-1-0)

Module- I

Water Technology: Impurities in water, Water analysis - Determination of different constituents in water:

Hardness, alkalinity, chloride, sulphate & dissolved oxygen, Types of hardness, Units of hardness and their

interrelation. Disadvantage of hard water. Water softening technology both internal and external (limesoda,

zeolite, and ion exchange methods) Desalination(electrodialysis, reverse osomosis, Sterilization of water by

bleaching powder, chlorine, ozone, chloramine.

Corrosion: Definition, Examples, Types, Theory of corrosion, Dry corrosion (Direct chemical attack),

Wet corrosion(electrochemical attack), Mechanism of wet corrosion, Factors affecting corrosion,

Corrosion Control: (Protective coating, Cathodic protection, Passivation).

Module-II

Fuels: Classification of fuels, Solid, liquid & gaseous fuels, Characteristics and their use, advantages &

disadvantages, Calorimetry, calorific value : HCV, LCV, GCV, NCV.

Liquid fuel: Classification of petroleum, Refining of petroleum, Cracking, Knocking and anti knocking, cetane

and octane number. Unleaded petrol, synthetic petrol, power alcohol.

Gaseous Fuel: Producer gas, Water gas, LPG, CNG, Kerosene gas, Combustion Calculation.

Battery technology: Introduction, Batteries and cells, Basic components of battery, its Classification

characteristics, Chemical batteries(dry, Lead acid & gel batteries), Alkaline batteries(zinc-air, aluminium-air,

Nickel metal hydride battery), Reserve batteries(magnesium-copper, Gordan-magnesium battery), Nickel

cadmium battery, Fuel cell (Hydrogen-Oxygen only) types, advantages.

Module III

Materials in Chemistry: Polymers: Types, molecular mass of a polymer, polymerization process and

mechanisms, Preparation, Properties and uses of the polymer (polyethylene, PVC, PMMA, PTFE, PS, Nylon 6 :

6, Nylon 6, Bakelite, polyurethanes, polycarbonate, polyesters), Elastomers, Vulcanization of rubber,

Conducting polymers(poly aniline, poly acetylene),

Ceramics: Types, Structure, Properties, Applications.

Composite Materials: Classification (Based on type of matrix and types of reinforcement),

Agglomerated Materials, Cermets, Polymer matrix composite (Glass fiber reinforced plastics, Carbon

fibre reinforced plastics and aramid fiber reinforced plastics), Metal matrix composites, Ceramic matrix

composite, Hybrid Composite & their applications.

Nano materials: Basic idea, Synthesis of CNT(LASER irradiation & Electric arc-discharge method), properties

& applications of CNT, applications of other Nano materials in medicine, fuel cell, catalysis(only general idea).

Text Books:

1. A text book of Engineering Chemistry by Shashi Chawla, Dhanpat rai & Co.

2. Engineering Chemistry by P.C Jain and M. Jain, Dhanpat rai Publication

3. Materials Science and Engineering William D. Callister, John welley & sons, 6th edition

Reference Books:

1. Materials Science by S.K.Tripathy, Arun K.Padhy & A.K.Panda, SCITECH publication

2. Engineering Chemistry by O.P.Aggarwal, Khanna Publication

MSCL 3501 CHEMISTRYLABORATORY-3 (0-0-3)

1. Determination of specific reaction rate of the hydrolysis of methyl acetate/ ethyl acetate at room

temperature in O.5M H2S04 and O.5M HCl media.

2. Study of distribution of iodine between water and carbon tetrachloride or benzoic acid between

benzene and water.

3. Study of adsorption of acetic acid from aqueous solution by animal charcoal.

4. Study of the effect of a solute (e.g. NaCl, succinic acid) on the critical solution temperature of two

partially miscible' liquids (phenol-water system) and determination of the concentration of that solute

in the given phenol-water system.

5. Determination of molecular weight of a non-volatile solute by Rast method.

6. Estimation of calcium and magnesium in a mixture by EDTA titration.

7. Estimation of copper and zinc in brass.

8. Estimation of Mn in mild steel.

9. Preparation of nickel dimethylglyoximecomplex,[Ni(DMG)2].

10. Preparation of copper tetrammine complex, [(Cu (NH3)4]SO4.

Text Book:

1. Experiments in Physical Chemistry: R.C.Das and B.Behera, Tata-Mc-Graw Hills

2. Advanced Practical physical Chemistry, J.N. Gurtu and R.Kapoor

3. Selected experiments in physical Chemistry: N.G. Mukherjee, J.N. Ghose and Sons, Bharati Bhawan

4. Vogel’s Text Book of quantitative inorganic analysis, ELBS with Longmann.

5. Hand book of preparative inorganic chemistry Vol 1& 2, Braucer, Academic Press, 2nd ed.

6. Experiments in general chemistry: C.N.R.Rao and U.C. Agarwal, Macmillian.

7. Practical Chemistry:Y.R.Sharma and R.C. Acharya, Kalyani Publisher.

MSCL 3502 CHEMISTRYLABORATORY-4 (0-0-3)

1. Estimation of phenol and aniline by bromination method.

2. Estimation of Glucose.

3. Determination of equivalent mass of organic acids by volumetric and gravimetric method.

4. Preparation of m-dinitrobenzene, p-nitroacetanilide, p-bromoacetanilide, picric acid, methyl orange,

methyl red, benzoic acid, ethyl benzoate.

Text Books:

1. Vogel text book of practical organic chemistry, ELBS, with Longmann.

2. Laboratory manual in organic chemistry: R.K.Bansal, Wiley Eastern Ltd.

3. Experimental Organic Chemistry Vol:I & II, P.R.Singh, D.S.Gupta and K.S.Bajpai, Tata-Mc Graw Hills.

6TH SEMESTER

MSCH 3601 PHYSICAL CHEMISTRY-III (3-1-0)

Module -I

Elementary Quantum Mechanics: Failure of classical mechanics, quantum mechanics, postulates of

quantum mechanics, Hamiltonian operator, Schrodinger’s wave equation, normalized & orthogonal wave

function, physical interpretation of wave function, particle in a one dimensional box, three dimensional

box, electron in a ring.

Chemical Kinetics: Kinetics of complex reactions: Opposing or reversible reactions, consecutive

reactions, chain reactions, Steady state approximation.

Module-II

Catalysis: Types of catalysis, Homogeneous catalysis, Heterogeneous catalysis, Characteristics of

catalytic reactions, promoters, catalytic poisoning, Autocatalysis, Negative catalyst, Activation energy of

catalysts, theories of catalysis, the intermediate compound formation theory, Adsorption theory, Enzyme

catalysis, mechanism &characteristics of enzyme catalysis.

Third law of thermodynamics: Nernst heat theorem, statement and concept of residual entropy,

evaluations of absolute entropy from heat capacity data, Gibbs-Helmholtz functions, Gibbs function(G),

Helmholtz function(A), A and G as criteria for thermodynamic equilibrium and spontaneity, their

advantage over entropy change, variation of G and A with P,V and T.

Module-III

Photochemistry: Interaction of radiation with matter, difference between thermal & photochemical

reactions, laws of photochemistry, Grothus-Draper law, Lambert-Beer’s law, Stark-Einstein law of

photochemical equivalence, Quantum yield of photochemical reactions, Decomposition of HI and HBr,

the hydrogen halogen reactions, Jablonski diagram, Elementary ideas about photosensitized reactions and

photosynthesis, fluorescence, phosphorescence and chemiluminescence.

Text Books:

5. Elements of Physical Chemistry: P.W.Atkins, Oxford University Press

6. A text book of Physical Chemistry: S.Glasstone, The Macmillan Press Ltd

7. Principles of Physical Chemistry: B.R.Puri, L.R.Sharma, and M.S.Pathania,Vishal Publishing co.

8. Essentials of Physical Chemistry: B.S.Bahl, G.D.Tuli & A.Bahl, S. Chand & co.

Reference Books:

1. Advanced Physical Chemistry: Gurdeep Raj, Goel Publishing House, Meerut.

2. Advanced Physical Chemistry: Gurtu Snehi, Pragati Prakashan, Meerut.

MSCH 3602 INORGANIC CHEMISTRY-III (3-1-0)

Module- I

Chemistry of some transition Elements: Vanadium, Chromium, Manganese, Nickel and their

compounds.

Chemistry of second and third row transition elements: General characteristics, comparative

treatment with their 3rd analogues in respect of ionic radii, oxidation states, magnetic behavior, spectral

properties & stereochemistry.

Chemistry of Actinides: General features & Chemistry of actinides, separation of Np, Pu from U,

similarities between later actinides & later lanthanides.

Module-II

Metal–Ligand bonding in transition metal complexes: Crystal field theory, Qualitative idea about d-

orbital splitting in tetrahedral & octahedral field, elementary treatment of spectra and paramagnetism of

transition metal complexes, factors affecting crystal field parameters.

Magnetic properties of transition metal complexes: Types of magnetic behavior, methods of

determining magnetic susceptibility, spin-only formula, L-S coupling, correlation of µs & µeff values,

orbital contribution to magnetic moments, application of magnetic moment data for 3d metal complexes.

Electronic spectra of transition metal complexes: Types of electronic transitions, selection rules of d-d

transitions, spectroscopic ground states, spectrochemical series, Orgel energy level diagram for d1 & d9

states, discussion of the electronic spectrum of [Ti(H2O)6]3+ complex ion.

Thermodynamic & Kinetic aspects of metal complexes, stability of metal complexes, factors affecting

stability, substitution reactions of square planar complexes.

Module III

Hard and soft acids & bases: Classification of acids & bases as hard & soft, Pearson’s SHAB concept, acid-

base strength, hardness & softness, symbiosis, theoretical basis of hardness & softness, electronegativity in

hardness & softness.

Organometallic Chemistry: Definition, nomenclature & classification of organometallic compounds,

preparation & properties, bonding & application of metal alkyls & aryls of Li, Mg & Al, brief account of metal-

ethylenic complexes & homogeneous hydrogenation.

Text Books:

1. Basic Inorganic Chemistry: F.A.Cotton, G.Wilkinson & P.Gaus, John wiley and sons.

2. Advanced Inorganic Chemistry, Vol-I: Gurdeep Raj, Goel publishing House.

3. Selected Topics in Inorganic Chemistry: Malik, Madan & Tuli, S.Chand & Company Ltd.

4. Principles of Inorganic Chemistry: B.R.Puri, L.R.Sharma, and Kalia, Vishal Publishing co.

5. Modern College Chemistry(Vol III): S.Guru, B.K.Mahapatra, R.C.Mishra, K.D.Sharma, Kalyani

Publishers.

Reference Books:

1. Concise Inorganic Chemistry: J.D.Lee, ELBS with Champman& Hall.

2. Inorganic Chemisty: Principles of Structure and Reactivity : James E. Huheey

MSCH 3603 ORGANIC REACTION MECHANISM (3-1-0)

Module-I

Reaction path way: Homolytic and Heterolytic fission, Different types of arrow notation, Reactions

Intermediate: Carbocation, Carbanion, Free radical, Carbene, Nitrene, Benzene, Enamines: their

formation, stability & reactions.

Molecular rearrangements: Pinacol-pinacolone, Wagner-Meerwein, Demjanov, Benzil-Benzilic acid,

Favorskii, Arndt-eistert synthesis,Neber, Beckmann, Hoffman, Curtius, Schmidt, Baeyer-Villiger.

Module- II

Organic Reactions :

(1) Aldol (2) Baeyer-Villiger (3) Barbier-Wieland (4) Barton (5) Bechamp (6) Birch (7) Bouveault (8)

Chi Chi Babin (9) Clemmensen (10) Dieckmann (11) Darzen (12) Dakein (13) Diels Alder (14) Friedal-

crafts (15) Leuckart (16) Mannich (17) Meerwien-pondorf (18) Michael addition (19) Oppenauer (20)

Perkin (21) Reimer-Tiemann (22) Reformatsky (23) Stobbe (24) Wittig (25) Wolff Kishner

Module-III

Important Reagents used in Organic Synthesis:

A) Oxidation: Applications of oxidizing agents like KMnO4, chromium trioxide, manganese dioxide,

Osmium tetraoxide, Woodward-Prevost hydroxylation, DDQ, Chloranil, hydrogen peroxide,

HIO4, Lead acetate.

B) Reductions: Catalytic hydrogenation using homogeneous and heterogeneous catalysts, Use of :

Sodium borohydride, Lithium Aluminium hydride (LAH), Sodium in alcohol, Fe in HCl & Zn in

HCl.

C) Baker yeast, Dicyclohexyl carbodimide, 1,3-Dithiane, Gillman’s reagent, Lithium

diisopropylamine (L.D.A), Lithium dimethyl cuprate, Osmium tetroxide, Selenium dioxide

Trimethyl silyliodide, Tri-n-butylene hydride, Wilkinson’s catalyst, Phase transfer catalyst,

Crownethers and Merrifield resin.

Text Book:

1. Reaction Mechanism and Reagents Inorganic Chemistry - Gurdeep R Chatwa, Himalaya

Publishing House.

2. Advanced organic chemistry (IV edition) - Jerry March, John Wiley & Sons.

3. Organic Chemistry - I.L. Finar, 6th Edition (Low price) Pearson Education, 2003

Reference Books:

1. Organic Chemistry (VI edition) - R.T Morrison, R.N. Boyd. Prentice Hall of India Pvt. Ltd,

(2003)

2. Organic Chemistry- (V edition) - John Mc Murry), Asian Book Pvt. Ltd, New Delhi

3. Reaction Mechanisms and Problems in Organic Chemistry– P. Chattopadhyay, Asian Book Pvt.

Ltd, New Delhi (2003)

4. Reactive Intermediates in Organic Chemistry-J. P. Trivedi, Univ. Granth Nirman Board

5. A text book of Organic Chemistry, - Raj K. Bansal, New Age International (P) Ltd. 4th Edition

2003

6. Advanced Organic Chemistry - Jerry March Wiley Eastern Ltd.

MSCH 3604 CHEMISTRY OF NATURAL PRODUCTS (3-1-0)

MODULE-I

Alkaloids: Definition, Occurrence, classification and isolation, General methods of structural

elucidation, synthesis and biological Properties of Quinine, Nicotine and Papaverine.

Terpenoids: Classification, Nomenclature, Occurrence and isolation of terpenes, Isoprene rule, General

methods of determining structure. Synthesis of citral, menthol, and camphor.

MODULE-II

Anthocyanines and flavones: General nature of anthocyanins, introduction and biological importance of

Anthocyanines, Structure and general methods of synthesis of anthocyanines: Cyanidine chloride

Flavones: General nature & biological importance of flavones, Structure determination of flavone &

flavonoids, Quercetin.

MODULE-III

Steroids & Purines

Steroids: Occurance, Nomenclature, Isolation, Classification and spectral properties of steroids,

synthesis of cholesterol, progesterone and bile acids.

Purines: Introduction, biological importance, Synthesis of Uric acid, Xanthine & Caffeine.

Natural Dyes: Classification, isolation, purification and properties. Occurrence, colour and constitution,

Structural determination and synthesis of indigoitin and alizarin.

Text books:

1. O. P. Agarwal, , Chemistry of Natural Products, Vol-1, Goel Publishing House, 1997.

2. Gurdeep Chatwal and Anand, Chemistry of Natural Products, Himalayan Publishing Co,2001

Reference book:

1. L. Finar, Organic Chemistry, Vol-2, 5th edition, Pearson education, London, 1975.

2. New Trends in Natural Product Chemistry, Atta-Ur-Rahman & M.I.Choudhury, Harwod

Academic Publishers.

MSCH 3605 INSTRUMENTAL METHODS OF ANALYSIS (3-1-0)

MODULE-I

Electromagnetic radiation (EMR): Nature & Features of a Electromagnetic spectrum , Interaction of

EMR with matter.

Microwave spectroscopy: Principle, Rotational Spectrum: Diatomic molecules, Energy levels of a rigid

rotator, selection rules, spectral intensity, determination of bond length, non rigid rotator and isotope

effect.

Ultraviolet absorption spectroscopy (UV): Electronic Spectrum: Qualitative description of selection

rules and Franck-Condon principles, σ, π and n molecular orbits, their energy levels and transitions, types

of electronic transition, σ → σ*, n→ σ* and π→π*, Effect of conjugation, concept of chromophores and

auxochromes, bathochromic, hypsochromic, hyperchromic and hypochromic shifts, Absorption law

(Beer-Lambert Law), molar absorptivity, principle & instrumentation of UV spectroscopy, UV spectra of

conjugated dienes and enones.

MODULE-II

Infrared Spectroscopy (IR): Vibrational Spectrum: Energy level of simple harmonic oscillator, selection

rules, pure vibrational spectrum, Basic principles of IR, molecular vibrations, instrumentation, Hooke’s

law, determination of force constant and its relation with bond energy. Characteristic absorptions of

various functional groups, Idea of vibrational frequencies of different functional groups such as

hydrocarbons, alcohols, amines, aldehydes, ketones, acids and aromatic ring, finger print region.

Nuclear magnetic resonance spectroscopy (NMR): Principle: Proton magnetic resonance (PMR),

nuclear shielding and dishielding, chemical shift and molecular structure, spin-spin coupling, coupling

constants, area of signals, Instrumentation.

Interpretation of spectra of simple organic molecules such as ethyl alcohol, ethyl bromide, acetaldehyde,

1,3-dichloro propane, 1,1,2 tribromoethane, ethyl acetate, toluene and acetophenone, structure elucidation

of simple organic compounds using UV, IR and PMR data.

MODULE-III

Mass spectroscopy: Basic principle, instrumentation, determination of molecular formula, parent and

metastable peaks, mass spectra of some organic molecules (hydrocarbon, alcohol and amines only).

Chromatography: Basic ideas on principles of chromatography, paper, column & thin layer

chromatography, gas-liquid chromatography & HPLC.

Text Books:

4. Analytical Chemistry: Y.R.Sharma, Kalyani Publishers

5. Analytical Chemistry: A.Gupta, Pragati Prakashan

6. Instrumental methods of Chemical Analysis: B.K.Sharma, Goel Publishing house.

Reference Books:

1. Basic concepts of Analytical Chemistry: S.Khopkar, New Age International Publishers

2. Principles of Instrumental Analysis: D.A.Skoog, J.L.Loary & W.B.Saunders

3. Fundamentals of Analytical Chemistry: D.A.Skoog, D.M.West, F.J.Holler & W.B.Saunders

4. Analytical Chemistry; Principles & Techniques: L.G.Hargis

5. Spectroscopy of Organic Compounds: P.S.Kalsi, New Age International

6. Spectroscopic identification of Organic Compounds: R.M.Silverstein, G.C.Bassier & T.C.Morril,

John Wiley & Sons.

7. Basic Principles of Spectroscopy: S.D.Bhattamisra, P.N.Gouda, Vishal Publishing co.

8. Fundamentals of Spectroscopy: C.N.Banwell, McGraw Hill.

MSCL 3601 CHEMISTRYLABORATORY-5 (0-0-3)

1. Determination of purity of commercial vinegar.

2. Determination of alkali content of antacid tablet using HCl.

3. Determination of surface tension & specific gravity of a liquid.

4. Determination of effect of temperature and concentration of reactant and catalyst on the rate of a

reaction.

5. Determination of absolute viscosity of a liquid.

6. Determination of strength of a strong acid and a weak acid in a mixture using potentiometer/ pH-

meter

7. Determination of the ionization constant of a weak acid conductometrically.

8. Titration of the given ferrous ammonium sulphate solution using KMnO4/K2Cr2O7 as titrant

potentiometrically and calculation of the redox potential of Fe2+/Fe3+ system on the hydrogen

scale.

9. Separation and estimation of Mg (II) and Fe (II).

10. Separation and estimation of Mg (II) and Zn (II).

Text Books:

1. Experiments in Physical Chemistry: R.C.Das and B.Behera, Tata-Mc-Graw Hills

2. Advanced Practical physical Chemistry, J.N. Gurtu and R.Kapoor

3. Selected experiments in physical Chemistry: N.G. Mukherjee, J.N. Ghose and Sons, Bharati

Bhawan

4. Vogel’s Text Book of quantitative inorganic analysis, ELBS with Longmann.

5. Hand book of preparative inorganic chemistry Vol 1& 2 Braucer, Academic Press, 2nd ed.

6. Experiments in general chemistry:C.N.R.Rao and U.C. Agarwal.Macmillian.

7. Practical Chemistry:Y.R.Sharma and R.C. Acharya, Kalyani Publisher.

MSCL 3602 CHEMISTRYLABORATORY-6 (0-0-3)

1. Determination of the-solubility and solubility product of a sparingly soluble electrolyte

conductometrically.

2. Determination of temperature dependence of EMF of a cell.

3. Determination of specific rotation of cane sugar by polarimetry.

4. Study of the saponification value of ethyl acetate conductometrically.

5. Estimation of halide by potentiometry.

6. Spectroscopic determination of Iron.

7. Estimation of metal ions (Na, K or Li) using Flame photometry.

8. Verification of Beer-Lambert law for KMnO4 /K2Cr2O7 and determination of the concentration of

the given solution of the substance:

9. Separation and identification of the sugars present in the given mixture of glucose, fructose and

sucrose by paper chromatography and determination of Rf values.

10. Separation and identification of the amino acids present in the given mixture of alanine, aspartic

acid and leucine by thin layer chromatography and determination of Rf values.

Text Books:

1. Experiments in Physical Chemistry: R.C.Das and B.Behera, Tata-Mc-Graw Hills

2. Advanced Practical Physical Chemistry, J.N. Gurtu and R.Kapoor

3. Selected experiments in physical Chemistry: N. G. Mukherjee, J. N. Ghose and Sons, Bharati

Bhawan

4. Vogel’s Text Book of quantitative inorganic analysis, ELBS with Longmann.

5. Hand book of preparative inorganic chemistry Vol 1& 2 Braucer, Academic Press, 2nd ed.

6. Experiments in general chemistry: C.N.R.Rao and U.C. Agarwal.Macmillian.

7. Practical Chemistry: Y.R.Sharma and R.C. Acharya, Kalyani Publisher.